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Search Results: 1 - 10 of 78309 matches for " Guoqiang Chen "
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Current advances in the application of proteomics in apoptosis research
LiShun Wang,GuoQiang Chen
Science China Life Sciences , 2011, DOI: 10.1007/s11427-010-4123-0
Abstract: Apoptosis, or programmed cell death, is a complex, genetically-determined process involved in the development and maintenance of homeostasis in multicellular organisms. Dysregulation of apoptosis has been implicated in a number of diseases, including cancer and autoimmune disease. Thus, the investigation of apoptotic regulation has evoked considerable interest. Many apoptotic proteins have been shown to be post-translationally modulated, such as by protein cleavage, translocation, protein-protein interaction, and various post-translational modifications, which fall precisely within the range of proteomic analysis. Recently, contemporary proteomic technologies have achieved significant advances and have accelerated research in functional and chemical proteomics, which have been applied to the field of apoptosis research and have the potential to be a driving force for the field. This review highlights some of the major achievements in the application of proteomics in apoptosis research and discusses new directions and challenges for the near future.
Space-variant polarized Airy beam
Hao Chen,Guoqiang Li
Physics , 2015,
Abstract: We experimentally generate an Airy beam with polarization structure while keeping its original amplitude and phase profile intact. This class of Airy beam preserves the acceleration properties. By monitoring their initial polarization structure we have provided insight concerning the self-healing mechanism of Airy beams. We investigate both theoretically and experimentally the self-healing polarization properties of the space-variant polarized Airy beams. Amplitude as well as the polarization structure tends to reform during propagation in spite of the severe truncation of the beam by finite apertures.
Energy flow structuring in the focused field
Hao Chen,Guoqiang Li
Physics , 2015,
Abstract: We propose an iterative method of energy flow shaping in the focal region with the amplitude, phase and polarization modulation of incident light. By using an iterative optimization based on the diffraction calculation with help of the fast Fourier transform, we can tailor the polarization and phase structure in the focal plane. By appropriate design of the polarization and phase gradients, arbitrary energy flow including spin and orbital parts can be designed and tailored independently. The capability of energy flow structuring is demonstrated by the measurement of the Stokes parameters and self-interference pattern. This provides a novel method to control the vectorial feature of the focal volume.
Study on the Performance Optimization of Knitted Fabric Anti-Roll by Tissue Structure  [PDF]
Guoqiang Chen, Yanan Zhu
Journal of Materials Science and Chemical Engineering (MSCE) , 2018, DOI: 10.4236/msce.2018.64001
Will use the same number of positive and negative coil longitudinal organization of fabric is ta edge sex used in the work of the organization to warp fabric edge sex, between restrained knitting principle, design a kind of weft basketwork weaving method, especially in weft knitting machine woven from has the edge of weft knitted fabric performance weaving method. In order to overcome the existing technology aims to make weft basketwork structure of a single organization, edge sex is bad, or can’t produce rich weft knitted fabric appearance of shortage, provide a resistance to edge weft knitted fabric weaving method.
The coast evolution and regulation in Wanquan River Estuary, Hainan Island

GAO Jianhua,CHEN Guoqiang,

地理学报 , 2004,
Abstract: In this paper, sediment samples were collected along the Wanquan beaches and sieved in the laboratory in order to obtain the grain size distributions and associated parameters, i.e. mean grain size, sorting coefficient and skewness. Furthermore, we have calculated the longshore drift sediment transport rates and equilibrium cross-sectional areas of the entrance channel by using the method of sedimentary dynamics. The results indicate that the longshore drift sediment transport is dominated by waves with a direction from south to north, which result in rapid changes of the entrance channel. Therefore, some suggestions were proposed for improving the water quality and restoring the ecosystem of estuary. The engineering method includes increasing the sea-route of entrance channel, tidal prism and water exchanges in Shamei Lagoon.
Screening of Microalgae for Biodiesel Feedstock  [PDF]
Xi Chen, Guoqiang He, Zhiping Deng, Nan Wang, Wei Jiang, Sanfeng Chen
Advances in Microbiology (AiM) , 2014, DOI: 10.4236/aim.2014.47044

Three heterotrophic microalgae identified as Scenedesmus sp. Y5, Scenedesmus sp. Y7 and Chorellasp. Y9 were isolated and screened from natural water based on biomass yield and lipid productivity. Fatty acids’ composition analysis showed that both Y5 and Y7 mainly contained C16:0, C18:1 (n - 9), C18:2 (n - 6) and C18:3 (n - 3) and Y9 mainly contained C16:0, C18:0 and C18:2 (n - 6), suggesting that these microalgae can be ideal feedstock for biodiesel. Considering the specific growth rate and lipid productivity, the culture conditions were optimized for Scenedesmus sp. Y5, Scenedesmus sp. Y7 and Chorellasp. Y9. Based on the optimization of cultural conditions, all of these three microalgae were tested in fed-batch fermentation, and their biomass productivities were 4.960 g·L-1·d-1, 5.907 g·L-1·d-1 and 4.038 g·L-1

Reconstruction of cytosolic fumaric acid biosynthetic pathways in Saccharomyces cerevisiae
Guoqiang Xu, Liming Liu, Jian Chen
Microbial Cell Factories , 2012, DOI: 10.1186/1475-2859-11-24
Abstract: In this study, the fumarate biosynthetic pathway involving reductive reactions of the tricarboxylic acid cycle was exogenously introduced in S. cerevisiae by a series of simple genetic modifications. First, the Rhizopus oryzae genes for malate dehydrogenase (RoMDH) and fumarase (RoFUM1) were heterologously expressed. Then, expression of the endogenous pyruvate carboxylase (PYC2) was up-regulated. The resultant yeast strain, FMME-001 ↑PYC2 + ↑RoMDH, was capable of producing significantly higher yields of fumarate in the glucose medium (3.18 ± 0.15 g liter-1) than the control strain FMME-001 empty vector.The results presented here provide a novel strategy for fumarate biosynthesis, which represents an important advancement in producing high yields of fumarate in a sustainable and ecologically-friendly manner.Fumaric acid, a four-carbon dicarboxylic acid, is widely used in modern day industries ranging from materials to human and animal food and therapeutic drugs. Its abilities to be converted into pharmaceutical products and act as starting material for polymerization and esterification reactions have led to the U.S. Department of Energy to designate fumaric acid among the top 12 biomass building-block chemicals with potential to significantly enhance the economy [1]. Fumaric acid is currently produced in large scale by one of three different routes: (i) chemical synthesis; (ii) enzymatic catalysis; and (iii) fermentation. The process of chemical synthesis requires heavy metal catalysts, organic solvents, high temperature and high pressures [2], which makes the conversion of maleic anhydride to fumarate can be ecologically destructive. Enzymatic conversion of maleic anhydride derived from petroleum into fumarate is unsustainable and costly due to the dwindling global supply of petroleum resources and increasing oil prices, despite the fact that a high conversion yield is achievable [3]. A fermentation process based on fungi, such as Rhizopus oryzae and Rhizopus arrhiz
Active compounds-based discoveries about the differentiation and apoptosis of leukemic cells
GuoQiang Chen,Jing Zhang,Qian Zhao
Chinese Science Bulletin , 2009, DOI: 10.1007/s11434-009-0628-y
Abstract: Acute myeloid leukemia (AML) is a heterogeneous group of hematopoietic malignancies which are characterized by the blockage of hematopoietic cell differentiation with uncontrolled proliferation and/or impaired apoptosis. Over the past 20 years, there has been tremendous progress in the biological, molecular, and cytogenetic aspects of the disease, accompanied by significant advancements in the treatment of AML patients. For example, all-trans retinoic acid (ATRA) and arsenic trioxide (As2O3) have been used clinically for effective treatments of patients with acute promyelocytic leukemia (APL, a unique subtype of AML) through differentiation and/or apoptosis induction. More intriguingly, these active compounds-based chemical biological studies greatly accelerated our understanding on leukemogenesis and targeted therapy of AML patients. Based on some recent findings mainly from our group, this review attempts to summarize the related advances from Chinese researchers.
Enzymes related with NAD synthesis promote conversion of 1,4-butanediol to 4-hydroxybutyrate

Xin Zhang,Guoqiang Chen,

生物工程学报 , 2011,
Abstract: Besides medical application, 4-hydroxybutyrate (4-HB) is a precursor of P3HB4HB, a bioplastic showing excellent physical properties and degradability. Escherichia coli S17-1 (pZL-dhaT-aldD) can transform 1, 4-butanediol (1,4-BD) into 4HB with participation of cofactor NAD. To enhance productivity, nicotinic acid phosphoribosyltransferase (PncB) and nicotinamide adenine dinucleotide synthetase (NadE) were overexpressed to increase intracellular nicotinamide adenine dinucleotide concentration and promote reaction process. The shake flask fermentation result showed that the conversion rate increased by 13.03% with help of PncB-NadE, leading to 4.87 g/L 4HB from 10 g/L 1,4-BD, and productivity was increased by 40.91% to1.86 g/g. These results demonstrated that expression of PncB and NadE is beneficial for conversion of 1,4-BD to 4HB.
Domains via Graphs
Zhang Guoqiang,CHEN Yixiang,

计算机科学技术学报 , 2001,
Abstract: This paper provides a concrete and simple introduction to two pillars of domain theory : (1) solving recursive domain equations, and (2) universal and saturated domains. Our exposition combines Larsen and Winskel's idea on solving domain equations using information systems with Girard's idea of stable domain theory in the form of coherence spacest or graphs. Detailed constructions are given for universal and even homogeneous objects in two categories of graphs: one representing binary complete, prime algebraic domains with complete primes covering the bottom; the other representing w-algebraic, prime algebraic lattices. The back- and-forth argument in model theory helps to enlighten the constructions.
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