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Search Results: 1 - 10 of 11497 matches for " Guoxiang Cai "
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Better Long-Term Survival in Young Patients with Non-Metastatic Colorectal Cancer after Surgery, an Analysis of 69,835 Patients in SEER Database
Qingguo Li, Guoxiang Cai, Dawei Li, Yuwei Wang, Changhua Zhuo, Sanjun Cai
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0093756
Abstract: Objective To compare the long-term survival of colorectal cancer (CRC) in young patients with elderly ones. Methods Using Surveillance, Epidemiology, and End Results (SEER) population-based data, we identified 69,835 patients with non-metastatic colorectal cancer diagnosed between January 1, 1988 and December 31, 2003 treated with surgery. Patients were divided into young (40 years and under) and elderly groups (over 40 years of age). Five-year cancer specific survival data were obtained. Kaplan-Meier methods were adopted and multivariable Cox regression models were built for the analysis of long-term survival outcomes and risk factors. Results Young patients showed significantly higher pathological grading (p<0.001), more cases of mucinous and signet-ring histological type (p<0.001), later AJCC stage (p<0.001), more lymph nodes (≥12 nodes) dissected (p<0.001) and higher metastatic lymph node ratio (p<0.001). The 5-year colorectal cancer specific survival rates were 78.6% in young group and 75.3% in elderly group, which had significant difference in both univariate and multivariate analysis (P<0.001). Further analysis showed this significant difference only existed in stage II and III patients. Conclusions Compared with elderly patients, young patients with colorectal cancer treated with surgery appear to have unique characteristics and a higher cancer specific survival rate although they presented with higher proportions of unfavorable biological behavior as well as advanced stage disease.
Prognostic and Predictive Value of CpG Island Methylator Phenotype in Patients with Locally Advanced Nonmetastatic Sporadic Colorectal Cancer
Yuwei Wang,Yadong Long,Ye Xu,Zuqing Guan,Peng Lian,Junjie Peng,Sanjun Cai,Guoxiang Cai
Gastroenterology Research and Practice , 2014, DOI: 10.1155/2014/436985
Abstract: Purpose. In the present study, the prognostic significance of CpG island methylator phenotype (CIMP) in stage II/III sporadic colorectal cancer was evaluated using a five-gene panel. Methods. Fifty stage II/III colorectal cancer patients who received radical resection were included in this study. Promoter methylation of p14ARF, hMLH1, p16INK4a, MGMT, and MINT1 was determined by methylation specific polymerase chain reaction (MSP). CIMP positive was defined as hypermethylation of three or more of the five genes. Impact factors on disease-free survival (DFS) and overall survival (OS) were analyzed using Kaplan-Meier method (log-rank test) and adjusted Cox proportional hazards model. Results. Twenty-four percent (12/50) of patients were characterized as CIMP positive. Univariate analysis showed stage III ( ) and CIMP positive ( ) patients who had significantly inferior DFS. In Cox regression analysis, CIMP positive epigenotype was independently related with poor DFS with HR = 2.935 and 95% CI: 1.193–7.220 ( ). In patients with CIMP positive tumor, those receiving adjuvant chemotherapy had a poor DFS than those without adjuvant chemotherapy ( ). Conclusions. CIMP positive was significantly correlated with decreased DFS in stage II/III colorectal cancer. Patients with CIMP positive locally advanced sporadic colorectal cancers may not benefit from 5-fluorouracil based adjuvant chemotherapy. 1. Introduction Colorectal cancer is a major cause of mortality and morbidity throughout the world. With adjuvant chemotherapy as standard management following surgery to treat stage III and stage II patients with high risk factors, the 5-year relative survival rate of locally advanced colorectal cancer was still 69.2% compared with 90.1% among patients with localized disease [1], which highlighted the need of better prognostic and predictive markers to identify those high-risk individuals. Promoter CpG island hypermethylation resulting in the transcriptional silencing of tumor suppressor genes has been widely observed in colorectal cancer and been increasingly recognized to contribute to the pathogenesis of colorectal cancer. The subset of colorectal cancers with exceptionally high frequency of CpG island methylation were referred to as CpG island methylator phenotype (CIMP) [2] and showed distinct clinicopathological characteristics [3–5]. Tumor-specific hypermethylated loci of p14ARF, hMLH1, p16INK4a, MGMT, and MINT1 were proved to be closely related with colorectal cancers [2, 6]. However, the prognostic and predictive value of CIMP in sporadic locally advanced
Pathological Features and Survival Outcomes of Young Patients with Operable Colon Cancer: Are They Homogeneous?
Qingguo Li, Changhua Zhuo, Guoxiang Cai, Hongtu Zheng, Dawei Li, SanJun Cai
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0102004
Abstract: Objective To compare the pathological features and survival outcomes at different age subgroups of young patients with colon cancer. Methods Using Surveillance, Epidemiology, and End Results (SEER) population-based data, we identified 2,861 young patients with colon cancer diagnosed between 1988 and 2005 treated with surgery. Patients were divided into four groups: group 1 (below 25 years), group 2 (26–30 years), group 3 (31–35 years) and group 4 (36–40 years). Five-year cancer specific survival data were obtained. Kaplan-Meier methods were adopted and multivariable Cox regression models were built for the analysis of long-term survival outcomes and risk factors. Results There were significant different among four groups in pathological grading, histological type, AJCC stage, current standard (≥12 lymph nodes retrieval), mean number of lymph nodes examined and positive lymph nodes (p<0.001). The 5-year cause specific survival was 71.0% in group 1, 75.1% in group 2, 80.6% in group 3 and 82.5% in group 4, which had significant difference in both univariate (P = 0.002) and multivariate analysis (P = 0.041). Conclusions Young patients with colon cancer at age 18–40 years are essentially a heterogeneous group. Patients at age 31–35, 36–40 subgroups have more favorable clinicopathologic characteristics and better cancer specific survival than below 30 years.
结直肠癌腹膜转移的多学科综合治疗
Multidisciplinary treatment of colorectal cancer peritoneal metastasis

蔡国响,孟献珂,蔡三军
CAI Guoxiang
, MENG Xianke, CAI Sanjun

- , 2015, DOI: 10.3969/j.issn.1007-3969.2015.11.008
Abstract: 腹膜转移是结直肠癌常见转移部位之一,传统观念认为其预后差,没有手术治疗的价值。近年来,随着外科技术、精确控温的腹腔热灌注化疗以及多学科综合治疗的进步,对结直肠癌腹膜转移的认识和治疗策略发生很大的变化,拟就这一问题进行综述。在预后方面,如果仅行姑息性化疗,结直肠癌腹膜转移的预后差于肝、肺等非腹膜部位的转移;但对于一部分合适的患者施行完全性腹膜减瘤术联合腹腔热灌注化疗,则可能使部分患者获得长期生存;腹膜转移癌的预后因素包括腹膜播散癌指数、减瘤术完全性程度、是否合并腹膜外转移(肝脏等)、腹膜表面疾病严重程度评分和日本腹膜分期等。在治疗方面,完全性腹膜减瘤术联合腹腔热灌注化疗以及全身治疗(化疗+靶向治疗),可能是最佳的多学科综合治疗策略。
Adjuvant therapy for T3N0 rectal cancer in the total mesorectal excision era- identification of the high risk patients
Ji Zhu, Ye Xu, Weilie Gu, Junjie Peng, Gang Cai, Guoxiang Cai, Wenjie Sun, Weiqi Shen, Sanjun Cai, Zhen Zhang
Radiation Oncology , 2010, DOI: 10.1186/1748-717x-5-118
Abstract: A total of 122 patients with T3N0 rectal cancer were analyzed in this study from January 2000 to December 2005. Clinicopathologic and biomarkers were used to predict local recurrence (LR), disease-free survival (DFS), and overall survival (OS).The median follow-up interval was 45.4 months. Five-year LR, DFS, and OS rates were 10.4%, 68.3%, and 88.7%. Having a lower tumor location and showing low P21 and high CD44v6 expression were identified as risk factors for LR: patients with two or three of these risk factors had a higher 5-year LR rate (19.3%) than did patients with none or one of these risk factors (6.8%) (p = 0.05). A poorer DFS was related to low P21 nor high CD44v6 expression but not to tumor location: the 5-year DFS rates were 79.3% for those with neither, 65.9% for those with either one or the other, and 16.9% for those with both (p = 0.00).The prognostic model including tumor location, P21 and CD44v6 expressions could help to distinguish these patients with high risk T3N0 patients and determine whether adjuvant therapy was beneficial.Current guidelines from the National Comprehensive Cancer Network recommend that all patients with clinical stage II/III rectal cancer should be treated with preoperative chemoradiation followed by total mesorectal excision (TME). However, whether patients with T3N0 rectal cancer, i.e., those with tumors invades through the muscularis propria into perirectal fasia but no invasion of adjacent organs, and without lymph nodes invasion, should undergo such therapy is still controversial. It is believed that not all T3N0 patients but those with high risk patients should be treated. Clinical assessments of T and N status are mainly based on findings from clinical examination, supplemented by magnetic resonance imaging (MRI) and endoscopic ultrasonography (EUS). However, this approach has led to over- or under-staging of disease in approximately 20% of cases, leading to speculation that those patients may not have gotten optimal th
OPTIMUM DESIGN OF HIGH GAIN MICROSTRIP ANTENNAS COVERED WITH DIELECTRIC LAYERS
介质加盖高增益微带天线的优化

Meng Qingxiang,Zhu Shouzheng,Cai Guoxiang,
孟庆翔
,朱守正,蔡国祥

电子与信息学报 , 1998,
Abstract: In this paper an optimum design method for high gain microstrip antenna covered with dielectric layers is proposed. In the method, the moment method and optimization for the gain of a point source model are used to find the optimum thickness for every dielectric layer, so that the highest antenna gain can be acquired. Besides, the use of point source model much decreased the computation needed in the method. The calculated results also show that the high gain microstrip antennas covered with dielectric layers can still have rather high radiation efficiency.
Gene Expression Analysis of Peripheral Blood Cells Reveals Toll-Like Receptor Pathway Deregulation in Colorectal Cancer
Ye Xu, Qinghua Xu, Li Yang, Fang Liu, Xun Ye, Fei Wu, Shujuan Ni, Cong Tan, Guoxiang Cai, Xia Meng, Sanjun Cai, Xiang Du
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0062870
Abstract: Colorectal cancer is the leading cause of cancer-related deaths worldwide. The disease is curable when detected at an early stage. However, the compliance rate with current screening recommendations remains poor. An accurate, minimally invasive blood test that has the potential for greater patient compliance would be a welcome addition to the current methods. Recent data have shown that gene expression profile of peripheral blood cells can reflect disease states and thus have diagnostic value. In this study, genome-wide gene expression profiling of peripheral blood cells from 20 healthy controls and 20 colorectal cancer patients were performed using PAXgene? technology and Affymetrix GeneChip? microarrays. We identified a list of 1,469 genes that were differentially expressed between the healthy controls and cancer patients. Gene annotation and functional enrichment analysis revealed that those genes are mainly related to immune functions. Particularly, a set of genes belonging to the Toll-Like Receptor pathways were up-regulated in the colorectal cancer patients. These findings provide a new understanding of blood gene expression profile in colorectal cancer. Our result may serve as the basis for further development of blood biomarkers for the diagnosis and treatment of colorectal cancer.
Signal Detection Based on Walsh Transform for Spectrum Sensing  [PDF]
Guoxiang Yang, Guangliang Ren, Kun Wu
Communications and Network (CN) , 2013, DOI: 10.4236/cn.2013.53B2070
Abstract: Spectrum sensing is a key technology to improve spectrum efficiency. In this paper, we propose a novel signal detection method based on Walsh transform for spectrum sensing. The main idea behind is that the received signal is transformed into another domain by Walsh transform and the test statistic is obtained by exploiting the feature of the useful signal in the new domain. The new method can perform well at low signal-to-noise rate (SNR). Simulation results show that the proposed method has better performance than the spectral feature detection based on power spectrum.
Paeoniflorin Inhibits Pulmonary Artery Smooth Muscle Cells Proliferation via Upregulating A2B Adenosine Receptor in Rat
Guoqing Qian, Jin Cao, Chan Chen, Liangxing Wang, Xiaoying Huang, Cheng Ding, Xueding Cai, Fengying Yin, Jinguo Chu, Guoxiang Li, Jinyan Ye
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0069141
Abstract: Paeoniflorin (PF), which is the main active ingredient in the root of Paeonia Radix, has many pharmacological effects. Here, we investigated the effect of PF on rat pulmonary artery smooth muscle cells (PASMCs) under hypoxic conditions and explored the mechanisms of the effects. The anti-proliferative effect of PF increased in a dose dependent manner. At the highest dose (20 μmol/L), the anti-proliferative effect of PF peaked at 24 h after administration. However, the selective A2B adenosine receptor (A2BAR) antagonist MRS1754 abolished it. PF increased A2BAR mRNA levels from 0.0763±0.0067 of β-actin mRNA levels (hypoxia group) to 0.1190±0.0139 (P<0.05) measured by Real Time Reverse Transcription-Polymerase Chain Reaction. A2BAR protein expression measured by Western Blot was also increased. PF inhibited the proliferation of PASMCs by blocking cell cycle progression in the S phase. These data indicated that activation of A2BAR might be involved in the anti-proliferative effect of PF on PASMCs under hypoxic conditions. The results suggested that a new mechanism of PF could be relevant to the management of clinical hypoxic pulmonary hypertension.
A Key-Lock Access Control
Huang Guoxiang,Liu Jian
计算机科学技术学报 , 1987,
Abstract: Access control is one of the serious problems in modern information systems.In this paperwe suggest a key-lock strategy to represent the privilege relationship involving lineartransformations and nonlinear constraints.The implementation shows that this strategy hasgot the properties of security,and information hidden,and satisfies the least privilege principle,This distributed management of sensitive data adapts the distributed systems well.
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