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Search Results: 1 - 10 of 5161 matches for " Goang-Won Cho "
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HCCR-1, a novel oncogene, encodes a mitochondrial outer membrane protein and suppresses the UVC-induced apoptosis
Goang-Won Cho, Seung Shin, Hyun Kim, Seon-Ah Ha, Sanghee Kim, Joo-Hee Yoon, Soo Hur, Tae Kim, Jin Kim
BMC Cell Biology , 2007, DOI: 10.1186/1471-2121-8-50
Abstract: To investigate the biological function of HCCR-1 in the cell, we predicted biological features using bioinformatic tools, and have identified a LETM1 homologous domain at position 75 to 346 of HCCR-1. This domain contains proteins identified from diverse species predicted to be mitochondrial proteins. Fluorescence microscopy and fractionation experiments showed that HCCR-1 is located in mitochondria in the COS-7, MCF-7 and HEK/293 cell lines, and subcompartamentally at the outer membrane in the HEK/293 cell line. The topological structure was revealed as the NH2-terminus of HCCR-1 oriented toward the cytoplasm. We also observed that the D1-2 region, at position 1 to 110 of HCCR-1, was required and sufficient for posttranslational mitochondrial import. The function of HCCR-1 on mitochondrial membrane is to retard the intrinsic apoptosis induced by UVC and staurosporine, respectively.Our experiments show the biological features of HCCR-1 in the cell, and suggest that uncontrolled expression of HCCR-1 may cause mitochondrial dysfunction that can result in resisting the UVC or staurosporine-induced apoptosis and progressing in the tumor formation.Mitochondria are responsible for a number of metabolic tasks in eukaryotic cells. Their primary function is to generate energy through oxidative phosphorylation in organelles. Mitochondria also play an important role in other biological activities such as programmed cell death [1], calcium signaling and generation of detoxification of reactive oxygen species [2].Mitochondria consist of four subcompartments – an outer membrane, an inner membrane, an inter-membrane space and matrix. The chaperone proteins, and the translocase components, help mitochondrial transport into the subcompartments through their membranes [3]. During the cytoplasmic translation of mitochondrial proteins, they are recognized by chaperone proteins which interfere with the folding of the protein. A positively charged signal sequence, on the mitochondrial pr
TCF/β-catenin plays an important role in HCCR-1 oncogene expression
Goang-Won Cho, Mi-Hwa Kim, Seung Kim, Seon-Ah Ha, Hyun Kim, Sanghee Kim, Jin W Kim
BMC Molecular Biology , 2009, DOI: 10.1186/1471-2199-10-42
Abstract: In this study, we showed how the expression of HCCR-1 is modulated. The luciferase activity assay indicated that the HCCR-1 5'-flanking region at positions -166 to +30 plays an important role in HCCR-1 promoter activity. Computational analysis of this region identified two consensus sequences for the T-cell factor (TCF) located at -26 to -4 (Tcf1) and -136 to -114 (Tcf2). Mutation at the Tcf1 site led to a dramatic decrease in promoter activity. Mobility shift assays (EMSA) revealed that nuclear proteins bind to the Tcf1 site, but not to the Tcf2 site. LiCl, Wnt signal activator by GSK-3β inhibition, significantly increased reporter activities in wild-type Tcf1-containing constructs, but were without effect in mutant Tcf1-containing constructs in HEK/293 cells. In addition, endogenous HCCR-1 expression was also increased by treatment with GSK-3β inhibitor, LiCl or AR-A014418 in HEK/293 and K562 cells. Finally, we also observed that the transcription factor, TCF, and its cofactor, β-catenin, bound to the Tcf1 site.These findings suggest that the Tcf1 site on the HCCR-1 promoter is a major element regulating HCCR-1 expression and abnormal stimulation of this site may induce various human cancers.Proto-oncogenes normally help regulate cell growth and differentiation under well-controlled conditions, including mitogenic signal transductions in cells [1,2]. Uncontrolled expression of proto-oncogenes due to mutations or activation of signaling can give rise to a tumor-inducing agent, which is known as an oncogene [2,3]. For more than a decade, there has been a focus on the transcriptional regulation of oncogenes or proto-oncogenes in search of therapeutic clues against cancers which are induced by over-transcription of their oncogenes.Wnt is known as a proto-oncogene and its signaling pathway is a complex network of proteins with roles in embryogenesis [4-6] and cancer [7]. Wnt and its signaling pathway is also involved in normal physiologic processes, including cell pola
Two symmetry breaking mechanisms for the development of orientation selectivity in a neural system
Myoung Won Cho
Quantitative Biology , 2015,
Abstract: Orientation selectivity is a remarkable feature of the neurons located in the primary visual cortex. Provided that the visual neurons acquire orientation selectivity through activity-dependent Hebbian learning, the development process could be understood as a kind of symmetry breaking phenomenon in the view of physics. The key mechanisms of the development process are examined here in a neural system. Found is that there are at least two different mechanisms which lead to the development of orientation selectivity through breaking the radial symmetry in receptive fields. The first, a simultaneous symmetry breaking mechanism, bases on the competition between neighboring neurons, and the second, a spontaneous one, bases on the nonlinearity in interactions. It turns out that only the second mechanism leads to the formation of a columnar pattern which characteristics accord with those observed in an animal experiment.
The Application of the Korean Dietary Pattern Score; KNHANES (Korean National Health and Nutrition Examination Survey) 2007  [PDF]
Kyung Won Lee, Ji Eun Oh, Mi Sook Cho
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.312221
Abstract: The aim of this study was to apply the Korean Dietary Pattern Score (KDPS) to Korean subjects based on traditional Korean-style meals. The KDPS is based on the 3-Chup Bansang (the traditional Korean daily table setting) and considers the intake of 6 major food groups according to the Korean Dietary Reference Intakes (KDRIs). The KDPS consists of 2 parts: the Korean-Style Meal Score (KSMS) and the Food Group Score (FGS). The KDPS was applied dietary data collected during the Korean National Health and Nutrition Examination Survey (KNHANES) in 2007. Socio-demographic status, gender, age, and body mass index are all factors that have been shown to be meaningful predictors for the KDPS. When the effect of the KDPS on risk of disease was evaluated, a higher total KDPS was associated with a decreased risk of elevated systolic blood pressure (p < 0.05) and hypercholesterolemia (p < 0.05). In addition, as the KSMS increased, the risk of central obesity (p < 0.05) and hypertension (p < 0.01) significantly decreased. A higher total KDPS suggests a greater diversity of food intake, and therefore greater dietary diversity appears to lower the risk of disease. The KDPS is relevant because it integrates scores for Korean-style meal patterns and meal evaluation from a nutritional perspective. In conclusion, the KDPS is appropriate for evaluating the quality of diet, adherence to Korean-style meal patterns, and risk of related diseases. These results will be useful for evaluating the nation’s dietary patterns, nutrition, and health status when planning nutrition policies and programs.
The bone morphogenetic protein antagonist gremlin 1 is overexpressed in human cancers and interacts with YWHAH protein
Hong Namkoong, Seung Shin, Hyun Kim, Seon-Ah Ha, Goang Cho, Soo Hur, Tae Kim, Jin Kim
BMC Cancer , 2006, DOI: 10.1186/1471-2407-6-74
Abstract: We used the differential display (DD) RT-PCR method using normal cervical, cervical cancer, metastatic cervical tissues, and cervical cancer cell lines to identify genes overexpressed in cervical cancers and identified gremlin 1 which was overexpressed in cervical cancers. We determined expression levels of gremlin 1 using Northern blot analysis and immunohistochemical study in various types of human normal and cancer tissues. To understand the tumorigenesis pathway of identified gremlin 1 protein, we performed a yeast two-hybrid screen, GST pull down assay, and immunoprecipitation to identify gremlin 1 interacting proteins.DDRT-PCR analysis revealed that gremlin 1 was overexpressed in uterine cervical cancer. We also identified a human gremlin 1 that was overexpressed in various human tumors including carcinomas of the lung, ovary, kidney, breast, colon, pancreas, and sarcoma. PIG-2-transfected HEK 293 cells exhibited growth stimulation and increased telomerase activity. Gremlin 1 interacted with homo sapiens tyrosine 3-monooxygenase/tryptophan 5-monooxygenase activation protein, eta polypeptide (14-3-3 eta; YWHAH). YWHAH protein binding site for gremlin 1 was located between residues 61–80 and gremlin 1 binding site for YWHAH was found to be located between residues 1 to 67.Gremlin 1 may play an oncogenic role especially in carcinomas of the uterine cervix, lung, ovary, kidney, breast, colon, pancreas, and sarcoma. Over-expressed gremlin 1 functions by interaction with YWHAH. Therefore, Gremlin 1 and its binding protein YWHAH could be good targets for developing diagnostic and therapeutic strategies against human cancers.The identification of molecular alterations in cancerous and pre-cancerous cells has provided insight into the role of oncogenes and tumor suppressor genes in tumor initiation and progression [1]. Oncogenes are derived from highly conserved proto-oncogenes that are altered by chromosomal point mutations, gene amplifications, or gene rearrangements
Probing the Messenger of SUSY Breaking with Gaugino Masses
Cho, Won Sang;Choi, Kiwoon
High Energy Physics - Phenomenology , 2007, DOI: 10.1063/1.2803808
Abstract: Gaugino masses might provide useful information on the underlying scheme of supersymmetry breaking as they are least dependent on the unknown physics between the TeV scale and the high messenger scale of supersymmetry breaking. We discuss the pattern of low energy gaugino masses in various schemes of supersymmetry breaking together with the possibility to determine the gaugino masses at LHC.
Instability of planar vortices in two-dimensional easy-plane Heisenberg model with distance-dependent interactions
Myoung Won Cho,Seunghwan Kim
Physics , 2003, DOI: 10.1103/PhysRevB.70.024405
Abstract: It is known that magnetic vortices in two dimensional Heisenberg models with easy-plane anisotropy exhibit an instability depending on the anisotropy strength. In this paper, we study the statistic behavior of the two-dimensional easy-plane Heisenberg models with distance-dependent interactions, $J_{xy}(r)$ and $J_z(r)$ for in-plane and out-of-plane components. We develop analytical and numerical methods for accurate determination of critical anisotropy, above which out-of-plane vortices are stable. In particular, we explore the vortex formation of the Gaussian-type interaction model and determine the critical anisotropy accurately for square, hexagonal and triangular lattices.
Understanding visual map formation through vortex dynamics of spin Hamiltonian models
Myoung Won Cho,Seunghwan Kim
Physics , 2003, DOI: 10.1103/PhysRevLett.92.018101
Abstract: The pattern formation in orientation and ocular dominance columns is one of the most investigated problems in the brain. From a known cortical structure, we build spin-like Hamiltonian models with long-range interactions of the Mexican hat type. These Hamiltonian models allow a coherent interpretation of the diverse phenomena in the visual map formation with the help of relaxation dynamics of spin systems. In particular, we explain various phenomena of self-organization in orientation and ocular dominance map formation including the pinwheel annihilation and its dependency on the columnar wave vector and boundary conditions.
General representation of collective neural dynamics with columnar modularity
Myoung Won Cho,Seunghwan Kim
Quantitative Biology , 2004,
Abstract: We exhibit a mathematical framework to represent the neural dynamics at cortical level. Our description of neural dynamics with columnar and functional modularity, named fibre bundle representation (FBM) method, is based both on neuroscience and informatics, whereas they correspond with the conventional formulas in statistical physics. In spite of complex interactions in neural circuitry and various cortical modification rules per models, some significant factors determine the typical phenomena in cortical dynamics. The FBM representation method reveals them plainly and gives profit in building or analyzing the cortical dynamic models. Not only the similarity in formulas, the cortical dynamics can share the statistical properties with other physical systems, which validated in primary visual maps. We apply our method to proposed models in visual map formations, in addition our suggestion using the lateral interaction scheme. In this paper, we will show that the neural dynamic procedures can be treated through conventional physics expressions and theories.
Different ocular dominance map formation by influence of orientation columns in visual cortices
Myoung Won Cho,Seunghwan Kim
Quantitative Biology , 2003, DOI: 10.1103/PhysRevLett.94.068701
Abstract: In animal experiments, the observed orientation preference (OP) and ocular dominance (OD) columns in the visual cortex of the brain show various pattern types. Here, we show that the different visual map formations in various species are due to the crossover behavior in anisotropic systems composed of orientational and scalar components such as easy-plane Heisenberg models. We predict the transition boundary between different pattern types with the anisotropy as a main bifurcation parameter, which is consistent with experimental observations.
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