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Search Results: 1 - 10 of 446 matches for " Girish Tillu "
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Cancer, Inflammation, and Insights from Ayurveda
Venil N. Sumantran,Girish Tillu
Evidence-Based Complementary and Alternative Medicine , 2012, DOI: 10.1155/2012/306346
Abstract: A recent, exciting discovery relates to the concept of “shared pathology” between cancer and metabolic syndrome. One major pathway common to cancer and metabolic syndrome is chronic inflammation, which is a major driving force in carcinogenesis. Indeed, chronic inflammation precedes most cancers and is considered a “hallmark” of the neoplastic process. We discuss molecular and biochemical evidence which links diet, obesity, abnormal lipid metabolism, and type 2 diabetes mellitus with chronic inflammation. We also explain how each of these factors is linked with biochemical aberrations of carcinogenesis and the prevalence and risk of cancer. While there are reliable biomarkers for chronic inflammation, there are few markers for a mechanistic link between early inflammation and digestive disorders. Discovery of such a marker could lead to identification of a new subtype of patients with digestive disorders that predispose them to cancer and/or metabolic syndrome. In this context, we discuss the ayurvedic concept of “Ama” which is thought to be a toxic, proinflammatory waste-product of improper digestion. We then develop hypotheses and outline preclinical and clinical experiments designed to prove whether “Ama” can serve as a novel and reliable biomarker that links abnormal digestive status, with the onset of chronic inflammation.
A Randomized Controlled Exploratory Evaluation of Standardized Ayurvedic Formulations in Symptomatic Osteoarthritis Knees: A Government of India NMITLI Project
Arvind Chopra,Manjit Saluja,Girish Tillu,Anuradha Venugopalan,Sanjeev Sarmukaddam,Ashwini Kumar Raut,Lata Bichile,Gumdal Narsimulu,Rohini Handa,Bhushan Patwardhan
Evidence-Based Complementary and Alternative Medicine , 2011, DOI: 10.1155/2011/724291
Abstract: The multidisciplinary “New Millennium Indian Technology Leadership Initiative” Arthritis Project was undertaken to validate Ayurvedic medicines. Herbal formulations in popular use were selected by expert consensus and standardized using modern tools. Our clinical strategy evolved from simple exploratory evaluations to better powered statistically designed drug trials. The results of the first drug trial are presented here. Five oral formulations (coded A, B, C, D and E), with a common base of Zingiber officinale and Tinospora cordifolia with a maximum of four plant extracts, were evaluated; with placebo and glucosamine as controls. 245 patients suffering from symptomatic OA knees were randomized into seven arms (35 patients per arm) of a double blind, parallel efficacy, multicentric trial of sixteen weeks duration. The groups matched well at baseline. There were no differences for patient withdrawals (17.5%) or adverse events (AE) of mild nature. Intention-to-treat efficacy analysis, demonstrated no significant differences (<.05) for pain (weight bearing) and WOMAC questionnaire (knee function); placebo response was high. Based on better pain relief, significant (<.05) least analgesic consumption and improved knee status, “C” formulation was selected for further development. Controlled exploratory drug trials with multiple treatment arms may be used to economically evaluate several candidate standardized formulations.
Multi-Scale Structural Studies of Sequential Ionic Liquids and Alkali Pretreated Corn Stover and Sugarcane Bagasse  [PDF]
Ishwinder Kaur, Girish Sahni
Green and Sustainable Chemistry (GSC) , 2018, DOI: 10.4236/gsc.2018.81007
Abstract: The complexity of plant cell walls impedes the conversion of cellulosic biomass to sugars. Pretreatment becomes a necessity to increase the digestibility of biomass. An in-depth understanding of the structure and underlying mechanisms governing deconstruction process is important. In the present study, the comprehensive investigation of morphological and structural changes in corn stover and sugarcane bagasse following ionic liquids dissolution and alkaline extraction was done using Fourier transform infrared spectroscopy, Thermogravimetric analysis, Confocal scanning laser microscopy, Atomic force microscopy and Dynamic light scattering studies. Both the substrates were pretreated with ILs 1-ethyl-3-methylimidazolium acetate and 1-butyl-3-methylimidazolium acetate followed by alkaline extraction. The pronounced changes such as lignin, hemicelluloses removal and decreased cellulose crystallinity after the pretreatments lead to the structural transformation of matrix polymers. The enzymatic hydrolysis showed 90% theoretical sugar yield in case of sugarcane bagasse and 80% in corn stover following synergistically combined pretreatments.
Impact of Implementation of Goods and Services Tax on Nifty 50 Index of National Stock Exchange of India  [PDF]
G. P. Girish
Theoretical Economics Letters (TEL) , 2019, DOI: 10.4236/tel.2019.91014
Abstract:

The main purpose of this study is to investigate the impact of implementation of goods and services tax on national stock exchange (NSE) of India by considering nifty 50 index of NSE India and by applying event study technique. India embarked upon a new era of global practices by embracing and implementing goods and services tax on 1st July 2017 which was considered as the “event” for this study. Nifty 50 index daily data from 12th June 2017 to 21st July 2017 (t ± 14 days) are used for the study. The result of the study suggests that implementation of GST impacted nifty 50 index of NSE in a positive way resulting in abnormal returns which is statistically significant. The results of the study provide fresh evidences on our understanding about impact of structural changes on stock market in short-run to regulators, potential investors and high net worth individuals, fund managers, hedge funds and policymakers.

Pleistocene Radiolaria from Leg 119 Site 738B (Sections 1H1-1H2): Systematics and Biostratigraphy  [PDF]
Girish Kumar Sharma, Sheetal Kanojia
Open Journal of Geology (OJG) , 2013, DOI: 10.4236/ojg.2013.38048
Abstract:

This paper presents a record of radiolarian species from the sections (1H1-1H2) Leg 119 Site 738B of Southern Ocean region. Well diversified taxa of typical Antarctic assemblage are present in the sections. Thirty species were identified and illustrated from twenty-nine samples. On the basis of appearance, disappearance and abundance of taxa, viz. Omega and Psi zones are established and systematics of stratigraphically important species is described. These zones are equivalent to NR1 and NR2 of Upper Quaternary.

Is Stock Prices and Economic Activity in India Co-Integrated?  [PDF]
G. P. Girish, S. Vijayalakshmi
Theoretical Economics Letters (TEL) , 2016, DOI: 10.4236/tel.2016.62030
Abstract: In this study we investigate whether stock prices and economic activity in India are co-integrated by using monthly data from 1960 to 2013 and applying high-powered co-integration tests which have an inherent advantage of permitting structural changes in the relationships being tested and in asymmetric co-integration, along with frequently applied co-integration tests of Engle and Granger (1987) and Johansen (1988). The results of the study provide empirical evidence for reasonably saying that stock prices and economic activity in India are co-integrated and validate the prediction in financial economics literature.
Does Indian Spot Electricity Price Series Exhibit Inverse-Leverage Effect?  [PDF]
G. P. Girish, S. Vijayalakshmi
Theoretical Economics Letters (TEL) , 2018, DOI: 10.4236/tel.2018.83017
Abstract: In this study, we investigate whether Indian Spot Electricity Price Series exhibit Inverse-Leverage effect by modeling Indian spot electricity price using ARIMA-EGARCH model using data given by Indian Energy Exchange from January 1st 2014 to 31st December 2015 accounting for 730 days and 17,520 hourly spot prices for all the five regions of Indian electricity market. Conditional mean and conditional variance equations are estimated. The results of the study provide crucial insights for power market participants/open access consumers whose numbers have surpassed 3530 in Indian Energy Exchange to strategically plan their exposure in Indian spot electricity market.
Nosocomial pneumonia in critically ill patients
Dandagi Girish
Lung India , 2010,
Abstract: The care of critically ill patients in the intensive care unit (ICU) is a primary component of modern medicine. ICUs create potential for recovery in patients who otherwise may not have survived. However, they may suffer from problems associated with of nosocomial infections. Nosocomial infections are those which manifest in patients 48 hours after admission to hospital. Nosocomial infections are directly related to diagnostic, interventional or therapeutic procedures a patient undergoes in hospital, and are also influenced by the bacteriological flora prevailing within a particular unit or hospital. Urinary tract infections are the most frequent nosocomial infection, accounting for more than 40% of all nosocomial infections. Critical care units increasingly use high technology medicine for patient care, hemodynamic monitoring, ventilator support, hemodialysis, parenteral nutrition, and a large battery of powerful drugs, particularly antibiotics to counter infection. It is indeed a paradox that the use of high-tech medicine has brought in its wake the dangerous and all too frequent complication of nosocomial infections
Transdermal Drug Delivery Systems : A Review
Girish Chopda
Pharmaceutical Reviews , 2006,
Abstract: At present, the most common form of delivery of drugs is the oral route. While this has the notable advantage of easy administration, it also has significant drawbacks -- namely poor bioavailabiltity due to hepatic metabolism (first pass) and the tendency to produce rapid blood level spikes (both high and low), leading to a need for high and/or frequent dosing, which can be both cost prohibitive and inconvenient.(1)To overcome these difficulties there is a need for the development of new drugdelivery system; which will improve the therapeutic efficacy and safety of drugsby more precise (ie site specific ) , spatial and temporal placement withinthe body thereby reducing both the size and number of doses. New drug deliverysystem are also essential for the delivery of novel , genetically engineeredpharmaceuticals (ie peptides , proteins ) to their site of action , withoutincurring significant immunogenecity or biological inactivation. Apart fromthese advantages the pharmaceutical companies recognize the possibility of repatteningsuccessfull drugs by appling the concepts and techniques of controlled drugdelivery system coupled with the increased expense in bringing new drug moietyto the market(1).One of the methods most often utilized has been transdermaldelivery - meaning transport of therapeutic substances through the skin forsystemic effect. Closely related is percutaneous delivery, which is transportinto target tissues, with an attempt to AVOID systemic effects (2).
Research: ROLE OF ANTIOXIDANT VITAMINS IN IMMUNE FUNCTION IN LEPROSY
Sunita Girish
Pharmacie Globale : International Journal of Comprehensive Pharmacy , 2011,
Abstract: Leprosy is a chronic infectious disease caused by Mycobacterium leprae. (Hansen, 1875) affecting mainly the immune system. Oxidation-mediated tissue injury is a particular hazard to the immune system, since phagocytic cells produce reactive oxygen species as part of the body's defense against infection. Adequate amounts of neutralizing antioxidants are required, therefore, to prevent damage to the immune cells themselves. Vitamin E, C, and beta-carotene (provitamin A) are essential nutrients that the human organism cannot synthesize and which act as antioxidants by stabilizing highly reactive and potentially harmful molecules, as are the free radicals. To assess the severity of oxidation stress, all subjects and controls were studied for plasma lipid peroxide levels. The plasma levels of vitamin C, vitamin E and β carotene were measured to know the status of antioxidant vitamins. The estimation of lipid peroxide levels gave an idea about the possibility of oxidation mediated tissue damage while the levels of antioxidant vitamins indicated that these vitamins have an unfavorable action in cell and humoral immune responses and therefore produce immunosuppression due to increase in the peroxide level.
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