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Search Results: 1 - 10 of 912 matches for " Giulia Midena "
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Hyperreflective Intraretinal Spots in Diabetics without and with Nonproliferative Diabetic Retinopathy: An In Vivo Study Using Spectral Domain OCT
Stela Vujosevic,Silvia Bini,Giulia Midena,Marianna Berton,Elisabetta Pilotto,Edoardo Midena
Journal of Diabetes Research , 2013, DOI: 10.1155/2013/491835
Abstract: Purpose. To evaluate the presence of hyperreflective spots (HRS) in diabetic patients without clinically detectable retinopathy (no DR) or with nonproliferative mild to moderate retinopathy (DR) without macular edema, and compare the results to controls. Methods. 36 subjects were enrolled: 12 with no DR, 12 with DR, and 12 normal subjects who served as controls. All studied subjects underwent full ophthalmologic examination and spectral domain optical coherence tomography (SD-OCT). SD-OCT images were analyzed to measure and localize HRS. Each image was analyzed by two independent, masked examiners. Results. The number of HRS was significantly higher in both diabetics without and with retinopathy versus controls ( ) and in diabetics with retinopathy versus diabetics without retinopathy ( ). The HRS were mainly located in the inner retina layers (inner limiting membrane, ganglion cell layer, and inner nuclear layer). The intraobserver and interobserver agreement was almost perfect ( ). Conclusions. SD-OCT hyperreflective spots are present in diabetic eyes even when clinical retinopathy is undetectable. Their number increases with progressing retinopathy. Initially, HRS are mainly located in the inner retina, where the resident microglia is present. With progressing retinopathy, HRS reach the outer retinal layer. HRS may represent a surrogate of microglial activation in diabetic retina. 1. Introduction An increasing body of evidence suggests that retinal neurodegeneration and inflammation occur in human diabetes even before the development of clinical signs of diabetic retinopathy (DR) [1]. Retinal neural cell loss (neurodegeneration) has already been demonstrated in vivo (as thinning of retinal nerve fiber and ganglion cell layers), both in type 1 and 2 diabetes [2–7]. Retinal microglia activation has been recognized as the main responsible for the initial inflammatory response, even though the exact mechanism through which inflammatory cytokines are released remains poorly known [8]. Some experimental studies have shown that retinal inflammation occurring during the course of diabetes mellitus is a relatively early event and that it precedes both vascular dysfunction and neuronal degeneration [1, 8]. Joussen at al. demonstrated in animal models of diabetes mellitus that ICAM-1- and CD18-mediated leukocyte adhesion is increased in the retinal vasculature and accounts for many of the signature lesions of DR [1]. Ibrahim et al. demonstrated in rats that the accumulation of Amadori-glycated albumin (AGA) within the 8-week diabetic retina elicits microglial
Microperimetría Microperimetry
E. Midena
Archivos de la Sociedad Espa?ola de Oftalmología , 2006,
Abstract:
Retinal Layers Changes in Human Preclinical and Early Clinical Diabetic Retinopathy Support Early Retinal Neuronal and Müller Cells Alterations
Stela Vujosevic,Edoardo Midena
Journal of Diabetes Research , 2013, DOI: 10.1155/2013/905058
Abstract: Purpose. To evaluate the changes in thickness of individual inner and outer macular and peripapillary retinal layers in diabetes. Methods. 124 subjects (124 eyes) were enrolled: 74 diabetics and 50 controls. Macular edema, proliferative diabetic retinopathy (DR), any intraocular treatment and refractive error diopters were the main exclusion criteria. Full ophthalmic examination, stereoscopic fundus photography, and spectral domain-OCT were performed. After automatic retinal segmentation (layering) in 5 layers, the thickness of each layer was calculated, and values compared among groups. Results. Thirty patients had no DR, 44 patients had non proliferative DR. A significant increase of inner plexiform and nuclear layers was found in DR eyes versus controls ( ). A significant decrease ( ) of retinal nerve fiber layer (RNFL) and at specific sites of retinal ganglion cell layer ( ) was documented in the macula. In the peripapillary area there were no differences between diabetics and controls. Conclusions. Decreased RNFL thickness and increased INL/OPL thickness in diabetics without DR or with initial DR suggest early alterations in the inner retina. On the contrary, the outer retina seems not to be affected at early stages of DM. Automatic intraretinal layering by SD-OCT may be a useful tool to diagnose and monitor early intraretinal changes in DR. 1. Introduction Diabetic retinopathy (DR) is the first cause of visual impairment and blindness in the adult working-age population [1]. For a long period of time, DR has been considered primarily a retinal microvascular disorder caused by the direct effects of hyperglycemia and by the metabolic pathways it activates [2]. Nevertheless, some recent studies have demonstrated that retinal neurodegeneration (the result of a negative balance between neurotoxic and neuroprotective factors) is present even before the development of clinically detectable microvascular damage. Retinal neurodegeneration may therefore represent an early event in the pathophysiology of DR and may anticipate the onset of microvascular changes [2–4]. The term neurodegeneration used in this paper encompasses pathologic phenomena affecting both the pure neuronal component and the glial one. The hypothesis according to which neurodegeneration precedes the vascular one is confirmed by some electrophysiological and psychophysical studies, which show that the alterations are present even before the microvascular damage becomes ophthalmoscopically or angiographically visible. Such retinal function alterations mainly consist in contrast sensitivity
A Semantic Model for Socially Aware Objects  [PDF]
Giulia Biamino
Advances in Internet of Things (AIT) , 2012, DOI: 10.4236/ait.2012.23006
Abstract: The Internet of Things (IoT) assumes that things interact and exchange information thus defining the future of pervasive computing environments. The integration between people and interconnected objects realizes a new physical and social space and opens new frontiers in context awareness and objects adaptation. In this paper we investigate the possibility of creating socially aware objects able to interact not only among themselves but also with human beings sharing the same environment. The main contribution of this work is to provide a knowledge model for social context-awareness and reasoning using an ontology-based context modeling, a user model and exploiting of social networks. This model is part of a larger framework called So Smart that aims at empowering networks of interconnected objects with social context awareness in order to improve their social interaction with people.
The Dialogue and the Relationship with Parents and Friends: A Research on Italian Adolescents’ Representations  [PDF]
Giulia Savarese
Psychology (PSYCH) , 2016, DOI: 10.4236/psych.2016.74066
Abstract:

The goal was to understand what representations Italian adolescents have about the dialogue and the relationship with their parents and with the peer group, as well as to evaluate any differences. We interviewed 400 Italian adolescents, 200 males and 200 females, aged between 14 and 19 years. The instruments used were an ad hoc questionnaire and a free story. The results show significant differences in the communicative/relational support by parents and by the peer group, especially in relation to the confidences of their personal problems, the choice autonomy and the behaviors that encourage independence.

Everolimus Associated with Activated Vitamin D for Post-Transplant Increase Epstein-Barr-Virus Load Treatment. Two Case Reports  [PDF]
Luciano Moscarelli, Giulia Antognoli
International Journal of Clinical Medicine (IJCM) , 2012, DOI: 10.4236/ijcm.2012.37119
Abstract:

Post-transplant lymphoproliferative disease (PTLD) is an uncommon but life-threatening complication of solid-organ and blood stem-cell transplants. It is caused by an uncontrolled expansion of B lymphocytes infected with Epstein-Barr virus (EBV). It responds poorly to therapy, including reduction of immunosuppression, interferon, antivirals or chemotherapy. Therefore the optimal strategy for management is currently focused on prevention. Some centers have already introduced chemoprophylaxis and/or preemptive strategies using EBV viral load as a surveillance. Some experimental studies suggest that mTOR inhibitors inhibits growth of human EBV-transformed B lymphocytes and vitamin D had an immune response to EBV. We report two cases of an increased of blood BKV viral load after renal transplantation that were successfully treated with everolimus in association with calcitriol. This report suggests that everolimus associated with calcitriol could be an effective and safe treatment for the prevention of PTLD in transplant recipients.

Revisiting the Influence of Numerical Language Characteristics on Mathematics Achievement: Comparison among China, Romania, and U.S.
Jian Wang,Emily Lin,Madalina Tanase,Midena Sas
International Electronic Journal of Mathematics Education , 2008,
Abstract: Eastern Asian students repeatedly outperform U.S. students in mathematics. Some suggest that number-naming languages consistent with the base-10 number system found in many Eastern Asian countries presumably contribute to their students’ better understanding of the base-10 system and consequential performance. Such language features do not exist in English or other Western languages. The current study tests this assumption by comparing base-10 knowledge of students in kindergarten and first-grade from China, Romania, and U.S. who have developed number-naming language abilities but received relatively little formal school instruction. It is expected that since Chinese number-naming is linguistically more transparent and consistent with the base-10 system, Chinese students should outperform both their Romanian and U.S. peers. Romanians should show intermediate performance between Chinese and U.S. students since Romanian language is somewhat transparent and consistent with a base-10 system while English number-naming language is least consistent. However, the analysis of this study revealed that although Chinese children outperformed both Romanian and U.S. counterparts in accomplishing base-10 tasks, there were no significant differences between Romanian and U.S. children. This finding suggests that the extent to which number-naming language is linguistically transparent and consistent with the base-10 system may not necessarily align with the level of children’s understanding of the base-10 system and relevant mathematics performances.
Mindfulness for Disabled University Students—A Sporting-Motor Activity and Meditative Workshop Aimed at Reducing Stress and Increasing Coping Resources  [PDF]
Giulia Savarese, Maria Teresa Ingino
Psychology (PSYCH) , 2018, DOI: 10.4236/psych.2018.914164
Abstract: The data collected from disabled university students who participated in a mindfulness workshop in Italy are presented. The workshop activities are also described. These were aimed at reducing stress and improving coping skills, the sense of self and social relationships. This is the first experience of a mindfulness course with university students with varying types of disability. The initial results were positive in creating the following within the participants: a less emotional interpretation of the world; a greater acceptance of their own difficulties; reduced stress; and, at the same time, implementation of various coping methods and improved self-esteem and social interaction.
O grotesco como estratégia de afirma??o da produ??o pictórica feminina
Crippa, Giulia;
Revista Estudos Feministas , 2003, DOI: 10.1590/S0104-026X2003000100007
Abstract: a proposal of gender interpretation of female artistic production during the so called modernism, based on common elements in tarsila do amaral's, frida kalho's, tamara de lempicka's and georgia o'keeffe's art works, without denying their individual dimension, built upon the esthetic definition of grotesque. grotesque, in its gender and historical expression, seems to represent a face of the common language used by women, trying to meet a strategy in order to be recognized by critics and markets. though, at one side, visual and decorative tradition set the "idealized feminine", on the other side grotesque, as a way of breaking reality as rational and coherent, historically related to anti-classic movement, offers an opening to a sexuated and non-conformist expression to female artists.
Representa??es iconográficas e literárias da produ??o de alimentos: espa?os, atores e ideologias entre Antiguidade e Idade Média
Crippa, Giulia;
Revista de Nutri??o , 2010, DOI: 10.1590/S1415-52732010000100016
Abstract: an iconographic and literary study on seasonal work as productive cycle between antiquity and the late middle ages is proposed, looking for boundaries between the iconographies and economy and society that produced them. the auspicious representation prevails in the historical view of iconographies associated with the prediction and hope of abundance. within the medieval society they are deeply bounded to main themes such as season changes, cyclic passage of time, journey through birth, death and resurrection. the representations of monthly work and activities change, and this change is much more than a mirror reflection, a reflection of society on the space and actors of the food production cycle. the legacy of antiquity to the middle ages is a great amount of images based on notions of personification as well of reference for the activities associated with the seasonal changes, a legacy that will be assessed and changed based on the new social and religious experience. these permeate the century during which most of the month cycles illustrated by productive works in the field are produced.
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