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Search Results: 1 - 10 of 14983 matches for " Giuliano Di Pietro "
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N-acetyltransferase 2: Slow, intermediate or fast? A booming question of the molecular epidemiology in cancer research  [PDF]
Giuliano Di Pietro, Sandra Rocha Gadelha, Sandra Mara Bispo Sousa, Paulo Roberto Santana de Melo, Fabricio Rios Santos
Open Journal of Genetics (OJGen) , 2012, DOI: 10.4236/ojgen.2012.24028
Abstract: Throughout history, humanity has referred to reactions occurring with food, plants and, recently, medicines or drugs. The increase in pulmonary tuberculosis cases and the availability of treatment showed that genetic human differences can interfere in the capacity to metabolize drugs. There are remarkable genetic polymorphisms of N-acetyltransferase 2 (NAT2) activity that have been associated with different levels of susceptibility to developing many kinds of cancers. This review considers the field as an open window for the application of molecular epidemiology tools that led to the development of pharmacogenomics. We cover historical data and the most recent knowledge about NAT2 genetic polymorphisms and its distribution in different populations, which is an important concept being incorporated in epidemiological studies of cancer risk. We present up to date information about these studies, including meta-analysis based on the NAT2 distribution in different types of cancer. A critical broad at advances in NAT2 research, high-lighting recent studies related to NAT2 alleles in cancer susceptibility. Although there are multifactorial aspects involved in cancer risk, the variability in NAT2 allelic frequency can be related to carcinogenesis through alterations in the metabolic rate after exposure to carcinogens.
Two-Stage Liver Transplantation with Temporary Porto-Middle Hepatic Vein Shunt
Giovanni Varotti,Enzo Andorno,Marco Casaccia,Stefano Di Domenico,Giuliano Bottino,Pietro Diviacco,Nicola Morelli,Chiara Ferrari,Roberto Ferrante,Umberto Valente
Journal of Transplantation , 2010, DOI: 10.1155/2010/570392
Abstract: Two-stage liver transplantation (LT) has been reported for cases of fulminant liver failure that can lead to toxic hepatic syndrome, or massive hemorrhages resulting in uncontrollable bleeding. Technically, the first stage of the procedure consists of a total hepatectomy with preservation of the recipient's inferior vena cava (IVC), followed by the creation of a temporary end-to-side porto-caval shunt (TPCS). The second stage consists of removing the TPCS and implanting a liver graft when one becomes available. We report a case of a two-stage total hepatectomy and LT in which a temporary end-to-end anastomosis between the portal vein and the middle hepatic vein (TPMHV) was performed as an alternative to the classic end-to-end TPCS. The creation of a TPMHV proved technically feasible and showed some advantages compared to the standard TPCS. In cases in which a two-stage LT with side-to-side caval reconstruction is utilized, TPMHV can be considered as a safe and effective alternative to standard TPCS.
Interethnic diversity of NAT2 polymorphisms in Brazilian admixed populations
Jhimmy Talbot, Luiz Magno, Cinthia VN Santana, Sandra MB Sousa, Paulo RS Melo, Ronan X Correa, Giuliano Di Pietro, Fabrício Rios-Santos
BMC Genetics , 2010, DOI: 10.1186/1471-2156-11-87
Abstract: Overall, there were no statistically significant differences in the distribution of NAT2 polymorphism when Afro-Brazilian and White groups were compared. Even the allele frequency of 191A, relatively common in African descendents, was not different between the Afro-Brazilian and White groups. However, allele and genotype frequencies of G590A were significantly higher in the Amerindian group than either in the Afro-Brazilian or White groups. Interestingly, a haplotype block between G590A and A803G was verified exclusively among Amerindians.Our results indicate that ethnic admixture might contribute to a particular pattern of genetic diversity in the NAT2 gene and also offer new insights for the investigation of possible new NAT2 gene-environment effects in admixed populations.Genetic functional polymorphisms of xenobiotic/drug metabolizing enzymes have been associated with pharmacotherapy response differences and disease risk susceptibility [1,2]. Special emphasis has been placed on a phase II metabolizing enzyme, N-acetyltransferase type 2 (Nat2, EC 2.3.1.5), a milestone in the pharmacogenetics field as one of the first enzymes to be associated as a cause of interindividual variation in drug metabolism [3]. Nat2 catalyzes a transfer of an acetyl group from the cofactor acetyl-coenzyme A (acetyl-CoA) to the amine nitrogen atom of aromatic amines and hydrazines [4]. This enzyme is important in the aromatic and heterocyclic amine conjugating reaction, preventing their metabolic activation into electrophilic intermediates that could initiate DNA damage and potentially induce carcinogenic mutations [5]. Moreover, Nat2 plays a role in the metabolism of different hydrazine and arylamine drugs, such as isoniazid and dapsone, both used in the treatment of Mycobacterium spp. infections [6,7].The human NAT2 gene has an intronless open reading frame of 870 base pairs and is primarily expressed in the liver and intestines [8-10]. It has long been recognized that some single nucl
Two-Stage Liver Transplantation with Temporary Porto-Middle Hepatic Vein Shunt
Giovanni Varotti,Enzo Andorno,Marco Casaccia,Stefano Di Domenico,Giuliano Bottino,Pietro Diviacco,Nicola Morelli,Chiara Ferrari,Roberto Ferrante,Umberto Valente
Journal of Transplantation , 2010, DOI: 10.1155/2010/570392
Abstract: Two-stage liver transplantation (LT) has been reported for cases of fulminant liver failure that can lead to toxic hepatic syndrome, or massive hemorrhages resulting in uncontrollable bleeding. Technically, the first stage of the procedure consists of a total hepatectomy with preservation of the recipient's inferior vena cava (IVC), followed by the creation of a temporary end-to-side porto-caval shunt (TPCS). The second stage consists of removing the TPCS and implanting a liver graft when one becomes available. We report a case of a two-stage total hepatectomy and LT in which a temporary end-to-end anastomosis between the portal vein and the middle hepatic vein (TPMHV) was performed as an alternative to the classic end-to-end TPCS. The creation of a TPMHV proved technically feasible and showed some advantages compared to the standard TPCS. In cases in which a two-stage LT with side-to-side caval reconstruction is utilized, TPMHV can be considered as a safe and effective alternative to standard TPCS. 1. Introduction The two-stage total hepatectomy with temporary portocaval shunt and subsequent liver transplantation (LT) were first described by Ringe et al. [1] in 1988. The rationale for the procedure is based upon the concept that patients with fulminant hepatic failure or graft failure that can lead to a toxic hepatic syndrome, or massive haemorrhages resulting in uncontrollable bleeding, can benefit from urgent removal of the native liver followed by LT when an organ becomes available [2, 3]. The first stage of the procedure consists of a total hepatectomy with preservation of the recipient’s inferior vena cava (IVC) and suture of the three hepatic veins. Then a temporary end-to-side portocaval shunt (TPCS) is created to re-establish the splanchnic outflow during the anhepatic phase. The second stage consists of removing the TPCS and implanting the liver graft when one becomes available [4]. We report a case of a two-stage total hepatectomy and LT in which a temporary end-to-end anastomosis between the portal vein and the middle hepatic vein (TPMHV) was performed as an alternative to the classic end-to-end TPCS. 2. Case Report A 43-year-old woman underwent urgent laparotomy for spontaneous massive rupture of a subcapsular liver hematoma associated with HELLP syndrome. The right lobe of the liver was entirely replaced by a large hematoma and areas of necrosis, and there were deep ruptures in both lobes. After establishing that neither conservative surgical treatments nor partial resections would have been effective; a total hepatectomy was performed to
Indoor Air Quality in a Real Operating Theatre under Effective Use Conditions  [PDF]
Carla Balocco, Giuseppe Petrone, Giuliano Cammarata, Pietro Vitali, Roberto Albertini, Cesira Pasquarella
Journal of Biomedical Science and Engineering (JBiSE) , 2014, DOI: 10.4236/jbise.2014.711086
Abstract: The aim of this study is to investigate the impact of surgical staff on the indoor air quality in a uni-directional ventilation Operating Theatre (OT). Experimental measurements of particles and microclimate were acquired at rest and in operational conditions. The real OT (operational) use was simulated by a sham hip arthroplasty. CFD simulations were carried out outlining the studied environment used for experimental measurement campaign. A standard k-ε closure scheme based on RANS equations was implemented to solve the velocity and pressure field using an eddy viscosity approach. Temperature and relative humidity distributions were also computed keeping into account sensible and latent heat sources inside the OT. An Euler-based approach was applied to solve the concentration fields of gaseous contaminant and small particles (up to 5 μm in diameter) in the indoor air. An innovative strategy is proposed to estimate, by an iterative comparison between experimental data and numerical results, the emission rate of particles (differentiated by diameters) released by the occupants to be considered as source terms in the numerical model. Compliance with literature evidence concerning thermal and velocity fields and CO2 concentration was confirmed. From our analyses, some IAQ indexes were deduced, allowing monitoring of the local and overall OT air quality level supplied by the ventilating system during real operational conditions. The highest values of microbial air contamination were recorded during surgical activity; nevertheless, results showed the suitability of the ventilation system in providing the expected air quality.
José Ingenieros: "Algunas aproximaciones sobre las fuerzas morales"
Di Pietro,Alejandro;
Cuadernos de la Facultad de Humanidades y Ciencias Sociales. Universidad Nacional de Jujuy , 2008,
Abstract: jose ingenieros warns in the prologue of his texts 'moral strengths', that his book completes the panoramic vision of a functional ethics. 'mediocre man' is a critique to morality; 'to wards a moral without dogmas' a morality theory, 'moral strengths', a deontology of morality. it prevails in cell these works of his the concept of ethical idealism in the function of social experience, unmistakable with captions idealism of ancient metaphysics. ingenieros affirms that a man who treasures these forces acquires moral values, honorable duty feeling that conditions his dignity. a man that thinks as he must, says what he feels and acts as he wants. a man that does not pursues rewards nor he fears misfortunes. a man who receives contrast with serenity and victory with prudence. a man who accepts the responsibilities of his own errors and who refuses any complicity with other people's errors. moral values are the only ones that support the ones who expend their lives for their country or their own doctrines trying to achieve heroism. nothing is less similar to the occasional temerity of that of the bully or that of the praetorian, who face futile risks due to vanity of stipend. an hour of episodic bravery does not equate socrates' valour, that of christ's, nor spinoza's, which is a constant convergence of thought and action, pulchritude of sentence in opposition to insane of past superstitions. pointing out some comparisons with our nation's present time is trying to demonstrate that time has thought ingenieros is right or he is not and this is partly the purpose of this contribution about an argentinian thinker of substance put away and forgotten in every library of this country.
New Dry Grassland Associations from the Ausoni-Aurunci Mountains (Central Italy) - Syntaxonomical Updating and Discussion on the Higher Rank Syntaxa
Romeo Di Pietro
Hacquetia , 2011, DOI: 10.2478/v10028-011-0011-9
Abstract: A phytosociological study on the most extensive dry grassland communities of the coastal limestone massif of the Ausoni-Aurunci mountains (southern Latium, central Italy) is here presented. Violo pseudogracilis-Koelerietum splendentis ass. nova is restricted to the montane belt of the Aurunci mountains where it is dynamically related to the mesophilous Ostrya carpinifolia or Fagus sylvatica woodlands. Helichryso italici-Brometum erecti ass. nova is found within the upper hilly and submontane belt of both the Ausoni mountains (typical aspect) and the Aurunci mountains (subassociation saturejetosum montanae), where it is dynamically related with termophilous Ostrya carpinifolia woods and mesophilous Quercus ilex woods. Helichryso-Brometum is differentiated from Violo-Koelerietum in that it has a higher incidence of the steno-Mediterranean therophytic component. As far as the higher rank syntaxa are concerned, in this study the following changes were made in accordance with the rules of ICPN: the name Phleo ambigui-Bromion erecti Biondi et al. 1995 was considered invalid due to the invalidity of its nomenclatural type Asperulo purpureae-Brometum erecti. In contrast, the validity of the old name Cytiso spinescentis-Bromion erecti Bonin 1978 was demonstrated and its nomenclatural type, Lavandulo-Asphodelinetum luteae Bonin 1978, was lectotypified. Thus Cytiso spinescenti-Bromion erecti Bonin 1978 henceforth substitutes Phleo ambigui-Bromion erecti (nom. inval.) as the syntaxonomical reference for the endemic alliance of the hilly and montane limestone dry grasslands of the central and southern Apennines. Cytiso-Bromion is here divided into two suballiances: Sideritidenion italicae Biondi et al. 1995, Phleo ambigui-Bromenion erecti Biondi et al. ex Di Pietro suball. nov. Cytiso-Bromion belong to the new suborder Festuco circummediterraneae-Seslerienalia nitidae (Ubaldi 2003) stat. nov. and to the order Artemisio albae-Brometalia erecti Ubaldi ex Mucina & Dengler 2009. New and updated packages of characteristic and differential species for both Cytiso spinescenti-Bromion erecti and its related suballiances are proposed. Furthermore the validity of the name Astragaletum calabrici Giacomini & Gentile ex Bonin 1978, was proved and the association lectotypified. This association, which was previously included in Cytiso-Bromion erecti, is moved into Koelerio brutiae-Astragalion calabrici. Finally some interesting coenological and syndynamical similarities with Scorzonero-Chrysopogonetalia western Dalmatia submediterranean dry pastures are discussed.
Habitus, política y educación
Susana Beatriz di Pietro
Política y cultura , 2002,
Abstract: For Bourdieu, the concept of habitus is essential in the consideration about central issues of political and educational theory. Topics as those of power, domination, legitimacy, State, social reproduction and the contribution in it of the scholar system, would request the use of that notion, able to surmount, in addition, the dichotomy between objectivism and subjectivism that characterizes social science. The present article displays the notion of habitus in the frame of the broader thinking of its author, attempting to formulate some critical considerations on the described theory, its limits and explanatory possibilities. In order to do so, it s focused specially in the subjects of order, politics and body, closely bounded with it.
Scale factor duality in quintessence models ?
Elisa Di Pietro
Physics , 2001,
Abstract: We consider several kinds of quintessence models in the framework of scale factor duality. We show that this symmetry exists only for a very small number of quintessence potentials. We then apply the duality transformations found to several analytical solutions. It turns out that, in some cases, the presence of the potential allows a smooth connection between the pre- and the post-Big Bang phases. This may be a first step toward the resolution of the singularity problem.
Topological Classification of Holomorphic, Semi-Hyperbolic Germs, in "Quasi-Absence" of Resonances
Pietro Di Giuseppe
Mathematics , 2005,
Abstract: The classification, by topological conjugacy, of invertible holomorphic germs $f:(\mathbb{C}^n,0)\to (\mathbb{C}^n,0)$, with $\lambda_1,...,\lambda_n$ eigenvalues of $df_0$, and $|\lambda_i|\neq 1$ for $i=2,...,n$ while $\lambda_1$ is a root of the unity, is given, in the suitable hypothesis of ``quasi-absence'' of resonances.
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