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Search Results: 1 - 10 of 429 matches for " Grampurohit ND "
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Shingade GM,Aamer Quazi,Sabale PM,Grampurohit ND
Journal of Drug Delivery and Therapeutics , 2012,
Abstract: Today about 74% of drugs are taken orally and are found not to be as effective as desired. To improve such characters transdermal drug delivery system was emerged. Drug delivery through the skin to achieve a systemic effect of a drug is commonly known as transdermal drug delivery and differs from traditional topical drug delivery. Transdermal drug delivery systems (TDDS) are dosage forms involves drug transport to viable epidermal and or dermal tissues of the skin for local therapeutic effect while a very major fraction of drug is transported into the systemic blood circulation. The adhesive of the transdermal drug delivery system is critical to the safety, efficacy and quality of the product. Topical administration of therapeutic agents offers many advantages over conventional oral and invasive methods of drug delivery. Several important advantages of transdermal drug delivery are limitation of hepatic first pass metabolism, enhancement of therapeutic efficiency and maintenance of steady plasma level of the drug.
Sonali Thorat, Dhananjay Deshmukh*, Dushant Gaikwad and Nirmala Grampurohit
International Journal of Pharmaceutical Sciences and Research , 2013,
Abstract: ABSTRACT: Ficus religiosa L (Moraceae) is widely distributed in northern part of India has traditionally been used in India as medicinal plant for the treatment of diarrhoea and dysentery. In the present study ethanolic extract of Ficus religiosa L was used for investigation of antiulcer activity by using pylorus ligation as antisecretory model and ethanol induced ulceration models as cytoprotective model. Animals pretreated with ethanolic extract of Ficus religiosa L at the dose 200 mg/kg and 400 mg/kg showed significant decrease in ulcer index and percentage ulcer protection in all models. The results suggested that the extract at 200 mg/kg and 400 mg/kg showed significant protection (P<0.001) by reducing ulcerative lesions when compared with control group of animals. These findings indicate that Ficus religiosa L. bark and root extract shows significant antiulcer activity.
Acute renal failure in patients with chronic kidney disease
ND Madala
Continuing Medical Education , 2007,
Investigation and Implementation of a PIC-Based Sensor Node for Wireless Sensor Networks  [PDF]
?mer ?zcan, Mesut Gündüz
Journal of Computer and Communications (JCC) , 2014, DOI: 10.4236/jcc.2014.24013

The basic component of wireless sensor networks is sensor node, and it is one of the most investigated complex issues in wireless sensor networks. Within this investigation concept, one of the major topics focused on wireless sensor networks is designing sensor node equipment. In this study, a new wireless sensor node design was proposed. In this design, a low-power PIC and a low-power transceiver-receiver device were used. In order to connect various sensors to the node, an expansion slot was designed. The software that runs on the microcontroller was written in the PIC-C language, and it could be adapted for different routing algorithms and sensor types. So this paper presents an alternative low cost and low powered sensor node design and implementation for usage of the researchers and practitioners.

The Analysis of Peculiar Control Parameters of Artificial Bee Colony Algorithm on the Numerical Optimization Problems  [PDF]
Mustafa Servet Kiran, Mesut Gündüz
Journal of Computer and Communications (JCC) , 2014, DOI: 10.4236/jcc.2014.24017

Artificial bee colony (ABC) algorithm is one of the popular swarm intelligence algorithms. ABC has been developed by being inspired foraging and waggle dance behaviors of real bee colonies in 2005. Since its invention in 2005, many ABC models have been proposed in order to solve different optimization problems. In all the models proposed, there are only one scout bee and a constant limit value used as control parameters for the bee population. In this study, the performance of ABC algorithm on the numeric optimization problems was analyzed by using different number of scout bees and limit values. Experimental results show that the results obtained by using more than one scout bee and different limit values, are better than the results of basic ABC. Therefore, the control parameters of the basic ABC should be tuned according to given class of optimization problems. In this paper, we propose reasonable value ranges of control parameters for the basic ABC in order to obtain better results on the numeric optimization problems.

Shinde Sachin K,Grampurohit Nirmala D,Banerjee Subir K,Jadhav Suresh L
International Research Journal of Pharmacy , 2012,
Abstract: Ginger (Zingiber officinale Roscoe Family- Zingiberaceae), have been used in Chinese and Indian folk medicine for centuries. There are no reported UV‐visible methods for quick estimation of this extract, which is necessary in the development of suitable formulations for this drug. Hence, a simple UV spectroscopic method was developed for direct estimation of this extract. Ginger rhizome extract obtained from simple maceration process. Calibration curve of rhizome extract was prepared in methanol on three consecutive days at λmax 281.40 nm. The absorbance values (mean of three determinations) with their standard deviations at different concentration in the range of 20‐100 μg/ml was determined. Extract was found to obey Beer‐Lambert’s law in the concentration range of 20‐100 μg/ml with regression coefficient (r2) values 0.9995. The regression equations were calculated as y = 0.0097x + 0.0132 for methanol. The developed calibration curve was validated for intra‐day and inter‐day variations as per ICH Q2A guideline and was found to be a stable method.
Waghmare A. S.,Grampurohit N.D.,Gadhave M.V.,Gaikwad D.D.
International Research Journal of Pharmacy , 2012,
Abstract: Solid lipid nanoparticles are at the forefront of the rapidly developing field of nanotechnology with several potential applications in drug delivery, research and clinical medicine, as well as in other varied sciences. Solid lipid nanoparticles (SLNs) technology represents a promising new approach to lipophilic drug delivery. Nanoparticles are solid colloidal particles ranging in size from 1 to 1000 nm and composed of macromolecular material. The biodegradable and bioacceptable nature of SLNs makes them less toxic as compared to polymeric nanoparticles. SLNs can also be used to improve the bioavalability of drugs. In this present review this new approach is discussed in terms of their advantages, characterization, pharmacokinetic studies, in-vivo studies, in-vitro studies, and special features.
Sabale Pramod M.,Grampurohit Nirmala D,Banerjee Subir K,Gaikwad Dushant D
International Research Journal of Pharmacy , 2012,
Abstract: In India, use of different parts of several medicinal plants to cure specific ailments has been in vogue from ancient times and inherited traditionally. The fruits of Helicteres isora Linn (Sterculiaceae) have been used in the indigenous system of medicine in India for the treatment of griping bowels and diarrheal diseases. The roots and the bark are expectorant, demulcent, hypoglycemic and useful in colic, scabies, gastropathy, diabetes, diarrhoea and dysentery. The fruits are astringents, refrigerant, stomachic, vulnerary and useful in griping of bowels, flatulence of children and antispasmodic. The barks of H.isora showed prominent antimicrobial activity against Staphylococcus aureus, Bacillus subtilis, Pseudomonas aeruginosa and Escherichia coli and fruits against Candida albicans. The presence of flavones, triterpenoids, cucurbitacin, phytosterols, saponins, sugars and phlobatannins were demonstrated in roots and barks H.isora L. The use of medicinal plants in India contributes significantly in primary health care and it is interesting to determine whether actual pharmacological effects support the traditional uses or merely based on folklore. The review revealed that the fruits of H.isora L. were used in diarrhoeal infection and it is anti-candidial but so far no information on antibacterial activities of fruits of H. isora is available hence, attempt was made to find out phytochemical contents and antibacterial potentials of fruits of H.isora against diarrhoeal/enteric bacterial pathogens.
Higher Education as an African Public Sphere and the University as a Site of Resistance and Claim of Ownership for the National Project
ND Assié-Lumumba
Africa Development , 2011,
Abstract: Throughout the African continent, albeit a product of imperial domination, every state at independence conceived a national project, which aimed at building a nation-state with a clearly articulated development agenda. Education as a social institution was considered requisite toward the actualisation of the national project. The sub-sector of higher education, and particularly the university, appeared as an indispensable agency. Given the general colonial policy of exclusion of Africans from university education, the right of African states to build their national/public universities epitomised self-determination at independence. The independence movements in the 1950s-1960s coincided also with the regained popularity of human capital theory that stipulated that education, especially the highest levels, constituted an investment for individual socio-economic attainment and social mobility as well as national and structural development. From its inception, the Western style of university that was conceived out of the colonial experience represented a special site for contention and affirmation of the Africans to realize their national projects. In the context of globalisation, international organisations and programmes such as the World Bank and General Agreement on Trade in Services (GATS) have emerged as proxies of the old colonial powers with the same goal of influencing the policies that restrict or shape higher education in African countries. Key constituencies of African universities, namely students and teaching staff, have resisted such infringement on Africans’ rights to university education and autonomy in determining their domestic policies. The main objective of this article is to analyse the evolution of the African university as a site for the continued struggle for self-determination. It will be argued that, in spite of the history of a few institutions in a handful of countries, the African university in the 21st Century reflects essentially the colonial relations. Thus, for instance, the new Information and Communication Technologies (ICTs) and distance learning programmes, and the emerging private universities in the context of liberalisation mantra, will also be analysed in the framework of the liberalisation policies that have been promoted by the global colonial proxies. In this article, the public mission of the university, be it public or private, will be examined. The approach will be basically historical, assessing the actors and their transformations and mutations within the same reality of the structural inequality of power in the global system and various African responses through continued resistance and affirmation. It will address the fundamental question of the search for the public university or the university with a public mission for the production of relevant knowledge in the various disciplines, critical thinking and new paradigms, and methodologies to promote social progress amidst the challenges of the dom
Stem cell therapeutics: potential in the treatment of inflammatory bowel disease
ES Swenson, ND Theise
Clinical and Experimental Gastroenterology , 2010, DOI: http://dx.doi.org/10.2147/CEG.S6836
Abstract: em cell therapeutics: potential in the treatment of inflammatory bowel disease Review (5433) Total Article Views Authors: ES Swenson, ND Theise Published Date January 2010 Volume 2010:3 Pages 1 - 10 DOI: http://dx.doi.org/10.2147/CEG.S6836 ES Swenson1, ND Theise2 1Department of Internal Medicine, Section of Digestive Diseases, Yale University School of Medicine, New Haven, CT, USA; 2Departments of Pathology and Medicine (Division of Digestive Diseases), Beth Israel Medical Center – Albert Einstein College of Medicine, New York, NY, USA Abstract: Stem cell therapies may be valuable in treatment of inflammatory bowel disease (IBD). Here we focus on two very different types of stem cells – hematopoietic stem cells and mesenchymal stem cells. Myeloablation and hematopoietic stem cell transplantation alter host immune response by reconstituting the recipient’s blood cell lines with donor cells. Autologous hematopoietic reconstitution may “reboot” mucosal immunity to a normal baseline state, but does not alter any underlying genetic predisposition to IBD. In contrast, allogeneic hematopoietic transplantation reconstitutes all blood lineages from a tissue-matched donor who presumably does not have a genetic predisposition to IBD. Compared with autologous hematopoietic transplantation, allogeneic hematopoietic transplantation carries a much greater risk of complications, including graft-versus-host disease. Mesenchymal stem cells can give rise to cartilage, bone and fat in vitro, but do not reconstitute hematopoiesis after transplantation. Systemically infused mesenchymal stem cells appear to favorably downregulate host immune responses through poorly understood mechanisms. In addition, mesenchymal stem cells may be applied topically to help close fistulas associated with Crohn’s disease. For all of these stem cell therapy applications for IBD, only cases and small series have been reported. Larger clinical trials are planned or ongoing.
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