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Search Results: 1 - 10 of 29079 matches for " González Geraldo "
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Debería realizar la tesis doctoral?: una retrospectiva compartida
González Geraldo, J.L.
Ensayos : Revista de la Facultad de Educacion de Albacete , 2010,
Abstract: El presente artículo desnuda el proceso de tesis doctoral, a la luz del incipiente Espacio Europeo de Educación Superior (EEES), a través de enfoque en el que el propio autor es, al mismo tiempo, la muestra. A través de tres partes claramente diferenciadas, se expondrán los pasos que conforman el proceso general de investigación de una tesis doctoral para, después, comprobar su disección desde un doble prisma: externo e interno. Las reflexiones que deriven de su lectura deberían de ser de especial interés para futuros doctorandos y directores de tesis, pues muestran el inicio, desarrollo y gestación de una tesis que, objetivamente, puede ser considerada como una buena práctica para comenzar, o al menos plantearse realizar, una tesis doctoral, especialmente, en relación con el ámbito educativo.
Realising pedagogical potencial of the Bologna process third cycle
José Luis González Geraldo,Chris Trevitt,Susan Carter
Journal of Technology and Science Education , 2011, DOI: 10.3926/jotse.22
Abstract: The European Higher Education Area (EHEA) has been achieved, at least in structure, remapping Higher Education as we know it. This scenario offers a new framework in which the role of universities can be rethought, independently of the field of the new degrees and post grade studies. More specifically, the roles of teachers and students need to be reconsidered. Achieving an enhanced doctoral experience for the next generation of PhD students represents a measurable practical outcome of the Bologna Process. This doctoral case study is contextualised within the issues of internationalisation, standards and standardization of degree credit ratings, collaboration and competition, and language and writing.
Nanoinformatics: an emerging area of information technology at the intersection of bioinformatics, computational chemistry and nanobiotechnology
Fernando González-Nilo,Tomás Pérez-Acle,Sergio Guínez-Molinos,Daniela A Geraldo
Biological Research , 2011,
Abstract: After the progress made during the genomics era, bioinformatics was tasked with supporting the flow of information generated by nanobiotechnology efforts. This challenge requires adapting classical bioinformatic and computational chemistry tools to store, standardize, analyze, and visualize nanobiotechnological information. Thus, old and new bioinformatic and computational chemistry tools have been merged into a new sub-discipline: nanoinformatics. This review takes a second look at the development of this new and exciting area as seen from the perspective of the evolution of nanobiotechnology applied to the life sciences. The knowledge obtained at the nano-scale level implies answers to new questions and the development of new concepts in different fields. The rapid convergence of technologies around nanobiotechnologies has spun off collaborative networks and web platforms created for sharing and discussing the knowledge generated in nanobiotechnology. The implementation of new database schemes suitable for storage, processing and integrating physical, chemical, and biological properties of nanoparticles will be a key element in achieving the promises in this convergent field. In this work, we will review some applications of nanobiotechnology to life sciences in generating new requirements for diverse scientific fields, such as bioinformatics and computational chemistry.
Some New Questions about the Seasonal Decrease of the Ozone Layer  [PDF]
Jaime González Velasco
Green and Sustainable Chemistry (GSC) , 2012, DOI: 10.4236/gsc.2012.23016
Abstract: The depletion-recovery cycle of the ozone layer is explained on the basis of the magnetic properties of oxygen, ozone, nitrogen oxides and chlorine combinations, which upon interaction with the Earth’s magnetic field, give rise to gaseous fluxes polar- and equatorial-wards.
What Does “Noise Pollution” Mean?  [PDF]
Alice Elizabeth González
Journal of Environmental Protection (JEP) , 2014, DOI: 10.4236/jep.2014.54037
Abstract:

Noise features different characteristics that make it different from every other “classic” pollutant. Noise is invisible; it does not smell; it disappears when the source is turned off and leaves no traces in the environment. In addition, when people perceive something wrong about their hearing capacity, it is often long time after the beginning of noise exposure. This fact contributes to strengthening the misconception that noise is not harmful to human health or, at least, efforts and funds aim preferably at controling and decreasing the emission of other pollutants. Adding to this, most people tend to consider that noise is the price to pay for accessing to the amenities of the Technological Era and it is indivisible and inevitably linked to them. Last but not least, noise pollution could adversely affect ecosystems and ecological services. Then, how is it possible to convince the decision makers that noise pollution is one of the major current environmental problems? The aim of this paper is to discuss step by step the applicability of noise of a “pollution” definition, as a way to ease the understanding that lowering environmental noise levels should be prioritized: because it will lead to a healthier and better society.

Some Ideas about the Thermal Equilibrium in the Biosphere and the Entropy Variation Ascribed to Changes in the Radiations Wavelengths  [PDF]
Jaime González Velasco
Open Journal of Physical Chemistry (OJPC) , 2015, DOI: 10.4236/ojpc.2015.54011
Abstract: An explanation is given for the thermal equilibrium in the biosphere, which is based in the equality between the thermal energy received from the sun and the thermal energy reemitted from the atmosphere to the space. In order to understand the origin of the energy that gives rise to the processes and phenomena taking place in the biosphere, it is necessary to take into account the free energy represented by the product of temperature times the change in entropy, T△S, whose magnitude can be attributed to the variation experimented by the wavelengths (or, consequently, the frequencies) of the radiations composing the radiation spectrum received from the sun compared with the radiation spectrum reemitted from the biosphere into the space. A simple discussion allows to predict that the entropy increase driving the processes is connected with a spontaneous conversion of high frequency radiations (with lower “content” of entropy) in radiations of lower frequencies (with higher “content” of entropy). A consequence of this is that high frequency radiations would correspond to more ordered states and, therefore, to less probable states than those corresponding to radiations of lower frequencies.
Aprendizajes colaterales: límites y retos del aprendizaje por competencias [Collateral learning: limits and challenges of competency-based learning]
José Luis González Geraldo,Benito del Rincón Igea,ángel A. Bonilla Sánchez,José Manuel Sáez López
Ensayos : Revista de la Facultad de Educacion de Albacete , 2012,
Abstract: Resumen: La presente investigación trata de analizar la adquisición y desarrollo de las competencias en el proceso de ense anza aprendizaje en los contextos universitarios, y contribuir a una reflexión respecto a una mejora en su aplicación. Concretamente se analiza la información que aportan los estudiantes en el primer curso del grado de Educación Social (N = 54) a través de dos cuestionarios. Por otra parte, se triangulan y contrastan estos datos con grupos de discusión. En general, la valoración del grado de percepción de las competencias adquiridas por el alumnado es bastante positiva. Sin embargo, llama la atención que algunas de las competencias que no estaban planificadas para las asignaturas del semestre obtuvieron valoraciones muy altas, mientras que otras competencias de gran importancia en nuestra sociedad actual obtuvieron valoraciones más bajas. Se interpreta el carácter decisivo del factor humano o que posiblemente la percepción de los alumnos respecto a las competencias está sesgada. Es por esto que hemos acu ado el término “aprendizaje colateral”. Abstract: This research tries to analyze the acquisition and development of competencies in teaching-learning process within university contexts; therefore it contributes to a reflection regarding improvement in their application. Specifically, it analyzes the information provided by students in the first degree course of Social Education (N = 54) through two questionnaires. Moreover, data is triangulated and contrasted using discussion groups. In general, students assess very positively the degree of perception of the competencies acquired; however it is noteworthy that some of the competencies that were not planned for the semester received very high ratings, while other important competencies in our society were rated lower. We interpret the key role of the human factor or possibly the perceptions of students regarding competencies are biased. This is why we have coined the term “collateral learning”.
Insights into the Interactions of Fasciola hepatica Cathepsin L3 with a Substrate and Potential Novel Inhibitors through In Silico Approaches
Lilian Hernández Alvarez?,Dany Naranjo Feliciano?,Jorge Enrique Hernández González,Rosemberg de Oliveira Soares?,Diego Enry Barreto Gomes?,Pedro Geraldo Pascutti
PLOS Neglected Tropical Diseases , 2015, DOI: 10.1371/journal.pntd.0003759
Abstract: Background Fasciola hepatica is the causative agent of fascioliasis, a disease affecting grazing animals, causing economic losses in global agriculture and currently being an important human zoonosis. Overuse of chemotherapeutics against fascioliasis has increased the populations of drug resistant parasites. F. hepatica cathepsin L3 is a protease that plays important roles during the life cycle of fluke. Due to its particular collagenolytic activity it is considered an attractive target against the infective phase of F. hepatica. Methodology/Principal Findings Starting with a three dimensional model of FhCL3 we performed a structure-based design of novel inhibitors through a computational study that combined virtual screening, molecular dynamics simulations, and binding free energy (ΔGbind) calculations. Virtual screening was carried out by docking inhibitors obtained from the MYBRIDGE-HitFinder database inside FhCL3 and human cathepsin L substrate-binding sites. On the basis of dock-scores, five compounds were predicted as selective inhibitors of FhCL3. Molecular dynamic simulations were performed and, subsequently, an end-point method was employed to predict ΔGbind values. Two compounds with the best ΔGbind values (-10.68 kcal/mol and -7.16 kcal/mol), comparable to that of the positive control (-10.55 kcal/mol), were identified. A similar approach was followed to structurally and energetically characterize the interface of FhCL3 in complex with a peptidic substrate. Finally, through pair-wise and per-residue free energy decomposition we identified residues that are critical for the substrate/ligand binding and for the enzyme specificity. Conclusions/Significance The present study is the first computer-aided drug design approach against F. hepatica cathepsins. Here we predict the principal determinants of binding of FhCL3 in complex with a natural substrate by detailed energetic characterization of protease interaction surface. We also propose novel compounds as FhCL3 inhibitors. Overall, these results will foster the future rational design of new inhibitors against FhCL3, as well as other F. hepatica cathepsins.
Modeling of the Water Table Level Response Due to Extraordinary Precipitation Events: The Case of the Guadalupe Valley Aquifer  [PDF]
Javier González Ramírez, Rogelio Vázquez González
International Journal of Geosciences (IJG) , 2013, DOI: 10.4236/ijg.2013.46088
Abstract:

A two-dimensional algorithm for underground water flow simulation was modified and adapted to the geohydrologic conditions of the Guadalupe valley located in the state of Baja California in northern México. In order to solve the numerical model using the balance equation, the central finite differences with spatial and temporal constant increments method were used. Such model considers a heterogeneous and transient unconfined aquifer. Modeling and calibration processes are presented using the data of water table levels provided by the water level data loggers installed in a monitoring network and precipitation data from climatic stations of both seasons: 2009-2010 and 2010-2011. It was possible to locate, correlate and model specific rainfall-recharge events with the aim of obtaining an estimation of how these events are directly reflected on the water table level of the aquifer and how it reacts against simulated extraordinary events.

Thermodynamic and Dynamic of Chromium Biosorption by Pectic and Lignocellulocic Biowastes  [PDF]
Luis Sala, Juan González
Journal of Water Resource and Protection (JWARP) , 2010, DOI: 10.4236/jwarp.2010.210106
Abstract: Orange peel (OP) and rice husk (RH) were tested as low-cost biosorbents for Cr(III) removal from aqueous solutions. Dynamics of the biosorption process indicated that intraparticle mass transfer represents the rate-limiting step in the system that attained equilibrium at 120 min. While the OP sorbent material was capable of taking up 39.11 mg Cr(III)/g at the optimum pH 4.4, RH immobilized 3.20 mg Cr(III)/g at the optimum pH 3.0. The fitting of different sorption isotherms models resulted in the best fit with the Langmuir isotherm model. The mean free energy of the metal sorption process was in the range of 8-16 kJ/M. Abiotic Cr(VI) reduction was observed at various contact times and Cr-laden biomass was characterized by XPS, XAFS and EPR spectroscopy. These instrumental analyses confirmed that Cr(VI) removed from the solution was reduced and bound to the biomass as Cr(III). Results indicated that OP and RH materials are efficient biosorbents for eliminating Chromium from aqueous solutions.
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