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Comments on the article ′Antimicrobial and analgesic activities of Wendlandia thyrsoidea leaf extracts′
Gupta Kanchan,Chopra S,Kaushal Sandeep
International Journal of Green Pharmacy , 2010,
Abstract:
A rare association of spontaneous pneumorrhachis with spondylolisthesis and lumbosacral vacuum phenomenon: A case report with review of literature
Kumaran Sunitha,Gupta Kanchan,Singh Shambanduram
Neurology India , 2011,
Abstract: Spontaneous pneumorrhachis, non-traumatic, non-iatrogenic air within the spinal canal, is a very rare occurrence. We report a case of spontaneous pneumorrhachis, multiple air pockets in the epidural space, with vacuum discs and spndylolisthesis. Probably this is the first report of such case.
Suppressor of Cytokine Signalling-6 Promotes Neurite Outgrowth via JAK2/STAT5-Mediated Signalling Pathway, Involving Negative Feedback Inhibition
Sakshi Gupta, Kanchan Mishra, Avadhesha Surolia, Kakoli Banerjee
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0026674
Abstract: Background Suppressors of cytokine signalling (SOCS) protein family are key regulators of cellular responses to cytokines and play an important role in the nervous system. The SOCS6 protein, a less extensively studied SOCS family member, has been shown to induce insulin resistance in the retina and promote survival of the retinal neurons. But no reports are available about the role of SOCS6 in neuritogenesis. In this study, we examined the role of SOCS6 in neurite outgrowth and neuronal cell signalling. Methodology/Principal Findings The effect of SOCS6 in neural stem cells differentiation was studied in neural stem cells and PC12 cell line. Highly elevated levels of SOCS6 were found upon neural cell differentiation both at the mRNA and protein level. Furthermore, SOCS6 over-expression lead to increase in neurite outgrowth and degree of branching, whereas SOCS6 knockdown with specific siRNAs, lead to a significant decrease in neurite initiation and extension. Insulin-like growth factor-1 (IGF-1) stimulation which enhanced neurite outgrowth of neural cells resulted in further enhancement of SOCS6 expression. Jak/Stat (Janus Kinase/Signal Transducer And Activator Of Transcription) pathway was found to be involved in the SOCS6 mediated neurite outgrowth. Bioinformatics study revealed presence of putative Stat binding sites in the SOCS6 promoter region. Transcription factors Stat5a and Stat5b were involved in SOCS6 gene upregulation leading to neuronal differentiation. Following differentiation, SOCS6 was found to form a ternary complex with IGFR (Insulin Like Growth Factor-1 Receptor) and JAK2 which acted in a negative feedback loop to inhibit pStat5 activation. Conclusion/Significance The current paradigm for the first time states that SOCS6, a SOCS family member, plays an important role in the process of neuronal differentiation. These findings define a novel molecular mechanism for Jak2/Stat5 mediated SOCS6 signalling.
Diagnosis of intracranial hydatid cyst by magnetic resonance spectroscopy
Gupta Kanchan,Rajeswaran Rangasami,Joseph Santosh,Ganesh Krishnamurthy
Journal of Pediatric Neurosciences , 2008,
Abstract:
Prescribing pattern of antibiotics in the department of pediatrics in a tertiary care medical college hospital in Northern India
Ravika Kanish, Kanchan Gupta, Shivani Juneja, HS Bains, Sandeep Kaushal
Asian Journal of Medical Sciences , 2014, DOI: 10.3126/ajms.v5i4.10213
Abstract: Background: Systemic antibiotics account for more than one?third of all prescriptions in children; hence, antibiotic prescriptions in children are a major public health concern. Moreover, data regarding rational antibiotic use in children is very limited. Hence, it is essential that the antibiotic prescribing pattern be evaluated periodically for its rationality of use and cost. The aim of our study is to identify the prescribing pattern and to carry out direct cost analysis of antibiotic use in the patients admitted in pediatrics department of a tertiary care hospital of North India. Methods: The study was conducted for two months (June, July, 2012) in pediatric ward and ICU. The data regarding patient demographics and antibiotic use was collected daily in a structured proforma. A descriptive analysis of the data was done. Results: A total of one hundred and ninety one patients were enrolled, most of them belonging to the age group 2?14 years. Majority of them were male pediatric patients (75.9%) with mean age of 4.6 years. On an average 1.9 AMAs were prescribed per patient. The most common AMAs prescribed were cephalosporins followed by aminoglycosides. The preferred route of administration was injectable (92%). The average direct cost of treatment per patient was estimated to be Rs. 3338. The percentage of drugs prescribed by generic name was 58%. Conclusions: Male pediatric patients have better access to tertiary medical care as compared to female pediatric patients. The average number of anti?microbials prescribed is 1.9 which is not too high. Newer generation of antibiotics are more commonly prescribed leading to increased cost of therapy. This baseline study will help in formulating an antibiotic policy and standard treatment guidelines for appropriate use of antibiotics. DOI: http://dx.doi.org/10.3126/ajms.v5i4.10213 Asian Journal of Medical Sciences 2014 Vol.5(4); 69-72
Aggressive nasopharyngeal carcinoma presenting as diminution of vision: a case report
Kaleem Ahmad, Sajid Ansari, Kanchan Dhungel, Mukesh Kumar Gupta, Raj Kumar Rauniyar, Mohammad Azfar Siddiqui
Asian Journal of Medical Sciences , 2014, DOI: 10.3126/ajms.v5i2.8297
Abstract: Nasopharyngeal carcinoma is a malignant disease and is more common in males than in females with M:F ratio of 3:1. It has a bimodal peak at 16-20 and 46-50 years of age. Orbital involvement is seen in 3.2% and bilateral orbital invasion occurs in 0.7% of patients with nasopharyngeal carcinoma. Imaging has significant role in detecting the early nasopharyngeal carcinoma, tumor staging, involvement of lymph node, monitoring the patients after the therapy, to detect recurrence and radiation associated changes in the soft tissue and bone. We report a case of aggressive nasopharyngeal carcinoma in 22 years old male who presented with rapidly progressive diminution of vision. DOI: http://dx.doi.org/10.3126/ajms.v5i2.8297 Asian Journal of Medical Science, Volume-5(2) 2014: 130-133
Extraocular Myocysticercosis Involving Levator Palpebrae Superioris-Superior Rectus Complex: A Rare case Report
Sajid Ansari, Mukesh Kumar Gupta, Kaleem Ahmad, Kanchan Dhungel, Abhishek Kumar, Raj Kumar Rauniyar
Asian Journal of Medical Sciences , 2013, DOI: 10.3126/ajms.v4i4.8163
Abstract: The ocular involvement of the cysticercosis is a rare entity involving eyelids, extraocular muscles, orbit, conjunctiva, anterior chamber, uvea, retina, vitreous and optic nerve. All the extraocular muscles are involved in myocysticercosis. Ultrasonography and Computed tomography are the imaging modalities for evaluation of ocular cysticercosis. The patients can be treated with systemic steroids and albendazole; however surgical excision is the treatment of choice. We report a rare case of extraocular myocysticercosis in nine years old boy diagnosed on ultrasonography and computed tomography. Asian Journal of Medical Science, Volume-4 (2013), Pages 36-39 DOI: http://dx.doi.org/10.3126/ajms.v4i4.8163 ?
Review of Build It Now: Socialism for the Twenty-First Century
Kanchan Sarker
Studies in Social Justice , 2009,
Abstract:
Cost-effectiveness of childbirth strategies for prevention of mother-to-child transmission of HIV among mothers receiving nevirapine in India
Mukherjee Kanchan
Indian Journal of Community Medicine , 2010,
Abstract: Background: Mother-to-child transmission of HIV is an important mode of spread of HIV in India. With strategies like caesarian section and nevirapine therapy, this spread has been reduced. However, they have costs attached. In this context, this paper attempts to compare the cost-effectiveness of alternative childbirth strategies among HIV-positive mothers receiving nevirapine. Materials and Methods: Using sentinel surveillance data from three districts in Tamil Nadu, a model was created to test the cost-effectiveness of vaginal delivery against elective caesarian section among mothers receiving nevirapine. Sensitivity analysis was applied to evaluate cost per HIV infection prevented. Results: Vaginal delivery is not only cheaper in HIV-infected mothers receiving nevirapine but also cost-effective as compared to elective caesarian section. The incremental cost for preventing an additional HIV infection through caesarian section was Rs. 76,000. Sensitivity analysis reveals that the findings are robust over a range of HIV transmission probabilities, 0.04-0.14 for vaginal delivery and 0.00-0.02 for caesarian section. Conclusions: From a clinical perspective, the findings suggest that pregnant HIV-infected women receiving nevirapine should consider the benefits of a cheaper and safer vaginal delivery. From an economic perspective, the findings support the strategy of vaginal delivery in mothers receiving nevirapine.
Sirenomelia
Kanchan Kayastha
APSP Journal of Case Reports , 2010,
Abstract: A case of sirenomelia is being presented.
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