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Search Results: 1 - 10 of 1601 matches for " Goswami Manish "
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AN OVERVIEW ON VARIOUS APPROACHES TO ORAL CONTROLLED DRUG DELIVERY SYSTEM VIA GASTRORETENTIVE DRUG DELIVERY SYSTEM
Bhalla.Neetika,Deep Arsh,Goswami Manish
International Research Journal of Pharmacy , 2012,
Abstract: In recent years scientific and technological advancements have been made in the research and development of oral drug delivery system. Oral sustained drug delivery system is complicated by limited gastric residence times (GRTs). In order to understand various physiological difficulties to achieve gastric retention, we have summarized important factors controlling gastric retention. To overcome these limitations, various approaches have been proposed to increase gastric residence of drug delivery systems in the upper part of the gastrointestinal tract includes floating drug dosage systems (FDDS), swelling or expanding systems , mucoadhesive systems , magnetic systems, modified-shape systems, high density system and other delayed gastric emptying devices.
FORMULATION AND EVALUATION OF COLON TARGETED TABLETS OF MESALAZINE
Sharma Madhu,Joshi Baibhav,Bansal Monika,Goswami Manish
Journal of Drug Delivery and Therapeutics , 2012,
Abstract: In the present investigation an attempt was made to formulate the time and pH dependent drug delivery system, reduce the frequency of dose administeration, to prevent ulcerative colitis by developing sustained delayed release tablets of Mesalazine using combination of Eudragit S-100 and L-100 as enteric coating. The core tablets of Mesalazine were prepared using wet granulation containing a superdisintegrant. The aim of present study is to develop colon specific drug delivery of Mesalazine sustained release matrix tablets for ulcerative colitis using HPMC K-4M and HPMC K-15M as a semisynthetic polymer. Effect of polymer concentration and superdisintegrant level was also investigated. The matrix tablets of Mesalazine are subjected to an in-vitro drug release study using simulated gastric fluid (0.1N HCl) for 2 hours, simulated intestinal fluid (pH 7.4) for 3 hours and simulated colonic fluid (pH 6.8) for 7 hours as dissolution fluid. The study showed that, lag time prior to drug release was highly affected by the coating. Colon drug delivery is advantageous in treatment of colonic disease and oral delivery of drugs that are unstable and susceptible to enzymatic degradation in upper GI tract. The disintegration data obtained from tablets demonstrated that disintegration data rate of studied tablets is dependent on: (i) The polymer used to coat the tablets (ii) pH of disintegration media. Results also demonstrated
COLON SPECIFIC DELIVERY SYSTEM: THE LOCAL DRUG TARGETING
Sharma Madhu,Joshi Baibhav,Bansal Monika,Goswami Manish
International Research Journal of Pharmacy , 2011,
Abstract: Oral administration of different dosage forms is most commonly used method due to greater flexibility in design of dosage form and high patient acceptance, but gastrointestinal tract presents several formidable barriers to drug delivery. The colon is a site where both local and systemic delivery of drugs takes place. Local delivery could, for example, allow topical treatment of inflammatory bowel diseases. In colon specific drug delivery system, colon has a large amount of lymphoma tissue (facilitates direct absorption into blood), negligible brush border membrane activity, and much less pancreatic enzyme activity as compared with small intestine. Colon specific drug delivery has gained potential for delivery of proteins and therapeutic peptides. Different approaches are designed based on prodrug formulation, pH sensitivity, time dependency, microbial degradation and osmotic pressure etc. But these systems have limited success. Newly developed CDDS are developed which includes pressure controlled colonic delivery capsules, osmotic controlled drug delivery systems which are unique in terms of achieving in vivo site specificity and feasibility of manufacturing process.
Molecular Characterization and Expression of a Novel Alcohol Oxidase from Aspergillus terreus MTCC6324
Mitun Chakraborty, Manish Goel, Somasekhar R. Chinnadayyala, Ujjwal Ranjan Dahiya, Siddhartha Sankar Ghosh, Pranab Goswami
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0095368
Abstract: The alcohol oxidase (AOx) cDNA from Aspergillus terreus MTCC6324 with an open reading frame (ORF) of 2001 bp was constructed from n-hexadecane induced cells and expressed in Escherichia coli with a yield of ~4.2 mg protein g?1 wet cell. The deduced amino acid sequences of recombinant rAOx showed maximum structural homology with the chain B of aryl AOx from Pleurotus eryngii. A functionally active AOx was achieved by incubating the apo-AOx with flavin adenine dinucleotide (FAD) for ~80 h at 16°C and pH 9.0. The isoelectric point and mass of the apo-AOx were found to be 6.5±0.1 and ~74 kDa, respectively. Circular dichroism data of the rAOx confirmed its ordered structure. Docking studies with an ab-initio protein model demonstrated the presence of a conserved FAD binding domain with an active substrate binding site. The rAOx was specific for aryl alcohols and the order of its substrate preference was 4-methoxybenzyl alcohol >3-methoxybenzyl alcohol>3, 4-dimethoxybenzyl alcohol > benzyl alcohol. A significantly high aggregation to ~1000 nm (diameter) and catalytic efficiency (kcat/Km) of 7829.5 min?1 mM?1 for 4-methoxybenzyl alcohol was also demonstrated for rAOx. The results infer the novelty of the AOx and its potential biocatalytic application.
A Characterization of Jacobson Radical in Γ-Banach Algebras  [PDF]
Nilakshi Goswami
Advances in Pure Mathematics (APM) , 2012, DOI: 10.4236/apm.2012.26062
Abstract: Let V1 and V2 be two -Banach algebras and Ri be the right operator Banach algebra and Li be the left operator Banach algebra of Vi(i=1,2). We give a characterization of the Jacobson radical for the projective tensor product V1rV2 in terms of the Jacobson radical for R1rL2. If V1 and V2 are isomorphic, then we show that this characterization can also be given in terms of the Jacobson radical for R2rL1.
Lifshitz Transition Including Many-Body Effects in Bi-Layer Graphene and Change in Stacking Order  [PDF]
Partha Goswami
Graphene (Graphene) , 2013, DOI: 10.4236/graphene.2013.22013
Abstract: We consider the AB-(Bernal) stacking for the bi-layer graphene (BLG) system and assume that a perpendicular electric field is created by the external gates deposited on the BLG surface. In the basis (A1, B2, A2, B1) for the valleyKand the basis (B2, A1, B1, A2) for the valley K′, we show the occurrence of trigonal warping [1], that is, splitting of the energy bands or the density of states on the kx - ky plane into four pockets comprising of the central part and three legs due to a (skew) interlayer hopping between A1 and B2. The hopping between A1 - B2 leads to a concurrent velocity v3 in addition to the Fermi velocity vF. Our noteworthy outcome is that the above-mentioned topological change, referred to as the Lifshitz transition [2, 3], is entirely bias-tunable. Furthermore, the many-body effects, which is known to yield logarithmic renormalizations [4] in the band dispersions of monolayer graphene, is found to have significant effect on the bias-tunability of this transition. We also consider a variant of the system where the A atoms of the two layers are over each other and the B atoms of the layers are displaced with respect to each other. The Fermi energy density of statesfor zero bias corresponds to the inverted sombrero-like structure. The structure is found to get deformed due to the increase in the bias.
Importance of integrin receptors in the field of pharmaceutical & medical science  [PDF]
Sumit Goswami
Advances in Biological Chemistry (ABC) , 2013, DOI: 10.4236/abc.2013.32028
Abstract: Integrin receptors have remained as a key subject of interest in the pharmaceutical industry for the last few years. There are a total of 24 different types of integrin heterodimers. Each of these heterodimers plays important role in various biological processes that are inherent to different pathological conditions. As a result, integrin receptors have been extensively evaluated for their role in therapeutic targeting. There are different classes of inhibitors against integrin receptors and this review provides an overview on different classes of integrin inhibitors that are currently available. A number of review articles have been written on the possible application of integrin receptors in therapeutic targeting. Many of these articles have heavily emphasized on the importance of αvβ3 & αvβ5 receptors as major pharmaceutical target in cancer but little emphasis has been given on the importance of other integrin receptors, such as α5β1, αIIbβ3, α4β7, αvβ6 etc. While this review gives due importance to both αvβ3 & αvβ5 receptors and provides an historical perspective on how these two receptors have evolved as a potential target for cancer, significant emphasis has also been given on the other integrin receptors that have started enjoying the status of important drug target over the course of last few years. Effort has been maintained to discuss briefly on the key physiological basis of their importance as drug target. For example, involvement of αvβ3 in angiogenesis has made it a therapeutic target for the treatment of cancer. At the same time expression of this receptor on the surface of osteoclast has made it a target for the treatment of osteoporosis. Thus, emphasis has been given on discussing the role of the integrin receptors in different disease conditions followed by specific examples of drug molecules that have been trialed against these receptors. While hundreds of candidate molecules have been developed against different integrin receptors only a handful of them has been subject to phase-III clinical trial. That necessitates careful consideration of certain concerns that are associated with direct targeting of integrins and thus has also been an important goal of this review. In the last few years application of integrin receptors have extended beyond mere therapeutic targeting. Several integrin receptors are currently are studied for their potential of aiding at diagnostic imaging and drug delivery. In this review a brief overview has also been provided on how integrin are being
Ectopic Autosomal Dominant Polycystic Kidney Disease (ADPKD)—An Extremely Rare Radiological Finding  [PDF]
Manish Gupta
Open Journal of Radiology (OJRad) , 2014, DOI: 10.4236/ojrad.2014.41015
Abstract:

ADPKD is an inherited systemic disorder that predominantly affects the kidney, but may affect other organs including liver, pancreas, brain, and arterial blood vessel. APKPD occurs worldwide affecting about 1 in 500 - 1000 people. Hypertension is the most common manifestation of ADPKD and the major contributor to renal disease progression. A definite diagnosis of ADPKD relies on image testing. Renal ultrasound is commonly used because of its cost effectiveness.

An Experience Based Learning Controller  [PDF]
Debadutt Goswami, Ping Jiang
Journal of Intelligent Learning Systems and Applications (JILSA) , 2010, DOI: 10.4236/jilsa.2010.22011
Abstract: The autonomous mobile robots must be flexible to learn the new complex control behaviours in order to adapt effectively to a dynamic and varying environment. The proposed approach of this paper is to create a controller that learns the complex behaviours incorporating the learning from demonstration to reduce the search space and to improve the demonstrated task geometry by trial and corrections. The task faced by the robot has uncertainty that must be learned. Simulation results indicate that after the handful of trials, robot has learned the right policies and avoided the obstacles and reached the goal.
A New Rectangular Finite Element Formulation Based on Higher Order Displacement Theory for Thick and Thin Composite and Sandwich Plates  [PDF]
Sanjib Goswami, Wilfried Becker
World Journal of Mechanics (WJM) , 2013, DOI: 10.4236/wjm.2013.33019
Abstract:

A new displacement based higher order element has been formulated that is ideally suitable for shear deformable composite and sandwich plates. Suitable functions for displacements and rotations for each node have been selected so that the element shows rapid convergence, an excellent response against transverse shear loading and requires no shear correction factors. It is completely lock-free and behaves extremely well for thin to thick plates. To make the element rapidly convergent and to capture warping effects for composites, higher order displacement terms in the displacement kinematics have been considered for each node. The element has eleven degrees of freedom per node. Shear deformation has also been considered in the formulation by taking into account shear strains ( rxz and ryz) as nodal unknowns. The element is very simple to formulate and could be coded up in research software. A small Fortran code has been developed to implement the element and various examples of isotropic and composite plates have been analyzed to show the effectiveness of the element.

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