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Search Results: 1 - 10 of 202 matches for " Gioia Altobelli "
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Genome-Wide Methylation and Gene Expression Changes in Newborn Rats following Maternal Protein Restriction and Reversal by Folic Acid
Gioia Altobelli, Irina G. Bogdarina, Elia Stupka, Adrian J. L. Clark, Simon Langley-Evans
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0082989
Abstract: A large body of evidence from human and animal studies demonstrates that the maternal diet during pregnancy can programme physiological and metabolic functions in the developing fetus, effectively determining susceptibility to later disease. The mechanistic basis of such programming is unclear but may involve resetting of epigenetic marks and fetal gene expression. The aim of this study was to evaluate genome-wide DNA methylation and gene expression in the livers of newborn rats exposed to maternal protein restriction. On day one postnatally, there were 618 differentially expressed genes and 1183 differentially methylated regions (FDR 5%). The functional analysis of differentially expressed genes indicated a significant effect on DNA repair/cycle/maintenance functions and of lipid, amino acid metabolism and circadian functions. Enrichment for known biological functions was found to be associated with differentially methylated regions. Moreover, these epigenetically altered regions overlapped genetic loci associated with metabolic and cardiovascular diseases. Both expression changes and DNA methylation changes were largely reversed by supplementing the protein restricted diet with folic acid. Although the epigenetic and gene expression signatures appeared to underpin largely different biological processes, the gene expression profile of DNA methyl transferases was altered, providing a potential link between the two molecular signatures. The data showed that maternal protein restriction is associated with widespread differential gene expression and DNA methylation across the genome, and that folic acid is able to reset both molecular signatures.
Condensating into vivid portraits: l’intertestualità nascosta nella poesia di Medbh McGuckian
Gioia Gamerra
Studi Irlandesi : a Journal of Irish Studies , 2011,
Abstract: The following essay aims at investigating the semantic and intertextual denseness of McGuckian’s poems, going beyond her supposed incommunicability. She has often highlighted the “balancing” and “clarifying” power of her own poems, and the unbiased reader will realise that they do contain an immediate and outspoken quality. This is often mysteriously conveyed by certain images which emerge from the intermingling of textual and intertextual places. Usually, in many of her works, McGuckian quotes or refers to wide parts of some texts, whose source is not indicated. Sometimes her poems rise from the way these fragments are interwoven, even without any ‘new’ word, in order to define and confirm a contemporary and intimally feminine poetical identity. This essay will discover and enlighten some of these intertextual processes and devises, which, necessarily, add meaning to her already semantically and iconographically dense poetic visions.
On sequences of integers for Hankel planes Σ of P^m
Gioia Failla
Le Matematiche , 2009,
Abstract: For a vector space R k^{m+1} of dimension r + 1 on the algebraically closed field k we determine, for any i ≤ r, the possible numbers of Hankel i planes contained in the r plane P(R), linear space in P^m .
Evolution of X-ray Luminous Clusters from z=0.3 to z=0.8
Isabella Gioia
Physics , 2001,
Abstract: Observations of the highest redshift clusters provide the longest lever arm in the attempt to evaluate the evolution of their bulk properties. I present the most recent results on galaxy cluster evolution based on data from the ROSAT North Ecliptic Pole survey. At $z>0.3$ there is a deficit of clusters with respect to the local universe which is significant at $>$ 4.7$\sigma$. The evolution appears to begin at L$_{0.5-2.0} > 1.8\times10^{44}$ erg s$^{-1}$ in the NEP survey data and goes in the same direction as the original EMSS result. At lower redshifts there is no evidence for evolution, a result in agreement with all the existing cluster surveys.
A Cluster Deficit in the ROSAT NEP Survey
Isabella Gioia
Physics , 1999,
Abstract: We have used data from the deepest region of the ROSAT All-Sky Survey, the North Ecliptic Pole (NEP) region, to produce a complete and unbiased X-ray selected sample of distant clusters to understand the nature of cluster evolution and determine implications for large scale structure models. In this contribution results are presented from a comparison between the number of the observed clusters in the NEP survey and the number of expected clusters assuming no-evolution models. There is a deficit by a factor of 2.5-4 of high luminosity, high redshift clusters with respect to the present. The evolution goes in the same direction as the original EMSS result, and the results from the CfA-IfA 160 deg^{2} survey by Vikhlini et al. 1998.
Random Hysteresis Loops
Gioia Carinci
Mathematics , 2011,
Abstract: Dynamical hysteresis is a phenomenon which arises in ferromagnetic systems below the critical temperature as a response to adiabatic variations of the external magnetic field. We study the problem in the context of the mean-field Ising model with Glauber dynamics, proving that for frequencies of the magnetic field oscillations of order $N^{2/3}$, with $N$ the size of the system, the "critical" hysteresis loop becomes random.
The Galois closure for rings and some related constructions
Alberto Gioia
Mathematics , 2015,
Abstract: Let $R$ be a ring and let $A$ be a finite projective $R$-algebra of rank $n$. Manjul Bhargava and Matthew Satriano have recently constructed an $R$-algebra $G(A/R)$, the Galois closure of $A/R$. Many natural questions were asked at the end of their paper. Here we address one of these questions, proving the existence of the natural constructions they call intermediate $S_n$-closures. We will also study properties of these constructions, generalizing some of their results, and proving new results both on the intermediate $S_n$-closures and on $G(A/R)$.
Indication to Open Anatrophic Nephrolithotomy in the Twenty-First Century: A Case Report
Alfredo Maria Bove,Emanuela Altobelli,Maurizio Buscarini
Case Reports in Urology , 2012, DOI: 10.1155/2012/851020
Abstract: Introduction. Advances in endourology have greatly reduced indications to open surgery in the treatment of staghorn kidney stones. Nevertheless in our experience, open surgery still represents the treatment of choice in rare cases. Case Report. A 71-year-old morbidly obese female patient complaining about occasional left flank pain, and recurrent cystitis for many years, presented bilateral staghorn kidney stones. Comorbidities were obesity (BMI 36.2), hypertension, type II diabetes, and chronic obstructive pulmunary disease (COPD) hyperlipidemia. Due to these comorbidities, endoscopic and laparoscopic approaches were not indicated. We offered the patient staged open anatrophic nephrolithotomy. Results. Operative time was 180 minutes. Blood loss was 500 cc. requiring one unit of packed red blood cells. Hospital stay was 7 days. The renal function was unaffected based on preoperative and postoperative serum creatinine levels. Stone-free status of the left kidney was confirmed after surgery with CT scan. Conclusions. Open surgery can represent a valid alterative in the treatment of staghorn kidney stones of very selected cases. A discussion of the current indications in the twenty-first century is presented.
Indication to Open Anatrophic Nephrolithotomy in the Twenty-First Century: A Case Report
Alfredo Maria Bove,Emanuela Altobelli,Maurizio Buscarini
Case Reports in Urology , 2012, DOI: 10.1155/2012/851020
Abstract: Introduction. Advances in endourology have greatly reduced indications to open surgery in the treatment of staghorn kidney stones. Nevertheless in our experience, open surgery still represents the treatment of choice in rare cases. Case Report. A 71-year-old morbidly obese female patient complaining about occasional left flank pain, and recurrent cystitis for many years, presented bilateral staghorn kidney stones. Comorbidities were obesity (BMI 36.2), hypertension, type II diabetes, and chronic obstructive pulmunary disease (COPD) hyperlipidemia. Due to these comorbidities, endoscopic and laparoscopic approaches were not indicated. We offered the patient staged open anatrophic nephrolithotomy. Results. Operative time was 180 minutes. Blood loss was 500?cc. requiring one unit of packed red blood cells. Hospital stay was 7 days. The renal function was unaffected based on preoperative and postoperative serum creatinine levels. Stone-free status of the left kidney was confirmed after surgery with CT scan. Conclusions. Open surgery can represent a valid alterative in the treatment of staghorn kidney stones of very selected cases. A discussion of the current indications in the twenty-first century is presented. 1. Introduction Surgical management of nephrolithiasis has changed dramatically in the last few decades. While previously, the majority of patients required an open surgical approach, today less invasive procedures, such as extracorporeal shock waves lithotripsy (ESWL), ureterorenoscopy (URS), and percutaneous nephrolithotripsy (PNL), have promoted a rapid decrease of the use of open surgery for both ureteral and renal stones [1, 2]. The subsequent introduction of laparoscopic approach has almost eliminated the need for open operations in the treatment of renal and ureteral stones. Laparoscopy is needed in complex staghorn stones that would necessitate multiple, simultaneous or subsequent, percutaneous renal accesses [3–10]. Even if anatrophic nephrolithotomy is currently performed laparoscopically, in patients affected by severe cardiac or pulmonary diseases or with a previous laparotomy, laparoscopic approach may not be indicated. In the era of mininvasive treatments, laparotomy is rarely required, but it is important to recognize patients in whom open anatrophic nephrolithotomy could represent a valid choice of treatment [11]. This paper presents one of such patients as well as a discussion of the modern indications for this technique. 2. Case Report A 71-year-old female patient with a BMI of 36,2 was referred from General Medicine Department with
Anaplastic Thyroid Carcinoma
Augusto Taccaliti,Gioia Palmonella
Frontiers in Endocrinology , 2012, DOI: 10.3389/fendo.2012.00084
Abstract: Thyroid cancers represent about 1% of all human cancers. Differentiate thyroid carcinomas (DTCs), papillary and follicular cancers, are the most frequent forms, instead Anaplastic Thyroid Carcinoma (ATC) is estimated to comprise 1–2% of thyroid malignancies and it accounts for 14–39% of thyroid cancer deaths. The annual incidence of ATC is about one to two cases/million, with the overall incidence being higher in Europe (and area of endemic goiter) than in USA. ATC has a more complex genotype than DTCs, with chromosomal aberrations present in 85–100% of cases. A small number of gene mutations have been identified, and there appears to be a progression in mutations acquired during dedifferentiation. The mean survival time is around 6 months from diagnosis an outcome that is frequently not altered by treatment. ATC presents with a rapidly growing fixed and hard neck mass, often metastatic local lymph nodes appreciable on examination and/or vocal paralysis. Symptoms may reflect rapid growth of tumor with local invasion and/or compression. The majority of patients with ATC die from aggressive local regional disease, primarily from upper airway respiratory failure. For this reason, aggressive local therapy is indicated in all patients who can tolerate it. Although rarely possible, complete surgical resection gives the best chance of long-term control and improved survival. Therapy options include surgery, external beam radiation therapy, tracheostomy, chemotherapy, and investigational clinical trials. Multimodal or combination therapy should be useful. In fact, surgical debulking of local tumor, combined with external beam radiation therapy and chemotherapy as neoadjuvant (before surgery) or adjuvant (after surgery) therapy, may prevent death from local airway obstruction and as best may slight prolong survival. Investigational clinical trials in phase I or in phase II are actually in running and they include anti-angiogenetic drugs, multi-kinase inhibitor drugs.
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