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Search Results: 1 - 10 of 12685 matches for " Gomes Catarina "
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Cutaneous Phaeohyphomycosis Caused by Alternaria alternata Unresponsive to Itraconazole Treatment
Joana Gomes,Catarina Vilarinho,Maria da Luz Duarte,Celeste Brito
Case Reports in Dermatological Medicine , 2011, DOI: 10.1155/2011/385803
Abstract: Cutaneous alternariosis is an opportunistic infection that has been described mainly in patients treated with corticosteroids. We report a case of dermal alternariosis occurring in a woman treated with corticosteroids after a neurosurgery that was unresponsive to itraconazole. Treatment with intravenous voriconazole was initiated, followed by oral protocol, with marked improvement of the lesions.
Activation of microglial cells triggers a release of brain-derived neurotrophic factor (BDNF) inducing their proliferation in an adenosine A2A receptor-dependent manner: A2A receptor blockade prevents BDNF release and proliferation of microglia
Gomes Catarina,Ferreira Raquel,George Jimmy,Sanches Rui
Journal of Neuroinflammation , 2013, DOI: 10.1186/1742-2094-10-16
Abstract: Background Brain-derived neurotrophic factor (BDNF) has been shown to control microglial responses in neuropathic pain. Since adenosine A2A receptors (A2ARs) control neuroinflammation, as well as the production and function of BDNF, we tested to see if A2AR controls the microglia-dependent secretion of BDNF and the proliferation of microglial cells, a crucial event in neuroinflammation. Methods Murine N9 microglial cells were challenged with lipopolysaccharide (LPS, 100 ng/mL) in the absence or in the presence of the A2AR antagonist, SCH58261 (50 nM), as well as other modulators of A2AR signaling. The BDNF cellular content and secretion were quantified by Western blotting and ELISA, A2AR density was probed by Western blotting and immunocytochemistry and cell proliferation was assessed by BrdU incorporation. Additionally, the A2AR modulation of LPS-driven cell proliferation was also tested in primary cultures of mouse microglia. Results LPS induced time-dependent changes of the intra- and extracellular levels of BDNF and increased microglial proliferation. The maximal LPS-induced BDNF release was time-coincident with an LPS-induced increase of the A2AR density. Notably, removing endogenous extracellular adenosine or blocking A2AR prevented the LPS-mediated increase of both BDNF secretion and proliferation, as well as exogenous BDNF-induced proliferation. Conclusions We conclude that A2AR activation plays a mandatory role controlling the release of BDNF from activated microglia, as well as the autocrine/paracrine proliferative role of BDNF.
Studies on the effectiveness of diarylheptanoids derivatives against Leishmania amazonensis
Araujo, Catarina AC;Alegrio, Leila V;Gomes, Denise CF;Lima, Marco Edilson F;Gomes-Cardoso, Leonardo;Leon, Leonor L;
Memórias do Instituto Oswaldo Cruz , 1999, DOI: 10.1590/S0074-02761999000600015
Abstract: in a previous work we demonstrated that diarylheptanoids extracted from centrolobium sclerophyllum are very active against leishmania amazonensis promastigotes. in order to continue our studies with these class of compounds, we decided to evaluate the activity of several diarylheptanoids derived from curcumin (diferuloyl methane) against the extracellular form (promastigotes) of l. amazonensis. furthermore, an experiment against the intracellular form of the parasite (amastigotes) was carried out, comparing the most active compound among the curcumin derivatives (the methylcurcumin) with des-o-methylcentrolobine, the most active diarylheptanoid derived from c. sclerophyllum.
Cutaneous Manifestations of Systemic Lupus Erythematosus
Luís Uva,Diana Miguel,Catarina Pinheiro,Jo?o Pedro Freitas,Manuel Marques Gomes,Paulo Filipe
Autoimmune Diseases , 2012, DOI: 10.1155/2012/834291
Abstract: Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease of unknown etiology with many clinical manifestations. The skin is one of the target organs most variably affected by the disease. The American College of Rheumatology (ACR) established 11 criteria as a classificatory instrument to operationalise the definition of SLE in clinical trials. They were not intended to be used to diagnose individuals and do not do well in that capacity. Cutaneous lesions account for four of these 11 revised criteria of SLE. Skin lesions in patients with lupus may be specific or nonspecific. This paper covers the SLE-specific cutaneous changes: malar rash, discoid rash, photosensitivity, and oral mucosal lesions as well as SLE nonspecific skin manifestations, their pathophysiology, and management. A deeper thorough understanding of the cutaneous manifestations of SLE is essential for diagnosis, prognosis, and efficient management. Thus, dermatologists should cooperate with other specialties to provide optimal care of SLE patient. 1. Introduction The nosographic concept of lupus erythematosus (LE) includes 3 major subtypes: chronic cutaneous LE, subacute cutaneous LE, and systemic or acute cutaneous LE. Besides these 3 subtypes, other less frequent clinical varieties may occur [1]. Systemic lupus erythematosus (SLE) is a multiorgan autoimmune disease of unknown etiology that can have many clinical manifestations (Table 1). The skin is involved in up to 85% of systemic lupus erythematosus (SLE) cases and may be the only organ involved in cutaneous lupus erythematosus (CLE). Table 1: Cutaneous manifestations of SLE. The diagnosis of the cutaneous manifestations of LE is based on clinical, histopathology, and immunohistology of skin lesions. In addition, serum autoantibodies are considered immunologic markers for distinct clinical types of the illness. The Cutaneous Lupus Erythematosus Disease Area and Severity Index (CLASI) is used as a clinical tool that standardizes the way disease activity is described and provides guidelines for identifying a clinical change. This clinical tool quantifies disease activity and damage in cutaneous lupus erythematosus. The activity score is based on the erythema, scale, mucous membrane lesions, and nonscarring alopecia. A recent study gives us a foundation for the practical use of the CLASI in clinical trials as a tool to measure disease severity and responsiveness to therapy [2]. In 1982, the diagnosis criteria for SLE were published by the American College of Rheumatology (ACR) which were revised in 1997 and are currently
Proposta de um protocolo de avalia??o fisioterapêutica para os pés de diabéticos
Mendon?a, Sarah de Souza;Morais, Juliana de Sant'Anna;Moura, Maria Catarina Gomes Gadelha de;
Fisioterapia em Movimento , 2011, DOI: 10.1590/S0103-51502011000200010
Abstract: introduction: because of the high social and economic costs caused by complications of diabetes and knowing that a clinical evaluation minute can prevent or reduce the impact of this disorder, have become increasingly need to develop specific assessments. objective: this study aims to propose an assessment protocol for physical therapy for feet of diabetics. materials and methods: the composition of this article resulted from a literature review that was conducted a literature search through the journals indexed in the databases lilacs, scielo, pubmed and medline. the keywords used were "diabetes mellitus", "risk factors", "diabetic foot" and "assessment". results: the proposed protocol consists of three steps to assess the socio-demographic, lifestyle, disease history, history of foot problems, the skin conditions, circulatory, neurological, functional and structural and the evaluation of self-care with the feet. conclusion: the evaluation suggested may be useful for detailed characterization of diabetics, and so identify those who pose a greater risk of developing complications and may facilitate the determination of preventive measures and treatment.
Revis?o do gênero Klossinemella Costa, 1961 (Nematoda, Cobboldinidae), com descri??o de uma nova subfamília e de uma nova espécie
Costa, Sylvio Celso Gon?alves da;Motta, Catarina da Silva;Gomes, Delir Corrêa;
Memórias do Instituto Oswaldo Cruz , 1968, DOI: 10.1590/S0074-02761968000200004
Abstract: in the present work the authors give a new sistematic organization for the generic components of the family cobboldinidae skriabin, 1948. a new species of klossinemella costa, 1961 is described (k. travassosi) and the description of k. iheringi and k. conciliatus is given. finally the authors discuss the biological cycle of klossinemella costa, 1961 in comparison with the cycle of rondonia travassos, 1919.
Qualidade da madeira de cinco espécies florestais para o envelhecimento da cacha?a
Cat?o, Catarina G.;Paes, Juarez B.;Gomes, Josivanda P.;Araújo, Gilmar T.;
Revista Brasileira de Engenharia Agrícola e Ambiental , 2011, DOI: 10.1590/S1415-43662011000700013
Abstract: this research aimed to evaluate the wood quality of amburana cearencis (fr. allem.) a.c. sm., myroxylon peruiferum l.f., tabebuia chrysotricha (mart. ex dc.) standl., hymenaea courbaril l. var. stilbocarpa (hayne) lee et lang. and cariniana legalis (mart.) kuntze in the storage of "cacha?a" (brazilian sugar cane spirit); to compare the "cacha?a" studied with the stored one in barrel of oak (quercus sp.), to analyze the effect of the aging and to compare the values obtained with the standard ones for the brazilian legislation. thus, the "cacha?as" were stored in wooden and glass barrels and their chemical (volatile acidity, methyl alcohol, superior alcohol, aldehyde, cupper, ester, dry extract to 100 oc, furfural contents and alcoholic degree) and organoleptic (color, flavor and aroma) characteristics were analysed. after six months of storage the "cacha?as" were compared with the standard values according to brazilian legislation. independent of the species, the wood improves the sensorial qualities of "cacha?a", incorporating the drink taste, color and characteristic flavor. all "cacha?as" evaluated continued to be with in the standards of quality established by brazilian legislation.
Polymorphism in the internal transcribed spacer (ITS) of the ribosomal DNA of 26 isolates of ectomycorrhizal fungi
Gomes Eliane A.,Kasuya Maria Catarina M.,Barros Everaldo G. de,Borges Arnaldo C.
Genetics and Molecular Biology , 2002,
Abstract: Inter- and intraspecific variation among 26 isolates of ectomycorrhizal fungi belonging to 8 genera and 19 species were evaluated by analysis of the internal transcribed sequence (ITS) of the rDNA region using restriction fragment length polymorphism (RFLP). The ITS region was first amplified by polymerase chain reaction (PCR) with specific primers and then cleaved with different restriction enzymes. Amplification products, which ranged between 560 and 750 base pairs (bp), were obtained for all the isolates analyzed. The degree of polymorphism observed did not allow proper identification of most of the isolates. Cleavage of amplified fragments with the restriction enzymes Alu I, Hae III, Hinf I, and Hpa II revealed extensive polymorphism. All eight genera and most species presented specific restriction patterns. Species not identifiable by a specific pattern belonged to two genera: Rhizopogon (R. nigrescens, R. reaii, R. roseolus, R. rubescens and Rhizopogon sp.), and Laccaria (L. bicolor and L. amethystea). Our data confirm the potential of ITS region PCR-RFLP for the molecular characterization of ectomycorrhizal fungi and their identification and monitoring in artificial inoculation programs.
A Rede de Programas de Pós-Gradua o em Administra o no Brasil: Análise de Rela es Acadêmicas e Atributos de Programas
Tomás de Aquino Guimar?es,Adalmir de Oliveira Gomes,Catarina Cecilia Odelius,Claudio Zancan
Revista de Administra??o Contemporanea , 2009,
Abstract: This article investigates the influence exerted by relationships between academic institutions and attributes of graduate management programs in shaping the structure of the Brazilian Graduate Management Program network. The research was designed according to a social network approach and the data collection was undertaken between February and July of 2007 and included the coordinators of the 58 programs that were operating at that time, to whom a link to an electronic questionnaire was e-mailed. Thirty two (55%) of these coordinators completed the questionnaire, providing information on the relationships between their programs and the other 57 programs in the following activities: joint research, shared scientific production, promotion of scientific events, shared courses, academic staff exchanges, graduate student exchanges and participation in examination boards for dissertations and theses. The programs’ attributes were obtained from the websites of each program and CAPES. The main results showed: (1) a low density network with mostly weak relationships between programs, (2) a network structure defined by geographical location and research area, with the better connected networks in the areas of Organization and Organizational Behaviour and Strategy; and (3) a network in which UFRGS is the most central program and the FGV/SP, USP/SP, UFRGS and FGV/RJ are the most prestigious.
Conhecimento das gestantes adolescentes sobre o trabalho de parto prematuro e os riscos à saúde do feto
Kelly Cristina Gomes de Lima, Ednaldo Cavalcante de Araújo, Ana Catarina Torres de Lacerda
Revista de Enfermagem UFPE On Line , 2008,
Abstract: To identify the knowledge of pregnant teenagers about labor premature birth and the risks for the fetus health, at a maternity of Recife, Pernambuco (PE) - Brazil, was conducted this descriptive exploratory study, from quantitative nature. The data were collected through a questionnaire with 18 pregnant, analyzed and discussed according to the literature, showing that 78% were in the age group of 16 to 19 years old, 72% carried the metropolitan Recife area, 78% lived in consensual union; 72% looked to the fundamental teaching incomplete; 55% had family income from one to two minimum wages; 88% done prenatal, 61% were primiparous, 61% of the pregnancies were not planned; 27% said be aware that the pain in the lower belly, 20% the contractions, 14% to back pain and 14% losses vaginal symptoms were of labor premature birth, 32% indicated as a result of the labor premature birth to the fetus, the prematurity fetal; 28% to infection and neonatal mortality, 44% said the doctor as the professional who informed about his health condition, 6% were for nurses, and 44% do not have any information. Finally, must offer better quality service and the guidance for pregnant adolescents, which in most cases, are not ready for a risk gestation, both for lack of knowledge for themselves as to the fetus on the diseases that affect them.
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