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Search Results: 1 - 10 of 4693 matches for " Guan Sudong "
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Upregulation of excitatory neurons and downregulation of inhibitory neurons in barrel cortex are associated with loss of whisker inputs
Zhang Guanjun,Gao Zilong,Guan Sudong,Zhu Yan
Molecular Brain , 2013, DOI: 10.1186/1756-6606-6-2
Abstract: Loss of a sensory input causes the hypersensitivity in other modalities. In addition to cross-modal plasticity, the sensory cortices without receiving inputs undergo the plastic changes. It is not clear how the different types of neurons and synapses in the sensory cortex coordinately change after input deficits in order to prevent loss of their functions and to be used for other modalities. We studied this subject in the barrel cortices from whiskers-trimmed mice vs. controls. After whisker trimming for a week, the intrinsic properties of pyramidal neurons and the transmission of excitatory synapses were upregulated in the barrel cortex, but inhibitory neurons and GABAergic synapses were downregulated. The morphological analyses indicated that the number of processes and spines in pyramidal neurons increased, whereas the processes of GABAergic neurons decreased in the barrel cortex. The upregulation of excitatory neurons and the downregulation of inhibitory neurons boost the activity of network neurons in the barrel cortex to be high levels, which prevent the loss of their functions and enhances their sensitivity to sensory inputs. These changes may prepare for attracting the innervations from sensory cortices and/or peripheral nerves for other modalities during cross-modal plasticity.
The Functional Upregulation of Piriform Cortex Is Associated with Cross-Modal Plasticity in Loss of Whisker Tactile Inputs
Bing Ye, Li Huang, Zilong Gao, Ping Chen, Hong Ni, Sudong Guan, Yan Zhu, Jin-Hui Wang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0041986
Abstract: Background Cross-modal plasticity is characterized as the hypersensitivity of remaining modalities after a sensory function is lost in rodents, which ensures their awareness to environmental changes. Cellular and molecular mechanisms underlying cross-modal sensory plasticity remain unclear. We aim to study the role of different types of neurons in cross-modal plasticity. Methodology/Principal Findings In addition to behavioral tasks in mice, whole-cell recordings at the excitatory and inhibitory neurons, and their two-photon imaging, were conducted in piriform cortex. We produced a mouse model of cross-modal sensory plasticity that olfactory function was upregulated by trimming whiskers to deprive their sensory inputs. In the meantime of olfactory hypersensitivity, pyramidal neurons and excitatory synapses were functionally upregulated, as well as GABAergic cells and inhibitory synapses were downregulated in piriform cortex from the mice of cross-modal sensory plasticity, compared with controls. A crosswire connection between barrel cortex and piriform cortex was established in cross-modal plasticity. Conclusion/Significance An upregulation of pyramidal neurons and a downregulation of GABAergic neurons strengthen the activities of neuronal networks in piriform cortex, which may be responsible for olfactory hypersensitivity after a loss of whisker tactile input. This finding provides the clues for developing therapeutic strategies to promote sensory recovery and substitution.
Upregulation of Barrel GABAergic Neurons Is Associated with Cross-Modal Plasticity in Olfactory Deficit
Hong Ni,Li Huang,Na Chen,Fengyu Zhang,Dongbo Liu,Ming Ge,Sudong Guan,Yan Zhu,Jin-Hui Wang
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013736
Abstract: Loss of a sensory function is often followed by the hypersensitivity of other modalities in mammals, which secures them well-awareness to environmental changes. Cellular and molecular mechanisms underlying cross-modal sensory plasticity remain to be documented.
硫化氢对1型糖尿病大鼠膈肌损伤的保护作用及其抗凋亡机制
Protective effects of hydrogen sulfide on diaphragmatic muscle of Type 1 diabetic rats and its anti-apoptotic mechanisms

杨锐,贾强,郭晓磊,刘小粉,马善峰,高琴,关宿东
YANG Rui
, JIA Qiang, GUO Xiaolei, LIU Xiaofen, MA Shanfeng, GAO Qin, GUAN Sudong

- , 2015, DOI: 10.11817/j.issn.1672-7347.2015.11.002
Abstract: 目的:观察硫化氢(H2S)对1型糖尿病大鼠膈肌损伤的保护作用及其抗凋亡机制。方法:将30只雄性Sprague Dawley大鼠随机分为对照组、糖尿病组和治疗组,每组10只。采用腹腔注射链脲佐菌素的方法制备1型糖尿病大鼠模型,治疗组采用腹腔注射给予硫氢化钠干预治疗。造模成功8周后,利用离体灌流大鼠膈肌条的方法,测定单收缩张力(peak twitch tension,Pt)、最大强直张力(maximum tetanic tension,Po)、峰值收缩时间(time to peak contraction,CT)、半舒张时间(half relaxation time,1/2RT)、张力最大上升/下降速率(maximal rates of contraction/relaxation,±dT/dtmax);透射电镜观察膈肌细胞超微结构改变;测定膈肌组织脂质过氧化物丙二醛(malondialdehyde,MDA)含量、超氧化物歧化酶(superoxide dismutase,SOD)和caspase-3蛋白的活性; RT-PCR测定膈肌组织Bcl-2和Bax mRNA表达。结果:与对照组比较,糖尿病组Pt,Po和±dT/dtmax明显降低(均P<0.01);CT和1/2RT明显延长(均P<0.01);膈肌超微结构损伤明显,膈肌组织MDA含量和caspase-3活性明显增加(均P<0.01);SOD活性明显降低(P<0.01);Bcl-2/Bax mRNA比值降低(P<0.01)。与糖尿病组比较,治疗组膈肌收缩功能明显好转,膈肌超微结构损伤明显改善,膈肌组织MDA含量和caspase-3活性明显降低(分别P<0.05,P<0.01),SOD活性明显升高(P<0.01),Bcl-2/Bax mRNA比值升高(P<0.01)。结论:外源性补充H2S对1型糖尿病大鼠膈肌损伤具有保护作用,其机制可能与减轻氧化应激损伤及抗细胞凋亡作用有关
Habitat evaluation for target species following deep-waterchannel project in the Yangtze River
Xu Sudong, Li Rui, Yin Kai
- , 2015, DOI: 10.3969/j.issn.1003-7985.2015.04.022
Abstract: In order to optimize the design of a 12.5 m deep-water channel project and protect the ecological environment, it is necessary to study the habitat evaluation of species in the engineered area. A coupled eco-hydrodynamic model, which combines a hydrodynamic model(ADCIRC)and a habitat suitability index(HSI)model is developed for target fish(Coilia nasus)and benthos(Corbicula fluminea)in the Yangtze River in order to predict the ecological changes and optimize the regulation scheme. Based on the existing research concerning the characteristics of Coilia nasus and Corbicula fluminea, the relationship between the target species and water environment factors is established. The verification results of tidal level, velocity and biological density show that the proposed coupling model performs well when predicting ecological suitability in the studied region. The results indicate a slight improvement in the potential habitat availability for the two species studied as the natural hydraulic conditions change after the deep-water channel regulation works.
Adaptive Motion Segmentation for Changing Background  [PDF]
Yepeng Guan
Journal of Software Engineering and Applications (JSEA) , 2009, DOI: 10.4236/jsea.2009.22014
Abstract: Segmentation of moving objects efficiently from video sequence is very important for many applications. Background subtraction is a common method typically used to segment moving objects in image sequences taken from a statistic camera. Some existing algorithms cannot adapt to changing circumstances and require manual calibration in terms of specification of parameters or some hypotheses for changing background. An adaptive motion segmentation method is developed according to motion variation and chromatic characteristics, which prevents undesired corruption of the background model and does not consider the adaptation coefficient. RGB color space is selected instead of introducing complex color models to segment moving objects and suppress shadows. A color ratio for 4-connected neighbors of a pixel and multi-scale wavelet transformation are combined to suppress shadows. The mentioned approach is scene-independent and high correct segmentation. It has been shown that the approach is robust and efficient to detect moving objects by experiments.
Moved Score Confidence Intervals for Means of Discrete Distributions  [PDF]
Yu Guan
Open Journal of Statistics (OJS) , 2011, DOI: 10.4236/ojs.2011.12009
Abstract: Let X denote a discrete distribution as Poisson, binomial or negative binomial variable. The score confidence interval for the mean of X is obtained based on inverting the hypothesis test and the central limit theorem is discussed and recommended widely. But it has sharp downward spikes for small means. This paper proposes to move the score interval left a little (about 0.04 unit), called by moved score confidence interval. Numerical computation and Edgeworth expansion show that the moved score interval is analogous to the score interval completely and behaves better for moderate means; for small means the moved interval raises the infimum of the coverage probability and improves the sharp spikes significantly. Especially, it has unified explicit formulations to compute easily.
Ethnic Difference of Disease Prevalence in Rural China: Examples and Explanations  [PDF]
Ming Guan
Health (Health) , 2015, DOI: 10.4236/health.2015.74052
Abstract: Ethnic difference of disease prevalence has attracted great attentions in recent years in China, but few researches have summarized analysis available on ethnic difference of disease prevalence in rural China. The PubMed Central, Wiley Inter science, Science direct, Biomed central, CNKI and Springer-link were searched to identify studies published between January 1984 and October 2014 on ethnic inequality of health status in rural China. Distinct ethnic differences of disease prevalence exist in rural China. Results across disciplines put different explanations on the ethnic differences from ethnicity, infant feeding, and inequality in maternal health services utilization angles. The ethnic inequality of health status in rural China can be reduced by policy makers to allocate more resources towards health service in ethnic rural China.
A Strong Law of Large Numbers for Set-Valued Random Variables in Gα Space  [PDF]
Guan Li
Journal of Applied Mathematics and Physics (JAMP) , 2015, DOI: 10.4236/jamp.2015.37097
Abstract:

In this paper, we shall represent a strong law of large numbers (SLLN) for weighted sums of set- valued random variables in the sense of the Hausdorff metric dH, based on the result of single-valued random variable obtained by Taylor [1].

Study on Relativity between China’s Nominal GDP and the Shanghai Securities Composite Index  [PDF]
Dahong Guan
Journal of Service Science and Management (JSSM) , 2018, DOI: 10.4236/jssm.2018.115036
Abstract: By implementing X-11 process to eliminate the seasonal effect from the data of nominal GDP and Shanghai Securities Composite Index from 1996 to 2015, conducting co-integration test and Granger causality test on these processed data, and examining the leading characteristics of the securities index with the Lag regression model, the present thesis finally conducts a detailed analysis of the research results and puts forward some policy recommendations. The study suggests that there is a stable positive-correlating long-term relationship between Shanghai securities composite index and nominal GDP, the former being the Grainger causes for the latter, which mainly arises from the improvement in the institution of the stock market and the larger ratio of the stock market capitalization to that of nominal GDP. In addition, the increasing liquidity of long-term stock market and investors’ speculation to the stock market based on the national macro-control policies also elucidated the inherent property of Shanghai Composite Index as a leading indicator of Chinese Nominal GDP in the results presented.
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