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Search Results: 1 - 10 of 725 matches for " Gohar Sultan "
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Renal Tumors in Young Adults A Single-Center Experience From a Developing Country
Rehan Mohsin,Altaf Hashmi,Gohar Sultan,Asad Shehzad
Urology Journal , 2012,
Abstract: Purpose: To determine the pattern and outcome of renal tumors in young adults in a large surgical series in Pakistan. Materials and Methods: We retrospectively analyzed 133 young adults (age: ≥ 16 to ≤ 40 years) with 136 renal tumors, who underwent surgical treatment for suspected renal cancer from 1994 till 2010. The clinical and pathological parameters were determined and their impact on final outcome was analyzed. Results: The mean age of the patients was 33.3 ± 6.2 years. Of 136, 121 (88.9%) renal tumors were malignant and 15 (11%) were benign. Among malignancies, 76 (62.7%) patients had stage I or II tumors, 22 (18.1%) stage III, and 23 (19%) stage IV at surgery. The overall cancer-specific survival for malignant tumors at 1, 5, and 10 years was 97%, 83%, and 83%, whereas the cancer-free survival (CFS) was 80%, 63%, and 37%, respectively. Patients with age ≤ 35 years had 1 and 5-year CFS of 83% and 71%, respectively, as compared with 76% and 49% for patients > 35 years (P = .02; odds ratio = 2.3; P = .03). Regarding tumor size, 1 and 5-year CFS for tumors ≤ 10 cm was 93% and 75%, while tumors > 10 cm showed CFS of 56% and 41%, respectively (P = .0001; odds ratio = 4.2; P = .0001). For stage I tumors, CFS at 1 and 5 years was 98% and 84%; for stage II, 82% and 63%; and for stage III, 62% and 50%, respectively. One-year survival for stage IV was 48% only (P = .0001). Conclusion: A wide heterogeneity of renal tumors is seen in young adults with delayed presentation.
Neuropathic hand pruritus
Gohar Amr
Indian Journal of Dermatology, Venereology and Leprology , 2009,
Abstract:
Toward a Revolutionary Emirati Poetics : Ghabesh's Beman Ya Buthayn Taluthin?
Saddik Gohar.
Nebula , 2008,
Abstract:
Frontiers of Violence and Fear: A Study of Native American and Palestinian Intifada Poetry.”
Saddik Gohar
Nebula , 2005,
Abstract:
Optimal regularity in the optimal switching problem
Gohar Aleksanyan
Mathematics , 2014,
Abstract: In this article we study the optimal regularity for solutions to the following weakly coupled system with interconnected obstacles \begin{equation*} \begin{cases} \min (-\Delta u^1+f^1, u^1-u^2+\psi^1)=0 \\ \min (-\Delta u^2+f^2, u^2-u^1+\psi^2)=0, \end{cases} \end{equation*} arising in the optimal switching problem with two modes. We derive the optimal $C^{1,1}$-regularity for the minimal solution under the assumption that the zero loop set $\mathscr{L}:= \{ \psi^1+\psi^2=0\}$ is the closure of its interior. This result is optimal and we provide a counterexample showing that the $C^{1,1}$-regularity does not hold without the assumption $\mathscr{L} = \overline{ \mathscr{L}^0} $.
Identification of Temporal Shifting Trends of Submarine Indus Canyon, Pakistan  [PDF]
Gohar Ali Mahar, Nayyer Alam Zaigham
Journal of Water Resource and Protection (JWARP) , 2013, DOI: 10.4236/jwarp.2013.55052
Abstract:

Indus Canyon is one of the most prominent sub-aqueous features of the Indus Delta. Indus River, originating from the Manasarovour Lake, hosting at the foot of high Himalayan Mountains Glaciers, forms a huge delta after travelling more than 300 km at the north eastern coastline of the Arabian Sea. In view to assess the temporal geomorphic change associated with the Indus Canyon, a study has been carried out based on the bathymetric surveyed data compiled in 1895 and satellite data compiled in 1998. The result of the study shows distinct changes in the orientation of the Indus submarine Canyon. Moreover, significant erosional activities have also been identified, associated with the Canyon channel and the channel’s walls. Canyon’s head has shifted westward rotating about 22°. In addition, the chronological study of the water flow and sediment discharge of the Indus River shows a drastic decline in the flow of river water into the Indus Delta and the sea. This phenomenon appears to modify the fluvial as well as marine dynamics of Indus River consequently affecting the Indus Canyon on a significant scale.

Silver and Gold Nanoparticles Embedded in Potato Starch Gel Films  [PDF]
Karen Khachatryan, Gohar Khachatryan, Maciej Fiedorowicz
Journal of Materials Science and Chemical Engineering (MSCE) , 2016, DOI: 10.4236/msce.2016.42003
Abstract: Facile and environmentally friendly method of the preparation of silver and gold nanoparticles embedded in potato starch matrix (Sp) was developed. UVVIS spectroscopy, transmission electron microscopy (TEM) and Fourier transform infrared (FTIR) spectra confirmed formation of ball shaped Ag and Au nanoparticles situated within the polysaccharide template. EDS spectra confirm presence of silver and gold nanocrystals in the obtained composites. Differential scanning calorimetry (DSC) showed that Sp/Au composite started to decompose earlier. The decomposition is slower and two-step, in contrast to Sp and Sp/Ag. NanoAg accelerates carbonization. Molecular weights of polysaccharide chains of the matrix were estimated with the size exclusion chromatography coupled with multiangle laser light scattering and refractometric detectors (HPSEC-MALLS-RI). Formation of nanosilver containing composites led to partial depolymerisation of polysaccharides from the amylose fraction. In the case of nanogold we observed depolymerisation of polysaccharide chains from both fractions.
Genetic Polymorphisms of Nervous System Development and the Risk of Posttraumatic Stress Disorder  [PDF]
Diana Avetyan, Arsen Arakelyan, Gohar Mkrtchyan
American Journal of Molecular Biology (AJMB) , 2018, DOI: 10.4236/ajmb.2018.81005
Abstract: Background: Posttraumatic stress disorder (PTSD) is a complex severe polygenic psychiatric disease, influenced by environmental and genetic factors. PTSD development and progression is characterized by cognitive impairment, which may result in altered processes of nervous system development and synaptic plasticity, where a number of growth factors and their receptors were shown to play important role. Since neurotrophins play an essential role in the development of central nervous system, it is widely implicated in psychiatric disorders. The aim of this study is to investigate the potential association functional polymorphisms of genes encoding netrin G1 (NTNG1), brain-derived neurotrophic factor (BDNF), nerve growth factor (NGF) and its receptor (NGFR) with PTSD. Methods: Study groups consisted of 200 combat veterans with PTSD and an equal number of controls with no family or past history of any psychiatric disorders. The DNA samples were genotyped for NTNG1 rs62811; BDNF rs6265; NGF rs6330, rs4839435; NGFR rs11466155, rs734194 SNPs using polymerase chain reaction with sequence specific primers. Results: According to the results, NGF rs6330 was overrepresented in patients with PTSD compared to controls. Furthermore, negative association for BDNF rs6265, NGF rs4839435 and NGFR rs734194 was observed in PTSD patients. Conclusions: In summary, BDNF rs6265, NGF rs6330, rs4839435 and NGFR rs734194 are implicated in PTSD in Armenian population. However, further research is required to provide the definitive evidence of selected polymorphism association with gene expression.
Association of Bax and Bcl-2 Functional Polymorphisms and Protein Levels with Posttraumatic Stress Disorder  [PDF]
Diana Avetyan, Arsen Arakelyan, Gohar Mkrtchyan
Journal of Biosciences and Medicines (JBM) , 2018, DOI: 10.4236/jbm.2018.62003
Abstract: Background: Posttraumatic stress disorder (PTSD) is an anxiety disease influenced by both environmental and genetic factors, which affects a patient’s quality of life and social stability. Recent studies have shown that the pathogenesis of PTSD is associated with apoptosis; however, the molecular mechanisms that cause such damage are not well-understood. Also it is unclear whether these pathologic alterations are genetically determined or caused by other factors. The aim of this study was to investigate the genetic association of functional polymorphisms in genes coding for apoptosis-related Bcl-2 and Bax proteins with PTSD as well as proteins levels in the blood of affected subjects. Methods: The study groups consisted of 200 combat veterans with PTSD and an equal number of healthy subjects with no family- or past-history of any psychiatric disorders. Bax and Bcl-2 proteins levels in blood were measured by ELISA. DNA samples were genotyped for SNPs using PCR-SSP. Results: According to our results, PTSD patients are characterized by increased levels of apoptotic proteins and the imbalance in the Bax/Bcl-2 ratio compared to healthy subjects. Our results also demonstrate that rs956572*A minor allele of the BCL2 gene was overrepresented in patients with PTSD compared to healthy subjects. Conclusions: The results implicate Bcl-2 and Bax in pathogenesis of PTSD on genetic and protein levels, though further studies on enlarged cohort and in different populations are required.
Record Values from the Inverse Weibull Lifetime Model: Different Methods of Estimation  [PDF]
Khalaf S. Sultan
Intelligent Information Management (IIM) , 2010, DOI: 10.4236/iim.2010.211072
Abstract: In this paper, we use the lower record values from the inverse Weibull distribution (IWD) to develop and discuss different methods of estimation in two different cases, 1) when the shape parameter is known and 2) when both of the shape and scale parameters are unknown. First, we derive the best linear unbiased estimate (BLUE) of the scale parameter of the IWD. To compare the different methods of estimation, we present the results of Sultan (2007) for calculating the best linear unbiased estimates (BLUEs) of the location and scale parameters of IWD. Second, we derive the maximum likelihood estimates (MLEs) of the location and scale parameters. Further, we discuss some properties of the MLEs of the location and scale parameters. To compare the different estimates we calculate the relative efficiency between the obtained estimates. Finally, we propose some numerical illustrations by using Monte Carlo simulations and apply the findings of the paper to some simulated data.
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