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Search Results: 1 - 10 of 5364 matches for " Giuseppe Mele "
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The FIMP Medicines for Children Research Network
Ettore Napoleone, Giuseppe Mele
Italian Journal of Pediatrics , 2010, DOI: 10.1186/1824-7288-36-46
Abstract: The main role of children becomes of primary importance in social organisation and the lack of availability of medicine for children creates an important problem. This problem relates to all the children in the world, not only of developing countries but also from richer parts of the world [1]. Although many generations of paediatricians and other physicians have learned to cope with the fact that off-label or unlicensed medicines are prescribed to more than half of the children, the time has come to be sure that medicinal preparations used to treat the paediatric population should undergo a higher quality ethical research and should be appropriately authorized for use in the paediatric population [2].Paediatricians must plan specific clinical trials and must favour experiments of medicines for children with higher protection using the right balance between risks and benefits that are implied in every experiment carried out on children considering real scientific needs. In comparison to adults, metabolic changes during childhood and adolescence determine fundamental changes which involve different dosage, administration and elimination of the medicines which require specific safety and efficacy studies [3].To improve drug therapy in children and adolescents, the EUPR publication No 1901/2006 describes the necessity for clinical trials of drugs under development, for drugs for which changes in dosage forms or new indications are submitted for approval, and for off-patent drugs that are unlicensed or used off-label in paediatrics [4,5].One of the targets of Family Paediatrics is to carry out clinical research and experimentations on paediatric medicines with the ethicality and quality needed to guarantee the broadening of knowledge and the improvement of prescription appropriateness. Authorised drugs should be used only after having the results of specific studies which evaluate the effectiveness/safety profile and dosage for paediatric age groups; pharmacology cultur
Cardanol-Based Materials as Natural Precursors for Olefin Metathesis
Giuseppe Vasapollo,Giuseppe Mele,Roberta Del Sole
Molecules , 2011, DOI: 10.3390/molecules16086871
Abstract: Cardanol is a renewable, low cost natural material, widely available as a by-product of the cashew industry. It is a mixture of 3-n-pentadecylphenol, 3-(pentadeca-8-enyl)phenol, 3-(pentadeca-8,11-dienyl)phenol and 3-(pentadeca-8,11,14-trienyl)phenol. Olefin metathesis (OM) reaction on cardanol is an important class of reactions that allows for the synthesis of new olefins that are sometime impossible to prepare via other methods. The application of this natural and renewable material to both academic and industrial research will be discussed.
Whole-Body 64-Slice Multidetector Computed Tomography (MDCT) Identifies High-Risk Myeloma  [PDF]
Giuseppe Mele, Grazia D’Agostino, Giacomo Loseto, Maria Rosaria Coppi, Angela Melpignano, Grazia Angone, Giovanni Quarta
International Journal of Clinical Medicine (IJCM) , 2012, DOI: 10.4236/ijcm.2012.37115

Background: In Multiple Myeloma (MM) the individuation of bone lesions at baseline is mandatory because the detection of cortical damage reflects prognostic implications. Conventional Radiography (CR) shows osteolytic bone lesions only when the cortical bone damage is more than 30%. Whole-body 64-slice multidetector computed tomography (MDCT) has recently been employed for detecting early osteolytic disease. Patients and Methods: Twenty-height patients with Asymptomatic MM according to IMWG criteria underwent a 64 MDCT. Results: In our experience MDCT revealed osteolysis in 14/28 patients with normal skeletal survey and in 6 patients with normal Magnetic Resonance Imaging (MRI). Patients with radiological evidence of bone disease on MDCT were at high risk of progression with a median time to progression of 5 months (range 1 - 26 months) in comparison with patients without radiological evidence of bone disease who, conversely, showed a median time to progression of 20 months (range 8 - 40 months) (P = 0.0001). Conclusions: MDCT is able to identify MM patients with a high risk of progression, who might benefit from early therapy.

óleo da castanha de caju: oportunidades e desafios no contexto do desenvolvimento e sustentabilidade industrial
Mazzetto, Selma Elaine;Lomonaco, Diego;Mele, Giuseppe;
Química Nova , 2009, DOI: 10.1590/S0100-40422009000300017
Abstract: the new millennium is marked by a growing search for renewable fuels and alternative raw materials from biomass in the petrochemicals industry. however, there are many challenges to overcome regarding technological and human resources aspects. in this scenario, cashew nut oil, which is rich in natural phenols, is considered to be very promising for the development of synthetic and functional products and as a feedstock for production of fine chemicals and a wide variety of new materials.
First Example of a Lipophilic Porphyrin-Cardanol Hybrid Embedded in a Cardanol-Based Micellar Nanodispersion
Ermelinda Bloise,Luigi Carbone,Giuseppe Colafemmina,Lucia D’Accolti,Selma Elaine Mazzetto,Giuseppe Vasapollo,Giuseppe Mele
Molecules , 2012, DOI: 10.3390/molecules171012252
Abstract: Cardanol is a natural and renewable organic raw material obtained as the major chemical component by vacuum distillation of cashew nut shell liquid. In this work a new sustainable procedure for producing cardanol-based micellar nanodispersions having an embedded lipophilic porphyrin itself peripherally functionalized with cardanol substituents (porphyrin-cardanol hybrid) has been described for the first time. In particular, cardanol acts as the solvent of the cardanol hybrid porphyrin and cholesterol as well as being the main component of the nanodispersions. In this way a “green” micellar nanodispersion, in which a high percentage of the micellar system is derived from renewable “functional” molecules, has been produced.
Sfamare un mondo di nove miliardi di persone: le sfide per una zootecnia sostenibile
Giuseppe Pulina,Ana Helena Dias Francesconi,Marcello Mele,Bruno Ronchi
Italian Journal of Agronomy , 2011, DOI: 10.4081/ija.2011.6.s2.e7
Abstract: A dramatic increase of the demand for products of animal origin is expected to occur due to: i) the exponential growth of world’s population, which should reach 9 billion people in 2050, according to FAO predictions, ii) the process of urbanization which will likely lead to a concentration of 60% of the population in urban areas by the same year, and iii) the increase of income of a large part of the population in emergent countries such as China and India. So far, the increased demand for food has been supplied by agriculture due to improvement of techniques, increase of cultivated land areas and increase of consumption of water and energy. Despite that, unequal food distribution throughout the world has lead to almost 1 billion undernourished or starving people at the first decade of the twenty-one century. In the future, it will be necessary to achieve a sustainable supply of food, especially of animal origin, because land and other production factors are not unlimited resources. This work deals with related problems and possible sustainable solutions for the increasing demand for products of animal origin, by a detailed analysis of the Animal footprint, i.e. the Ecological footprint of animal production.
Effect of soybean oil supplementation on milk fatty acid composition from Saanen goats fed diets with different forage:concentrate ratios
Marcello Mele,Andrea Serra,Arianna Buccioni,Giuseppe Conte
Italian Journal of Animal Science , 2010, DOI: 10.4081/ijas.2008.297
Abstract: Twelve lactating Saanen goats were randomly assigned to four experimental diets, which differed in terms of forage:concentrate ratio and soybean oil supplementation. A 4×4 Latin square design was used. On a dry matter (DM) basis, forage:concentrate ratios were 63:37 (‘high-forage’ diet) and 35:65 (‘low-forage’ diet/high beet pulp). These diets were given either with oil (100 g·d-1) or without. The inclusion of soybean oil in the diet resulted in a significant increase in milk yield (but with HF diet) and in milk fat yield and concentration (P<0.05). Milk protein content remained unchanged across the diets. Milk protein yield was, however, higher for the high-forage diet containing added oil (forage × oil interaction, P<0.05). Soybean oil in the diet modified the milk fatty acid composition, reducing the levels of medium-chain and saturated fatty acids and increasing the levels of C18:2 n-6 and conjugated linoleic acid (CLA). The addition of soybean oil to the diet resulted in a significant increase in rumenic acid (cis-9, trans-11 CLA) and vaccenic acid (trans-11 C18:1) content in the milk fat. Interactions between forage and oil resulted in a significant increase in rumenic acid and vaccenic acid in animals fed a high-forage plus oil diet, and in trans-10 C18:1 and trans-10, cis-12 CLA in animals fed a low-forage plus oil diet, probably due to a shift in the rumen’s biohydrogenation of linoleic acid.
Temporal changes of conjugated linoleic acid in milk from Sarda ewes with different milk fat secretion ability
Marcello Mele,Andrea Serra,Giuseppe Conte,Alice Pollicardo
Italian Journal of Animal Science , 2010, DOI: 10.4081/ijas.2009.s2.414
Abstract: Individual milk samples were weekly collected from 48 ewes during eight weeks. Ewes were at the second month of lactation and they were fed the same dietary regimen. The animals were grouped according to the amount of daily milk fat yield: A) 38-57g/d, B) 58-63g/d, C) 64-73g/d, D) 75-110g/d. Milk from group D showed a higher content of FA from C4 to C10 and a lower content of monounsaturated FA (MUFA) and conjugated linoleic acids (CLA) than Group A (+12%, -11%, and -18%, for C4 to C10, MUFA and CLA, respectively), while Group B and C showed intermediate values. CLA content increased with days of lactation in a similar way for all groups. The mean correlation among all records within each individual lactation was 0.45 for CLA content. Six milk FA pair ratios representing a proxy for SCD activity were also evaluated: group A showed higher values of FA ratios than Group D (+26% on average for all FA pairs). In conclusion, increasing ability of daily milk fat yield was associated with lower milk content of MUFA and CLA and higher content of FA from C4 to C10.
Fatty acid profile in the ruminal fluid and in the m. longissimus dorsi of lambs fed herbage or concentrate with or without tannins
Valentina Vasta,Marcello Mele,Andrea Serra,Giuseppe Luciano
Italian Journal of Animal Science , 2010, DOI: 10.4081/ijas.2009.s2.555
Abstract: Twenty-eight male lambs were divided into two groups at age 45 d. Fourteen lambs were given fresh herbage (vetch); the remaining lambs were fed a concentrate-based diet. Within each treatment, seven lambs received a supplementation of quebracho tannins. At slaughter (age 105 d) the ruminal content and the muscle longissimus dorsi (LD) were collected. Ruminal fluid and LD fatty acid composition was determined by gas chromatography. Among the concentrates-fed lambs, tannins supplementation reduced (P < 0.05) the concentration of C18:0 (- 49 %) and increased vaccenic acid (VA; + 69 %) in the ruminal fluid. When tannins were included into the concentrate, the LD contained double levels of rumenic acid (RA) as compared to the LD of the lambs fed the tannins-free concentrate (0.96 vs. 0.46 % of total extracted fatty acids, respectively; P < 0.05). The concentration of PUFA was higher (P < 0.05) and SFA (P < 0.01) lower in the LD from lambs fed the tannin diets as compared to the animals receiving the tannin-free diets. In conclusion, tannins reduce the biohydrogenation of the PUFA in the rumen. This implies that tannins supplementation could be a strategy to increase the RA and PUFA content and to reduce the SFA into ruminant meats.
Obesity and childhood survivors of acute lymphoblastic leukemia: Do genetics play a role?  [PDF]
Cheryl Mele
Open Journal of Genetics (OJGen) , 2012, DOI: 10.4236/ojgen.2012.21010
Abstract: Childhood survivors of acute lymphoblastic leukemia (ALL) are increased risk of several chronic complications, such as second cancers, pulmonary, metabolic complications and cardiovascular disease. Obesity and metabolic syndrome is one of the most common treatment related complication in children surviving cancer, which concurs with our nations childhood epidemic [1-3] Recent research has identified the role of genetics in the development of obesity and metabolic syndrome in childhood survivors of ALL. Growth hormone deficiency, Leptin regulation, fat mass obesity (FTO) gene and the insulin resistant ENPP1 variants disorders has been associated adverse effects of chemotherapeutic treatment and the cause of clinical manifestations of metabolic syndrome [4-8]. The illumination of the role of genetic variants can shed insights into obesity within high risk population, as well as, a target to prevent disease.
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