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Search Results: 1 - 10 of 26470 matches for " González Coto "
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LA AGENCIA DE LA NI A Y EL NI O EN LA CONDICIóN PRE-CIUDADANA AGENCY (CHILDHOOD IN THE PRE-CITIZEN CONDITION)
González Coto, Marcela
Revista Electrónica Actualidades Investigativas en Educación , 2012,
Abstract: Resumen: El presente ensayo se deriva del trabajo que recientemente han desarrollado la Fundación PANIAMOR y la Dirección General del Programa CEN-CINAI del Ministerio de Salud, sobre la formación ciudadana de los ni os y las ni as costarricenses en la primera infancia. Las acciones conjuntas se han enfocado en la capacidad de agencia de los ni os y las ni as, entendida como la disposición para explorar, reflexionar, actuar y valorarse en sus entornos como sujetos políticos. Para este fin, en este ensayo se lleva a cabo un análisis crítico de los modelos ideológicos y culturales que, en la sociedad contemporánea, legitiman y fomentan la condición de “pre-ciudadanía” de la infancia, mermando su desempe o, presente y futuro, como ciudadanos plenos de la sociedad. El análisis se sustenta en materiales diversos, de distintos orígenes, todos relativos a las condiciones actuales de la infancia y las formas como se restringen estas capacidades de agencia. El ensayo también aborda las dificultades y obstáculos que enfrenta un replanteamiento de las relaciones entre adultos y ni os. También se documentan los esfuerzos recientes, tanto locales como internacionales, para crear marcos alternativos desde los cuales replantear la relación institucional entre unos y otros. Como principal resultado del ensayo, se delinean un conjunto de directrices, con expresión curricular, que pueden sustentar el desarrollo de las capacidades de agencia infantil con una manifestación directa en la ni ez ciudadana, la cual, se plantea, se articula en tres dimensiones o ejes de desarrollo (la responsabilidad, la autonomía y el pensamiento complejo).Abstract: This essay is derived from the works that have recently developed the PANIAMOR Foundation and the General Board of Directors of the CEN-CINAI Program of the National Ministry of Health, on the civic education of Costa Rican children in early childhood. Joint activities have focused on the ability of agency to children in this age, understood as a willingness to explore, reflect, act and valued in their environments as political subjects. For this goal, this paper conducts a critical analysis of the ideological and cultural models, in the contemporary society, that legitimize and promote the status of "pre-citizens" of the children, diminishing their performance, present and future, as full citizens of their society. The analysis is based on different materials from distinct origins, all relating to the current conditions of childhood and the ways in which these capabilities are diminished. The essay also discusses the difficulties
Toxicidad subcrónica del extracto acuoso de las hojas y los brotes florales de Stachytarpheta jamaicensis (L.) Vahl. (Verbenaceae)
García-González,Mildred; Coto-Morales,Teresita; González-Camacho,Sara; Pazos,Liliana;
Revista Cubana de Plantas Medicinales , 2002,
Abstract: the toxicity of the leaves and floral buds of the botanical medicinal species stachytarpheta jamaicensis (l.) vahl was determined the botanical material (leaves and floral buds) was collected in february, 1996, by mr. victor rojas from the national biodiversity institute (witness number 400 vr), in santa rosa, guanacaste, in the following coordinates:10°50′20′′n-85°37′30′′w and an altitude of 290 msnm. the aqueous extracts prepared by decoction of the leaves and floral buds of stachytarpheta jamaicensis were orally administered to ngp male and female rats. the extract from the leaves was administered for 90 days and that of floral buds during 60 days. both extracts were given during 5 consecutive days per week. the control groups received 0.5 ml of distilled water per animal the aqueous extract from leaves caused 40 % of mortality both, in males and females. signs of toxicity were evidenced with the administration of extract from floral buds, with no mortality. all the registered signs suggest a general depressing effect on the central nervous system. that's why it is stated the need of making biological tests to validate the possible sedative-tranquilizing effect of this plant and the design of dose-effect curves of the toxicity of this plant.
Toxicidad subcrónica del extracto acuoso de las hojas y los brotes florales de Stachytarpheta jamaicensis (L.) Vahl. (Verbenaceae)
Mildred García-González,Teresita Coto-Morales,Sara González-Camacho,Liliana Pazos
Revista Cubana de Plantas Medicinales , 2002,
Abstract: Se determinó la toxicidad de las hojas y los brotes florales de la especie botánica medicinal Stachytarpheta jamaicensis (L.) Vahl. El material botánico (hojas y brotes florales) fue recolectado en febrero de 1996 por el se or Víctor Rojas del Instituto Nacional de Biodiversidad (número de testigo 400 VR) en Santa Rosa, Guanacaste en las siguientes coordenadas: 10°50′20′′N-85°37′30′′W y una altitud de 290 msnm. Los extractos acuosos, preparados por decocción, de las hojas y los brotes florales de Stachytarpheta jamaicensis, se administraron por vía oral a ratones NGP machos y hembras. El extracto de las hojas se administró durante 90 d y el de los brotes florales durante 60 d. Ambos extractos fueron administrados durante 5 d consecutivos por semana. Los grupos control recibieron 0,5 mL de agua destilada por animal. El extracto acuoso de las hojas causó 40 % de mortalidad tanto en machos como en hembras. Se evidenciaron signos de toxicidad con la administración del extracto de los brotes florales sin producir mortalidad. Todos los signos registrados sugieren un efecto general depresor sobre el sistema nervioso central, por lo que se plantea la necesidad de realizar pruebas biológicas dirigidas a la validación de un posible efecto sedante-tranquilizante de esta planta y la realización de curvas dosis-efecto de la toxicidad de esta especie. The toxicity of the leaves and floral buds of the botanical medicinal species Stachytarpheta Jamaicensis (L.) Vahl was determined The botanical material (leaves and floral buds) was collected in February, 1996, by Mr. Victor Rojas from the National Biodiversity Institute (witness number 400 VR), in Santa Rosa, Guanacaste, in the following coordinates:10°50′20′′N-85°37′30′′W and an altitude of 290 msnm. The aqueous extracts prepared by decoction of the leaves and floral buds of Stachytarpheta jamaicensis were orally administered to NGP male and female rats. The extract from the leaves was administered for 90 days and that of floral buds during 60 days. Both extracts were given during 5 consecutive days per week. The control groups received 0.5 mL of distilled water per animal The aqueous extract from leaves caused 40 % of mortality both, in males and females. Signs of toxicity were evidenced with the administration of extract from floral buds, with no mortality. All the registered signs suggest a general depressing effect on the central nervous system. That's why it is stated the need of making biological tests to validate the possible sedative-tranquilizing effect of this plant and the design of dose-effect curves of th
Homeostasis del magnesio: Etiopatogenia, clínica y tratamiento de la hipomagnesemia. A propósito de un caso
Pérez González,E.; Santos Rodríguez,F.; Coto García,E.;
Nefrología (Madrid) , 2009,
Abstract: magnesium is the fourth-most abundant cation in the human body and the second-most abundant intracellular cation after potassium. magnesium is pivotal in the transfer, storage, and utilization of energy as it regulates and catalyzes more than 300 enzyme systems. hypomagnesemia may thus result in a variety of metabolic abnormalities and clinical consequences. it results from an imbalance between gastrointestinal absorption and renal excretion of magnesium. the main consequence related directly to hypomagnesemia is cardiovascular arrhythmias secondary to hipokaliemia and if this is not recognized and treated it may be fatal. in this article we review the hypomagnesemic disorders in children with emphasis on the molecular mechanisms responsible for abnormalities in magnesium homeostasis, differential diagnosis and appropriate therapy, and we describe the clinical and biochemical manifestations as well as the genetic defect in a family with gitelman syndrome.
Toxicidad sub-crónica y prueba de irritabilidad ocular del extracto acuoso de las hojas de Plantago major (Plantaginaceae)
García González,Mildred; Coto Morales,Teresita; Soto Rodríguez,Gerardo A; Pazos,Liliana;
Revista de Biología Tropical , 2003,
Abstract: for the sub-chronic toxicity an aqueous preparation of plantago major leaves was tested in 20 male ngp mice, with an average weight of 20.15 g and separated in two groups of ten individuals each. the dose used was 2000 mg/kg and the control group received 0.5 ml of distilled water. the extract administration was done daily during five days at week for a total period of 40 days. signs of sub-chronic toxicity were observed in the days two and 12 of treatment. no significant change in corporal weight was observed. the ocular irritation was tested in five new zeland male rabbits, with an average weight of 3.640 kg. the dose used was a 200 μl the preparation (100 mg/ml) of plantago major leaves, instill into the right eye and the control was used the left eye instill 200 μl of distilled water. the administration was done daily during five days. the extract shows no significant irritation during the observation period
Subchronic and acute preclinic toxicity and some pharmacological effects of the water extract from leaves of Petiveria alliacea (Phytolaccaceae
García-González,Mildred; Coto Morales,Teresita; Ocampo,Rafael; Pazos,Liliana;
Revista de Biología Tropical , 2006,
Abstract: we tested the effects of the aqueous extract of petiveria alliacea leaves on acute and sub-chronic toxicity, hematocrit and blood glucose level and intestinal motility of male albino ngp mice of 20 to 25 g mean weight. treatments were in all cases doses of 1 000 and 2 000 mg/kg animal weight and a control treatment with 0.5 ml distilled water, using 10 animals per treatment and administered orally every day (5 days per week). experimental periods were 18 and 70 days for acute and sub chronic toxicity, respectively. no mortality nor any toxicity signs could be observed. a slight but significant increase in the glucose levels during the first three weeks was observed with the 1 000 mg/kg dose but not for the higher 2 000 mg/kg dose. after administering the doses once after a starving period of six hours, no significant differences in intestinal motility could be found. rev. biol. trop. 54 (4): 1323-1326. epub 2006 dec. 15
Resultados preliminares del pesquisaje neonatal inmunohistoquímico para la detección del síndrome de frágil X
Lardoeyt Ferrer,Roberto; Coto Rodeiro,Remigio; González Junco,Nereyda; Lantigua Cruz,Araceli; Willemsen,C. Rob;
Revista Cubana de Pediatr?-a , 2004,
Abstract: the fragile x syndrome is the genetic entity that is the first cause of hereditary mental retardation characterized by a very peculiar physical and psychoneuroconductal phenotype. innumerable studies, including the immunohistochemical techniques, have been conducted aimed at dilucidating the gene's function and the localization of the protein that it codified related to this affection. the immunohistochemical techique was used in order to detect individuals at genetical risk for presenting fragile x syndrome by neonatal screening in 14 months. a total of 2 914 male infants were screened of whom 2 414 showed histochemical results. 10 cases tested negative protein. their psychomotor development was exhaustively evaluated for 3 years and it was normal. the disease was not detected in any individual.
Resultados preliminares del pesquisaje neonatal inmunohistoquímico para la detección del síndrome de frágil X Preliminary results of the immunohistochemical neonatal screening for detecting the fragile X syndrome
Roberto Lardoeyt Ferrer,Remigio Coto Rodeiro,Nereyda González Junco,Araceli Lantigua Cruz
Revista Cubana de Pediatr?-a , 2004,
Abstract: El síndrome de frágil X constituye la entidad genética que ocupa el primer lugar como causa de retraso mental hereditario, caracterizado por un fenotipo físico y psiconeuroconductual muy peculiar. Han sido innumerables los estudios que se han realizado con el fin de dilucidar la función del gen y la localización de la proteína que la misma codifica relacionado con esta afección, entre los cuales se encuentran las técnicas inmunohistoquímicas. Se aplicó la técnica inmunohistoquímica con el objetivo de detectar individuos con riesgo genético de presentar el síndrome de frágil X a través de un pesquisaje neonatal en un período de 14 meses. Se pesquisaron un total de 2 914 recién nacidos varones, de los cuales 2 414 obtuvieron resultados inmunohistoquímicos. Diez casos fueron proteína negativos, en los cuales su desarrollo psicomotor fue evaluado exhaustivamente durante un período de 3 a os, y fue normal; no se detectó ningún individuo con la enfermedad. The Fragile X syndrome is the genetic entity that is the first cause of hereditary mental retardation characterized by a very peculiar physical and psychoneuroconductal phenotype. Innumerable studies, including the immunohistochemical techniques, have been conducted aimed at dilucidating the gene's function and the localization of the protein that it codified related to this affection. The immunohistochemical techique was used in order to detect individuals at genetical risk for presenting Fragile X syndrome by neonatal screening in 14 months. A total of 2 914 male infants were screened of whom 2 414 showed histochemical results. 10 cases tested negative protein. Their psychomotor development was exhaustively evaluated for 3 years and it was normal. The disease was not detected in any individual.
Subchronic and acute preclinic toxicity and some pharmacological effects of the water extract from leaves of Petiveria alliacea (Phytolaccaceae
Mildred García-González,Teresita Coto Morales,Rafael Ocampo,Liliana Pazos
Revista de Biología Tropical , 2006,
Abstract: We tested the effects of the aqueous extract of Petiveria alliacea leaves on acute and sub-chronic toxicity, hematocrit and blood glucose level and intestinal motility of male albino NGP mice of 20 to 25 g mean weight. Treatments were in all cases doses of 1 000 and 2 000 mg/kg animal weight and a control treatment with 0.5 ml distilled water, using 10 animals per treatment and administered orally every day (5 days per week). Experimental periods were 18 and 70 days for acute and sub chronic toxicity, respectively. No mortality nor any toxicity signs could be observed. A slight but significant increase in the glucose levels during the first three weeks was observed with the 1 000 mg/kg dose but not for the higher 2 000 mg/kg dose. After administering the doses once after a starving period of six hours, no significant differences in intestinal motility could be found. Rev. Biol. Trop. 54 (4): 1323-1326. Epub 2006 Dec. 15 Se evaluaron los efectos del estracto acuoso de las hojas de Petiveria alliacea, en la toxicidad aguda y toxicidad subcrónica, hematocritos, niveles de glucosa en la sangre y motilidad intestinal del ratón macho albino NGP, con un peso promedio de 20 a 25g. En todos los casos los tratamientos fueron dosis de 1 000 y 2 000 mg/kg de peso del animal y un tratamiento control con 0.5 ml de agua destilada, usando 10 animales por tratamiento y administrado oralmente cinco días por semana. Los períodos experimentales fueron de 18 y 70 días para toxicidad aguda y toxicidad subcrónica, respectivamente. No se observaron signos de mortalidad ni de toxidad en ambas pruebas. Con la dosis de 1 000 mg/kg hubo un leve pero significativo incremento en los niveles de glucosa durante las primeras tres semanas, pero no con la dosis más alta de 2 000 mg/kg. Después de administrar las dosis luego de un período de hambre de seis horas, no se encontraron diferencias significativas en la motilidad intestinal
Toxicidad sub-crónica y prueba de irritabilidad ocular del extracto acuoso de las hojas de Plantago major (Plantaginaceae)
Mildred García González,Teresita Coto Morales,Gerardo A Soto Rodríguez,Liliana Pazos
Revista de Biología Tropical , 2003,
Abstract: Se utilizaron 20 ratones albinos de la cepa NGP, machos, distribuidos en dos grupos de diez ratones cada uno con peso promedio de 20.15 ± 0.059 g los animales que recibieron el tratamiento (2000 mg/kg) y de 21.62 ± 0.03 g los animales que recibieron el control (0.5 ml de agua desionizada). Todos los tratamientos fueron administrados diariamente durante 5 días consecutivos por semana durante un período total de 40 días. No se presentó mortalidad con la dosis administrada por vía oral, sin embargo los animales presentaron disminución del reflejo de enderezamiento, de la actividad prensil anterior y posterior y de la reacción de alarma. Para la prueba de irritabilidad ocular se utilizaron 5 conejos de la cepa New Zeland, machos con peso promedio de 3.640 Kg. Se inoculó el ojo derecho con 200 μl del preparado acuoso (100 mg/ml) y el ojo izquierdo se instiló con 200 μl de agua destilada. La inoculación se realizó diariamente por un periodo de 5 días consecutivos, no se observó ninguna manifestación de irritabilidad ocular en el ojo de los conejos For the sub-chronic toxicity an aqueous preparation of Plantago major leaves was tested in 20 male NGP mice, with an average weight of 20.15 g and separated in two groups of ten individuals each. The dose used was 2000 mg/kg and the control group received 0.5 ml of distilled water. The extract administration was done daily during five days at week for a total period of 40 days. Signs of sub-chronic toxicity were observed in the days two and 12 of treatment. No significant change in corporal weight was observed. The ocular irritation was tested in five New Zeland male rabbits, with an average weight of 3.640 kg. The dose used was a 200 μl the preparation (100 mg/ml) of Plantago major leaves, instill into the right eye and the control was used the left eye instill 200 μl of distilled water. The administration was done daily during five days. The extract shows no significant irritation during the observation period
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