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Search Results: 1 - 10 of 8646 matches for " Giovanni Bernardo "
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Multimodality treatment of unresectable hepatic metastases from pancreatic glucagonoma
Guido Poggi,Laura Villani,Giovanni Bernardo
Rare Tumors , 2009, DOI: 10.4081/rt.2009.e6
Abstract: Glucagonomas are pancreatic islet cell tumors arising from the alpha cells which belong to neuroendocrine tumors. They frequently metastasize to the liver. We report the case of a 52- year old man with a pancreatic glucagonoma with synchronous multiple liver metastases treated by surgery, transarterial chemoembolization, percutaneous radiofrequency thermal ablation and long-acting octreotide. Our report confirms that a multimodal approach is very effective in patients with unresectable liver metastases from pancreatic endocrine tumors providing long-lasting palliation and probably prolonging survival.
Hitting Time Distributions in Financial Markets
Davide Valenti,Bernardo Spagnolo,Giovanni Bonanno
Physics , 2006, DOI: 10.1016/j.physa.2007.03.044
Abstract: We analyze the hitting time distributions of stock price returns in different time windows, characterized by different levels of noise present in the market. The study has been performed on two sets of data from US markets. The first one is composed by daily price of 1071 stocks trade for the 12-year period 1987-1998, the second one is composed by high frequency data for 100 stocks for the 4-year period 1995-1998. We compare the probability distribution obtained by our empirical analysis with those obtained from different models for stock market evolution. Specifically by focusing on the statistical properties of the hitting times to reach a barrier or a given threshold, we compare the probability density function (PDF) of three models, namely the geometric Brownian motion, the GARCH model and the Heston model with that obtained from real market data. We will present also some results of a generalized Heston model.
Contraction analysis of switched systems: the case of Caratheodory Systems and Networks
Mario di Bernardo,Davide Liuzza,Giovanni Russo
Mathematics , 2011,
Abstract: In this paper we extend to a generic class of piecewise smooth dynamical systems a fundamental tool for the analysis of convergence of smooth dynamical systems: contraction theory. We focus on switched systems satisfying Caratheodory conditions for the existence and unicity of a solution. After generalizing the classical definition of contraction to this class of dynamical systems, we give sufficient conditions for global exponential convergence of their trajectories. The theoretical results are then applied to solve a set of representative problems including proving global asymptotic stability of switched linear systems, giving conditions for incremental stability of piecewise smooth systems, and analyzing the convergence of networked switched linear systems.
Mean Escape Time in a System with Stochastic Volatility
Giovanni Bonanno,Davide Valenti,Bernardo Spagnolo
Quantitative Finance , 2006, DOI: 10.1103/PhysRevE.75.016106
Abstract: We study the mean escape time in a market model with stochastic volatility. The process followed by the volatility is the Cox Ingersoll and Ross process which is widely used to model stock price fluctuations. The market model can be considered as a generalization of the Heston model, where the geometric Brownian motion is replaced by a random walk in the presence of a cubic nonlinearity. We investigate the statistical properties of the escape time of the returns, from a given interval, as a function of the three parameters of the model. We find that the noise can have a stabilizing effect on the system, as long as the global noise is not too high with respect to the effective potential barrier experienced by a fictitious Brownian particle. We compare the probability density function of the return escape times of the model with those obtained from real market data. We find that they fit very well.
Global Entrainment of Transcriptional Systems to Periodic Inputs
Giovanni Russo,Mario di Bernardo ,Eduardo D. Sontag
PLOS Computational Biology , 2010, DOI: 10.1371/journal.pcbi.1000739
Abstract: This paper addresses the problem of providing mathematical conditions that allow one to ensure that biological networks, such as transcriptional systems, can be globally entrained to external periodic inputs. Despite appearing obvious at first, this is by no means a generic property of nonlinear dynamical systems. Through the use of contraction theory, a powerful tool from dynamical systems theory, it is shown that certain systems driven by external periodic signals have the property that all their solutions converge to a fixed limit cycle. General results are proved, and the properties are verified in the specific cases of models of transcriptional systems as well as constructs of interest in synthetic biology. A self-contained exposition of all needed results is given in the paper.
Ab initio optical properties of Si(100)
Maurizia Palummo,Giovanni Onida,Rodolfo Del Sole,Bernardo Mendoza
Physics , 1998, DOI: 10.1103/PhysRevB.60.2522
Abstract: We compute the linear optical properties of different reconstructions of the clean and hydrogenated Si(100) surface within DFT-LDA, using norm-conserving pseudopotentials. The equilibrium atomic geometries of the surfaces, determined from self-consistent total energy calculations within the Car-Parrinello scheme, strongly influence Reflectance Anisotropy Spectra (RAS), showing differences between the p(2x2) and c(4x2)reconstructions. The Differential Reflectivity spectrum for the c(4x2) reconstruction shows a positive peak at energies < 1 eV, in agreement with experimental results.
H3N2 Virus as Causative Agent of ARDS Requiring Extracorporeal Membrane Oxygenation Support
Adriano Peris,Giovanni Zagli,Pasquale Bernardo,Massimo Bonacchi,Morena Cozzolino,Lucia Perretta,Alberta Azzi,Giovanni Cianchi
Case Reports in Medicine , 2014, DOI: 10.1155/2014/560208
Abstract: Pandemic influenza virus A(H1N1) 2009 was associated with a higher risk of viral pneumonia in comparison with seasonal influenza viruses. The influenza season 2011-2012 was characterized by the prevalent circulation of influenza A(H3N2) viruses. Whereas most H3N2 patients experienced mild, self-limited influenza-like illness, some patients were at increased risk for influenza complications because of age or underlying medical conditions. Cases presented were patients admitted to the Intensive Care Unit (ICU) of ECMO referral center (Careggi Teaching Hospital, Florence, Italy). Despite extracorporeal membrane oxygenation treatment (ECMO), one patient with H3N2-induced ARDS did not survive. Our experience suggests that viral aetiology is becoming more important and hospitals should be able to perform a fast differential diagnosis between bacterial and viral aetiology. 1. Introduction Influenza viruses represent an important cause of severe lower respiratory disease. Pandemic influenza virus A(H1N1) 2009 was associated with a higher risk of viral pneumonia in comparison with seasonal influenza viruses [1, 2]. During the pandemic and the following influenza epidemic season 2010-2011, this led to an increased frequency of hospitalization in Intensive Care Units (ICUs) and of Acute Respiratory Distress Syndrome (ARDS) that is the most severe type of acute lung injury. The influenza season 2011-2012 was characterized by the prevalent circulation of influenza A(H3N2) viruses. Whereas most H3N2 patients experienced mild, self-limited influenza-like illness, some patients were at increased risk for influenza complications because of age or underlying medical conditions. Here we show our experience of treating two cases of adult patient with ARDS due to H3N2 pneumonia treated with venovenous extracorporeal membrane oxygenation (ECMO). 2. Methods 2.1. Setting The patients were admitted to the Intensive Care Unit (ICU) of Careggi Teaching Hospital (Florence, Italy) as ECMO Referral Center in season 2011-2012. Data were collected from ICU databases and the Italian Group for the Evaluation of Interventions in Intensive Care Medicine database (GiViTI Margherita Project, Istituto Mario Negri, Bergamo, Italy). Table 1 summarized baseline and clinical characteristic of patients. Internal Review Board approved the study and informed consent for data publication was obtained. Table 1: Clinical characteristic of H3N2-pneumonia patients. 2.2. Ventilation Strategies and Extracorporeal Membrane Oxygenation (ECMO) ECMO was used to support the respiratory function after the
Indexicals in Virtual Environments  [PDF]
Bernardo Alonso
Open Journal of Philosophy (OJPP) , 2014, DOI: 10.4236/ojpp.2014.42018
Abstract:

In this paper I explored three well-known cases that seem to cast doubt on the notion that a speaker is always at the place of the utterance when the utterance occurs. I gave a few examples produced in Second Life environment, which cannot be handled correctly by evaluating the expression at issue with respect to the traditional view, i.e., the kaplanian framework—where the agent and the utterer will always be identical, and the referent of “I” will always be the utterer. The same happens to “here” and “now”; in each case the character of the indexical is a function from a contextual parameter to the referent of the expression. An example of logical truth peculiar to indexicals is the sentence “I am here now”, since, according to that view, no utterance can take place in a context whose agent is not in its location in its time. Finally I concluded by claiming that particular kinds of utterances produced in virtual environments (VE) break with the logical truth status of “I am here now”.

Treatment of Chronic Hepatitis C in a Patient Affected by Systemic Sclerosis
Guido Poggi,Laura Villani,Federico Sottotetti,Barbara Tagliaferri,Benedetta Montagna,Alessio Amatu,Giovanni Bernardo
Gastroenterology Research and Practice , 2009, DOI: 10.1155/2009/475390
Abstract: The currently recommended treatment for patients infected with hepatitis C virus (HCV) is pegilated interferon α (IFN α) plus ribavirin. Despite the numerous benefits of this therapy, there is an increasing concern regarding his tolerance. Among the most common side effects, interferon may trigger the onset or exacerbation of autoimmune diseases. When chronic hepatitis C coexists with an autoimmune disorder, it is not clear whether using interferon is better than avoiding it. We evaluated the disease state of a 55-year old female affected by sistemic sclerosis (SSc), during and after therapy with IFNα pegilated plus ribavirin for chronic HCV infection. We were worried about the potential worsening of the autoimmune disease during the therapy, but we were confident that we would give our patient a short course of peginterferon and ribavirin. A mild, asymptomatic worsening of lung SSc was observed during IFN administration, without life threatening symptoms. After 24 months follow up we observed the maintenance of the virological response and a good control of the rheumatological disease. Thus, in liver disease at high risk of progression and concomitant SSc, the antiviral therapy with IFNα is a feasible approach.
Correla??o da medida de espessura intra-abdominal medida pela ultra-sonografia com os fatores de risco cardiovascular
Leite, Claudia C.;Matsuda, Daniella;Wajchenberg, Bernardo L.;Cerri, Giovanni G.;Halpern, Alfredo;
Arquivos Brasileiros de Endocrinologia & Metabologia , 2000, DOI: 10.1590/S0004-27302000000100009
Abstract: the objective of our study was to determine if intra abdominal thickness measured by ultrasonography (iatu) has correlation with cardiovascular risk factors, and if it is a better predictor of cardiovascular risk than waist circumference and sagittal diameter. finally we tried to find a cut off point for abdominal thickness measured by ultrasonography to predict cardiovascular disease (cvd). one hundred ninety one healthy men and 231 healthy women were submitted to anthropometric evaluation and blood pressure measure. blood samples were drawn for total plasma cholesterol, hdl, triglyceride and glucose determination. intra-abdominal ultrasonography was performed to measure abdominal thickness. the population was divided in three groups according to the presence of cvd risk factors: 1) moderately risk group (mr) with two or more of the following: total chol > 200mg/dl, hdl-cholesterol < 45mg/dl, trig > 200mg/dl, glu > 126mg/di, sbp > 140mmhg, dbp > 90mmhg; 2) high risk group (hr) with two or more of the indicated: total chol > 240mg/dl, hdl-cholesterol < 35mg/dl, trig > 200mg/dl + hdl-cholesterol < 35mg/dl, glu > 126mg/dl, sbp > 140mmhg, dbp > 90mmhg; 3) no risk group (nr) - with only one or none of the risk factors indicated in the moderate and high group. the results showed that iatu has association with all cardiovascular risk factors and has better specificity and accurately for cvd risk than waist circumference and sagittal diameter. the values of 7cm for both sexes was the cut off lengths obtained by iatu to predict moderate cv risk; 8 and 9cm were the cut off length obtained by iatu to predict high cv risk for men and for women respectively. the iatu is a useful way to determine visceral fat and seems to be predictive of cardiovascular risk.
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