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Search Results: 1 - 10 of 370983 matches for " Gupta P N "
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Embedded Metallic Bangle in Vagina
T Gupta,N Gupta,P Bhatia,S Gupta,J Jain
Journal of Universal College of Medical Sciences , 2014, DOI: 10.3126/jucms.v2i2.11174
Abstract: BACKGROUND: Uterovaginal prolapse is a very common morbidity among Indian women. Vaginal pessaries still have role in the management of uterovaginal prolapse. Long forgotten pessaries get incarcerated in the vagina and their removal poses problems. A 65 year old postmenopausal lady presented with pain lower abdomen and thin vaginal discharge. Speculum examination revealed embedded metallic bangle in the vagina. Attempts at removal by gentle traction resulted in pain. Metallic bangle was removed under general anaesthesia and biopsy from the overlying tissue revealed no evidence of malignancy. Vaginal pessary gives symptomatic relief and does not cause any discomfort, women tend to forget it. This case report is unique as here ordinary metallic bangle was used as a vaginal pessary and in spite of long duration it did not cause much discomfort or any serious complication.
Vaccines and Antibodies for Therapeutic Use in Cancers  [PDF]
G. P. Talwar, Jagdish C. Gupta, M. Diwan, J. Frick, S. K. Sharma, S. N. Wadhwa, R. M. Gupta, S. K. Gupta, Shilpi Purswani, Hemant K. Vyas
Journal of Cancer Therapy (JCT) , 2016, DOI: 10.4236/jct.2016.76040
Abstract: This review describes briefly the beneficial use of two vaccines developed by us for treatment of cancers. The vaccine against Luteinizing Hormone Releasing Hormone (LHRH) is effective in carcinoma of prostate as well as in breast cancers dependent on androgens and estrogens respectively. LHRH being identical in both males and females, the same vaccine is usable in both Prostate and Breast steroid hormones-dependent-cancers. Monoclonal antibodies are finding therapeutic utility in several cancers, and many have received Drugs Regulatory approval. The monoclonals developed by us against hCG and against epitopes present on androgen-independent castration resistant prostate cancers are briefly recapitulated. Anti-hCG antibodies kill several cancers expressing hCG. An example is given of A549 lung carcinoma. MoAb730 and MoAb7B2G10 kill DU-145 and PC-3 androgen-independent castration resistant prostate cancer cells. Some cancers such as MOLT-4, a T-lymphoblastic leukemia, though expressing hCG are not killed by PiPP, the high affinity anti-hCG antibody. Linking the antibody to curcumin however works like a “Magic Bullet”. All MOLT-4 cells are killed by this conjugate, the antibody homes selectively to cancer cells expressing hCG to deliver curcumin which exercises the killing effect. A recombinant vaccine, hCGβ-LTB (human chorionic gonadotropin subunit β linked to B subunit of heat-labile enterotoxin of E. coli) has been made, which induces high titre bioeffective antibodies not only in BalbC, but also in other genetic strains of mice. The vaccine employs autoclaved Mycobacterium indicus pranii (MiP) as adjuvant. MiP invigorates both humoral and cell mediated immune responses against Human chorionic gonadotropin (hCG). Besides being a potent adjuvant, MiP used alone heals anogenital warts in humans and has the property of preventing and curing SP2/O Myelomas in mice.
Which treatment for anal fistula? Cut or cover, plug or paste, loop or lift
Gupta Pravin J.,Shalini Gupta N.,Heda P.S.
Acta Chirurgica Iugoslavica , 2012, DOI: 10.2298/aci1202015g
Abstract: Anorectal fistulas are common maladies. The challenge in therapy of perianal fistulas balances between the best possible cure and the preservation of continence. Complex fistulous disease challenges even the most experienced surgical specialists. The management options in these groups of patients are inadequate, with treatment often requiring multiple procedures, causing a risk for continued symptoms and fecal incontinence. This has lead to a serious search for newer and safer treatment options. Use of different types of setons and advancement flaps have their own advantages and pitfalls. Invasive methods with high rates of incontinence have given way to sphincter-sparing methods that have a much lower associated morbidity. Treatment with fibrin glue is an attractive option whenever continence might be endangered by operative procedures. Initial results with fistula plugs are promising but need further critical observations. Recently, the ligation of fistula tract had shown few promising results though it will be too early to comment on its long-term efficacy.
Oncogenomics: Clinical pathogenesis approach
Gupta G.,Gupta N.,Trivedi S.,Patil P.
International Journal of Genetics , 2009,
Abstract: Oncogenomics is new research sub-field of genomics, which applies high throughputtechnologies to characterize genes associated with cancer and synonymous with cancer genomics. Thegoal of oncogenomics is to identify new oncogenes or tumor suppressor genes that may provide newinsights into cancer diagnosis, predicting clinical outcome of cancers, and new targets for cancer therapies.Oncoproteomics is the term used to describe the application of proteomic technologies in oncology andparallels the related field of oncogenomics. It is now contributing to the development of personalizedmanagement of cancer. Genomics has generated a wealth of data that is now being used to identifyadditional molecular alterations associated with cancer development. Mapping these alterations in thecancer genome is a critical first step in dissecting oncological pathways.
Toxicogenomics and cancer pathogenesis
Gupta N.,Gupta G.,Trivedi S.,Patil P.
International Journal of Genetics , 2009,
Abstract: Toxicogenomics is emerging field give idea of the application of large-scale differential geneexpression data to toxicology, starting to influence drug discovery and development in the pharmaceuticalindustry. Its future potential in cancer pathogenesis, study of poisons and poisoning and has an ancient andvenerable history. Toxicogenomics is the merging of toxicology with technologies that have been developed,together with bioinformatics, to identify and quantify global gene expression changes for gene therapy.Immunotoxic processes and the development of in vitro screening assays is therefore expected to be ofvalue for mechanistic insight into immunotoxicity and hazard identification of existing and novel compounds.Successful application of toxicogenomic approaches, such as DNA microarrays, inextricably relies onappropriate data management, the ability to extract knowledge from massive amounts of data and theavailability of functional information for data interpretation. Toxicogenomics is considered a valuable tool forreducing pharmaceutical candidate attrition by facilitating earlier identification, prediction and understandingof toxicities. Pharmaco-epidemiological (toxicogenomics) data is now available for both antiepileptic drugs,evidence for human carcinogenicity. Therapeutic researches converge triad of rejuvenation, regeneration orreplacement strategies that rely on self-healing processes, stem cell regeneration organ transplantation.Metastases studies usually display more genetic changes than the primary tumour. Helix-loop-helixapplication in translational and functional toxicogenomics transcription factors has been implicated indiverse cellular processes such as proliferation, apoptosis, differentiation, and migration.
Widespread dissemination of warts in prexisting dermatoses
Gupta Somesh,Gupta Usha,Tiwari N,Saraswat P
Indian Journal of Dermatology, Venereology and Leprology , 1997,
Gunther′s Disease
Gupta Somesh,Gupta Usha,Tiwari N K,Saraswat P K
Indian Journal of Dermatology , 1998,
Abstract: A three year old female child of Gunthera€ s disease with blistering over exposed parts of body, mutilation of nose and fingers, scanning alopecia and erythrodontia, is reported. Her urine was strongly positive for uropoprhyrinogen. The blistering could not be prevented by strict avoidance of sun, sunscreen with high SPF, chloroquine, high doses of activated charcoal and betacarotene, though there was significant symptomatic improvement by repeated packed erythrocyte transfusion.
Pharmacogenomics and Clinical Pathogenesis
Patil P,Gupta G,Gupta N,Trivedi S
International Journal of Pharmaceuticals Analysis , 2009,
Abstract: Pharmacogenomics are very important and refers to drug discovery based on knowledge ofgenes, but it is a discipline that offers insight into aetiologic mechanisms, and possible prevention andtreatment.
Study of Spectral Lag for Short GRBs
Varsha Gupta,Patrick Das Gupta,P. N. Bhat
Physics , 2002,
Abstract: This paper reports statistically significant correlations between various burst parameters, observed in a sample of 156 GRBs belonging to BATSE 4B catalog with T90 less than 2 s. The number of subpulses in a burst is strongly correlated not only with the object's duration but also with its fluence and hardness ratio, suggesting that when the central engine is more powerful, ejecting matter with typically higher values of Lorentz factor, the bulk energy is dissipated on longer time scales in the form of larger number of gamma pulses. We estimate hard-to-soft lag in bursts by taking the difference between centroids corresponding to time profiles at energies $> 100$ keV and $<100$ keV. The number of short GRBs that show soft-to-hard spectral evolution is slightly over one quarter of the total, in the sample considered here. Bursts that exhibit hard-to-soft spectral change appear to form a distinct class, with strength as well as hardness of individual subpeaks tending to decrease with peak position. Opposite is true for objects with softer photons arriving earlier than the harder ones, implying some kind of a rejuvenation of the central engine (may be due to enhanced accretion of matter towards the end). The two classes also show other diverging trends. For instance, objects belonging to the larger of the two classes display strong correlations between spectral lag and the fluence, the hardness ratio as well as the number of pulse, respectively. While no such correlations are seen in bursts that evolve from soft to hard. However, the magnitude of lag is strongly correlated with burst duration in both the classes.
Morphological properties of Short Duration GRBs
Varsha Gupta,Patrick Das Gupta,P. N. Bhat
Physics , 1999,
Abstract: In this paper, we study a sample of 65 short duration bursts contained in the 3B catalogue. We fit the time profiles of these GRBs with lognormal functions and study various temporal properties. In most of the multi-peaked bursts, our analysis leads to a statistical evidence for the evolution of temporal asymmetry in individual pulses i.e. subsequent pulses in a GRB, on an average, tend to be more symmetric. Using a peak asymmetry evolution parameter, we find that 90% of short duration GRBs with 3 or more peaks exhibit the above trend individually.
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