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STUDIES OF ANTI INFLAMMATORY, ANTIPYRETIC AND ANALGESIC EFFECTS OF AQUEOUS EXTRACT OF TRADITIONAL HERBAL DRUG ON RODENTS
Gupta Mradu,Banerjee Dalia,Mukherjee Arup
International Research Journal of Pharmacy , 2013, DOI: 10.7897/2230-8407.04321
Abstract: Aqueous extract of combination of stems of Tinospora cordifolia, fruits of Emblica officinalis and rhizomes of Cyperus rotundus has been used as traditional herbal drug in Indian medicine system for treatment of fever, body ache, joint pain and inflammation. The collected botanicals were subject to physiochemical, pharmacognostical & phytochemical screening before animal experiments. After acute toxicity studies, anti-inflammatory effect was assessed using carrageen induced paw oedema test and antipyretic effect using yeast induced pyrexia method. Tail immersion, hot plate and writhings test were used for determining the analgesic properties. Phytochemical analysis revealed the presence of polyphenolic flavonoids, tannin and saponins. Significant anti-inflammatory, antipyretic and analgesic properties were noticed in dose dependant manner after aqueous extract administration especially at 600 mg/kg dose. These test drug activities were sustained and comparable to the standard drugs while exhibiting no acute toxicity. Aqueous extract of test drug possesses significantly high anti-inflammatory, antipyretic and analgesic properties without any acute toxicity possibly due to presence of flavonoids.
Therapeutic Effects of Acetone Extract of Saraca asoca Seeds on Rats with Adjuvant-Induced Arthritis via Attenuating Inflammatory Responses
Mradu Gupta,Saumyakanti Sasmal,Arup Mukherjee
ISRN Rheumatology , 2014, DOI: 10.1155/2014/959687
Abstract: Saraca asoca has been traditionally used in Indian system for treatment of uterine, genital, and other reproductive disorders in women, fever, pain, and inflammation. The hypothesis of this study is that acetone extract of Saraca asoca seeds is an effective anti-inflammatory treatment for arthritis in animal experiments. The antiarthritic effect of its oral administration on Freund’s adjuvant-induced arthritis has been studied in Wistar albino rats after acute and subacute toxicities. Phytochemical analysis revealed presence of high concentrations of phenolic compounds such as flavonoids and tannins, while no mortality or morbidity was observed up to 1000?mg/kg dose during acute and subacute toxicity assessments. Regular treatment up to 21 days of adjuvant-induced arthritic rats with Saraca asoca acetone extract (at 300 and 500?mg/kg doses) increases RBC and Hb, decreases WBC, ESR, and prostaglandin levels in blood, and restores body weight when compared with control (normal saline) and standard (Indomethacin) groups. Significant ( ) inhibitory effect was observed especially at higher dose on paw edema, ankle joint inflammation, and hydroxyproline and glucosamine concentrations in urine. Normal radiological images of joint and histopathological analysis of joint, liver, stomach, and kidney also confirmed its significant nontoxic, antiarthritic, and anti-inflammatory effect. 1. Introduction Arthritis affects around 0.5–1% of the world population with more women being affected than men. The immune system is a well-organized and well-regulated structure. The deregulation of the immune system may lead to the development of autoimmune diseases such as Rheumatoid arthritis (RA) which is a prototype of the groups of illnesses with chronic systemic disorders with destructive inflammatory polyarticular joint potentially resulting in progressive destruction of articular and periarticular structure. Persistent inflammation produces swollen joints with severe synovitis, decreased nociceptive threshold, and massive subsynovial infiltration of mononuclear cells, which along with angiogenesis leads to pannus formation. Expansion of the pannus induces bone erosion and cartilage thinning, leading to the loss of joint function in due course. This results in a high degree of morbidity and disturbed daily life of the patient. Corticosteroids have not been able to fully control the incidence because of its limitations and risk of side effects. Many patients and practitioners are seeking alternative approach to provide an effective cure in the treatment of arthritis and to
Selected Topics Of Dermatophysics
Gupta
Indian Journal of Dermatology , 1995,
Abstract:
Social determinants of health—Street children at crossroads  [PDF]
Anjali Gupta
Health (Health) , 2012, DOI: 10.4236/health.2012.49100
Abstract: 1The term “street children” has been used inter changeably with “children in especially difficult circumstances” in the remaining document. This paper discusses the findings of a research project which is an exploratory cum descriptive study [1] that aims to describe and examine the state and nature of the quality of life of street children accommodated at an unorganised colony in the city of Delhi. It provides a social profile of children and their families, and exploring the needs and aspirations of these children living in especially difficult circumstances. A non-probability sample of 100 street children in the age group of 5-16 years was randomly selected guided by their availability. An interview schedule was constructed and administered to gather data. The statistical analyses comprised frequencies and percentages on all the sections of the interview schedule. Thematic content analysis was used to analyse data from open-ended questions and observations. Case studies were supportive in giving an insight into the lives of children living in especially difficult circumstances. Findings suggest that the quality of life of the participants in this study was depressed due to a lack of access or substandard educational and medical facilities, or absence of emotional support from their poverty stricken families. The existing limited programmes by the government or the civil society for the welfare of street children are lacking in their focus and do not include the voices and needs of the beneficiaries. Although service providers expressed sympathy for street children, many regarded them as deviants, delinquents, future criminals, and a public nuisance. Based on the findings, it has been suggested that the street child phenomenon necessitates a partnership between governmental and non-governmental organizations to provide for policy and legislation, funding and resources to translate programs into concrete plans of action. It has further been argued that such an approach should extend to children using their resourcefulness and creativity, and show that they can be significant in development interventions. Children illustrate both the need for participatory approaches and the problems that arise when perceptions of participants conflict with those of experts.
Ectopic Autosomal Dominant Polycystic Kidney Disease (ADPKD)—An Extremely Rare Radiological Finding  [PDF]
Manish Gupta
Open Journal of Radiology (OJRad) , 2014, DOI: 10.4236/ojrad.2014.41015
Abstract:

ADPKD is an inherited systemic disorder that predominantly affects the kidney, but may affect other organs including liver, pancreas, brain, and arterial blood vessel. APKPD occurs worldwide affecting about 1 in 500 - 1000 people. Hypertension is the most common manifestation of ADPKD and the major contributor to renal disease progression. A definite diagnosis of ADPKD relies on image testing. Renal ultrasound is commonly used because of its cost effectiveness.

A Rare Case of Acute Cerebrovascular Accident in the Post-Partum Period after Primary Angioplasty during Pregnancy  [PDF]
Ruchi Gupta
International Journal of Clinical Medicine (IJCM) , 2015, DOI: 10.4236/ijcm.2015.612118
Abstract: Pregnancy-related acute myocardial infarction is rare, but a serious event. We report a case of acute myocardial infarction in a 33-year-old female with 5 months of pregnancy. Angiography, under abdominal shield, revealed 100% thrombotic occlusion in the left anterior descending artery, which was treated successfully with a stent implantation. The patient was found to have hyperhomocysteinemia within the first week of primary percutaneous coronary intervention (PCI). Rest of the follow-up was uneventful with delivery of a healthy baby by elective caesarean section at about 36 weeks of gestation. Within 7 days of post-partum period, the patient displayed signs of cerebrovascular infarction and was managed successfully. To the best of our knowledge, the association between primary PCI during pregnancy and cerebrovascular event in the postpartum period has not been reported previously.
An Exploratory Case Study in Designing and Implementing Tight Versus Loose Frameworks  [PDF]
Manjari GUPTA, Ratneshwer GUPTA, A. K. TRIPATHI
Journal of Software Engineering and Applications (JSEA) , 2009, DOI: 10.4236/jsea.2009.23029
Abstract: Frameworks provide large scale reuse by providing skeleton structure of similar applications. But the generality, that a framework may have, makes it fairly complex, hard to understand and thus to reuse. Frameworks have been classified according to many criteria. This paper proposes two types of framework (based on the concept of ‘generality’) named as: tight framework and loose framework. A case study is done by developing loose and tight frameworks for the appli-cation sets of Environment for Unit testing (EUT) domain. Based on the experience that we got by during this case study, we tried to find out the benefits of one (tight or loose) framework over the other. This work attempts to provide an initial background for meaningful studies related to the concept of ‘Design and Development of Framework’.
Co-Orelation of Histological Dating and Glycogen Content by Histochemical Stain during Various Phases of Menstrual Cycle in Primary Infertility  [PDF]
Anshu Gupta, S. K. Mathur, Anjali Gupta
Open Journal of Pathology (OJPathology) , 2013, DOI: 10.4236/ojpathology.2013.32012
Abstract:

Glycogen and its products of metabolism are considered to be the most important and direct source of nutrient for the early conceptus. The premenstrual biopsies were taken from 100 women with primary infertility whose male partners had normal semenograms. The biopsies were then subjected to Haematoxylin and Eosin (H & E) and Periodic Acid Schiff (PAS) staining with and without diastase to study histological and histochemical changes particularly glycogen content in the endometrium respectively. Histolomorphologic spectrum of endometrium on H & E stained sections revealed early proliferative phase (4%), late proliferative phase (7%) and early secretory phase (7%), mid secretory phase (33%) and late secretory phase (49%). PAS staining with or without diastase for glycogen was performed and glycogen content, as demonstrated by magenta color, was graded from + to ++++. Glycogen content was observed to be + to ++ in proliferative phase, where as in secretory phase, it varied from ++ to +++. Glycogen was confirmed by treatment with diastase enzyme, after that PAS stain gave negative staining, i.e. loss of magenta color as glycogen was digested by diastase. Glycogen deficiency was observed in 24.7% of secretory phase endometrium of infertile women. Depletion of glycogen results in inadequate preparation of endometrium at the time of implantation, and hence, may be one of the causes of infertility.

Design of Aperture Coupled Microstrip Antenna Using Radial Basis Function Networks  [PDF]
Tanushree Bose, Nisha Gupta
Wireless Engineering and Technology (WET) , 2010, DOI: 10.4236/wet.2010.12010
Abstract: This paper, two Artificial Neural Network (ANN) models using radial basis function (RBF) nets are developed for the design of Aperture Coupled Microstrip Antennas (ACMSA) for different number of design parameters. The effect of increasing the number of design parameters on the ANN model is also discussed in this work. The performances of the models when compared are found that on decreasing the number of design parameters, accuracy of the model is in-creased. The results given by the prepared models are comparable with the results of the IE3D software. So, these models are accurate enough to measure the design parameters of ACMSAs. Thus the neural network approach elimi-nates the long time consuming process of finding various designing parameters using costly software packages.
Brain initiated interaction  [PDF]
Rajesh Singla, Balraj Gupta
Journal of Biomedical Science and Engineering (JBiSE) , 2008, DOI: 10.4236/jbise.2008.13028
Abstract: Brain-Computer Interfaces (BCI) are developed to help locked-in patients, who lose control of their bodies and are unable to perform simple tasks such as speech, locomotion, and can’t even effectively interact, with their environment. BCI shows promise in allowing these individuals to interact with a computer using EEG. A Brain Computer Interface is a communication system in which messages or commands that an indi-vidual sends to the external world do not pass through the brain’s normal output pathways of peripheral nerves and muscles. A system is created to allow individuals with motor disabili-ties to control the motion of the bed on which they are bedridden via BCI for drug delivery and other activities, with the help of eye motion and changes in the absolute power in alpha rhythms of an EEG signal of the patient.
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