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Search Results: 1 - 10 of 191881 matches for " Guadalupe Gónzalez-Mateo "
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Are the Mesothelial-to-Mesenchymal Transition, Sclerotic Peritonitis Syndromes, and Encapsulating Peritoneal Sclerosis Part of the Same Process?
Jesús Loureiro,Guadalupe Gónzalez-Mateo,José Jimenez-Heffernan,Rafael Selgas
International Journal of Nephrology , 2013, DOI: 10.1155/2013/263285
Abstract:
Are the Mesothelial-to-Mesenchymal Transition, Sclerotic Peritonitis Syndromes, and Encapsulating Peritoneal Sclerosis Part of the Same Process?
Jesús Loureiro,Guadalupe Gónzalez-Mateo,José Jimenez-Heffernan,Rafael Selgas,Manuel López-Cabrera,Abelardo Aguilera Peralta
International Journal of Nephrology , 2013, DOI: 10.1155/2013/263285
Abstract: Mesothelial-to-mesenchymal transition (MMT) is an autoregulated physiological process of tissue repair that in uncontrolled conditions, such as peritoneal dialysis (PD), can lead to peritoneal fibrosis. The maximum expression of sclerotic peritoneal syndromes (SPS) is the encapsulating peritoneal sclerosis (EPS) for which no specific treatment exists. The SPS includes a wide range of peritoneal fibrosis that appears progressively and is considered as a reversible process, while EPS does not. EPS is a serious complication of PD characterized by a progressive intra-abdominal inflammatory process that results in bridles and severe fibrous tissue formation which cover and constrict the viscera. Recent studies show that transdifferentiated mesothelial cells isolated from the PD effluent correlate very well with the clinical events such as the number of hemoperitoneum and peritonitis, as well as with PD function (lower ultrafiltration and high Cr-MTC). In addition, in peritoneal biopsies from PD patients, the MMT correlates very well with anatomical changes (fibrosis and angiogenesis). However, the pathway to reach EPS from SPS has not been fully and completely established. Herein, we present important evidence pointing to the MMT that is present in the initial peritoneal fibrosis stages and it is perpetual over time, with at least theoretical possibility that MMT initiated the fibrosing process to reach EPS. 1. Introduction Peritoneal dialysis (PD) is a form of renal replacement therapy that uses the peritoneal membrane (PM) as semipermeable barrier for the exchange of toxic substances and water. This technique has increased during the last years, in parallel to its complications. Currently, prolonged survival on PD has been reached due to technological advances, prevention, and early diagnosis of uremic complications. The basic objective of DP is the long-term preservation of the PM function. The PM is lined by a monolayer of MCs that have characteristics of epithelial cells and act as a permeability barrier across which ultrafiltration and diffusion take place. The long-term exposure to hyperosmotic, hyperglycaemic, and low pH of dialysis solutions and repeated episodes of peritonitis or hemoperitoneum cause injury of the peritoneum, which progressively becomes denuded of MCs and undergoes fibrosis and neovascularization [1]. Such structural alterations are considered the major cause of ultrafiltration failure [1, 2]. In this context, it has been proposed that local production of vascular endothelial growth factor (VEGF), a potent proangiogenic cytokine,
Tamoxifen Ameliorates Peritoneal Membrane Damage by Blocking Mesothelial to Mesenchymal Transition in Peritoneal Dialysis
Jesús Loureiro, Pilar Sandoval, Gloria del Peso, Guadalupe Gónzalez-Mateo, Vanessa Fernández-Millara, Beatríz Santamaria, Maria Auxiliadora Bajo, José Antonio Sánchez-Tomero, Gonzalo Guerra-Azcona, Rafael Selgas, Manuel López-Cabrera, Abelardo I. Aguilera
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0061165
Abstract: Mesothelial-to-mesenchymal transition (MMT) is an auto-regulated physiological process of tissue repair that in uncontrolled conditions such as peritoneal dialysis (PD) can lead to peritoneal fibrosis. The maximum expression of peritoneal fibrosis induced by PD fluids and other peritoneal processes is the encapsulating peritoneal sclerosis (EPS) for which no specific treatment exists. Tamoxifen, a synthetic estrogen, has successfully been used to treat retroperitoneal fibrosis and EPS associated with PD. Hence, we used in vitro and animal model approaches to evaluate the efficacy of Tamoxifen to inhibit the MMT as a trigger of peritoneal fibrosis. In vitro studies were carried out using omentum-derived mesothelial cells (MCs) and effluent-derived MCs. Tamoxifen blocked the MMT induced by transforming growth factor (TGF)-β1, as it preserved the expression of E-cadherin and reduced the expression of mesenchymal-associated molecules such as snail, fibronectin, collagen-I, α-smooth muscle actin, and matrix metalloproteinse-2. Tamoxifen-treatment preserved the fibrinolytic capacity of MCs treated with TGF-β1 and decreased their migration capacity. Tamoxifen did not reverse the MMT of non-epitheliod MCs from effluents, but it reduced the expression of some mesenchymal molecules. In mice PD model, we demonstrated that MMT progressed in parallel with peritoneal membrane thickness. In addition, we observed that Tamoxifen significantly reduced peritoneal thickness, angiogenesis, invasion of the compact zone by mesenchymal MCs and improved peritoneal function. Tamoxifen also reduced the effluent levels of vascular endothelial growth factor and leptin. These results demonstrate that Tamoxifen is a therapeutic option to treat peritoneal fibrosis, and that its protective effect is mediated via modulation of the MMT process.
Antigüedad, costumbre y exenciones frente a innovación en una institución medieval: el conflicto entre el maestrescuela y el Cabildo de la Catedral de Burgos (1456-1472)
Guijarro Gónzalez, Susana
Hispania Sacra : Revista de Historia Eclesiástica , 2008,
Abstract: This article studies the consequences that the introduction of the maestrescuela (schoolmaster) rank had for the members of the Cathedral chapter of Burgos in the middle of the fifteenth century. The long conflict, which set the schoolmaster against the Cathedral chapter, illustrates the extraordinary ability that had been developed by this institution to avoid Papal and Episcopal justice. The strength of this ability resided in the primacy of its historical statutes and customs. And, above all, on the direct dependence of the Burgos Episcopal See to the Papal Court. In practice, the remoteness of Rome allowed a certain degree of freedom. In the same context in which Bishop Acu a tried to carry out his reforms, the schoolmaster had to deal with the debate put forward by the Burgos Cathedral chapter between tradition and innovation. El artículo estudia las consecuencias que tuvo para el cabildo de la Catedral de Burgos la introducción de la dignidad de maestrescuela entre sus miembros a mediados del siglo XV. El prolongado conflicto que enfrenta al maestrescuela con el cabildo pone de manifiesto la extraordinaria habilidad desarrollada por la institución para eludir la justicia pontificia y episcopal. Su fuerza reside en la primacía de sus estatutos y costumbres históricas; y, sobre todo, en la dependencia directa de la sede burgalesa de la Corte pontificia. La lejanía de Roma permitía cierta libertad en la práctica. En el mismo contexto en que el Obispo Acu a trató de aplicar sus reformas, el maestrescuela se enfrentó al debate planteado por el cabildo burgalés entre tradición e innovación.
Ongamira, Intihuasi y otros recuerdos
Alberto Rex Gónzalez
Revista del Museo de Antropologia , 2008,
Abstract: This short comunnication was presented originally to be published in the journal PublicacionesArqueología del CIFFyH (UNC). Because this publication it is no longer available we have decided torescue of their files some contributions that by different reasons have been without publishing. In thisfirst delivery we offer a personal glance written by Alberto Rex González of its relation with OsvaldoMenghin during their personal experiences in the excavations of two sites that marked a landmark inthe regional Archaeology of Sierras Centrales and the whole country.
Aspectos teóricos para el estudio sociodemográfico del embarazo adolescente
Humberto Gónzalez Galbán
Frontera norte , 2000,
Abstract: El embarazo adolescente se presenta como un tópico de interés en una buena parte de los países del mundo actualmente. Ello se explica tanto por la gran incidencia que tiene en numerosas regiones como por las implicaciones sociales, familiares y personales a que es vinculado. Esta situación ha motivado la realización de investigaciones en las que las gestaciones en edades tempranas son centro de atención, sin embargo, en estos estudios el tema es presentado generalmente de manera inadecuada. En este articulo se retoma, desde el punto de vista sociodemográfico, el análisis de aspectos teóricos sobre el embarazo adolescente, presentando críticamente la forma en que es problematizado, así como los diferentes supuestos que es posible encontrar en la literatura especializada sobre el tema.
La Política de las Mujeres, de A. Valcarcel
Amalia Gónzalez Suárez
Política y Sociedad , 1999, DOI: -
Abstract: Sin resumen
Sistema urbano y comercio en la comunidad autónoma de Galicia
Alejandro López Gónzalez
Cuadernos Geográficos , 1999,
Abstract: Este artículo posee una doble vertiente. En primer lugar, pretende realizar un breve repaso de los trabajos de distintos geógrafos sobre la red urbana gallega. En segundo lugar, ofrece una interpretación personal sobre la base de determinadas variables como el equipamiento y la cuota comercial. De este análisis destacamos dos elementos: su marcada bipolaridad y el relativo vacío en el estrato de núcleos medianos, realidades responsables de cierto desequilibrio.
Addenda al capricho de Goya Tú que no puedes
Mateo Gómez, Isabel
Archivo Espa?ol de Arte , 2005,
Abstract: En el número de Archivo Espa ol de Arte, correspondiente a diciembre del 2004, puse en relación formal —no de contenido— algunos grabados de los Caprichos, con otros que ilustraban un Exemplario, publicado en Zaragoza en 1531, y que pudieron servir de inspiración al pintor aragonés. Revisando el libro de Randall, sobre márgenes miniados, he tropezado con un motivo más cercano al capricho Tú que no puedes (fig. 1), que el propuesto en mi anterior trabajo. Se trata de una miniatura en la que aparece un hombre cargando un asno sobre sus espaldas (fig. 2), de la misma manera que en la escena goyesca. Randall sugiere que puede tratarse de la ilustración de un proverbio o de una fábula…
A propósito de algunos Caprichos de Goya y un Exemplario aragonés de 1531
Mateo Gómez, Isabel
Archivo Espa?ol de Arte , 2004,
Abstract: Ante la abundante bibliografía sobre Goya, especialmente la referida al significado y fuentes de inspiración de sus obras, produce pudor insistir en este sentido, sobre todo teniendo en cuenta la originalidad del pintor. En alguna ocasión he llamado la atención sobre la influencia formal del Bosco en algunos grabados de Goya, hoy me atrevo a sugerir la posible inspiración que pudieron tener en él algunos de los grabados que ilustran el Exemplario contra los enga os y peligros del mundo, publicado en Zaragoza en 1531, y que sin duda conoció el pintor (fig. 1). Si observamos el Capricho titulado Tú que no puedes, vemos que en él aparecen dos hombres cargados con asnos (fig. 2). Una imagen similar se halla en el Exemplario, con la diferencia de que esta vez es un fraile el que soporta…
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