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Search Results: 1 - 10 of 5365 matches for " Giovan Battista Mauro "
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Can nebivolol be helpful in Beh et’s disease?
Antonella Tomassino,Giovan Battista Mauro
Anadolu Kardiyoloji Dergisi , 2013,
Analysis of surgical and perioperative complications in seventy-five right hepatectomies for living donor liver transplantation
Salvatore Gruttadauria, James Wallis Marsh, Giovan Battista Vizzini, Fabrizio di Francesco, Angelo Luca, Riccardo Volpes, Amadeo Marcos, Bruno Gridelli
World Journal of Gastroenterology , 2008,
Abstract: AIM: To present an analysis of the surgical and perioperative complications in a series of seventy-five right hepatectomies for living-donation (RHLD) performed in our center.METHODS: From January 2002 to September 2007, we performed 75 RHLD, defined as removal of a portion of the liver corresponding to Couinaud segments 5-8, in order to obtain a graft for adult to adult living-related liver transplantation (ALRLT). Surgical complications were stratified according to the most recent version of the Clavien classification of postoperative surgical complications. The perioperative period was defined as within 90 d of surgery.RESULTS: No living donor mortality was present in this series, no donor operation was aborted and no donors received any blood transfusion. Twenty-three (30.6%) living donors presented one or more episodes of complication in the perioperative period. Seven patients (9.33%) out of 75 developed biliary complications, which were the most common complications in our series.CONCLUSION: The need to define, categorize and record complications when healthy individuals, such as living donors, undergo a major surgical procedure, such as a right hepatectomy, reflects the need for prompt and detailed reports of complications arising in this particular category of patient. Perioperative complications and post resection liver regeneration are not influenced by anatomic variations or patient demographic.
Anandamide uptake by synaptosomes from human, mouse and rat brain: inhibition by glutamine and glutamate
Natalia Battista, Monica Bari, Alessandro Finazzi-Agrò, Mauro Maccarrone
Lipids in Health and Disease , 2002, DOI: 10.1186/1476-511x-1-1
Abstract: Endocannabinoids are an emerging class of lipid mediators, which activate cannabinoid receptors and regulate sleep induction, interact with GABAergic, serotonergic and dopaminergic neurotransmission, and are also formed during glutamate-induced neurotoxicity [1,2]. The biological activity of anandamide (N-arachidonoylethanolamine, AEA), a major endocannabinoid, is controlled by cellular uptake through a specific AEA membrane transporter (AMT) [3], followed by intracellular degradation by anandamide hydrolase (fatty acid amide hydrolase, FAAH) [4]. The critical role of AMT in controlling AEA action, and the potential use of AMT inhibitors in the treatment of human pathologies such as multiple sclerosis, Parkinson's disease and Huntington's disease [1,5,6], prompted us to investigate whether brain synaptosomes might be used as a new ex vivo system, able to accumulate AEA through a selective transporter with the features of AMT.Human brain specimens were obtained from twelve different male patients (aged 73–77), undergoing surgical operation to remove meningioma tumors from the pterional area. Brain tissues, removed and donated by Dr. G. De Caro (Neurosurgery Division, University of Rome "Tor Vergata", Sant'Eugenio Hospital, Rome, Italy), were kept on ice until processed (within 30 min). In each case the perilesional white matter (150 mg of fresh tissue) surrounding the tumor area (300 mg) was removed and used as healthy control [7]. Clearance of the local Ethnics Committee was obtained to use human brain biopsies. Swiss mice weighing 20–25 g were from Charles River (Calco, Italy), and Wistar rats weighing 250–280 g were from Morini (San Paolo D'Anza, Italy). All animal procedures met the guidelines of the U.S. National Institutes of Health, detailed in the Guide for the Care and Use of Laboratory Animals, and the European Community directives regulating animal research. The experimental procedures were also approved by the local Animal Care Committee. To prepare synap
Stage-variations of anandamide hydrolase activity in the mouse uterus during the natural oestrus cycle
Klinger Francesca G,Battista Natalia,De Felici Massimo,Maccarrone Mauro
Journal of Experimental and Clinical Assisted Reproduction (JECAR) , 2006, DOI: 10.1186/1743-1050-3-3
Abstract: Recent studies have demonstrated that the endogenous cannabinoids are important modulators of fertility in mammals. In particular, a role of the endocannabinoid system in early stages of embryo development, oviductal transport of embryos, pregnancy maintenance and labour has been demonstrated in rodents and/or in humans. In the present paper, we report the analysis of FAAH activity and protein content in the mouse uterus as a function of the natural oestrus cycle stages. Variations of FAAH activity are discussed in relationship to changes in sex steroid levels and to the possible action of AEA on remodelling of uterine tissues.
The endocannabinoid system: an overview
Natalia Battista,Monia Di Tommaso,Monica Bari,Mauro Maccarrone
Frontiers in Behavioral Neuroscience , 2012, DOI: 10.3389/fnbeh.2012.00009
Abstract: Upon the identification of anandamide (AEA) in the porcine brain, numerous studies contributed to the current state of knowledge regarding all elements that form the “endocannabinoid system (ECS).”How this complex system of receptors, ligands, and enzymes is integrated in helping to regulate fundamental processes at level of central nervous and peripheral systems and how its regulation and dysregulation might counteract disturbances of such functions, is nowadays still under investigation. However, the most recent advances on the physiological distribution and functional role of ECS allowed the progress of various research tools aimed at the therapeutic exploitation of endocannabinoid (eCB) signaling, as well as the development of novel drugs with pharmacological advantages. Here, we shall briefly overview the metabolic and signal transduction pathways of the main eCBs representatives, AEA, and 2-arachidonoylglycerol (2-AG), and we will discuss the therapeutic potential of new ECS-oriented drugs.
A Contribution Towards a Knowledge of Termites
Battista Grassi
Psyche , 1889, DOI: 10.1155/1889/19035
"La Gramática castellana (1914) de Manuel de Montolíu. Un análisis de sus concepciones gramaticales y lingüísticas" ["Manuel de Montolíu’s Gramática castellana (1914): An Analysis of His Conceptions of Grammar and Linguistics"]
Emiliano Battista
Revista Argentina de Historiografía Lingüística , 2011,
Abstract: This paper analyses Manuel de Montolíu’s Gramática castellana (1914), a school grammar for the first three forms of primary school. First we focus on preliminary remarks; then we analyse the concepts of grammar that emerge from the description of sentence structure; finally, we review Montolíu’s analysis of parts of speech; their number, types, and characterisation.The paper is aimed at showing that Montolíu’s views are the result of an original combination of approaches. On the one hand, he connects the contributions of the Spanish Royal Academy of Language to the rigorous methods of rationalist philosophical traditions, for which grammar is a fundamental discipline. On the other, he relates the latter to the theories in vogue in his time; mainly, idealism and dialectology. In the harmony of this heterogeneous approach lie the interest and originality of his views.
Type-1 Cannabinoid Receptors Reduce Membrane Fluidity of Capacitated Boar Sperm by Impairing Their Activation by Bicarbonate
Barbara Barboni,Nicola Bernabò,Paola Palestini,Laura Botto,Maria Gabriella Pistilli,Marco Charini,Enzo Tettamanti,Natalia Battista,Mauro Maccarrone,Mauro Mattioli
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0023038
Abstract: Mammalian spermatozoa acquire their full fertilizing ability (so called capacitation) within the female genital tract, where they are progressively exposed to inverse gradients of inhibiting and stimulating molecules.
Artificial Neural Networks in the Outcome Prediction of Adjustable Gastric Banding in Obese Women
Paolo Piaggi,Chita Lippi,Paola Fierabracci,Margherita Maffei,Alba Calderone,Mauro Mauri,Marco Anselmino,Giovanni Battista Cassano,Paolo Vitti,Aldo Pinchera,Alberto Landi,Ferruccio Santini
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0013624
Abstract: Obesity is unanimously regarded as a global epidemic and a major contributing factor to the development of many common illnesses. Laparoscopic Adjustable Gastric Banding (LAGB) is one of the most popular surgical approaches worldwide. Yet, substantial variability in the results and significant rate of failure can be expected, and it is still debated which categories of patients are better suited to this type of bariatric procedure. The aim of this study was to build a statistical model based on both psychological and physical data to predict weight loss in obese patients treated by LAGB, and to provide a valuable instrument for the selection of patients that may benefit from this procedure.
Differences in the Endocannabinoid System of Sperm from Fertile and Infertile Men
Sheena E. M. Lewis, Cinzia Rapino, Monia Di Tommaso, Mariangela Pucci, Natalia Battista, Rita Paro, Luke Simon, Deborah Lutton, Mauro Maccarrone
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0047704
Abstract: Male infertility is a major cause of problems for many couples in conceiving a child. Recently, lifestyle pastimes such as alcohol, tobacco and marijuana have been shown to have further negative effects on male reproduction. The endocannabinoid system (ECS), mainly through the action of anandamide (AEA) and 2-arachidonoylglycerol (2-AG) at cannabinoid (CB1, CB2) and vanilloid (TRPV1) receptors, plays a crucial role in controlling functionality of sperm, with a clear impact on male reproductive potential. Here, sperm from fertile and infertile men were used to investigate content (through LC-ESI-MS), mRNA (through quantitative RT-PCR), protein (through Western Blotting and ELISA) expression, and functionality (through activity and binding assays) of the main metabolic enzymes of AEA and 2-AG (NAPE-PLD and FAAH, for AEA; DAGL and MAGL for 2-AG), as well as of their binding receptors CB1, CB2 and TRPV1. Our findings show a marked reduction of AEA and 2-AG content in infertile seminal plasma, paralleled by increased degradation: biosynthesis ratios of both substances in sperm from infertile versus fertile men. In addition, TRPV1 binding was detected in fertile sperm but was undetectable in infertile sperm, whereas that of CB1 and CB2 receptors was not statistically different in the two groups. In conclusion, this study identified unprecedented alterations of the ECS in infertile sperm, that might impact on capacitation and acrosome reaction, and hence fertilization outcomes. These alterations might also point to new biomarkers to determine male reproductive defects, and identify distinct ECS elements as novel targets for therapeutic exploitation of ECS-oriented drugs to treat male fertility problems.
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