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Search Results: 1 - 10 of 3336 matches for " Ghosh Kanjaksha "
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Indian Journal of Human Genetics in PubMed: Cautious but confident steps
Ghosh Kanjaksha
Indian Journal of Human Genetics , 2010,
Abstract:
Coagulation disorders seen through the window of molecular biology
Ghosh Kanjaksha
Indian Journal of Human Genetics , 2007,
Abstract: Coagulation disorders have been traditionally worked up by their clinical phenotypes and coagulation factor assays which are dependent on APTT- and PT-based techniques. Development of chromogenic substrates in the late seventies and early eighties allowed coagulation factors to be measured like enzymes. There was still a major lacuna in the understanding of the biology of different coagulation disorders. Modern molecular biology - which developed as an unique synthesis of biochemistry, immunology, cell biology, and genetics - allowed us to have a more comprehensive understanding of the pathobiology of many of these coagulation disorders. This overview presents several examples which show how we have enriched our understanding about the varied clinical phenotypes of different coagulation disorders.
Non haematological effects of iron deficiency - A perspective
Ghosh Kanjaksha
Indian Journal of Medical Sciences , 2006,
Abstract: Iron deficiency is a continuum beginning from lowering of tissue stores to the phase of exhausted tissue stores, interference with iron driven biochemical reactions in the body, microcytosis, hypochromia, increasing severity of anaemia with all its attendant consequences. Iron deficiency anaemia is a very well known concept but what is often not appreciated is the effect of broad canvas of iron deficiency on various tissues, organs and systems in our body in addition to iron deficiency anaemia leading to concept of "Iron deficiency disease". In this condition not only tissue delivery of oxygen is compromised but proliferation, growth, differentiation, myelinogenesis, immunofunction, energy metabolism, absorption and biotransformation are compromised leading to abnormal growth and behaviour, mental retardation, reduced cardiac performance and work efficiency, infection etc which ultimately leads to the concept that "iron deficiency not only breaks the machine but also wrecks the machinery."
Algorithm for recall of HIV reactive blood donors
Ghosh Kanjaksha
Journal of Postgraduate Medicine , 2006,
Abstract:
Anti-idiotype antibodies in immune regulation of ANCA associated vasculitis
Pradhan Vandana,Ghosh Kanjaksha
Indian Journal of Dermatology , 2009,
Abstract: Background: Anti-idiotype antibodies (anti-ids) have a potential role in the immunomodulation of various autoimmune disorders. The immunoregulatory role of anti-idiotypic antibodies in ANCA-associated vasculitis needs to be studied. This study was conducted in clinically and histopathologically diagnosed ANCA-associated vasculitis (AAV) patients. Methods: Anti-ids were tested in 100 AAV patients of which 80 had anti-MPO and 20 had anti-PR3 antibodies at various stages of disease over a period of 2-3 years. The disease activity was estimated by the Birmingham vasculitis activity score (BVAS). The affinity-purified ANCA F(ab′)2 fragments were prepared using three each of anti-MPO and anti-PR3 high titer sera and were used as idiotype coats for anti-idiotype antibody detection by ELISA. Positivity was confirmed by fluid phase inhibition ELISA. Results: Patients who went into remission showed 53.8% anti-ids to anti-MPO and 52.9% to anti-PR3 with low BVAS values (0-8), whereas in patients with active disease, only 12.5% had anti-ids to anti-MPO and 10% had anti-ids to anti-PR3 with comparatively high BVAS (18-32), while five cases who had relapse (BVAS 18-20) did not have anti-ids to anti-MPO or anti-PR3. An inverse correlation was noted between ANCA and anti-ids ( r = -0.901). Conclusions: High prevalence of anti-ids in remission cases and low prevalence in active cases with absence of anti-ids in relapse cases as well as an inverse correlation of ANCA and anti-ids indicate its beneficial effect on the disease process, thus suggesting the dynamic role of anti-idiotype networks in the immunoregulation of AAV.
Integration of modern genetic knowledge and technology into public health in India
Ghosh Kanjaksha,Gorakshakar Ajit
Indian Journal of Human Genetics , 2010,
Abstract:
Bombay phenotype in Orissa: What could we make out of it?
Ghosh Kanjaksha,Vasantha K
Indian Journal of Human Genetics , 2007,
Abstract:
Chromosomal instability and cancer: An insight into the rhythm of life
Vundinti Babu,Ghosh Kanjaksha
Indian Journal of Human Genetics , 2009,
Abstract:
Ernest Beutler
Ghosh Kanjaksha,Gorakshakar Ajit
Indian Journal of Human Genetics , 2009,
Abstract:
Genetics of autism and mental retardation: A spoonful from the sea!
Ghosh Kanjaksha,Gorakshakar Ajit
Indian Journal of Human Genetics , 2009,
Abstract:
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