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Search Results: 1 - 10 of 5544 matches for " Giovanni Loriga "
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Synthesis of Tricyclic Condensed Rings Incorporating the Pyrazole or Isoxazole Moieties Bonded to a 4-Piperidinyl Substituent
Giansalvo Pinna,Giovanni Loriga,Gérard A. Pinna,Giorgio Chelucci
Molecules , 2013, DOI: 10.3390/molecules18078147
Abstract: In this paper we report the synthesis of new compounds based on the pyrazole and isoxazole framework fused to a cycloalkene unit, and bearing as a substituent the 1-piperidinyl group as new examples of potential antipsychotic molecules. The general synthesis involves the acylation of a chloro-substituted cyclic ketone with a 1-substituted piperidine-4-carboxylate derivative, followed by heterocyclization of the formed 1,3-dioxo compound with a hydrazine or hydroxylamine.
Old and New anticoagulants: The beginning of a new era?
Aida Crespo Guerra,Fidel Cáceres Loriga
Revista Cubana de Cardiología y Cirugía Cardiovascular , 2011,
Abstract: Use of coumarin and heparin for more than sixty years, has been an effective and powerfulmedical tool for treatment and prevention of thromboembolic diseases, tarnished nevertheless,by their little security and laboratory controls which are frequently needed. Such reasonsmake for an effective challenge and an active field, searching the ideal anticoagulant inscientific investigation, drugs to inhibit specific clot factors, able to exclude the weak pointsof the available ones is its goal. In this article, we consider physiopathology for thrombi formationand we review too the history, pharmacokinetics and pharmacodynamic properties ofold anticoagulants drugs, their limitations, just when new anticoagulants drugs haveemerged as inhibitors of thrombin or Xa factor, whose effectiveness and security are beingcontrasted with the traditional ones in wide programs of current execution with atrial fibrillationand coronary syndromes included, and they could potentially substitute the old ones ina near future.
Polluting Productions and Sustainable Economic Growth: A Local Stability Analysis  [PDF]
Giovanni Bella
Journal of Service Science and Management (JSSM) , 2009, DOI: 10.4236/jssm.2009.21007
Abstract: The aim of this paper is to analyze the link between natural capital and economic growth, in a Romer-type economy characterized by dirty emissions in the production process, and to examine the conditions under which a sustainable growth, which implies a decreasing level of dirty emissions, might be both feasible and optimal. This work is close to Aghion-Howitt (1998) with some more general specifications, in particular regarding the structure of preferences and the technological sector. We also deeply study the transitional dynamics of this economy towards the steady state, and conclude that a determinate saddle path sustainable equilibrium can be reached even in presence of a long run positive level of polluting emissions, thanks to a growing level of new home-made inventories, without whom some indetermi-nacy problems are likely to emerge.
Contestability and Collateral in Credit Markets with Adverse Selection  [PDF]
Giovanni Cesaroni
Theoretical Economics Letters (TEL) , 2012, DOI: 10.4236/tel.2012.21010
Abstract: The work discusses a basic proposition in the theory of competition in markets with adverse selection. By working out the sequence of market transactions, we show that the effectiveness of collateral in avoiding equilibrium rationing depends on an assumption of uncontestability of the loan market. If contestability is restored to its proper place, the sepa- ration of borrower by means of sufficient collateral does not impede the emergence of credit rationing, which results from a coordination failure among risk-neutral banks. As a consequence, even in a risk-neutral environment with suitable endowments, the use of collateral in credit contracts could not be a socially efficient screening-device. Our conclu- sion on rationing does not stand in contrast with a general result from Gale.
Endogenous Discounting and Global Indeterminacy  [PDF]
Giovanni Bella
Modern Economy (ME) , 2013, DOI: 10.4236/me.2013.411080
Abstract:

This paper innovates the literature on endogenous discounting in environmental economics, by studying the global properties of the equilibrium outside the small neighborhood of the steady state. The internalization of individual consumption in the social discount rate is rich of powerful consequences from the economic point of view, for it leads to a qualitative change in the steady state and its transitional dynamics, so that the perfect foresight equilibrium may not be unique, and thus both local and global indeterminacy can eventually emerge. The main implication for decision making is that if indeterminacy occurs, public policies become not sufficient to drive the economy towards the long-run equilibrium. In particular, we show that the onset of parametric restrictions for which both global indeterminacy in the full R3 vector field, and a quasi-periodic dynamics with trajectories wrapped around an invariant torus, may eventually emerge.

Addressing Biodiversity Conservation Methods with Fagus sylvatica Genetic Indicators  [PDF]
Giovanni Figliuolo
Open Journal of Genetics (OJGen) , 2014, DOI: 10.4236/ojgen.2014.42017
Abstract:


Species biological history revealed by genetic indicators can provide guidelines for long-term biodiversity conservation in Natura 2000 network. Fagus sylvatica is the keystone species which regulates in the Mediterranean Eco-Region ecosystem structure, function and composition. Six hundred fifty nine F. sylvatica individuals have been sampled across 20 sites of European interest in Southern Italy and analyzed at 5 microsatellite loci. For sites marked by both maximum heterozygosity (Ho) and minimum heterozygote deficit (Fis) (IT9210210, ITA070099, IT9210205 and IT9220075) it is suggested to avoid impacts by adopting very conservative measures. Promoting migration processes (pollen flow and seed flow) would be appropriate where it has been monitored low heterozygosity and high genetic disequilibrium. Margin effect due to dryness should be buffered with appropriate belts of thermophilus broad leaved tree species.


Palmar Intertriradial Ridge Counts in Sardinians  [PDF]
Giovanni Floris
Advances in Anthropology (AA) , 2015, DOI: 10.4236/aa.2015.53012
Abstract: Palmar intertriradial ridge counts (a-b, b-c, c-d, a-d) in 260 males and 260 females of Sardinian origin were considered. Bilateral and sex differences, correlation coefficients, skewness and kurtosis of the four distributions and an index of asymmetry were calculated. There are no sex differences, ridge counts show positive and almost always significant correlations. The a-d ridge count shows a normal distribution in both sexes.
Only One Goal: Economic Growth. How Can Environmentalism Survive in the 21st Century?  [PDF]
Giovanni Capulli
Advances in Applied Sociology (AASoci) , 2015, DOI: 10.4236/aasoci.2015.56017
Abstract: This paper is aimed to explore environmentalism in the 21st century: this broad philosophy has to overcome its limits in order to survive in a society where there seems to be only one goal, the economic growth. In the first part of the essay, I want to analyze the present condition as a result of a weak environmental consciousness. In the second part of the essay, I want to describe and compare two mainstreams of present environmentalism: de-growth theory and sustainable development.
New Road Infrastructures in Italy: Governance, Coordination and Regional Development—Actual Case: Quadrilatero S.p.A.  [PDF]
Giovanni Capulli
Advances in Applied Sociology (AASoci) , 2016, DOI: 10.4236/aasoci.2016.64015
Abstract: This essay is aimed to verify the following statement by an actual case from the Italian experience: when decisions are well coordinated and there is a strong cooperation within the hierarchy, new road infrastructures can solve congestion and at the same time, they can be an important flywheel for the regional economy especially in those regions that have economies export-orientated.
The Origin of the Color Charge into Quarks  [PDF]
Giovanni Guido
Journal of High Energy Physics, Gravitation and Cosmology (JHEPGC) , 2019, DOI: 10.4236/jhepgc.2019.51001
Abstract: Showing the origin of the mass in an additional coupling between field quantum oscillators, we formulate a hypothesis of a geometrical structure of the oscillators of “fields-particles”. In this way, we define the possible structure of quarks and hadrons (as the proton). This hypothesis is reasonable if one admits field oscillators composed by sub-oscillators at semi-quantum (IQuO) and in which a degree of internal freedom is definable. Using the IQuO model, we find the origin of the sign of electric charge in to particles and, in quarks, the isospin, the strangeness and colour charge. Finally, we formulate the structure of the gluons and the variation modality of the colour charge in quarks.
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