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Search Results: 1 - 10 of 1186 matches for " Giacomo Faldella "
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Neonatal arterial iliac thrombosis in type-I protein C deficiency: a case report
Elisabetta Tridapalli, Marcello Stella, Maria G Capretti, Giacomo Faldella
Italian Journal of Pediatrics , 2010, DOI: 10.1186/1824-7288-36-23
Abstract: Normal values of leukocities, red cells, haematocrit, hemoglobin, platelets. C-Reactive Protein negative. Electrolytes and coagulation tests were normal. Normal vitamin K coagulation proteins levels. Serological tests for TORCH (IgM) and Parvovirus (IgG and IgM) were negative.Sonography showed a reduced blood flow in the iliac artery and reported a 1 cm long vessel thrombosis.From 8 hours of life we administred an intravenous infusion of unfractionated heparin (UFH) 75 UI/Kg for the first 10 minutes then 28 UI/Kg/h.On the 2nd day tests were performed to assess absence of inhibiting-clot factors. The dosage of homocysteine, protein S and antithrombin was normal. FV Leiden and antiphospholipid antibodies were negative. The mapping of G20210A prothrombin's gene resulted normal, whereas the concentration of Protein C was lower than normal: activity 46% (68-150%), antigen 35% (70-150%).The same deficiency was also found in the father. The mother showed normal concentrations. No episodies of thrombosis events were documentated in the family.The intravenous unfractionated heparin (UFH) therapy was replaced after 64 hours by subcutaneous nadroparin 600 UI twice/day, which was stopped 5 days later when the vessel sonografic images were completely normal. During the hospitalization the infant didn't show bleeding.The child was followed-up yearly until 4 years of age: he was well and had a normal body and mental development.The final diagnosis is likely to be of a permanent protein C deficiency in heterozygous form. Our case is interesting because the first manifestation was an important thrombosis of large vessel that occurred within a few hours of life in absence of perinatal risk factors, as if it was a homozygous disease, but the patient had a heterozygotic form. In literature few cases are reported of heterozygous forms that became symptomatic, but only in old age.After a severe first manifestation, a normal and asymptomatic development is uncommon without new thrombotic
Pharmacological Therapy of Gastroesophageal Reflux in Preterm Infants
Luigi Corvaglia,Caterina Monari,Silvia Martini,Arianna Aceti,Giacomo Faldella
Gastroenterology Research and Practice , 2013, DOI: 10.1155/2013/714564
Abstract: Although gastroesophageal reflux (GER) is a very common phenomenon among preterm infants, its therapeutic management is still an issue of debate among neonatologists. A step-wise approach should be advisable, firstly promoting nonpharmacological interventions and limiting drugs to selected infants unresponsive to the conservative measures or who are suffering from severe GER with clinical complications. Despite of this, a concerning pharmacological overtreatment has been increasingly reported. Most of the antireflux drugs, however, have not been specifically assessed in preterm infants; moreover, serious adverse effects have been noticed in association to their administration. This review mainly aims to draw the state of the art regarding the pharmacological management of GER in preterm infants, analyzing the best piecies of evidence currently available on the most prescribed anti-reflux drugs. Although further trials are required, sodium alginate-based formulations might be considered promising; however, data regarding their safety are still limited. Few piecies of evidence on the efficacy of histamine-2 receptor blockers and proton pump inhibitors in preterm infants with GER are currently available. Nevertheless, a significantly increased risk of necrotizing enterocolitis and infections has been largely reported in association with their use, thereby leading to an unfavorable risk-benefit ratio. The efficacy of metoclopramide in GER’s improvement still needs to be clarified. Other prokinetic agents, such as domperidone and erythromycin, have been reported to be ineffective, whereas cisapride has been withdrawn due to its remarkable cardiac adverse effects. 1. Introduction Gastroesophageal reflux (GER) is very frequent in preterm infants. The incidence in those babies born before 34 weeks of gestation approximately amounts to 22% [1]. In the preterm population GER should not be usually considered a pathological phenomenon, as it might be promoted by a number of physiological factors. Among these, are included the supine posture, which enhances the migration of liquid gastric content through the looser gastroesophageal junction, the immature esophageal motility, which leads to a poor clearance of refluxate, and, eventually, the relatively abundant milk intakes [2]. The linkage between GER, apneas [3] and chronic lung disease is still controversial [4, 5]. In few cases, however, GER may be associated to clinical complications as, for instance, feeding problems, failure to thrive, esophagitis, and lung aspiration [6], thereby lengthening the hospital stay
Congenital Syphilis Like Many Years Ago
Giulia Brighi,Giorgia Farneti,Antonella Marangoni,Elisabetta Tridapalli,Iria Neri,Maria Grazia Capretti,Giacomo Faldella
Case Reports in Infectious Diseases , 2011, DOI: 10.1155/2011/235059
Abstract: This case concerns a premature infant with typical signs of congenital syphilis born to an untreated foreign mother. Syphilis prevalence in pregnant women has been rising in Italy since the beginning of the 21st century, mainly due to immigration. A correct antenatal syphilis screening and consequent adequate therapy of pregnant woman are fundamental to prevent the neonatal infection.
Predictors of Full Enteral Feeding Achievement in Very Low Birth Weight Infants
Luigi Corvaglia, Maria Pia Fantini, Arianna Aceti, Dino Gibertoni, Paola Rucci, Dante Baronciani, Giacomo Faldella, on behalf of the “Emilia Romagna Perinatal Network”
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0092235
Abstract: Background To elucidate the role of prenatal, neonatal and early postnatal variables in influencing the achievement of full enteral feeding (FEF) in very low birth weight (VLBW) infants and to determine whether neonatal intensive care units (NICUs) differ in this outcome. Methods Population-based retrospective cohort study using data on 1,864 VLBW infants drawn from the “Emilia-Romagna Perinatal Network” Registry from 2004 to 2009. The outcome of interest was time to FEF achievement. Eleven prenatal, neonatal and early postnatal variables and the study NICUs were selected as potential predictors of time to FEF. Parametric survival analysis was used to model time to FEF as a function of the predictors. Marginal effects were used to obtain adjusted estimates of median time to FEF for specific subgroups of infants. Results Lower gestational age, exclusive formula feeding, higher CRIB II score, maternal hypertension, cesarean delivery, SGA and PDA predicted delayed FEF. NICUs proved to be heterogeneous in terms of FEF achievement. Newborns with PDA had a 4.2 days longer predicted median time to FEF compared to those without PDA; newborns exclusively formula-fed had a 1.4 days longer time to FEF compared to those fed human milk. Conclusions The results of our study suggest that time to FEF is influenced by clinical variables and NICU-specific practices. Knowledge of the variables associated with delayed/earlier FEF achievement could help in improving specific aspects of routine clinical management of VLBW infants and to reduce practice variability.
SOV approach for integrable quantum models associated to general representations on spin-1/2 chains of the 8-vertex reflection algebra
S. Faldella,G. Niccoli
Physics , 2013, DOI: 10.1088/1751-8113/47/11/115202
Abstract: The analysis of the transfer matrices associated to the most general representations of the 8-vertex reflection algebra on spin-1/2 chains is here implemented by introducing a quantum separation of variables (SOV) method which generalizes to these integrable quantum models the method first introduced by Sklyanin. More in detail, for the representations reproducing in their homogeneous limits the open XYZ spin-1/2 quantum chains with the most general integrable boundary conditions, we explicitly construct representations of the 8-vertex reflection algebras for which the transfer matrix spectral problem is separated. Then, in these SOV representations we get the complete characterization of the transfer matrix spectrum (eigenvalues and eigenstates) and its non-degeneracy. Moreover, we present the first fundamental step toward the characterization of the dynamics of these models by deriving determinant formulae for the matrix elements of the identity on separated states, which apply in particular to transfer matrix eigenstates. The comparison of our analysis for the 8-vertex reflection algebra with that of [1, 2] for the 6-vertex one leads to the interesting remark that a profound similarity in both the characterization of the spectral problems and of the scalar products exists for these two different realizations of the reflection algebra once they are described by SOV method. As it will be shown in a future publication, this remarkable similarity will be at the basis of the simultaneous determination of form factors of local operators of integrable quantum models associated to general reflection algebra representations of both 8-vertex and 6-vertex type.
Complete spectrum and scalar products for the open spin-1/2 XXZ quantum chains with non-diagonal boundary terms
S. Faldella,N. Kitanine,G. Niccoli
Physics , 2013, DOI: 10.1088/1742-5468/2014/01/P01011
Abstract: We use the quantum separation of variable (SOV) method to construct the eigenstates of the open XXZ chain with the most general boundary terms. The eigenstates in the inhomogeneous case are constructed in terms of solutions of a system of quadratic equations. This SOV representation permits us to compute scalar products and can be used to calculate form factors and correlation functions.
Proposal of an Innovative Business Model for Customized Production in Healthcare  [PDF]
Golboo Pourabdollahian, Giacomo Copani
Modern Economy (ME) , 2014, DOI: 10.4236/me.2014.513107
Abstract: The growth of aging population in developed countries necessitates a better performance of the healthcare system in order to improve the healthy life expectancy of elderly people. Such a progress can be achieved both through improved services and medical products. Accordingly, providing patients with customized medical devices that are designed and produced based on individual requirements of each patient can be seen as a proper solution. In this regard, the emerging manufacturing technologies such an additive manufacturing not only facilitate customized production in healthcare sector, but also can change the role of the hospital from a solely user to a producer. However, successful pursuit of such strategy requires implementation of a new business model as a supporting tool. This paper aims at proposing an innovative business model to support hospitals for customized production in healthcare.
The Bethe Ansatz and the Tzitzéica-Bullough-Dodd equation
Patrick Dorey,Simone Faldella,Stefano Negro,Roberto Tateo
Physics , 2012, DOI: 10.1098/rsta.2012.0052
Abstract: The theory of classically integrable nonlinear wave equations, and the Bethe Ansatz systems describing massive quantum field theories defined on an infinite cylinder, are related by an important mathematical correspondence that still lacks a satisfactory physical interpretation. In this paper we shall describe this link for the case of the classical and quantum versions of the (Tzitz\'eica-)Bullough-Dodd model.
Supercritical Water Technology Applied to the Purification of Waters Contaminated by Toxic Micro-Polluting Organic Compounds  [PDF]
Gabriele Di Giacomo, Luca Taglieri
Journal of Water Resource and Protection (JWARP) , 2012, DOI: 10.4236/jwarp.2012.47053
Abstract: Purification of water contaminated by toxic organic compounds at low and very low concentration is a quite interesting challenge from both the technical and the economical point of view. In fact, the direct destruction of organic compounds dissolved in very diluted aqueous solution is very costly and hardly achievable. To overcome this problems it was studied and developed a new water purification process which is made of three steps: a) removal of the diluted and toxic polluting compounds by adsorption on activated carbon beds operating at ambient P ant T; b) regeneration of the exhausted carbon bed with supercritical water in order to obtain a mixture of water and polluting compounds signifi-cantly more concentrated than the contaminated liquid water; c) destruction of the toxic compounds in a continuous Supercritical Water Oxidation Reactor. Step a) was studied at laboratory scale in order to obtain all the required information for modeling the adsorption operation; step b) was modeled by using literature experimental data and, step c) was validated at pilot plant scale. In all the above mentioned steps, phenol was used as representative of polluting compounds.
Neuromorphic VLSI Models of Selective Attention: From Single Chip Vision Sensors to Multi-chip Systems
Giacomo Indiveri
Sensors , 2008, DOI: 10.3390/s8095352
Abstract: Biological organisms perform complex selective attention operations continuously and effortlessly. These operations allow them to quickly determine the motor actions to take in response to combinations of external stimuli and internal states, and to pay attention to subsets of sensory inputs suppressing non salient ones. Selective attention strategies are extremely effective in both natural and artificial systems which have to cope with large amounts of input data and have limited computational resources. One of the main computational primitives used to perform these selection operations is the Winner-Take-All (WTA) network. These types of networks are formed by arrays of coupled computational nodes that selectively amplify the strongest input signals, and suppress the weaker ones. Neuromorphic circuits are an optimal medium for constructing WTA networks and for implementing efficient hardware models of selective attention systems. In this paper we present an overview of selective attention systems based on neuromorphic WTA circuits ranging from single-chip vision sensors for selecting and tracking the position of salient features, to multi-chip systems implement saliency-map based models of selective attention.
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