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Search Results: 1 - 10 of 208487 matches for " Guetti L "
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Pulmonary resection for NSCLC in octogenarians: a single center experience
Di Russo S,Mani A,Guetti L,Camplese P
BMC Geriatrics , 2011, DOI: 10.1186/1471-2318-11-s1-a11
Assistência de enfermagem ao potencial doador de órg?os em morte encefálica
Guetti, Nancy Ramos;Marques, Isaac Rosa;
Revista Brasileira de Enfermagem , 2008, DOI: 10.1590/S0034-71672008000100014
Abstract: this study aimed at describing nurse's activities in the assistance for the physiological maintenance of potential organ donors. this is a non-structured bibliographic review that considered current publications having as basis the publications of the brazilian organ transplant association and of the brazilian intensive medicine association. results are organized according to the following structure: ethical issues related to organ and tissue removal, physiological repercussions of brain death (bd), clinical and technological signs of bd, and nursing assistance in the physiological maintenance of potential organ donors. it was concluded that it is essential for the nurse to have enough knowledge about possible physiological alterations resulting from bd. when that knowledge is put into practice, nurse's role will contribute for changes in transplants scenario.
Hemodynamic Changes during Hepatic Vascular Exclusion: Use of Intraoperative Transesophageal Echocardiography a Case Series
Franco Marinangeli,Alessandra Ciccozzi,Chiara Angeletti,Cristiana Guetti
ISRN Anesthesiology , 2011, DOI: 10.5402/2011/278545
Tramadol Extended-Release for the Management of Pain due to Osteoarthritis
Chiara Angeletti,Cristiana Guetti,Antonella Paladini,Giustino Varrassi
ISRN Pain , 2013, DOI: 10.1155/2013/245346
Abstract: Current knowledge on pathogenesis of osteoarticular pain, as well as the consequent several, especially on the gastrointestinal, renal, and cardiovascular systems, side effects of NSAIDs, makes it difficult to perform an optimal management of this mixed typology of pain. This is especially observable in elderly patients, the most frequently affected by osteoarthritis (OA). Tramadol is an analgesic drug, the action of which has a twofold action. It has a weak affinity to mu opioid receptors and, at the same time, can result in inhibition of the reuptake of noradrenaline and serotonin in nociceptorial descending inhibitory control system. These two mechanisms, “opioidergic” and “nonopioidergic,” are the grounds for contrasting certain types of pain that are generally less responsive to opioids, such as neuropathic pain or mixed OA pain. The extended-release formulation of tramadol has good efficacy and tolerability and acts through a dosing schedule that allows a high level of patients compliance to therapies with a good recovery outcome for the patients' functional status. 1. Background Pain is the most common symptom of osteoarthritis (OA), and, as pain levels rise, patients experience a reduced range of motion with a consequent increase of disability [1]. Pain and function limitations substantially reduce the life quality of people affected by OA. The treatment planning for OA is designed to essentially provide pain relief, to prevent from complications such as muscle atrophy or joint deformities, and to maintain and/or improve the functional status with the final aim to produce a sensible life quality improvement [2]. The effectiveness of pain relief not only may result in a reduction of the intensity of pain itself but can also lead to an improvement of life aspects that are strictly related to pain. As has been widely documented, chronic persistent pain can sensibly reduce the health-related quality of life, causing reduced sleep, interference with social/family relationships [3], activity of daily living and productivity, and increased anxiety and depression [4]. There is, therefore, a general need for optimized pharmacologic treatment strategies in patients with chronic/persistent pain due to OA. A management strategy for such patients also should require individualized therapies that are able to ensure a positive risk/benefit profile. It should also provide analgesia outcomes covering an extended period of time. Tramadol is a centrally acting synthetic analgesic with two mechanisms of action. It involves weak -opioid receptors agonism and
GlideScope and Frova Introducer for Difficult Airway Management
Alessandra Ciccozzi,Chiara Angeletti,Cristiana Guetti,Roberta Papola,Paolo Matteo Angeletti,Antonella Paladini,Giustino Varrassi,Franco Marinangeli
Case Reports in Anesthesiology , 2013, DOI: 10.1155/2013/717928
Abstract: The introduction into clinical practice of new tools for intubation as videolaringoscopia has dramatically improved the success rate of intubation and the work of anesthesiologists in what is considered the most delicate maneuver. Nevertheless intubation difficulties may also be encountered with good anatomical visualization of glottic structures in videolaringoscopia. To overcome the obstacles that may occur both in a difficult provided intubation such as those unexpected, associated endotracheal introducer able to facilitate the passage of the endotracheal tube through the vocal cords into the trachea may be useful. We report 4 cases of difficult intubation planned and unplanned and completed successfully using the GlideScope videolaryngoscope associated with endotracheal Frova introducer. 1. Introduction Difficult airway management is a major task for anesthesiologists [1, 2]. Failure in airway management indeed, is a major cause of mortality and morbidity in the setting of anesthesiology and intensive care units [3, 4]. The GlideScope (GS) is a videolaryngoscope (VLS), the last generation of intubation devices available in clinical practice in the last decade. GS provides an indirect airway view, improves the assessment of Cormack-Lehane score, and does not require a specific training [5, 6]. Recent studies underline the advantages of VLS in the management of predicted difficult airway [7, 8] as well as prehospital emergencies [9]. Unfortunately, the direct laryngeal view provided by VLS does not always assure the correct insertion of endotracheal tube (ETT), due to the 60-degree angle in the distal portion of GS blade, that tends to hamper the passage of the ETT from oropharynx to trachea. To facilitate the placement of the ETT, a rigid stylet shaped with the same angle as the blade, the GlideRite stylet (GRs), has been made up. Recently, the most suitable characteristics of the introducer have been largely debated: gum elastic bougie, rigid stylet, malleable stylet, and several experiences have been published with different endotracheal introducer utilized in combination with VLS to facilitate intubation maneuver [10–14]. We report our clinical experience in 4 patients, three characterized by potential and one by unexpected difficult intubation, in whom videolaryngo-GlideScope (VLGS) combined with Frova bougie has been used to facilitate endotracheal intubation. 2. Case??1 A 61-year-old woman (BMI: 22.6?kg/m2) was urgently admitted to the anesthesiological evaluation before undergoing the intervention of spinal decompression of cervical C3–C6
Complex Mutations & Subpopulations of Deletions at Exon 19 of EGFR in NSCLC Revealed by Next Generation Sequencing: Potential Clinical Implications
Antonio Marchetti, Maela Del Grammastro, Giampaolo Filice, Lara Felicioni, Giulio Rossi, Paolo Graziano, Giuliana Sartori, Alvaro Leone, Sara Malatesta, Michele Iacono, Luigi Guetti, Patrizia Viola, Felice Mucilli, Franco Cuccurullo, Fiamma Buttitta
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0042164
Abstract: Microdeletions at exon 19 are the most frequent genetic alterations affecting the Epidermal Growth Factor Receptor (EGFR) gene in non-small cell lung cancer (NSCLC) and they are strongly associated with response to treatment with tyrosine kinase inhibitors. A series of 116 NSCLC DNA samples investigated by Sanger Sequencing (SS), including 106 samples carrying exon 19 EGFR deletions and 10 without deletions (control samples), were subjected to deep next generation sequencing (NGS). All samples with deletions at SS showed deletions with NGS. No deletions were seen in control cases. In 93 (88%) cases, deletions detected by NGS were exactly corresponding to those identified by SS. In 13 cases (12%) NGS resolved deletions not accurately characterized by SS. In 21 (20%) cases the NGS showed presence of complex (double/multiple) frameshift deletions producing a net in-frame change. In 5 of these cases the SS could not define the exact sequence of mutant alleles, in the other 16 cases the results obtained by SS were conventionally considered as deletions plus insertions. Different interpretative hypotheses for complex mutations are discussed. In 46 (43%) tumors deep NGS showed, for the first time to our knowledge, subpopulations of DNA molecules carrying EGFR deletions different from the main one. Each of these subpopulations accounted for 0.1% to 17% of the genomic DNA in the different tumors investigated. Our findings suggest that a region in exon 19 is highly unstable in a large proportion of patients carrying EGFR deletions. As a corollary to this study, NGS data were compared with those obtained by immunohistochemistry using the 6B6 anti-mutant EGFR antibody. The immunoreaction was E746-A750del specific. In conclusion, NGS analysis of EGFR exon 19 in NSCLCs allowed us to formulate a new interpretative hypothesis for complex mutations and revealed the presence of subpopulations of deletions with potential pathogenetic and clinical impact.
Pain after earthquake
Chiara Angeletti, Cristiana Guetti, Roberta Papola, Emiliano Petrucci, Maria Laura Ursini, Alessandra Ciccozzi, Francesca Masi, Maria Rosaria Russo, Salvatore Squarcione, Antonella Paladini, Joseph Pergolizzi, Robert Taylor, Giustino Varrassi, Franco Marinangeli
Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine , 2012, DOI: 10.1186/1757-7241-20-43
Abstract: This observational retrospective study evaluated the prevalence and drug treatment of pain in the five weeks following the L'Aquila earthquake (April 6, 2009).958 triage documents were analysed for patients pain severity, pain type, and treatment efficacy.A third of pain patients reported pain with a prevalence of 34.6%. More than half of pain patients reported severe pain (58.8%). Analgesic agents were limited to available drugs: anti-inflammatory agents, paracetamol, and weak opioids. Reduction in verbal numerical pain scores within the first 24 hours after treatment was achieved with the medications at hand. Pain prevalence and characterization exhibited a biphasic pattern with acute pain syndromes owing to trauma occurring in the first 15 days after the earthquake; traumatic pain then decreased and re-surged at around week five, owing to rebuilding efforts. In the second through fourth week, reports of pain occurred mainly owing to relapses of chronic conditions.This study indicates that pain is prevalent during natural disasters, may exhibit a discernible pattern over the weeks following the event, and current drug treatments in this region may be adequate for emergency situations.
Computing Reachable Sets as Capture-Viability Kernels in Reverse Time  [PDF]
No?l Bonneuil
Applied Mathematics (AM) , 2012, DOI: 10.4236/am.2012.311219
Abstract: The set SF(x0;T) of states y reachable from a given state x0 at time T under a set-valued dynamic x’(t)∈F(x (t)) and under constraints x(t)∈K where K is a closed set, is also the capture-viability kernel of x0 at T in reverse time of the target {x0} while remaining in K. In dimension up to three, Saint-Pierre’s viability algorithm is well-adapted; for higher dimensions, Bonneuil’s viability algorithm is better suited. It is used on a large-dimensional example.
Three Dimensional Evolution of SN 1987A in a Self-Gravitating Disk  [PDF]
L. Zaninetti
International Journal of Astronomy and Astrophysics (IJAA) , 2013, DOI: 10.4236/ijaa.2013.32010

The introduction of an exponential or power law gradient in the interstellar medium (ISM) allows to produce an asymmetric evolution of the supernova remnant (SNR) when the framework of the thin layer approximation is adopted. Unfortunately both the exponential and power law gradients for the ISM do not have a well defined physical meaning. The physics conversely is well represented by an isothermal self-gravitating disk of particles whose velocity is everywhere Maxwellian. We derived a law of motion in the framework of the thin layer approximation with a control parameter of the swept mass. The photon’s losses, which are often neglected in the thin layer approximation, are modeled trough velocity dependence. The developed framework is applied to SNR 1987A and the three observed rings are simulated.

The Luminosity Function of Galaxies as Modeled by a Left Truncated Beta Distribution  [PDF]
L. Zaninetti
International Journal of Astronomy and Astrophysics (IJAA) , 2014, DOI: 10.4236/ijaa.2014.41013
Abstract: A first new luminosity function of galaxies can be built starting from a left truncated beta probability density function, which is characterized by four parameters. In the astrophysical conversion, the number of parameters increases by one, due to the addition of the overall density of galaxies. A second new galaxy luminosity function is built starting from a left truncated beta probability for the mass of galaxies once a simple nonlinear relationship between mass and luminosity is assumed; in this case the number of parameters is six because the overall density of galaxies and a parameter that regulates mass and luminosity are added. The two new galaxy luminosity functions with finite boundaries were tested on the Sloan Digital Sky Survey (SDSS) in five different bands; the results produce a better fit than the Schechter luminosity function in two of the five bands considered. A modified Schechter luminosity function with four parameters has been also analyzed.
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