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Search Results: 1 - 10 of 104153 matches for " Guogang Zhang "
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Effects of nanoparticle zinc oxide on spatial cognition and synaptic plasticity in mice with depressive-like behaviors
Yongling Xie, Yiyi Wang, Tao Zhang, Guogang Ren, Zhuo Yang
Journal of Biomedical Science , 2012, DOI: 10.1186/1423-0127-19-14
Abstract: Male Swiss mice were given lipopolysaccharides (LPS, 100 μg/kg, 100 μg/ml, every other day, 8 times, i.p.) from weaning to induce depressive-like behaviors. NanoZnO (5.6 mg/kg, 5.6 mg/ml, every other day, 8 times, i.p.) was given as the interaction. The mouse model was characterized using the methods of open field test, tail suspension test and forced swim test. Furthermore, the spatial memory was evaluated using Morris water maze (MWM) and the synaptic plasticity was assessed by measuring the long-term potentiation (LTP) in the perforant pathway (PP) to dentate gyrus (DG) in vivo.Results indicated that model mice showed disrupted spatial memory and LTP after LPS injections and the behavioral and electrophysiological improvements after nanoZnO treatment.Data suggested that nanoZnO may play some roles in CNS of mental disorders, which could provide some useful direction on the new drug exploring and clinical researches.Nanotechnologies, which have developed and popularized at an increasing rate, exploit materials and devices with functionally organization engineered at the nanometer scale. Nanostructured materials, primarily defined by unique properties and determined interaction with other disciplines, can interact with biological systems at basic molecular levels with high specificity. Making use of this molecular feature, nanodevices can stimulate and interact with objective cells in certain ways to induce and maximize desired physiological responses [1,2]. Presently, nanoscaled materials have been widely applied in many fields such as medicine, biotechnology, energy and environmental technology [1,3-5]. Nanotoxicology and the potential effects on human body have grown in significance over recent years fueled by the surge of nanomaterial-based consumer products or building materials in the market. Since they can pass through biological membranes, nanoparticles have potential toxic effects and significant pathological consequences in human [3,6-9]. Meanwhile, they'
The Radiological Impact of 210Pb and 210Po Released from the Iron- and Steel-Making Plant ILVA in Taranto (Italy) on the Environment and the Public
Guogang Jia
Journal of Chemistry , 2013, DOI: 10.1155/2013/964310
Abstract: Lead-210 and 210Po are naturally occurring radionuclides. Due to volatile characteristic of lead and polonium, environmental pollution of 210Pb and 210Po released from the coal power plant, steel-making industry and refractory material industry has been an exposure problem for the members of public. In this paper studies on the activity concentrations of 210Po and 210Pb in the raw materials, dust particles, surficial soils and atmospheric particulate samples collected in the area of the Iron- and Steel-Making Plant ILVA Taranto (Italy) were made. These data have been used to evaluate the source-term, distributions, inventories, mass balance, biological availability, ecological migration processes and public exposure risk of 210Pb and 210Po in the concerned environment. 1. Introduction In general, the main source of 210Pb and 210Po in the environment is the exhalation of 222Rn gas from the ground into the atmosphere. However, as a result of (i) the volatile characteristic of lead and polonium elements and (ii) the development of industries in recent decades, that is, mining, processing, and smelting of uranium, phosphate, lead and iron ore, burning of fossil fuels (coal), and burning leaded gasoline used for car engines during transportation, elevated activities of 210Pb and 210Po have been found in the atmosphere, hydrosphere, biosphere and surficial soil. A numerous of blood/food/dust/soil lead contamination cases have been reported [1–4]. Therefore, the artificial contamination of 210Po, 210Pb, and stable lead is more and more seriously affecting the public health via air inhalation and food ingestion. Some years ago, Italian researchers started the contamination source-term survey on the natural occurring radionuclides, including uranium isotopes, thorium isotopes, radium isotopes, 210Pb, and 210Po [5]. The purpose of the project was mainly focused on studies of the contamination process, the exposure risk evaluation to the public, and the remedial measures for radiation protection from the radionuclides released from the coal power plant, steel-making industry, and refractory material industry. The obtained results (Table 1) [5] showed that to lower the exposure risk to the public great attention should be given not only to the process of raw material supply and final product utility, but also to the process of by-product redistribution, high enriched waste management, and disposal of the natural occurring radionuclides in the studied industries, especially of the uranium isotopes, thorium isotopes, radium isotopes, 210Pb and 210Po, and so forth.

Duan Jiaqi,Mao Jinchang,Zhang Lizhu,Zhang Borui,Qin Guogang,

红外与毫米波学报 , 1992,
Abstract: Porous silicon (PS) samples treated by chemical etching were illuminated with laser uninterruptedly in atmosphere and oxygen, respectively. The photoluminescence (PL) band of porous silicon exhibited a continuous blue shift with the time of illumination, at last it reached a stationary value. In vacuum, the sample was treated in the same way as mentioned above. But its PL band showed no shift. X-ray photoelectron spectroscopy showed that no SiO_2 was detected in the two PS layers which were illuminated in atmos- phere and oxygen, respectively. Combining it with the infrared absorption spectra measurement it is suggested that the blue shift of the PL band was attributed to the replacement of Si atom on the inner walls of PS by oxygen atom and the formation of the Si -O-Si structure.
Ongoing Speciation in the Tibetan Plateau Gymnocypris Species Complex
Renyi Zhang, Zuogang Peng, Guogang Li, Cunfang Zhang, Yongtao Tang, Xiaoni Gan, Shunping He, Kai Zhao
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0071331
Abstract: Local adaptation towards divergent ecological conditions often results in genetic differentiation and adaptive phenotypic divergence. To illuminate the ecological distinctiveness of the schizothoracine fish, we studied a Gymnocypris species complex consisting of three morphs distributed across four bodies of water (the Yellow River, Lake Qinghai, the Ganzi River and Lake Keluke) in the Northeast Tibetan Plateau. We used a combination of mitochondrial (16S rRNA and Cyt b) and nuclear (RAG-2) genetic sequences to investigate the phylogeography of these morphs based on a sample of 277 specimens. Analysis of gill rakers allowed for mapping of phenotypic trajectories along the phylogeny. The phylogenetic and morphological analyses showed that the three sparsely rakered morphs were present at two extremes of the phylogenetic tree: the Yellow River morphs were located at the basal phylogenetic split, and the Lake Keluke and Ganzi River morphs at the peak, with the densely rakered Lake Qinghai morphs located between these two extremes. Age estimation further indicated that the sparsely rakered morphs constituted the oldest and youngest lineages, whereas the densely rakered morph was assigned to an intermediate-age lineage. These results are most compatible with the process of evolutionary convergence or reversal. Disruptive natural selection due to divergent habitats and dietary preferences is likely the driving force behind the formation of new morphs, and the similarities between their phenotypes may be attributable to the similarities between their forms of niche tracking associated with food acquisition. This study provides the first genetic evidence for the occurrence of convergence or reversal in the schizothoracine fish of the Tibetan Plateau at small temporal scales.
Influence of supercritical and natural drying methods on structure and properties of porous silicon
Dongsheng Xu,Guolin Guo,Linlin Gui,Youqi Tang,Bairui Zhang,Guogang Qin
Chinese Science Bulletin , 2000, DOI: 10.1007/BF02887409
Abstract: We have studied the surface morphology, photoluminescence (PL), Raman spectra and optical absorption of the porous silicon (PS) samples prepared under supercritical drying (SD) and natural drying (ND) process. The experimental results of scan electron microphotograph and Raman spectra show that there are obvious differences in microstructure between the SD and ND samples. No crack of the skeleton has been found in the SD sample, but the skeleton of the ND sample has heavily destroyed. Besides, the PL and absorption spectra of the SD sample are not the same as those of the ND sample.
Wintering behavior of black-faced spoonbill in Hainan Island

Guogang Zhang,Wei Liang,Guozhong Chu,

生物多样性 , 2006,
Abstract: 黑脸琵鹭(Plataleaminor)是全球濒危鸟类之一。海南北黎湾是继我国香港和台湾之后发现的黑脸琵鹭第三个重要的越冬地。为了深入了解黑脸琵鹭在该地的保护状况,以及影响其种群越冬的致危因素,作者于2004年1–3月,采用瞬时扫描和焦点动物观察法对北黎湾黑脸琵鹭的越冬行为进行了观察。结果表明:(1)在黑脸琵鹭的各种行为中,休息行为所占的比例最大,为69.72%;其次是站立行为,为10.42%;护理行为位居第3,占10.36%;位移、取食和社会行为在白天所占的比例相对较低。(2)白天黑脸琵鹭休息行为有明显的高峰和低谷,8:00–17:00主要以休息为主,而在17:00以后,休息行为明显减少,护理、取食和站立行为有所增加。位移和社会行为发生率较低,呈间歇性变化。黑脸琵鹭各种行为之间在持续时间上有显著差异,其中以休息行为持续时间最长,其次是取食行为,而行走行为持续时间最短。(3)黑脸琵鹭的取食频次在各时间段也有显著的差异,在16:00以后取食的频次较高。(4)黑脸琵鹭的取食行为受潮汐的影响,过高和过低的水位都将影响其取食活动。最后针对性地提出了黑脸琵鹭及其越冬地的保护和管理计划。
Bioavailability of Orally Administered rhGM-CSF: A Single-Dose, Randomized, Open-Label, Two-Period Crossover Trial
Wenping Zhang, Zhengbing Lv, Zuoming Nie, Guogang Chen, Jian Chen, Qing Sheng, Wei Yu, Yongfeng Jin, Xiangfu Wu, Yaozhou Zhang
PLOS ONE , 2009, DOI: 10.1371/journal.pone.0005353
Abstract: Background Recombinant human granulocyte-macrophage colony-stimulating factor (rhGM-CSF) is usually administered by injection, and its oral administration in a clinical setting has been not yet reported. Here we demonstrate the bioavailability of orally administered rhGM-CSF in healthy volunteers. The rhGM-CSF was expressed in Bombyx mori expression system (BmrhGM-CSF). Methods and Findings Using a single-dose, randomized, open-label, two-period crossover clinical trial design, 19 healthy volunteers were orally administered with BmrhGM-CSF (8 μg/kg) and subcutaneously injected with rhGM-CSF (3.75 μg/kg) respectively. Serum samples were drawn at 0.0h, 0.5h ,0.75h,1.0h,1.5h,2.0h ,3.0h,4.0h,5.0h,6.0h,8.0h,10.0h and 12.0h after administrations. The hGM-CSF serum concentrations were determined by ELISA. The AUC was calculated using the trapezoid method. The relative bioavailability of BmrhGM-CSF was determined according to the AUC ratio of both orally administered and subcutaneously injected rhGM-CSF. Three volunteers were randomly selected from 15 orally administrated subjects with ELISA detectable values. Their serum samples at the 0.0h, 1.0h, 2.0h, 3.0h and 4.0h after the administrations were analyzed by Q-Trap MS/MS TOF. The different peaks were revealed by the spectrogram profile comparison of the 1.0h, 2.0h, 3.0h and 4.0h samples with that of the 0.0h sample, and further analyzed using both Enhanced Product Ion (EPI) scanning and Peptide Mass Fingerprinting Analysis. The rhGM-CSF was detected in the serum samples from 15 of 19 volunteers administrated with BmrhGM-CSF. Its bioavailability was observed at an average of 1.0%, with the highest of 3.1%. The rhGM-CSF peptide sequences in the serum samples were detected by MS analysis, and their sizes ranging from 2,039 to 7,336 Da. Conclusions The results demonstrated that the oral administered BmrhGM-CSF was absorbed into the blood. This study provides an approach for an oral administration of rhGM-CSF protein in clinical settings. Trial Registration www.chictr.org ChiCTR-TRC-00000107
The Invasion and Metastasis Promotion Role of CD97 Small Isoform in Gastric Carcinoma
Daren Liu, Bogusz Trojanowicz, Longyun Ye, Chao Li, Luqing Zhang, Xiaowen Li, Guogang Li, Yixiong Zheng, Li Chen
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0039989
Abstract: CD97 is over-expressed in the majority of gastric adenocarcinomas and is associated with its dedifferentiation and aggressiveness. Our previous results demonstrated that out of three CD97 isoforms tested, only the small one was able to promote increased invasiveness in vitro. Based on these data we further aimed to investigate the role of CD97 small isoform in gastric cancer progression in vivo by employing the cells with a stable CD97 small isoform knock-down and an orthotopic gastric cancer mouse model. We could demonstrate that the knock down of CD97/EGF1,2,5, led to a significant decrease in the number of cells penetrating the gelatin coated membrane as compared with control cells. In the gastric cancer mouse model, both the hypodermic and the orthotopic yielded tumor masses of the CD97/EGF1,2,5kd group and were significantly smaller than the control. Metastatic tumor cell number in early metastatic regional lymph nodes on post-operative day 42 was distinctly decreased in the CD97/EGF1,2,5kd group as compared with the SGC-NS group, and was accompanied with the downregulation of CD44, VEGFR, CD31 and CD97. We concluded in this study that CD97 small isoform not only supported gastric cancer local growth, but also promoted metastatic spread in orthotopically implanted mouse model suggesting involvement of the CD97 small isoform in the preparation of (pre)metastatic niche.
A Compact Wideband Dual-Polarized Printed Antenna with Coaxial Feeds for TD-SCDMA Application  [PDF]
Yujie Liu, Wei Tang, Yuehe Ge, Guogang Li
Wireless Engineering and Technology (WET) , 2015, DOI: 10.4236/wet.2015.61001
Abstract: In this article, a low-profile wideband dual-polarized planar printed dipole antenna, fed by coaxial lines, is investigated for the TD-SCDMA operation. The antenna is composed of two printed dipoles, two pairs of feeding coaxial lines and a ground. The single-polarized planar printed rectangular dipole and petal dipole, with the similar configuration, are first studied, exhibiting the potential wideband operation. Two petal dipoles are then cross-arranged to design a dual-polarized planar printed antenna, giving a lower profile and a better bandwidth covering the Chinese TD-SCDMA band (1880-2400 MHz). The dual-polarized antenna is simply excited by two pairs of coaxial feeds. Simulated and measured results show that the antenna achieves a common impedance bandwidth of 42% at both ports, good isolation of more than 25 dB, stable radiation patterns and the gain of about 7 dBi over the operating bandwidth.
Safety and Immunogenicity of H5N1 Influenza Vaccine Based on Baculovirus Surface Display System of Bombyx mori
Rongzhong Jin, Zhengbing Lv, Qin Chen, Yanping Quan, Haihua Zhang, Si Li, Guogang Chen, Qingliang Zheng, Lairong Jin, Xiangfu Wu, Jianguo Chen, Yaozhou Zhang
PLOS ONE , 2008, DOI: 10.1371/journal.pone.0003933
Abstract: Avian influenza virus (H5N1) has caused serious infections in human beings. This virus has the potential to emerge as a pandemic threat in humans. Effective vaccines against H5N1 virus are needed. A recombinant Bombyx mori baculovirus, Bmg64HA, was constructed for the expression of HA protein of H5N1 influenza virus displaying on the viral envelope surface. The HA protein accounted for approximately 3% of the total viral proteins in silkworm pupae infected with the recombinant virus. Using a series of separation and purification methods, pure Bmgp64HA virus was isolated from these silkworm pupae bioreactors. Aluminum hydroxide adjuvant was used for an H5N1 influenza vaccine. Immunization with this vaccine at doses of 2 mg/kg and 0.67 mg/kg was carried out to induce the production of neutralizing antibodies, which protected monkeys against influenza virus infection. At these doses, the vaccine induced 1:40 antibody titers in 50% and 67% of the monkeys, respectively. The results of safety evaluation indicated that the vaccine did not cause any toxicity at the dosage as large as 3.2 mg/kg in cynomolgus monkeys and 1.6 mg/kg in mice. The results of dose safety evaluation of vaccine indicated that the safe dose of the vaccine were higher than 0.375 mg/kg in rats and 3.2 mg/kg in cynomolgus monkeys. Our work showed the vaccine may be a candidate for a highly effective, cheap, and safe influenza vaccine for use in humans.
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