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Nitric Oxide: Probably the in Vivo Mediator of the Bisulfite’s Effects  [PDF]
Loris Grossi
Journal of Biosciences and Medicines (JBM) , 2014, DOI: 10.4236/jbm.2014.27001
Abstract: The use of bisulfite in food and beverage preservation, as well as in commercial goods and pharmaceuticals as antimicrobial agents is well known, but not very much is reported on its action in vivo. It has been stressed that its action is connected to the presence of NO, and the only reported/ hypothesized evidence concerns the possible interaction with GSNO (S-nitrosoglutathione), an NO releaser. In this light, we investigated the interaction between GSNO and the bisulfite in an aqueous medium at pH = 6.4; actually, a positive effect of the sulfite was evidenced. i.e., the S-nitrosoglutathione becomes a more efficient NO-releaser. But, the nitrite is the real pool of NO in vivo, therefore we investigate its interaction with the bisulfite in an aqueous acidic solution at pH = 6.4; this time, a definitely efficient and abundant NO release, 3.61 times higher compared to the GSNO, has been evidenced. Therefore, these results allow hypothesizing a fundamental role of NO in the bisulfite’s action in vivo, or most probably the bisulfite acts simply as cofactor of NO-releasers.
A new species of Amblyodus Westwood, 1878 (Coleoptera, Melolonthidae, Dynastinae) from South America
Paschoal Grossi,Everardo Grossi
ZooKeys , 2011, DOI: 10.3897/zookeys.75.884
Abstract: A second species of Amblyodus Westwood, 1878, A. castroi sp. n., is described from the northern South America based on 12 specimens from Brazil and Peru (Amazonian subregion). The new species is here compared with the type species of the genus, A. taurus Westwood, 1878 and both species and their male genitalia are illustrated. Diagnostic characters for the genus are discussed, especially the metatibial teeth. A distribution map including the type species and the new species is provided. The genus Amblyodus is recorded for the first time from Peru and from Brazil states of Pará and Rond nia.
Medical concepts related to individual risk are better explained with "plausibility" rather than "probability"
Enzo Grossi
BMC Cardiovascular Disorders , 2005, DOI: 10.1186/1471-2261-5-31
Abstract: The author has reviewed the conceptual framework which has led to the use of probability theory in the medical field in a time when the principal causes of death were represented by acute disease often of infective origin.In the present scenario, in which chronic degenerative disease dominate and there are smooth transitions between health and disease the use of fuzzy logic rather than binary logic would be more appropriate. The use of fuzzy logic in which more than two possible truth-value assignments are allowed overcomes the trap of probability theory when dealing with uncertain outcomes, thereby making the meaning of a certain prognostic statement easier to understand by the patient.At individual subject level the recourse to the term plausibility, related to fuzzy logic, would help the physician to communicate to the patient more efficiently in comparison with the term probability, related to binary logic. This would represent an evident advantage for the transfer of medical evidences to individual subjects.The concept of risk has pervaded medical literature in the last decades and has become a familiar topic. Few articles by the way have tried to focus the concept of "risk" at the individual subject level rather than at population level [1]. The concept of medical risk for the single individual from a mathematical point of view opens an interesting philosophical debate on the appropriate use of the term probability.As I will try to explain, the recourse to the term plausibility, related to fuzzy logic, would help the physician to communicate to the patient more efficiently in comparison with the term probability, related to binary logic.The dictionaries tell us that risk is "the possibility of loss or injury". This definition is familiar to most of us when we think of the possibility of being involved in a crash when driving a car or when flying in a plane.In medicine like in many other contexts the assessment of a particular risk related to the occurrence of
How artificial intelligence tools can be used to assess individual patient risk in cardiovascular disease: problems with the current methods
Enzo Grossi
BMC Cardiovascular Disorders , 2006, DOI: 10.1186/1471-2261-6-20
Abstract: The author has identified three major pitfalls of these algorithms, linked to the limitation of the classical statistical approach in dealing with this kind of non linear and complex information. The pitfalls are the inability to capture the disease complexity, the inability to capture process dynamics, and the wide confidence interval of individual risk assessment.Artificial Intelligence tools can provide potential advantage in trying to overcome these limitations. The theoretical background and some application examples related to artificial neural networks and fuzzy logic have been reviewed and discussed.The use of predictive algorithms to assess individual absolute risk of cardiovascular future events is currently hampered by methodological and mathematical flaws. The use of newer approaches, such as fuzzy logic and artificial neural networks, linked to artificial intelligence, seems to better address both the challenge of increasing complexity resulting from a correlation between predisposing factors, data on the occurrence of cardiovascular events, and the prediction of future events on an individual level.In the past few years a number of algorithms for cardiovascular risk assessment has been proposed to the medical community [1-6]. Their purpose is to assist physicians in defining the risk level of an individual patient with regard to developing major cardiovascular events in the following years.These algorithms have been drawn from statistical analyses performed on longitudinal study cohorts. These analyses have taken into account events occurring in general populations undergoing adequate follow-up for a sufficient length of time. These algorithms consider a number of variables and express their results as the percentage risk of developing a major fatal or non-fatal cardiovascular event in the following 10 to 20 years. For example, if the algorithm gives origin to a 10% value, it means that 10 out of100 subjects in the reference population at a given time
Bar, fast food e tavole calde: nomi e funzioni dei locali di ristoro nelle città romane dell’Impero Bars, Fast Food and Diners: Names and Functions of Refreshment Stands in the Cities of the Roman Empire
Federica Grossi
Lanx , 2012, DOI: 10.6092/2035-4797/2205
Abstract: Le città di Pompei, Ercolano e Ostia costituiscono una notevole fonte di dati per quanto riguarda la vita quotidiana e commerciale di alcune botteghe, che avevano non solo la possibilità di vendere cibi e bevande calde e di mettere a disposizione dei clienti una serie di spazi in cui pranzare, ma anche di alloggiare con carri e animali: questo lavoro risulta essere un tentativo per mettere in relazione le testimonianze archeologiche rinvenute con le definizioni fornite dalle fonti e, allo stesso tempo, per creare una classificazione tipologica di tali locali sulla base degli arredi interni, delle dimensioni e della collocazione nel contesto urbano. The cities of Pompeii, Herculaneum and Ostia are a very remarkable source of data about the daily and commercial life of some shops, which had not only the possibility to sell food and drinks and to give the customers some rooms to have lunch, but also to accommodate with vehicles and animals: this work is the attempt to match the archaeological evidences with the definitions we have by ancient literature and, at the same time, to create a typological classification of these places by their dimensions, furniture and position in the urban contest.
Il problema storico-giuridico delle proprietà collettive in Italia
P. Grossi
Aestimum , 2001,
Paolo Grossi
Meritum : Revista de Direito da Universidade FUMEC , 2012,
Abstract: O sentido do discurso é substancialmente o convite a um diálogo entre historiador social, historiador do direito e jurista, um diálogo que deveria aproar em uma recupera o do jurídico à grande mesa daquele desenhista rico de cores e de tons que é o “novo historiador”. No fundo se encontra a convic o de que o direito é uma das tramas que naturalmente se inserem nos nervos do tecido de uma civiliza o. O convite, a recupera o, nesses termos metodológicos gerais, tem uma funda o e exatid o, mas exige ser verificado na concretude dos vários ambientes históricos, ser medido no papel que o direito tem efetivamente desempenhado nas sociedades e culturas.
Entretien avec Audrey Lasserre et Anne Simon
Alessandra Grossi
Altre Modernità , 2009,
Abstract: Entretien avec Audrey Lasserre et Anne Simon
Audrey Lasserre et Anne Simon (éds.), Nomadismes des romancières contemporaines de langue fran aise
Alessandra Grossi
Altre Modernità , 2009,
Abstract: Audrey Lasserre et Anne Simon (éds.), Nomadismes des romancières contemporaines de langue fran aise
La BD s’en va t-en guerre
Alessandra Grossi
Altre Modernità , 2011,
Abstract: La BD s’en va t-en guerre (Un film de Mark Daniels, Arte Editions, 100’, 2010) par Alessandra Grossi
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