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Search Results: 1 - 10 of 5112 matches for " Giuseppe Visani "
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AUTOLOGOUS STEM CELL TRANSPLANTATION FOR AGGRESSIVE LYMPHOMAS
Giuseppe Visani,Paola Picardi,Patrizia Tosi,Alessandro Isidori
Mediterranean Journal of Hematology and Infectious Diseases , 2012, DOI: 10.4084/mjhid.2012.
Abstract: The role of high-dose therapy (HDT) followed by autologous stem cell transplantation (ASCT) in the treatment armamentarium of aggressive B- and T-cell non-Hodgkin lymphoma (NHL) is still a matter of debate. In the pre-Rituximab era, the PARMA study demonstrated the superiority of HDT/ASCT over conventional salvage chemotherapy in chemosensitive, relapsed patients. Subsequently, HDT/ASCT has become a standard approach for relapsed NHL. With the advent of Rituximab in the landscape of NHL, transplantation as part of first-line therapy has been challenged. However, no benefit in terms of disease-free or overall survival of HDT/ASCT over standard therapy was shown when Rituximab was added to both arms. Moreover, the superiority of HDT/ASCT over conventional salvage therapy in patients relapsing from first-line therapy including Rituximab was not confirmed. From these disappointing results, novel strategies, which can enhance the anti-lymphoma effect, at the same time reducing toxicity have been developed, with the aim of improving the outcome of HDT/ASCT in aggressive NHL. In T-cell lymphoma, few publications demonstrated that consolidation of complete remission with HDT/ASCT is safe and feasible. However, up to one-third of patients may never receive transplant, mostly due to progressive disease, and relapse still remains a major concern even after transplant.
An American, a French and a Russian meet on a desert island… .The representation of the foreigner and the cultural transfer in Russian contemporary jokes.
Federica Visani
Studi Slavistici , 2005,
Abstract: An American, a French and a Russian meet on a desert island… .The representation of the foreigner and the cultural transfer in Russian contemporary jokes. With the progressive unification of Europe’s political space, the determination of the cultural identity through the juxtaposition of cultures is a central and semiotically innovative subject. The concept of border is applied to this juxtaposition, simultaneously separating and unifying cultures, and allowing the cultural dialogue. This mechanism is analysed through Russian jokes about foreigners. The jokes work as a filter translating the type of the foreigner into the Russian culture. The transfer from an external semiotic space to the Russian internal one transforms the foreigner into a simplified representation of himself adapting it to the hosting culture.
Considera??es sobre o diagnóstico precoce na clínica do autismo e das psicoses infantis
Visani, Paola;Rabello, Silvana;
Revista Latinoamericana de Psicopatologia Fundamental , 2012, DOI: 10.1590/S1415-47142012000200006
Abstract: this article is about an academic study based on marie-christine laznik's theory. the purpose is to investigate, through the study of patient's files, the way infantile autism and psychosis were diagnosed in a mental health institution. the study also investigated the children's family histories before arriving at the institution. the results show that the treatment of autistic and psychotic children begins as a very late age. health professionals and institutions fail to note the signs for early detection and take long periods to provide diagnoses and proposed adequate treatment procedures. in addition, most health professionals seem unprepared to deal with these psychopathologies. this study revealed measures that can be taken to allow treatment of autistic and psychotic children to begin earlier.
Economic Assessment and Socio-Economic Evaluation of Water Use Efficiency in Artichoke Cultivation  [PDF]
José García García, Fulgencio Contreras López, Domenico Usai, Caterina Visani
Open Journal of Accounting (OJAcct) , 2013, DOI: 10.4236/ojacct.2013.22008
Abstract: The aim of this work is to provide a methodology for analysing socioeconomic aspects of water resource management that will provide with an objective decision making tool. To validate the proposed analysis method here, we refer to three artichoke production options. The economic evaluations indicate that the drip irrigation systems are viable and profitable. The traditional method of flooding is not a viable option despite needing the lowest investment, but is close to the viability threshold. In reference to water use efficiency, option 1 is by far the most effective (3.60 kg·m-3 compared with 2.25 and 2.18 kg·m-3, respectively). In our analysis we find that the most productive systems generate the most employment per unit of surface area. Option 1 is the most competitive in relation with the water factor, since it could support prices up to 0.53 €·m-3 and still be economically viable. System 2 will not be viable if the price exceeds 0.22 €·m-3. Option 3 is viable up to 0.17 €·m-3, which is more than is paid at the present time in Sardinia, although such an option would not be viable in south-eastern Spain.
SNPs Array Karyotyping Reveals a Novel Recurrent 20p13 Amplification in Primary Myelofibrosis
Giuseppe Visani, Maria Rosaria Sapienza, Alessandro Isidori, Claudio Tripodo, Maria Antonella Laginestra, Simona Righi, Carlo A. Sagramoso Sacchetti, Anna Gazzola, Claudia Mannu, Maura Rossi, Michele De Nictolis, Massimo Valentini, Meris Donati, Roberto Emiliani, Francesco Alesiani, Stefania Paolini, Carlo Finelli, Stefano A. Pileri, Pier Paolo Piccaluga
PLOS ONE , 2011, DOI: 10.1371/journal.pone.0027560
Abstract: The molecular pathogenesis of primary mielofibrosis (PMF) is still largely unknown. Recently, single-nucleotide polymorphism arrays (SNP-A) allowed for genome-wide profiling of copy-number alterations and acquired uniparental disomy (aUPD) at high-resolution. In this study we analyzed 20 PMF patients using the Genome-Wide Human SNP Array 6.0 in order to identify novel recurrent genomic abnormalities. We observed a complex karyotype in all cases, detecting all the previously reported lesions (del(5q), del(20q), del(13q), +8, aUPD at 9p24 and abnormalities on chromosome 1). In addition, we identified several novel cryptic lesions. In particular, we found a recurrent alteration involving cytoband 20p13 in 55% of patients. We defined a minimal affected region (MAR), an amplification of 9,911 base-pair (bp) overlapping the SIRPB1 gene locus. Noteworthy, by extending the analysis to the adjacent areas, the cytoband was overall affected in 95% of cases. Remarkably, these results were confirmed by real-time PCR and validated in silico in a large independent series of myeloproliferative diseases. Finally, by immunohistochemistry we found that SIRPB1 was over-expressed in the bone marrow of PMF patients carrying 20p13 amplification. In conclusion, we identified a novel highly recurrent genomic lesion in PMF patients, which definitely warrant further functional and clinical characterization.
Supercritical Fluid Adsorption of Domperidone on Silica Aerogel  [PDF]
Giuseppe Caputo
Advances in Chemical Engineering and Science (ACES) , 2013, DOI: 10.4236/aces.2013.33024
Abstract:

Silica aerogel (SA) was loaded with domperidone to demonstrate the potentiality of adsorption processes based on the usage of supercritical carbon dioxide to treat poorly water-soluble drugs, forming new kinds of drug delivery systems. The effects of pressure, temperature and solution concentration on loaded SA were studied. Adsorption isotherms were measured at 35and 45 and fitted with Langmuir model. Release kinetics of the adsorbed drug were also evaluated by in vitro dissolution tests. Results showed that domperidone can be uniformly dispersed into the aerogel and that the release rate of domperidone from the composite, constituted by drug and silica aerogel, is much faster than that of the crystalline drug. The proposed adsorption method is suitable for the production of domperidone fast release tablets.

Modeling and simulation in tissue biomechanics: Modern tools to face an ancient challenge  [PDF]
Giuseppe Vairo
Journal of Biomedical Science and Engineering (JBiSE) , 2013, DOI: 10.4236/jbise.2013.612A001
Abstract:

This is the editorial for the specail issue on Modeling and Simulation in Tissue Biomechanics published in Journal of Biomedical Science and Engineering


Archimedes’ Psammites and the Tradition of Italic Thought of Science  [PDF]
Giuseppe Boscarino
Advances in Historical Studies (AHS) , 2015, DOI: 10.4236/ahs.2015.41002
Abstract: It is intended to confute the opinion of a Platonic Archimedes, through the study of the fundamental theses of his Sandreckoner (Psammites) and of its particular logical-linguistic aspects, but especially of an Aristotelic Archimedes, as Delsedine (1970) maintains in his article “L’infini numérique dans l’Arénaire d’Archimède”. He writes: The Sandreckonerrépond à la nécessitè d’adapter la notation numérique à l’idée de l’infinité potentielle de l’ensamble des nombres naturales”1. First, it is focused on the general aspects of the work, which highlight its Enlightenment and Py-thagorean—Democritean character, then it is passed to the analysis of its particular linguistic and logical aspects and of its fundamental theses, translated into symbolic form, in which it is still giving prominence to its Pythagorean-Democritean or Italic character (Boscarino, 1999, 2010, 2011, 2012).
Archimedes’ to Eratosthenes in the Palimpsest and Archimedes in Heron’s Metrikon  [PDF]
Giuseppe Boscarino
Advances in Historical Studies (AHS) , 2015, DOI: 10.4236/ahs.2015.45025
Abstract: It is argued that even with some new readings made by the publication of the Letter to Eratosthenes in the Archimedes Palimpsest, with the wonderful discovery of his so-called “mechanical method” (a certain way of theorizing in mathematical things by means of mechanical entities) at the beginning of the twentieth century, some important historical-philological and philosophicalepistemological issues still remain, which have already discussed in part in my writings. We produce some important testimonies taken from Metrikon by Heron of Alexandria in favour of our translations and interpretations of Archimedes’ lexicon, not without placing under investigation at the same time the personality and the importance of Hero in the history of philosophical, scientific and technological Greek-Hellenistic thought in line with Archimedes and the tradition of Italic thought of science (The quotations of the Greek texts of Archimedes, Heron and Pappus are my translations).
Endogenous Ranking in the Two-Sector Urn-Ball Matching Process  [PDF]
Giuseppe Rose
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.83024
Abstract: This paper contributes to the debate concerning micro-foundations of matching functions in frictional labor markets. The focus is on a particular matching regime, i.e., the so-called urn-ball process. It is shown that in a twosector economy, even in the presence of heterogeneous workers, the assumption of applicants-ranking may be misleading. Instead, the choice concerning the adoption of either ranking or no-ranking behavior is endogenous and it is affected by both the tightness of the two sectors and the composition of the labor force in terms of skills. Moreover it is proved that exogenous shocks may change the form of the matching function. This result casts additional doubts on the assumption of exogenous matching function often made in empirical works aimed at assessing the effectiveness of policy measures.
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