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Search Results: 1 - 10 of 62997 matches for " Guan Yang "
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Comparison and Design of Decoder in B3G Mobile Communication System  [PDF]
Mingxiang GUAN, Mingchuan YANG
Communications and Network (CN) , 2009, DOI: 10.4236/cn.2009.11003
Abstract: Turbo code has been shown to have ability to achieve performance that is close to Shannon limit. It has been adopted by various commercial communication systems. Both universal mobile telecommunications system (UMTS) TDD and FDD have also employed turbo code as the error correction coding scheme. It outperforms convolutional code in large block size, but because of its time delay, it is often only used in the non-real-time service. In this paper, we discuss the encoder and decoder structure of turbo code in B3G mobile communication System. In addition, various decoding techniques, such as the Log-MAP, Max-log-MAP and SOVA algorithm for non-real-time service are deduced and compared. The performance results of decoder and algorithms in different configurations are also shown.
Smad4-mediated TGF-β signaling in tumorigenesis
Guan Yang, Xiao Yang
International Journal of Biological Sciences , 2010,
Abstract: Transforming growth factor-β (TGF-β) family members exert their function via specific type I and type II serine/threonine kinase receptors and intracellular Smad transcription factors, including the common mediator Smad4. The dual effects of TGF-β signaling on tumor initiation and progression are cell-specific and yet to be determined under distinct contexts. A number of genetically manipulated mouse models with alterations in the TGF-β pathway genes, particularly the pivotal Smad4, revealed that these genes play crucial functions in maintaining tissue homeostasis and suppressing tumorigenesis. Loss of Smad4 plays a causal role in initiating squamous cell carcinomas of skin and upper digestive tract as well as adenocarcinomas of gastrointestinal tract. However, for some cancers like pancreatic and cholangiocellular carcinomas, Smad4 deficiency does not initiate the tumorigenesis but acts as a promoter to accelerate or synergize the development and progression of cancers that are started by other oncogenic pathways. Intriguingly, emerging evidences from mouse models have highlighted the important roles of non-cell autonomous effects of Smad4-mediated TGF-β signaling in the inhibition of oncogenesis. All these data have greatly deepened our understanding of molecular mechanisms of cell-autonomous and non-cell autonomous effect of Smad4-mediated TGF-β signaling in suppressing carcinogenesis, which may facilitate the development of successful therapies targeting TGF-β signaling for the treatment of human cancers.
Research on Channel Codec of DCR System Based on CMX7141  [PDF]
Yufeng Li, Jun Yang, Qingyang Guan
Communications and Network (CN) , 2013, DOI: 10.4236/cn.2013.53B2053
Abstract: This article introduces a digital private network of mobile communication dedicated chipset CMX7141 that used for the 4FSK modulation and demodulation in DCR system, and introduces the application of CMX7141 inthe DCR system. Focus research on the channel codec techniques of the chip and have a simulation on the channel coding and decoding. The simulation results indicate that, through channel error correction technique in CMX7141, the BER of DCR system reduces greatly and the transmission quality of DCR system is improved.
Gender Differences in Neural Mechanisms Underlying Moral Judgment of Disgust: A Functional MRI Study  [PDF]
Juan Yang, Lili Guan, Mingming Qi
Journal of Behavioral and Brain Science (JBBS) , 2014, DOI: 10.4236/jbbs.2014.45023
Abstract: Much recent research has sought to uncover the gender difference in neural mechanism of moral judgment; however, very few researches study the neural gender differences in a specific area of moral judgment. The aim of this functional magnetic resonance imaging (fMRI) study was to examine possible gender difference in neural response to (sexual) disgusting pictures versus neutral pictures. Seventeen participants (9 males) were scanned while viewing pictures of tactile intimacy in same-sex and being asked to evaluate whether the behaviors between the stimulus persons in the pictures were morally appropriate or not. Both the neural responses to pictures of tactile intimacy in same-sex between male participants and female participants and the neural response to pictures of male-male tactile intimacy and to pictures of female-female tactile intimacy were examined. The results showed that significantly increased differential activations to the disgusting pictures relative to the neutral pictures were observed in the dorsal medial prefrontal cortex (BA 9) and amygdala. Furthermore, greater activation to the pictures of female-female tactile intimacy was observed in the left superior frontal gyrus/dorsal medial prefrontal cortex (BA 6). These results suggested a possible neural gender difference between female’s immoral behavior and male’s immoral behavior.
Bridging the US and China together to conquer cancer: report of the 4th Annual Meeting of the US Chinese Anti-Cancer Association (USCACA)
Wancai Yang,Lingjie Guan
Chinese Journal of Cancer , 2012, DOI: 10.5732/cjc.012.10163
Abstract: A global collaborative effort is pivotal to conquer cancer. Themed "Emerging role of China in global clinical development of novel anti-cancer drugs", the US Chinese Anti-Cancer Association (USCACA) held its 4th annual meeting in Chicago on June 2, 2012, in conjunction with the American Society of Clinical Oncology (ASCO) annual meeting to further bridge the US and China together to outsmart cancer. Although a young organization, USCACA has made significant contributions to this goal in the 3 years since its inception through extensive collaboration with academic organizations, the pharmaceutical industry, and governmental agencies. USCACA has engaged various stakeholders in developing translational and personalized medical strategies to facilitate new anti-cancer drug development and clinical trials in China. USCACA has initiated and implemented the USCACA-National Foundation for Cancer Research (NFCR) scholarship to encourage overseas returnees to continue cancer research in China. USCACA announced the Hengrui-USCACA scholarship to fund clinical trial staff from China to conduct the observation of early oncologic clinical trials in the US. During the annual meeting, distinguished panelists and the audience discussed the following critical topics:(1) oncologic translational research and early development capabilities in China;(2) novel chemical entity development and partnership with Chinese companies; and (3) Chinese participation in global anti-cancer drug development. USCACA will continue to promote collaborations among cancer researchers and clinicians in the US and China by engaging in more frequent communications and joint efforts across fields, disciplines, and countries, diligently working together toward curing and eliminating cancers.
cDNA Cloning, Prokaryotic Expression of Two Splicing Products of mLRG, a Mouse Gene of Lipopolysaccharide Response  [PDF]
Zhongming Dai, Zanguo Nie, Liang He, Lina Guan, Yunsheng Yang
International Journal of Clinical Medicine (IJCM) , 2015, DOI: 10.4236/ijcm.2015.611114
Abstract: Aim: To clone two splicing products of the mouse mLRG-cDNA and to express mLRG protein. Methods: The sequence obtained was compared human lrg to mouse genome with a comparative BLAST genome search and found completely identical. We spliced some fragments to a whole mouse lrg-cDNA sequence and designed a pair of primers at completely homologous fragments in 5’-UTR and 3’-UTR, we amplified mouse lrg-cDNA by RT-PCR. Then the sequence encoding the mLRG protein was amplified by RT-PCR from the total RNA of NIH3T3 cell stimulated by lps (lipopolysaccharide), and we got two splicing products of mLRG (mLRGW, mLRGS) and two sequences encoding protein were cloned into the prokaryotic expression vector pTAT so as to construct the recombinant expression vector pTAT-MLRGW and pTAT-MLRGS. The proteins were expressed in E. coli BL21 (DE3). Results: We got a cDNA fragment with the length of 1905 bp. Its location is at chromosome X qF4 site and we amplified two encoding regions covered 1554 bp and 1404 bp respectively (mlrgW mlrgS). His-TAT-mLRGW and His-TAT-mLRGS fusion protein were expressed successfully. mlrgW is consist of 10 exons and 9 introns; mlrgS is consist of 11exons and 10 introns. Conclusion: Cloning of two splicing products of mouse novel gene MLRG and prokaryotic protein expressions are of help in the further study of this gene.
Changes in forest biomass carbon stock in the Pearl River Delta between 1989 and 2003

YANG Kun,GUAN Dongsheng,

环境科学学报(英文版) , 2008,
Abstract: Forest ecosystems play a significant role in maintaining climate stability at the regional and global scales as an important carbon sink. Regional forest carbon storage and its dynamic changes in the Pearl River Delta have been estimated using the continuous biomass expansion factor (BEF) method based on field measurements of forests plots in different age classes and forest inventory data of three periods (1989-1993, 1994-1998, 1999-2003). The results show that regional carbon storage increased by 16.76%, from 48.57×106 to 56.71×106 tons, 80% of which was stored in forest stands. Carbon storage of other types of vegetation, with the exception of shrubland and woodland, increased. Carbon density of the regional forest increased by 14.31%, from 19.08 to 21.81 ton/hm2. Potential carbon storage of the regional forest may reach 39.96×107 tons when the forest biomass peaks with succession.
Left Radial Approach versus Right Radial Approach of Coronary Angiography in the Diagnosis of Coronary Heart Disease  [PDF]
Pasupati Rajoria, Chenghong Xu, Yunfeng Zhang, Wenjun Guan, Hua Yang, Keping Yang
World Journal of Cardiovascular Diseases (WJCD) , 2016, DOI: 10.4236/wjcd.2016.68030
Abstract: Background: Transradial coronary angiography has established itself as safe alternative to transfemoral approach. Today, the artery of approach lies completely on the operator’s choice. The Right Radial Approach (RRA) has been a favorite for most of the interventional cardiologists due to the convenience in operating from the right side. The Left Radial Approach (LRA) has always been a neglected route. LRA does have many advantages over the right, the vascular anatomy being one of them. The aim of our study was to compare the right radial approach of diagnostic coronary angiography with left radial approach. Method: A total of 70 cases of Coronary Angiography (CAG) with normal Allen test and satisfying the inclusion criteria were prospectively observed and studied after randomly assigning them into two equal groups, LRA (Left Radial Approach) n = 35 and RRA (Right Radial Approach) n = 35. Multipurpose TIG (Tiger) catheter was used in both the approaches to catheterize the right as well as left coronary artery. Results: The access time, catheter manipulation time, procedure time, amount of contrast used, hospital stay, intensity of pain experienced, cost of the procedure and quality of coronary angiogram observed were statistically insignificant while the fluoroscopy time was slightly statistically significant which was independent to catheter manipulation time. Conclusions: The neglected Left Radial Approach to coronary angiography is as efficacious, safe and cost effective with reduction in arterial spasm complications when compared to the Right Radial Approach performed by multipurpose Tiger catheter.
New Progress regarding the Use of Lactic Acid Bacteria as Live Delivery Vectors, Treatment of Diseases and Induction of Immune Responses in Different Host Species Focusing on Lactobacillus Species  [PDF]
Seria Masole Shonyela, Guan Wang, Wentao Yang, Guilian Yang, Chunfeng Wang
World Journal of Vaccines (WJV) , 2017, DOI: 10.4236/wjv.2017.74004
Abstract: Lactobacillus species are non-spore-forming, gram-positive bacteria and lactic acid producing bacteria (LAPB) that naturally inhabit the human and animal gastrointestinal and mouth organs. The aim of this review was to evaluate the new progress regarding the use of Lactobacillus species as live delivery vectors, prevention, and treatment of pathogenic and metabolic diseases. Lactobacillus strains of probiotics have been extensively studied and have confirmed that they can absolutely improve performance as live delivery vectors, a treatment option of various diseases such as: Hemorrhagic cecal coccidiosis in young poultry, hypertension, avian flu, obesity, diabetes, Derzsy’s disease or parvovirus infection, human immunodeficiency virus infections, irritable bowel syndrome, gastrointestinal disorders, Fungal infections, vaginal eubiosis, fish and shellfish species diseases. We give you an idea about that Lactobacillus species have been proficient in preventing and treating both disorders in animal models and some are used for clinical trials. We present the most current studies on the use of Lactobacillus strains that had an impact on an effective immune response to a specific antigen because a variety of antigens have been expressed. Therefore Lactobacillus strains can be considered as good candidates because of its potential for diseases treatment and vaccine development as heterologous protein secretion to date.
Cytokines in the Progression of Pancreatic β-Cell Dysfunction
Chunjiong Wang,Youfei Guan,Jichun Yang
International Journal of Endocrinology , 2010, DOI: 10.1155/2010/515136
Abstract: The dysfunction of pancreatic β-cell and the reduction in β-cell mass are the decisive events in the progression of type 2 diabetes. There is increasing evidence that cytokines play important roles in the procedure of β-cell failure. Cytokines, such as IL-1β, IFN-γ, TNF-α, leptin, resistin, adiponectin, and visfatin, have been shown to diversely regulate pancreatic β-cell function. Recently, islet-derived cytokine PANcreatic DERived factor (PANDER or FAM3B) has also been demonstrated to be a regulator of islet β-cell function. The change in cytokine profile in islet and plasma is associated with pancreatic β-cell dysfunction and apoptosis. In this paper, we summarize and discuss the recent studies on the effects of certain important cytokines on pancreatic β-cell function. The imbalance in deleterious and protective cytokines plays pivotal roles in the development and progression of pancreatic β-cell dysfunction under insulin-resistant conditions. 1. Introduction Diabetes is a chronic disease that occurs when pancreatic islets fail to produce sufficient insulin and/or the sensitivity of glucose-metabolizing tissues to insulin decreases. Chronic hyperglycemia may lead to serious damage to many organs and cause the impairment of insulin production and action. The mechanisms of islet β cell failure are different in the progression of type 1 and type 2 diabetes. In the progression of type 1 diabetes, pancreatic islet β cells are mainly destructed by autoimmune-mediated apoptosis, leading to the loss of insulin production. Inflammatory cytokines play crucial roles in this process [1]. In the progression of type 2 diabetes, the failure of β-cell function and β-cell mass reduction are predominantly associated with the increase in circulating cytokines and in free fatty acids (FFAs) and with persistent hyperglycemia [2]. Chronic exposure of β cell to these mediators induces excessive production of reactive oxygen species (ROS) and activation of caspases, which inhibit insulin secretion and promote apoptosis of pancreatic β cells [3]. In the past decades, it had been well established that inflammatory cytokines including IL-1β, TNF-α, and IFN-γ play a critical role in the pathogenesis of type 1 diabetes. At the early stage of type 1 diabetes, some immune cells such as lymphocytes and macrophages infiltrate into the islets of pancreas and secrete inflammatory cytokines, resulting in high concentrations of cytokines within islets [1]. Chronic exposure of β cells to IL-1β, TNF-α, and IFN-γ finally induces islet dysfunction and β cell apoptosis. Since the discovery
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