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Search Results: 1 - 10 of 4461 matches for " Guilherme Rabello "
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Predictive Models for the Diagnostic of Human Visceral Leishmaniasis in Brazil
Tália S. Machado de Assis,Ana Rabello ,Guilherme L. Werneck
PLOS Neglected Tropical Diseases , 2012, DOI: 10.1371/journal.pntd.0001542
Abstract: Background and Objectives In Brazil, as in many other affected countries, a large proportion of visceral leishmaniasis (VL) occurs in remote locations and treatment is often performed on basis of clinical suspicion. This study aimed at developing predictive models to help with the clinical management of VL in patients with suggestive clinical of disease. Methods Cases of VL (n = 213) had the diagnosis confirmed by parasitological method, non-cases (n = 119) presented suggestive clinical presentation of VL but a negative parasitological diagnosis and a firm diagnosis of another disease. The original data set was divided into two samples for generation and validation of the prediction models. Prediction models based on clinical signs and symptoms, results of laboratory exams and results of five different serological tests, were developed by means of logistic regression and classification and regression trees (CART). From these models, clinical-laboratory and diagnostic prediction scores were generated. The area under the receiver operator characteristic curve, sensitivity, specificity, and positive predictive value were used to evaluate the models' performance. Results Based on the variables splenomegaly, presence of cough and leukopenia and on the results of five serological tests it was possible to generate six predictive models using logistic regression, showing sensitivity ranging from 90.1 to 99.0% and specificity ranging from 53.0 to 97.2%. Based on the variables splenomegaly, leukopenia, cough, age and weight loss and on the results of five serological tests six predictive models were generated using CART with sensitivity ranging from 90.1 to 97.2% and specificity ranging from 68.4 to 97.4%. The models composed of clinical-laboratory variables and the rk39 rapid test showed the best performance. Conclusion The predictive models showed to be a potential useful tool to assist healthcare systems and control programs in their strategical choices, contributing to more efficient and more rational allocation of healthcare resources.
The utility of omega-3 fatty acids in epilepsy: more than just a farmed tilapia!
Terra, Vera C.;Arida, Ricardo M.;Rabello, Guilherme M.;Cavalheiro, Esper A.;Scorza, Fulvio A.;
Arquivos de Neuro-Psiquiatria , 2011, DOI: 10.1590/S0004-282X2011000100022
Abstract: the epilepsies are one of the most common serious brain disorders and 20 to 30% of people developing epilepsy continue to have seizures and are refractory to treatment with the currently available therapies. approximately one in a 1000 patients with chronic epilepsy will die suddenly, unexpectedly, and without explanation, even with post-mortem examination and this phenomenon is called sudden unexplained death in epilepsy (sudep). understanding the mechanisms underlying sudep may lead to the identification of previously unrecognized risk factors that are more amenable to correction. we discuss here the possible implications of omega-3 fatty acids consumption on sudep prevention.
Toxicity symptoms of nickel in common bean
Campanharo, Marcela;Monnerat, Pedro Henrique;Espindula, Marcelo Curitiba;Rabello, Wanderson Souza;Ribeiro, Guilherme;
Revista Ciência Agron?mica , 2010, DOI: 10.1590/S1806-66902010000300024
Abstract: despite the importance of nickel (ni) in the n metabolism of legumes, common bean (phaseolus vulgaris l.) is considered very sensitive to ni doses. the objective in this study was to characterize the toxicity symptoms of ni in common bean cv. pérola. the experiment was conducted in greenhouse in the campus of the universidade estadual do norte fluminense - darcy ribeiro, campos dos goytacazes - rj. solutions containing 0; 20; 40; 60 and 100 mg l-1 of ni, in the form of nickel chloride hexahydrate (nicl2.6h2o), were applied to shoots of common bean plants at the rate of 2.5 ml of solution per plant of common bean, 25 days after sowing. plants of common bean treated with 0; 20; 40 and 60 mg l-1 of ni showed no toxicity symptoms. plants treated with 100 mg l-1 of ni showed chlorotic leaves with gray spots that coalesced and became necrotic in a more advanced stage.
Research proposal: evaluation of the ART approach in elderly patients
Rabello, Tiago;
Journal of Applied Oral Science , 2006, DOI: 10.1590/S1678-77572006000700007
Abstract: with the increase of life expectancy in the world's population, oral health care of elderly people has attracted considerably more attention over the last years. many elderly may benefit from oral health promotion measures that involve the atraumatic restorative treatment (art) approach. the purpose of this study will be to evaluate, over 3 years of follow-up, the clinical behavior of atraumatic restorations placed in elderly patients. the study will comprise a structured interview, intraoral clinical examination, oral hygiene instructions and the atraumatic restorative treatment. intraoral examination will be carried out as recommended by the world health organization (who). small to medium size class i, ii or v cavities without pulp involvement and spontaneous painful symptomatology will be selected to undergo the atraumatic restorative treatment. the restorations will be evaluated by direct observation at baseline and after 6, 12, 24 and 36 months, using modified usphs criteria. two dentists with training and expertise in the art approach, but who will not participate in the art procedures, will evaluate the restorations.
Acute human schistosomiasis mansoni
Rabello, Ana;
Memórias do Instituto Oswaldo Cruz , 1995, DOI: 10.1590/S0074-02761995000200026
Abstract: the acute schistosomiasis is the toxemic disease that follow the schistosoma cercariae active penetration trough screen in the immunologicaly naive vertebrate host. the clinical picture starts two to eight weeks after the first contact with the contaminated water. susceptible patients present a syndrome comprising fever, diarrhea, toxemia and hepatosplenomegaly. diagnosis is based on epidemiological and clinical features, presence of schistosoma eggs in the feces, enlargement of abdominal lymph nodes by ultrasonography and by detection of high antibodies levels against the antigen keyhole limpet haemocyanin. different rates of cure have been observed with specific medication and for the most severe clinical presentations the use of steroids reduces the systemic and allergic manifestations.
A contribui??o da história dos conceitos à ciência da informa??o: dimens?es categórico-abstratas e analítico-causais
Rabello, Rodrigo;
Ciência da Informa??o , 2010, DOI: 10.1590/S0100-19652010000300003
Abstract: the history of concepts, albeit still little explored by information science, can provide important contributions for the study of key concepts that constitute the theoretical-conceptual framework in a scientific context. thus, the history of concepts is presented as a tool for the study of diachronic and synchronic features of the scientific concept in information science. for such, it was imperative to understand the intersection of the categorical-abstract and analytical-causal dimensions, both relevant for constituting the very proposition of the history of concepts elaborated by reinhart koselleck.
A Ciência da Informa??o como objeto: epistemologias como lugares de encontro
Rabello, Rodrigo;
Perspectivas em Ciência da Informa??o , 2012, DOI: 10.1590/S1413-99362012000100002
Abstract: information science (is) counts on a singular investigative place where interdisciplinarity operates as a device to study phenomena related with its fuzzy object: information. it is one of the causes originating an "identity crisis" reflected in the demarches of validation, along with this productive setting, in epistemic terms of its disciplinarity. in order to introduce spaces where such theoretical efforts are produced, this paper aims to: a) introduce perspectives of analyses, or places of observation, where narratives within the field of is are produced; b) bring a theoretical framework containing explanations and/or controversies illustrating a search for the disciplinary construction of is. for such, three epistemologies were used as analysis categories: i) specific; ii) particular; and iii) global. these categories, taken from hilton japiassu, helped identifying the position of the subject, i.e. the philosopher, as for the study object - in this case, is. the narratives produced within the field have been directed in well defined epistemological spaces, although, at times, they seem to follow a transversal trajectory in intermediate sites, providing productive epistemological meeting spaces.
THE VALUE OF SANCTIONS AS AN INSTRUMENT OF PUNISHMENT INTHE VOCATIONAL TRAINING OF PHYSICAL EDUCATION
Rosangela Rabello
Ulbra e Movimento : Revista de Educa??o Física , 2010,
Abstract: Freedom of conscience (the last point in the process of development of moral judgments) should be the goal of all education, however, it is important to pass through a stage of heteronomous morality, because it is from the rules, although the source external to the individual, they are placed. The two moral (of heteronomy andautonomy) are essential sources of moral development and that is why we should not neglect any of them. Thus, it is understood that the action of the "other" for the education of man is paramount. Therefore, this article aims to analyze the extent to which punishment serves as a support for the moral development of physical education professional, contributing to the restructuring and rehabilitation of adult moral judgments in specific cases. It was, in addition to achieving this end may also serve to provoke a moral dilemma, triggering the process of moral development and an understanding as to the probable significance of the pedagogical applicability of the penalty for those who suffer it.
Diagnosing Schistosomiasis
Rabello Ana
Memórias do Instituto Oswaldo Cruz , 1997,
Abstract: The ideal diagnostic method for schistosomiasis detection seems to be still far from available. Paucity of egg output in low prevalence situations, low levels of circulating antigens in individuals with low intensity of infection and inadequate specificity of antibody detection systems outline pieces of a puzzle that challenges scientific efforts. Estimated prevalence, financial resources and operational reality must be taken into account when deciding the diagnostic method to be used. A combination of a screening step, using a fast strip test for antibody detection with a parasitological ratification step such as Kato-Katz repeated stool examination may serve as a diagnostic approach for a previously untreated low level endemic area. However, when eradication is the aim, and high financial investment is available, re-treatment may be based on the association between multiple stool examination and circulating antigen detection. Ethical aspects as well as cost-benefit rates between treatment and diagnosis approaches lead to the conclusion that in spite of the recent advances in simple administered and relatively safe drugs, treatment should only be performed when supported by appropriated diagnosis
Enhanced synaptic transmission at the squid giant synapse by artificial seawater based on physically modified saline
Soonwook Choi,Eunah Yu,Guilherme Rabello,Suelen Merlo,Kerry D. Walton,Herman Moreno,Jorge E. Moreira,Mutsuyuki Sugimori,Rodolfo R. Llinás
Frontiers in Synaptic Neuroscience , 2014, DOI: 10.3389/fnsyn.2014.00002
Abstract: Superfusion of the squid giant synapse with artificial seawater (ASW) based on isotonic saline containing oxygen nanobubbles (RNS60 ASW) generates an enhancement of synaptic transmission. This was determined by examining the postsynaptic response to single and repetitive presynaptic spike activation, spontaneous transmitter release, and presynaptic voltage clamp studies. In the presence of RNS60 ASW single presynaptic stimulation elicited larger postsynaptic potentials (PSP) and more robust recovery from high frequency stimulation than in control ASW. Analysis of postsynaptic noise revealed an increase in spontaneous transmitter release with modified noise kinetics in RNS60 ASW. Presynaptic voltage clamp demonstrated an increased EPSP, without an increase in presynaptic ICa++ amplitude during RNS60 ASW superfusion. Synaptic release enhancement reached stable maxima within 5–10 min of RNS60 ASW superfusion and was maintained for the entire recording time, up to 1 h. Electronmicroscopic morphometry indicated a decrease in synaptic vesicle density and the number at active zones with an increase in the number of clathrin-coated vesicles (CCV) and large endosome-like vesicles near junctional sites. Block of mitochondrial ATP synthesis by presynaptic injection of oligomycin reduced spontaneous release and prevented the synaptic noise increase seen in RNS60 ASW. After ATP block the number of vesicles at the active zone and CCV was reduced, with an increase in large vesicles. The possibility that RNS60 ASW acts by increasing mitochondrial ATP synthesis was tested by direct determination of ATP levels in both presynaptic and postsynaptic structures. This was implemented using luciferin/luciferase photon emission, which demonstrated a marked increase in ATP synthesis following RNS60 administration. It is concluded that RNS60 positively modulates synaptic transmission by up-regulating ATP synthesis, thus leading to synaptic transmission enhancement.
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