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EFECTO DE UN YOGUR CON INULINA SOBRE LA FUNCIóN INTESTINAL DE SUJETOS SANOS O CONSTIPADOS
Gotteland R,Martin; Brunser T,Oscar;
Revista chilena de nutrición , 2006, DOI: 10.4067/S0717-75182006000500012
Abstract: the effect of the consumption of a yogurt with 2.36 g inulin and 1.77g polydextrose was evaluated in 33 healthy and 37 constipated adults, compared with the same product without inulin. the study includes two 5-week periods, one with the experimental product and the other with the control product, separated by a three week wash-out. the subjects had to ingest 1 yougurt/day during the first week of each period, 2/day during the third week and 3/day during the fifth week; simultaneously they had to register daily the intensity of the digestive symptoms as well as the frequency and consistency of their stools. the results showed that in healthy subjects, the intake of 2 yogurts with inulin or more per day significantly increased the digestive symptoms (p=0.03), due to a greater emission of rectal gas (p=0.000). similar findings were observed in the constipated subjects consuming 3 yogurts daily (p=0.0085 y p=0.0048, respectively); stool frequency and consistency were significantly improved in these subjects (p=0.0039 and p=0.014, respectively). these results suggest that the consumption of 2 yogurts with inulin by day help to fight constipation in subjects with this complain while the intake of this same amount may increase discomfort in healthy subjects
EFECTO DE UN PRODUCTO LáCTEO CON PROBIóTICOS Y PREBIóTICOS SOBRE LA FUNCIóN DIGESTIVA DE SUJETOS SANOS Y CONSTIPADOS
Gotteland,Martín; Vizcarra,Marcela; Maury,Eduard;
Revista chilena de nutrición , 2010, DOI: 10.4067/S0717-75182010000300009
Abstract: constipation is a complex disorder, which affects an important part of the population and results in an increase of gastrointestinal symptoms and in lower stool frequency. the addition of soluble fibers (prebiotics) and probiotic in foodstuffs has been proposed as a useful tool to improve digestive wellbeing of affected individuals. the aim of this study was to evaluate the effect of the daily consumption of minishot, a milk drink with prebiotics (inulin i polydextrose) and probiotics (bifidobacterium lactis bb12), on the digestive comfort of healthy and constipated subjects. we conducted a randomized, controlled, double blind clinical trial in 33 healthy subjects and 64 constipated subjects (≤ 3 stools i week). subjects underwent a one-week observation period followed by two periods of two weeks of consumption of minishot or placebo, separated between them by a two-week washout period. the volunteers recorded daily in a table the presence and severity of distracters and digestive symptoms and the number and consistency of stools. neither minishot nor the placebo affected the digestive wellbeing or the stool frequency and consistency in the control subjects. in the constipated subjects, both consumption of minishot and the placebo improved digestive comfort and stool frequency. however, compared with the placebo, minishot significantly decreased the frequency of hard stools and the proportion of subjects emitting them, and increased the frequency of normal stools.
ALGUNAS VERDADES SOBRE EL CAFé
Gotteland,Martín; de Pablo V,Saturnino;
Revista chilena de nutrición , 2007, DOI: 10.4067/S0717-75182007000200002
Abstract: coffee is one of the most widely consumed beverages in the world due to its organoleptic properties and its ability to keep individuals alert. however, its consumption is frequently associated with negative health effects. this paper reviews the most recent information about the relation between coffee and health. a number of epidemiological studies carried out in the last decade consistently show that coffee intake is related to a lower risk of type-2 diabetes, liver damage, and neurodegenerative diseases such as parkinson. the mechanisms which could explain these observations are not clearly understood yet, but they could be related to the unique profile and high concentrations of antioxidants in coffee, particularly chlorogenic acid
Reuse of "end of life tyres" tyre chips - sand mixture mechanical study
E. Dembicki, M. Kowalczyk, P. Gotteland
Archives of Civil Engineering , 2012, DOI: 10.2478/v.10169-012-0021-0
Abstract: The use of shredded tyre in civil engineering applications is a significant potential end use market. The reuse of tyre chips may not only address growing environmental and economic concerns, but also help to solve geotechnical problems associated with low shear strength. The purpose of this paper is to investigate the properties of tyre chips and tyre chips - sand mixture, and to find the mixture with the highest shear strength. In this study, an experimental testing program was undertaken using a large - scale triaxial apparatus with the goal of evaluating the optimum percentage of tyre chips in sand. The effects on shear strength of varying percentage of tyre chips and varying confining pressure were studied. Tyre chips content was suspected to have influence on stress - strain and volumetric strain behaviour of the mixture. Some tests were conducted to check the influence of number of used membranes, of saturation and compaction, on sample properties.
La microbiota intestinal: Un nuevo actor en el desarrollo de la obesidad
MORALES,PAMELA; BRIGNARDELLO,JERUSA; GOTTELAND,MARTíN;
Revista médica de Chile , 2010, DOI: 10.4067/S0034-98872010000800013
Abstract: intestinal microbiota (im) plays a role in the development of obesity and its associated low grade inflammation. bacterial colonization of the gastrointestinal tract of germ free mice (without microbiota) increases by 60% their fat mass, alters their fasting glucose and insulin levels, triples their hepatic triglycerides and induces adipocyte hypertrophy. im favors fat storage in adipocytes through the inhibition of fiaf (fasting induced adipocyte factor), an inhibitor of lipoprotein lipase. compared with normal weight subjects, the im from obese exhibits a higher proportion of firmicutes/bacteroidetes and is more efficient in extracting energy from foodstuffs. the loss of bodyweight by a hypocaloric diet reverts the proportion of bacteria to that of lean subjects. the intake of a high fat diet also alters the im, affecting intestinal barrier function and favoring endotoxinemia. these events increase oxidative and pro-inflammatory processes in plasma and peripheral tissues and increment the risk of insulin resistance. such events are reverted by the administration of pre-biotics which stimulate the growth of bifdobacterium and lactobacillus species in the colon, reestablishing the gut homeostasis. interestingly, products resulting from the fermentation of prebiotics stimulate the differentiation of enteroendocrine cells and the release of glucagon like peptide 1 and peptide yy, that have insulin like and anorexigenic activities, thus contributing to body weight equilibrium.
ALGUNAS VERDADES SOBRE EL CAFé SOME TRUES CONCERNING COFFEE
Martín Gotteland,Saturnino de Pablo V
Revista Chilena de Nutricíon , 2007,
Abstract: El café es una de las bebidas más consumidas a nivel mundial, debido a sus propiedades organolépticas y a su capacidad de mantener a los individuos en estado de alerta. No obstante, su consumo se asocia frecuentemente con efectos negativos sobre la salud. Este artículo revisa la información más reciente acerca de la relación entre el consumo de café y la salud. Varios estudios epidemiológicos desarrollados en la última década muestran en forma consistente que el consumo de café se asocia a un menor riesgo de diabetes tipo-2, da o hepático y enfermedades neurodegenerativas como el Parkinson. Los mecanismos que podrían dar cuenta de estas observaciones aún no se comprenden completamente pero se podrían relacionar con el perfil específico de antioxidantes del café y con las altas concentraciones de éstos, en particular de ácido clorogénico Coffee is one of the most widely consumed beverages in the world due to its organoleptic properties and its ability to keep individuals alert. However, its consumption is frequently associated with negative health effects. This paper reviews the most recent information about the relation between coffee and health. A number of epidemiological studies carried out in the last decade consistently show that coffee intake is related to a lower risk of type-2 diabetes, liver damage, and neurodegenerative diseases such as Parkinson. The mechanisms which could explain these observations are not clearly understood yet, but they could be related to the unique profile and high concentrations of antioxidants in coffee, particularly chlorogenic acid
EFECTO DE UN PRODUCTO LáCTEO CON PROBIóTICOS Y PREBIóTICOS SOBRE LA FUNCIóN DIGESTIVA DE SUJETOS SANOS Y CONSTIPADOS EFFECT OF A MILK PRODUCT CONTAINING PROBIOTICS AND PREBIOTICS ON THE DIGESTIVE FUNCTION OF HEALTHY AND CONSTIPATED SUBJECTS
Martín Gotteland,Marcela Vizcarra,Eduard Maury
Revista Chilena de Nutricíon , 2010,
Abstract: La constipación es un trastorno complejo que afecta una parte importante de la población. El consumo de prebióticos y probióticos ha sido propuesta como una herramienta para mejorar el bienestar digestivo de las personas afectadas. El objetivo del estudio fue evaluar el efecto del consumo diario de una bebida láctea con inulina/polidextrosa y Bifidobacterium lactis Bbl2, Minishot, sobre el bienestar digestivo de sujetos sanos o constipados. Se realizó un ensayo clínico randomizado, controlado y en doble ciego en 33 sujetos sanos y 64 sujetos constipados (≤ 3 deposiciones / semana). Después de una semana de observación, cada sujeto tuvo 2 periodos de 2 semanas de consumo de Minishot o del placebo, espaciados entre si por 2 semanas de reposo. Los voluntarios registraron diariamente la presencia e intensidad de síntomas digestivos y el número y consistencia de deposiciones. El consumo de Minishot no afecto en forma importante el bienestar digestivo de los sujetos sanos ni alteró la frecuencia y consistencia de sus deposiciones. En los sujetos constipados, tanto el consumo de Minishot como del placebo mejoraron el bienestar digestivo y la frecuencia de deposición. Comparado con el placebo, el consumo de Minishot disminuyó significativamente la frecuencia de deposiciones muy duras y la proporción de sujetos emitiéndolas, y aumento la frecuencia de deposiciones normales/blandas y la proporción de sujetos emitiéndolas. Constipation is a complex disorder, which affects an important part of the population and results in an increase of gastrointestinal symptoms and in lower stool frequency. The addition of soluble fibers (prebiotics) and probiotic in foodstuffs has been proposed as a useful tool to improve digestive wellbeing of affected individuals. The aim of this study was to evaluate the effect of the daily consumption of Minishot, a milk drink with prebiotics (inulin I polydextrose) and probiotics (Bifidobacterium lactis BB12), on the digestive comfort of healthy and constipated subjects. We conducted a randomized, controlled, double blind clinical trial in 33 healthy subjects and 64 constipated subjects (≤ 3 stools I week). Subjects underwent a one-week observation period followed by two periods of two weeks of consumption of Minishot or placebo, separated between them by a two-week washout period. The volunteers recorded daily in a table the presence and severity of distracters and digestive symptoms and the number and consistency of stools. Neither Minishot nor the placebo affected the digestive wellbeing or the stool frequency and consistency in the cont
EFECTO DE UN YOGUR CON INULINA SOBRE LA FUNCIóN INTESTINAL DE SUJETOS SANOS O CONSTIPADOS EFFECT OF AN INULIN CONTAINING YOUGURT ON INTESTINAL FUNCTION OF HEALTHY AND CONSTIPATED VOLUNTEERS
Martin Gotteland R,Oscar Brunser T
Revista Chilena de Nutricíon , 2006,
Abstract: En 33 adultos sanos y 37 constipados se evaluó el efecto del consumo de un yogur que contenía 2.36 g de inulina y 1.77 g de polidextrosa, en comparación con un yogur control sin inulina. El estudio incluyó dos períodos de 5 semanas separados por tres semanas de reposo: uno con el producto experimental y otro con el control. Los sujetos consumieron 1 yogur al día la primera semana de cada período, 2 al día en la tercera y 3 al día en la quinta, y anotaron diariamente la intensidad de los síntomas digestivos así como el número de deposiciones emitidas y su consistencia. Los resultados muestran que a partir de un consumo diario de 2 yogures con inulina existe un aumento significativo de la sintomatología digestiva en los sujetos sanos (p=0.03), debido principalmente a la mayor emisión de gases réctales (p=0.000). Observaciones similares se realizaron en los sujetos constipados con el consumo de 3 productos diarios (p=0.0085 y p=0.0048, respectivamente); sin embargo en aquellos se observó además un mejoramiento significativo tanto en la frecuencia de las deposiciones (p= 0.0039) como en su consistencia (p= 0.014). Este estudio sugiere que el consumo del producto con inulina contribuye a aliviar las molestias de los individuos constipados pero que en los sujetos sanos un consumo de dos yogur al día aumenta los síntomas desagradables The effect of the consumption of a yogurt with 2.36 g inulin and 1.77g polydextrose was evaluated in 33 healthy and 37 constipated adults, compared with the same product without inulin. The study includes two 5-week periods, one with the experimental product and the other with the control product, separated by a three week wash-out. The subjects had to ingest 1 yougurt/day during the first week of each period, 2/day during the third week and 3/day during the fifth week; simultaneously they had to register daily the intensity of the digestive symptoms as well as the frequency and consistency of their stools. The results showed that in healthy subjects, the intake of 2 yogurts with inulin or more per day significantly increased the digestive symptoms (p=0.03), due to a greater emission of rectal gas (p=0.000). Similar findings were observed in the constipated subjects consuming 3 yogurts daily (p=0.0085 y p=0.0048, respectively); stool frequency and consistency were significantly improved in these subjects (p=0.0039 and p=0.014, respectively). These results suggest that the consumption of 2 yogurts with inulin by day help to fight constipation in subjects with this complain while the intake of this same amount may increase discomfo
Experimental study of the impact response of geocells as components of rockfall protection embankments
S. Lambert,P. Gotteland,F. Nicot
Natural Hazards and Earth System Sciences (NHESS) & Discussions (NHESSD) , 2009,
Abstract: Rockfall protection embankments are ground levees designed to stop falling boulders. This paper investigates the behaviour of geocells to be used as components of these structures. Geocells, or cellular confinement systems, are composite structures associating a manufactured envelope with a granular geomaterial. Single cubic geocells were subjected to the impact resulting from dropping a spherical boulder. The geocells were filled with fine or coarse materials and different boundary conditions were applied on the lateral faces. The response is analysed in terms of the impact force and the force transmitted by the geocell to its rigid base. The influence on the geocell response of both the fill material and the cell boundary conditions is analysed. The aim was to identify the conditions resulting in greatest reduction of the transmitted force and also to provide data for the validation of a specific numerical model.
La microbiota intestinal: Un nuevo actor en el desarrollo de la obesidad The association of intestinal microbiota with obesity
PAMELA MORALES,JERUSA BRIGNARDELLO,MARTíN GOTTELAND
Revista médica de Chile , 2010,
Abstract: Intestinal microbiota (IM) plays a role in the development of obesity and its associated low grade inflammation. Bacterial colonization of the gastrointestinal tract of germ free mice (without microbiota) increases by 60% their fat mass, alters their fasting glucose and insulin levels, triples their hepatic triglycerides and induces adipocyte hypertrophy. IM favors fat storage in adipocytes through the inhibition of Fiaf (Fasting Induced Adipocyte Factor), an inhibitor of lipoprotein lipase. Compared with normal weight subjects, the IM from obese exhibits a higher proportion of Firmicutes/Bacteroidetes and is more efficient in extracting energy from foodstuffs. The loss of bodyweight by a hypocaloric diet reverts the proportion of bacteria to that of lean subjects. The intake of a high fat diet also alters the IM, affecting intestinal barrier function and favoring endotoxinemia. These events increase oxidative and pro-inflammatory processes in plasma and peripheral tissues and increment the risk of insulin resistance. Such events are reverted by the administration of pre-biotics which stimulate the growth of Bifdobacterium and Lactobacillus species in the colon, reestablishing the gut homeostasis. Interestingly, products resulting from the fermentation of prebiotics stimulate the differentiation of enteroendocrine cells and the release of glucagon like peptide 1 and peptide YY, that have insulin like and anorexigenic activities, thus contributing to body weight equilibrium.
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