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Development and validation of discriminatory dissolution procedure for poorly soluble glyburide
Singh Sachin,Srinivasan K,Gowthamarajan K,Narayan G
Asian Journal of Pharmaceutics , 2010,
Abstract: In the present study, parameters such as solubility, medium pH, surfactant type and dissolution behavior of formulations, influence of sink conditions, stability and discriminatory effect of dissolution testing were studied for the selection of a proper dissolution medium for glyburide (BCS Class II drug). Results of solubility data revealed that solubility increased with an increase in pH. Sink conditions were exhibited in the 0.05 M borate buffer pH 9.6, 0.05 M phosphate buffer pH 6.5 containing 0.1-2% (w/v) cetyl trimethyl ammonium bromide (CTAB) and 0.05 M phosphate buffer pH 7.4 containing 0.1-2% CTAB (w/v), respectively. The 0.05 M phosphate buffer at pH 6.5 containing 0.1% CTAB (w/v) with an agitation speed of 50 rpm (USP II) showed a more discriminating drug release profile when compared with 0.05 M phosphate buffer at pH 7.4 containing 0.1% CTAB (w/v) with an agitation speed of 75 rpm. The spiked samples have shown better recovery at 50, 100 and 150% levels. There was no degradation, as observed in the mass spectrum of recovered dissolution samples when compared with the mass spectrum of standard drug solution, which promised that the method was specific and can be used for routine Quality Control analysis as well as for assessment of formulation variables in future dissolution studies of glyburide.
Development of controlled release spheroids using Buchanania cochinchinesis gum
Narayan Babulal Gaikwad,Giriraj Kulkarni,K Gowthamarajan,E. P. Kumar
Journal of Excipients and Food Chemicals , 2013,
Abstract: Chirauli nut gum was isolated from the bark of Buchanania cochinchinesis (fam. Anacadiacea) and was used as arelease modifier for the preparation of Diclofenac sodium spheroids using the extrusion spheronizationtechnique. The process was studied for the effects on variables when making spheroids with satisfactoryparticle shape, size and size distribution. The prepared spheroids were characterized for surface morphology,qualitative surface porosity, friability, bulk density and flow properties. In vitro studies demonstrated that therelease exhibited Fickian diffusion kinetics which was confirmed by the Higuchi and the Korsmeyer-Peppasmodels. The physico-chemical parameters of the gum could be correlated to the in vitro dissolution profile ofthe spheroids. The spheroids were not able to sustain the drug releases over 12 hours. A greater concentrationof Chirauli nut gum and a process that can accommodate such greater concentrations may produce aformulation capable of significant sustained release.
Development and Validation of an RP- UFLC Method for Simultaneous Estimation of Quercetin and Rutin
Shanmugam. R,Gowthamarajan. K,Priyanka D.L,Madhuri.K
Hygeia : Journal for Drugs and Medicines , 2013,
Abstract: Plan: Quercetin and rutin are the flavonoides possess good therapeuticproperties.The main objective of our work wasto develop a simple, rapid and sensitive UFLC method for simultaneousestimation of quercetin and rutin.Methodology: A simplechromatograph separation was done by using a reverse phase C8 column (250 x 4.6mm) by using isocratic flow with the constituted a mixture of 25 mM potassiumdihydrogen ortho phosphate (pH4) and acetonitrile mobile phase at the ratio of70:30 with the flow rate of l ml/min. Detection was carried out at 230 nm.Different validation parameters such as specificity,sensitivity, linearity, accuracy, precision, ruggedness and robustnesswere performed.Outcome: Optimizedchromatographic conditions were achieved and results showed good peakresolution between quercetin and rutin. The retention time was found at 7.4 minand 2.8 min. The LOD for quercetin and rutin was found to be 10 ng and 15 ng& LOQ was found to be 90 ng and 100 ng. The calibration curve was fixed at0-100000 ng/ml. With change in analytical method parameters, analyst,laboratory conditions did not affect the results. % CV was calculated for allthe parameters and found to be within specification limits. The developedmethod can be used for the quantitative and qualitative estimation of quercetinand rutin for the herbal medicinal products.Keywords: Herbal medicinal products,ICH, Quercetin, Rutin, UFLC
The Constrained Mean-Semivariance Portfolio Optimization Problem with the Support of a Novel Multiobjective Evolutionary Algorithm  [PDF]
K. Liagkouras, K. Metaxiotis
Journal of Software Engineering and Applications (JSEA) , 2013, DOI: 10.4236/jsea.2013.67B005
Abstract:

The paper addresses the constrained mean-semivariance portfolio optimization problem with the support of a novel multi-objective evolutionary algorithm (n-MOEA). The use of semivariance as the risk quantification measure and the real world constraints imposed to the model make the problem difficult to be solved with exact methods. Thanks to the exploratory mechanism, n-MOEA concentrates the search effort where is needed more and provides a well formed efficient frontier with the solutions spread across the whole frontier. We also provide evidence for the robustness of the produced non-dominated solutions by carrying out, out-of-sample testing during both bull and bear market conditions on FTSE-100.

Design of a Cantilever - Type Rotating Bending Fatigue Testing Machine  [PDF]
K. K. Alaneme
Journal of Minerals and Materials Characterization and Engineering (JMMCE) , 2011, DOI: 10.4236/jmmce.2011.1011078
Abstract: This research is centered on the design of a low–cost cantilever loading rotating bending fatigue testing machine using locally sourced materials. The design principle was based on the adaptation of the technical theory of bending of elastic beams. Design drawings were produced and components/materials selections were based on functionality, durability, cost and local availability. The major parts of the machine: the machine main frame, the rotating shaft, the bearing and the bearing housing, the specimen clamping system, pulleys, speed counter, electric motor, and dead weights; were fabricated and then assembled following the design specifications. The machine performance was evaluated using test specimens which were machined in conformity with standard procedures. It was observed that the machine has the potentials of generating reliable bending stress – number of cycles data; and the cost of design (171,000 Naira) was lower in comparison to that of rotating bending machines from abroad. Also the machine has the advantages of ease of operation and maintenance, and is safe for use.
FROM THE BOLOGNA DECLARATION IDEAS TO THE CREATION OF COL-LECTIVE INTELLIGENCE В Д ДЕЙ БОЛОНСЬКОЙ ДЕКЛАРАЦ ДО РЕАЛ Й СТВОРЕННЯ КОЛЕКТИВНОГО НТЕЛЕКТУ
K. Метешк?н,Х. Раковський
Information Technologies and Learning Tools , 2010,
Abstract: The results of Bologna process are investigated. It is underlined that theoretical – methodological bases of the Bologna process have been poorly developed. A scheme for master’s education both on requirements of separate states, and on requirements of EU is offered. Досл джуються п дсумки Болонського процесу. П дкреслю ться, що слабко розроблен теоретико-методолог чн основи Болонського процесу. Пропону ться схема навчання маг стр в, як для потреб окремих держав, так для потреб С.
THE FORMING OF NEW METHODOLOGICAL PARADIGM OF EDUCATION AND SCIENCE MANAGEMENT ФОРМУВАННЯ НОВО МЕТОДОЛОГ ЧНО ПАРАДИГМИ УПРАВЛ ННЯ ОСВ ТОЮ НАУКОЮ
Х.В. Раковський,Н.Х. Раковська,K.О. Метешк?н
Information Technologies and Learning Tools , 2010,
Abstract: The process and phenomena connected with the initiation of new methodological paradigm of the scientific and educational management in Ukraine has been investigated. The paradigm is conditioned by global tendencies of informatization, development of communicative means and integrative processes in education and science У статт досл джен процеси та явища, пов’язан з зародженням в Укра н ново методолог чно парадигми управл ння осв тою наукою, яка обумовлена глобальними тенденц ями нформатизац , розвитком комун кац йних засоб в, а також нтеграц йними процесами в осв т та науц .
ДОБ Р КОМП'ЮТЕРНОГО ПРОГРАМНОГО ЗАБЕЗПЕЧЕННЯ ДИСТАНЦ ЙНОГО НАВЧАННЯ ДЛЯ ОРГАН ЗАЦ П СЛЯДИПЛОМНО ОСВ ТИ ВЧИТЕЛ В НФОРМАТИКИ DISTANCE LEARNING COMPUTER SOFTWARE FOR THE ORGANIZATION OF THE POSTGRADUATE EDUCATION FOR INFORMATICS TEACHERS
K.Р. Ковальська
Information Technologies and Learning Tools , 2010,
Abstract: У статт визначено та охарактеризовано основн вимоги до дистанц йних систем, що використовуються для забезпечення потреб навчального процесу; наведено низку безкоштовних систем управл ння навчальними ресурсами; зроблено пор вняльний анал з основних систем для визначення оптимально дистанц йно платформи до розвитку предметно-ор нтовно компетентност вчител в у п слядипломн й педагог чн осв т . The main demands to the distance learning systems which are used for providing the needs of the studying process are defined and characterized in the article. There is also a list of free of charge systems for the management of the educational resources. A comparative analysis of the main systems has been done for determining the optimal distance learning platform for the development of the teachers’ subject-oriented competence in the postgraduate pedagogical education.
DISTANCE LEARNING AS A PERSPECTIVE FORM IN DEVELOPMENT OF SUBJECT-REFERENCE PROFESSIONAL COMPETENCE OF TEACHERS ДИСТАНЦ ЙНЕ НАВЧАННЯ ЯК ПЕРСПЕКТИВНА ФОРМА РОЗВИТКУ ПРЕДМЕТНО-ОР НТОВНИХ ПРОФЕС ЙНИХ КОМПЕТЕНТНОСТЕЙ УЧИТЕЛ В
K.Р. Ковальська
Information Technologies and Learning Tools , 2010,
Abstract: In the article the state and the level of studying of methodological and theoretical bases of distance learning were analyzed and researched; the methodological bases were formed, a list of characteristics was revealed, relevant only to distance learning; a list of advantages and disadvantages of distance learning using for the development of subject-reference competence of information technology teachers was revealed. У статт проанал зовано досл джено стан та р вень вивченост методолог чних теоретичних основ дистанц йного навчання; сформовано методолог чн основи, виявлено низку характеристик, притаманних лише дистанц йному навчанню; виявлено переваги та недол ки застосування дистанц йного навчання до розвитку предметно-ор нтовно компетентност вчител в нформатики.
ПРИЧИНИ НАСЛ ДКИ АСИМЕТР УВАГИ ДО ЗМ СТУ СКЛАДНИХ ПЕДАГОГ ЧНИХ ПОНЯТЬ ТА Х СУПЕРЕЧЛИВИХ ВИЗНАЧЕНЬ CAUSE AND IMPLICATION OF ATTENTION ASYMMETRY TO MAINTENANCE OF DIFFICULT PEDAGOGICAL CONCEPTS AND THEIR CONTRADICTORY DETERMINATIONS
K.В. Корсак
Information Technologies and Learning Tools , 2010,
Abstract: В статт акцентовано на шкоду для модерн зац вищо школи Укра ни використання невдалих терм н в понять, помилок в х визначеннях. Запропонован необх дн зм ни нновац , необх дн для осв тнього технолог чного прогрессу Harm for modernization of the higher education of Ukraine unsuccessful terms and concepts, errors in their definitions is accented. Changes and the innovations necessary for educational and technological progress are offered.
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