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Search Results: 1 - 10 of 464454 matches for " Ghosh A "
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Myelodysplastic syndrome: classification and changing concept
A Ghosh
Journal of Pathology of Nepal , 2011, DOI: 10.3126/jpn.v1i2.5410
Abstract: Myelodysplastic syndrome is a group of clonal disorders having wide range of outcome. Its classification and concept have been changed over time with better understanding of its prognosis and clinical significance. The first standard classification was FAB classification which came in 1982. It was based on findings on peripheral blood and bone marrow. Later in 2001, WHO incorporated clinical data into it and proposed a modified classification. The 2001 WHO classification made several criteria and entities more precise based on inputs from several studies. New terminologies (e.g., refractory cytopenia with multilineage dysplasia) and new group (e.g., myelodysplastic / myeloproliferative disorder) have been introduced and group like ‘refractory anemia with excess blasts in transformation’ was removed. Again in 2008, in collaboration with European Association for Haematopathology and the Society for Hematopathology, as well as considering several recommendations from a group of clinical experts, WHO published a revised and updated classification. In the latest MDS classification, the clinical implications of different groups have been given more importance and also the role of cytogenetics has been re-evaluated. Several groups were again redefined (e.g., myelodysplastic syndrome – unclassified, refractory anemia with excess blasts) or eliminated (e.g., refractory cytopenia with multilineage dysplasia and ringed sideroblasts) or newly introduced (e.g., refractory cytopenia with unilineage dysplasia). Childhood MDS was considered separately as demanded by several pediatric hematologists. It was also emphasized that the diagnosis and classification of MDS mainly require identification of dysplastic morphological features, routine stains and correlation with clinical data rather than cytogenetics which may be necessary only in rare cases. Keywords: Myelodysplastic syndrome; Refractory anemia; Ring sideroblasts; MDS classification DOI: http://dx.doi.org/10.3126/jpn.v1i2.5410 JPN 2011; 1(2): 142-150
Effectiveness of One-dimensional gas models for black holes
A. Ghosh
Physics , 1998, DOI: 10.1016/S0370-2693(98)00268-8
Abstract: A one-dimensional gas model has been constructed and shown to provide correct expressions for entropies for extremal and near-extremal BTZ black holes. Recently suggested boosting of black strings is used to compute the entropy for the Schwarzschild black hole also from this gas model.
Cholesterol crystals in Eales′ disease
Mishra R,Ghosh M,Ghosh A
Indian Journal of Ophthalmology , 1980,
Abstract:
Silymarin- A review on the Pharmacodynamics and Bioavailability Enhancement Approaches
GHOSH A,GHOSH T,JAIN S
Journal of Pharmaceutical Science and Technology , 2010,
Abstract: Silymarin, a flavonolignan from ‘milk thistle’ (Silybum marianum) plant is used from ancient times as a hepatoprotective drug. Along with hepatoprotective action other actions includes antioxidant, anti-lipid peroxidative, antifibrotic, anti-inflammatory, immunomodulatory and liver regenerating. Silymarin has clinical applications in alcoholic liver diseases, liver cirrhosis, Amanita mushroom poisoning, viral hepatitis, toxic and drug induced liver diseases, Psoriasis, and in Neuroprotective and neurotropic activity. Though silymarin doesnot have antiviral properties against hepatitis virus, it promotes protein synthesis, helps in regenerating liver tissue, controls inflammation, enhances glucoronidation and protects against glutathione depletion. The flavonoid silymarin and one of its structural components, silibinin, are substances with documentedhepatoprotective properties. They are proved to be a useful for hepatoprotection in hepatobiliary diseases and in hepatotoxicity due to drugs. The non traditional use of silymarin may make a breakthrough as a new approach to protect other organs in addition to liver. But the main drawback of silymarin is its poor solubility thereforedifferent approaches are been taken to enhance the solubility in turn the bioavailability of the drug. In this review we discuss about its Chemistry, Pharmacodynamics, safety, therapeutic efficacy and Bioavailability enhancement approaches used so far. As it is having a good safety profile, better patient tolerability and an effective drug at an affordable price, in near future new derivatives or new combinations of this drug may prove to be useful.
An audit of orthopedic operation notes: what are we missing?
A K Ghosh
Clinical Audit , 2010, DOI: http://dx.doi.org/10.2147/CA.S9665
Abstract: n audit of orthopedic operation notes: what are we missing? Original Research (5995) Total Article Views Authors: A K Ghosh Published Date May 2010 Volume 2010:2 Pages 37 - 40 DOI: http://dx.doi.org/10.2147/CA.S9665 A K Ghosh William Harvey Hospital, Ashford, UK Abstract: The importance of complete and legible operation notes is indisputable. Orthopedic operation notes at the author’s institution were audited against guidelines regarding content and legibility. Although of generally good standard it was found that in some cases important information was being missed and that a high proportion of notes had sections that were deemed illegible. A computerized proforma for writing notes has been proposed.
Colour perimetry
Prasad V,Ghosh A
Indian Journal of Ophthalmology , 1983,
Abstract:
National and ethnic human mutation database: A need of the day
Gorakshakar A,Ghosh K
Indian Journal of Human Genetics , 2008,
Abstract:
Digital blood circulation in paucibacillary leprosy
Ghosh Sanjay,Biswas A
Indian Journal of Dermatology, Venereology and Leprology , 1992,
Abstract: Digital vascular flow in paucibacillary leprosy was assessed photoplethysmography (PPG). In PPG, infra-red light emitting diode and an adjacent photosensor detect the blood flow in cutaneous capillaries, as represented graphically on a strip-chart. In 29 (6F, 23 M) untreated paucibacillary leprosy patients (7TT, 16 BT and 6 purely neural type) having ailment on limb/limbs, suffering for 5 months to 12 years, PPG recording were done by applying the device to the distal phalanges of all the digits of four limbs serially with Velcro-strap at an ambient temperature of 28 °C - 30 °C and humidity of 60-70 percent. Diminished digital vascular flow of the affected limb/limbs was seen in long-standing cases suffering for > 2 years irrespective of the type, site, morphology or phase (reactional) of the disease. This may be mostly due to specific vascular changes rather than reactional or functional changes. Specific vascular changes are terminal arteritis, vasculitis of vasa nervorum or truncular arteritis, i.e.. tuberculoid lesions of the major arteries. Two patients, suffering for 1.5 years, paradoxically showed increased digital blood flow which is probably due to reactive hyperaemia or paralytic vasodilatation as a result of autosympathectomy.
Digital blood flow in systemic sclerosis
Ghosh Sanjay,Biswas A
Indian Journal of Dermatology, Venereology and Leprology , 1992,
Abstract: Digital vascular status in 10 untreated patients suffering from systemic sclerosis for 1 to 4 years was evaluated by a method called photoplethysmography (PPG). The PPG probe was attached serially to the distal phalanges of all the digits of four limbs with Velcro-strap at an ambient temperature of 28° C - 32° C and humidity of 60-65 percent to record PPG tracings. Six patients (Group A) had clinical symptoms and signs of vascular impairment whereas 4 patients (Group B) did not have. Diminished vascular flow was seen in all the patients of both the groups. On an average, 9 digits (45%) in Group A and 7 digits (35%) in Group B had reduced blood circulation. The difference between the two groups was not statistically significant (p>0.5). Degree of vascular impairment had no bearing upon the duration of the disease (rxy=+0.41). Impairment of digital blood flow may be due to organic narrowing of digital artery, functional vasomotor changes, endothelial proliferation and damage, blood hyperviscocity and less deformable red blood cells.
A Review of Ventilation and Cooling Technologies in Agricultural Greenhouse Application
A. Ganguly,S. Ghosh
Iranica Journal of Energy and Environment (IJEE) , 2010,
Abstract: This article presents a comprehensive review of the literature that deal with ventilation and cooling technologies applied to agricultural greenhouses. The representative application of each technology as well as its advantages and limitations are discussed. Advance systems employing heat storage in phase change materials, earth-to-air heat exchangers and aquifer-coupled cavity flow heat exchangers have also been discussed. For an agricultural greenhouse equipped with cooling and artificial ventilation system, availability of uninterrupted electric supply is important. To achieve grid independence, dedicated power generation and storage systems need to be integrated with the greenhouse. The relevant literature on such power generation system for greenhouse application has been reviewed and is discussed here. This review concludes by identifying some important areas where further research needs to be undertaken.
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