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Search Results: 1 - 10 of 202811 matches for " Gisel; Martínez de Sandelices "
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Bases genéticas del síndrome de ovarios poliquísticos
Ovies Carballo,Gisel; Martínez de Sandelices,Alicia; Monteagudo Pe?a,Gilda; Sardi?as Díaz,Irelys;
Revista Cubana de Endocrinolog?-a , 2011,
Abstract: the syndrome of polycystic ovaries is the endocrine disorder involving more the reproductive sphere of the woman in fertile age, its causes are unknown with accuracy, but most of experts coincide in propose that it is a multifactor entity where the genetic factor more and more have a great significance. in past years, it has been possible to identify some genes involved in the pathogenic processes of this syndrome and among the more important are included those codifying for enzymes of the steroidogenesis, for the insulin receptor and other hormones related to the insulin action, as well as the gonadotropins and its receptors, features that are the aim of present review.
Bases genéticas del síndrome de ovarios poliquísticos Genetic bases of polycystic ovary syndrome
Gisel Ovies Carballo,Alicia Martínez de Sandelices,Gilda Monteagudo Pe?a,Irelys Sardi?as Díaz
Revista Cubana de Endocrinología , 2011,
Abstract: El síndrome de ovarios poliquísticos es el trastorno endocrino que más afecta la esfera reproductiva de la mujer en la edad fértil, sus causas se desconocen con exactitud, pero la mayoría de los expertos coinciden en plantear que es una entidad multifactorial, en la que los factores genéticos cada vez cobran mayor importancia. En los últimos a os se han identificado varios genes involucrados en los procesos patogénicos de este síndrome, y dentro de estos, los más importantes son aquellos que codifican para enzimas de la esteroidogénesis, para el receptor de insulina y otras hormonas relacionadas con la acción de la insulina, así como las gonadotropinas y sus receptores, aspectos sobre los cuales trata la siguiente revisión. The syndrome of polycystic ovaries is the endocrine disorder involving more the reproductive sphere of the woman in fertile age, its causes are unknown with accuracy, but most of experts coincide in propose that it is a multifactor entity where the genetic factor more and more have a great significance. In past years, it has been possible to identify some genes involved in the pathogenic processes of this syndrome and among the more important are included those codifying for enzymes of the steroidogenesis, for the insulin receptor and other hormones related to the insulin action, as well as the gonadotropins and its receptors, features that are the aim of present review.
Deep Sequencing of the Small RNAs Derived from Two Symptomatic Variants of a Chloroplastic Viroid: Implications for Their Genesis and for Pathogenesis
Francesco Di Serio,Andreas Gisel,Beatriz Navarro,Sonia Delgado,ángel-Emilio Martínez de Alba,Giacinto Donvito,Ricardo Flores
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0007539
Abstract: Northern-blot hybridization and low-scale sequencing have revealed that plants infected by viroids, non-protein-coding RNA replicons, accumulate 21–24 nt viroid-derived small RNAs (vd-sRNAs) similar to the small interfering RNAs, the hallmarks of RNA silencing. These results strongly support that viroids are elicitors and targets of the RNA silencing machinery of their hosts. Low-scale sequencing, however, retrieves partial datasets and may lead to biased interpretations. To overcome this restraint we have examined by deep sequencing (Solexa-Illumina) and computational approaches the vd-sRNAs accumulating in GF-305 peach seedlings infected by two molecular variants of Peach latent mosaic viroid (PLMVd) inciting peach calico (albinism) and peach mosaic. Our results show in both samples multiple PLMVd-sRNAs, with prevalent 21-nt (+) and (?) RNAs presenting a biased distribution of their 5′ nucleotide, and adopting a hotspot profile along the genomic (+) and (?) RNAs. Dicer-like 4 and 2 (DCL4 and DCL2, respectively), which act hierarchically in antiviral defense, likely also mediate the genesis of the 21- and 22-nt PLMVd-sRNAs. More specifically, because PLMVd replicates in plastids wherein RNA silencing has not been reported, DCL4 and DCL2 should dice the PLMVd genomic RNAs during their cytoplasmic movement or the PLMVd-dsRNAs generated by a cytoplasmic RNA-dependent RNA polymerase (RDR), like RDR6, acting in concert with DCL4 processing. Furthermore, given that vd-sRNAs derived from the 12–14-nt insertion containing the pathogenicity determinant of peach calico are underrepresented, it is unlikely that symptoms may result from the accidental targeting of host mRNAs by vd-sRNAs from this determinant guiding the RNA silencing machinery.
Random Route and Quota Sampling: Do They Offer Any Advantage over Probably Sampling Methods?  [PDF]
Vidal Díaz de Rada, Valentín Martínez Martín
Open Journal of Statistics (OJS) , 2014, DOI: 10.4236/ojs.2014.45038
Abstract:

The aim of this paper is to compare sample quality across two probability samples and one that uses probabilistic cluster sampling combined with random route and quota sampling within the selected clusters in order to define the ultimate survey units. All of them use the face-to-face interview as the survey procedure. The hypothesis to be tested is that it is possible to achieve the same degree of representativeness using a combination of random route sampling and quota sampling (with substitution) as it can be achieved by means of household sampling (without substitution) based on the municipal register of inhabitants. We have found such marked differences in the age and gender distribution of the probability sampling, where the deviations exceed 6%. A different picture emerges when it comes to comparing the employment variables, where the quota sampling overestimates the economic activity rate (2.5%) and the unemployment rate (8%) and underestimates the employment rate (3.46%).

Primary Care Practitioners’ Views on the Use of Proton Pump Inhibitors Associated with Alginate-Antacids for Better Gastroesophageal Reflux Disease Symptom Control: Results of a National Survey in Spain  [PDF]
Carlos Martín de Argila, Mercedes Ricote Belinchón, Agustín Albillos Martínez
Open Journal of Gastroenterology (OJGas) , 2014, DOI: 10.4236/ojgas.2014.410048
Abstract: Background: Gastroesophageal reflux disease (GERD) is a prevalent disease in Western countries. Despite effective treatment modalities, in some patients total symptom control is not achieved in clinical practice. A cross-sectional study was designed to assess primary care practitioners’ views on the effectiveness of proton pump inhibitors (PPI) as monotherapy in the control of the most common symptoms of GERD (heartburn and regurgitation), as well as to determine the level of implementation of the “combined therapy” (PPI + alginate-antacids). Methods: A questionnaire on different aspects of the management of GERD was completed by 1491 primary care physicians. The questionnaire was composed of 11 close-ended questions with one-choice answer, with a total of 52 items, covering the main data from patients presenting with GERD. Results: Treatment with PPI alone was mostly considered insufficient for the control of GERD symptoms. The combined treatment of PPI + alginate-antacids was used for 37% and 21% of physicians for treating heart-burn and regurgitation, respectively. A better control of symptoms, an increase in the onset of action and to reduce nocturnal acid breakthrough were the most frequently argued reasons for the use of PPI + alginate-antacids. A high percentage of participants believed that treatment with PPI alone was insufficient for the control of symptoms and 39.8% of physicians reported the persistence of heartburn, 38.6% the persistence of regurgitation and 43.2% the persistence of epigastric discomfort in more than 25% of their patients treated with PPI as monotherapy. The most common schedule for the use of the antacid medication was on demand. Conclusions: Spanish primary care physicians consider that a high proportion of GERD patients continue to suffer from symptoms during PPI treatment alone. Ondemand “combined therapy” (PPI + antacid) is considered an efficient option to control reflux symptoms still troublesome in patients with PPI treatment alone.
?ES POSIBLE UN VERDADERO ESTADO DE DERECHO DEMOCRáTICO? JüRGEN HABERMAS Y LAS APüRíAS DE LA SOCIEDAD LIBERAL
Martínez de Velasco,Luis;
Eidos , 2008,
Abstract: from his theory of communicative action (1981) until his later political writings, the philosopher jürgen habermas has put on the juridical language the main responsibility of describing the essence of civil society. that's why the habermasian analysis becomes a defence of a capitalistic conception of the actual society, turning around a strict notion of individual.
Efecto de la ticlopidina en los cambios morfológicos de cultivos endoteliales inducidos por la interacción endotoxina plaqueta
Martínez de Lima,Nina;
Revista de la Facultad de Medicina , 2007,
Abstract: induced by lipopolysaccharide is inhibited by ticlopidina. we investigated if ticlopidina could modify the effect of the lipopolysaccharide -platelets interaction, on endothelial cell morphology. the endothelial cells were isolated from rat embryos dermal microvasculature. the cultures were incubated with: lipopolysaccharide; lipopolysaccharide + platelet rich plasma; lipopolysaccharide + platelet rich plasma from rats treated with ticlopidina; lipopolysaccharide + ticlopidina solution; lipopolysaccharide + control platelet rich plasma + ticlopidina; ticlopidina solution. the results evidenced citoplasmatic alterations with lipopolysaccharide. this cellular damage was strengthen by platelet rich plasma; however, in the presence of platelet rich plasma from rats pretreated with ticlopidina, these changes did not become present. we concluded that ticlopidina suppresses some derived adverse effects of the lipopolysaccharide -platelet interaction on the endothelium, thus ticlopidina could have a therapeutic potential on septic shock
La deconstrucción del concepto de propiedad: Una aproximación intercultural a los derechos territoriales indígenas
Martínez de Bringas,Asier;
Utopìa y Praxis Latinoamericana , 2009,
Abstract: the objective of this study is to design contents for the threefold topic ?indigenous peoples-habitat-territory,? from a decolonizing perspective. from this starting point, the study confronts the complicated challenge of intercultural dialogue. the work was structured in four sections: a) terminological clarifications regarding the subject; what can we understand by territoriality, natural resources and biodiversity within the logical framework of the indigenous peoples, and how these same terms are understood differently by western law; b) critical analyses of indigenous claims in the multilateral environmental treaties that have emerged lately, from the perspective of indigenous peoples? rights; c) controversial central elements in this exciting intercultural dialogue, such as indigenous territoriality; d) an analysis of the jurisprudence that has been developed by the inter-american human rights court and commission, aware that this may be a first advancement toward intercultural law, latent in the different reports and decisions made by these two juridical institutions.
Economía ambiental y ordenación del territorio
Pablo Martínez de Anguita
Ecosistemas , 2004,
Abstract: Este artículo revisa la evolución de la disciplina de la economía denominada economía ambiental y de los recursos naturales hasta su estado en la actualidad. Asimismo analiza el papel que debe tener ésta en los planes de ordenación y modelos de planificación ambiental regional. Valorar económicamente algo significa comparar preferencias en función del poder adquisitivo que poseen los agentes que lo valoran. En determinadas circunstancias de justicia, o equidad, estas preferencias económicas pueden mostrar también preferencias sociales. Valorar ambientalmente un territorio o un ecosistema en términos económicos permite establecer un marco donde las comparaciones de preferencias puedan ser hechas considerando todos sus aspectos ambientales, estén o no en el mercado. Esto permite dotar a las ordenaciones territoriales de una información más adecuada para elaborar políticas y directrices de gestión de recursos naturales menos sesgadas hacia la producción y más eficientes de acuerdo con el valor que la sociedad da a sus recursos ambientales.
Influencia del inglés en el lenguaje bibliológico y tipográfico moderno
Martínez de Sousa, José
BiD : Textos Universitaris de Biblioteconomia i Documentació , 2002,
Abstract: Dissertació sobre l'argument i consolidació els darrers anys de tecnicismes estrangers, sobretot anglicismes, en el món bibliològic i tipogràfic en detriment dels termes tradicionals. Aquest fet però, ha produ t confusions terminològiques i que certa terminologia esdevingui estranya i llunyana. Finalment, l'autor mostra exemples sobre aquests tecnicismes i possibles solucions per adaptar-los millor a la nostra llengua.
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