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Search Results: 1 - 10 of 852 matches for " Ghio AJ "
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Deficiency of α-1-antitrypsin influences systemic iron homeostasis
Ghio AJ,Soukup JM,Richards JH,Fischer BM
International Journal of COPD , 2013,
Abstract: Andrew J Ghio,1 Joleen M Soukup,1 Judy H Richards,1 Bernard M Fischer,2 Judith A Voynow,2 Donald E Schmechel31US Environmental Protection Agency, Chapel Hill, NC, USA; 2Division of Pediatric Pulmonary Medicine, Department of Pediatrics,3Joseph and Kathleen Bryan Alzheimer Disease Research Center, Department of Medicine (Neurology), Duke University Medical Center, Durham, NC, USAAbstract: There is evidence that proteases and antiproteases participate in the iron homeostasis of cells and living systems. We tested the postulate that α-1 antitrypsin (A1AT) polymorphism and the consequent deficiency of this antiprotease in humans are associated with a systemic disruption in iron homeostasis. Archived plasma samples from Alpha-1 Foundation (30 MM, 30 MZ, and 30 ZZ individuals) were analyzed for A1AT, ferritin, transferrin, and C-reactive protein (CRP). Plasma samples were also assayed for metals using inductively coupled plasma atomic emission spectroscopy (ICPAES). Plasma levels of A1AT in MZ and ZZ individuals were approximately 60% and 20% of those for MM individuals respectively. Plasma ferritin concentrations in those with the ZZ genotype were greater relative to those individuals with either MM or MZ genotype. Plasma transferrin for MM, MZ, and ZZ genotypes showed no significant differences. Linear regression analysis revealed a significant (negative) relationship between plasma concentrations of A1AT and ferritin while that between A1AT and transferrin levels was not significant. Plasma CRP concentrations were not significantly different between MM, MZ, and ZZ individuals. ICPAES measurement of metals confirmed elevated plasma concentrations of nonheme iron among ZZ individuals. Nonheme iron concentrations correlated (negatively) with levels of A1AT. A1AT deficiency is associated with evidence of a disruption in iron homeostasis with plasma ferritin and nonheme iron concentrations being elevated among those with the ZZ genotype.Keywords: α-1-antitrypsin deficiency, serpins, proteinase inhibitor proteins, ferritin, transferrin
Deficiency of α-1-antitrypsin influences systemic iron homeostasis
Ghio AJ, Soukup JM, Richards JH, Fischer BM, Voynow JA, Schmechel DE
International Journal of Chronic Obstructive Pulmonary Disease , 2013, DOI: http://dx.doi.org/10.2147/COPD.S37897
Abstract: iency of α-1-antitrypsin influences systemic iron homeostasis Original Research (727) Total Article Views Authors: Ghio AJ, Soukup JM, Richards JH, Fischer BM, Voynow JA, Schmechel DE Published Date January 2013 Volume 2013:8 Pages 45 - 51 DOI: http://dx.doi.org/10.2147/COPD.S37897 Received: 08 September 2012 Accepted: 28 October 2012 Published: 22 January 2013 Andrew J Ghio,1 Joleen M Soukup,1 Judy H Richards,1 Bernard M Fischer,2 Judith A Voynow,2 Donald E Schmechel3 1US Environmental Protection Agency, Chapel Hill, NC, USA; 2Division of Pediatric Pulmonary Medicine, Department of Pediatrics,3Joseph and Kathleen Bryan Alzheimer Disease Research Center, Department of Medicine (Neurology), Duke University Medical Center, Durham, NC, USA Abstract: There is evidence that proteases and antiproteases participate in the iron homeostasis of cells and living systems. We tested the postulate that α-1 antitrypsin (A1AT) polymorphism and the consequent deficiency of this antiprotease in humans are associated with a systemic disruption in iron homeostasis. Archived plasma samples from Alpha-1 Foundation (30 MM, 30 MZ, and 30 ZZ individuals) were analyzed for A1AT, ferritin, transferrin, and C-reactive protein (CRP). Plasma samples were also assayed for metals using inductively coupled plasma atomic emission spectroscopy (ICPAES). Plasma levels of A1AT in MZ and ZZ individuals were approximately 60% and 20% of those for MM individuals respectively. Plasma ferritin concentrations in those with the ZZ genotype were greater relative to those individuals with either MM or MZ genotype. Plasma transferrin for MM, MZ, and ZZ genotypes showed no significant differences. Linear regression analysis revealed a significant (negative) relationship between plasma concentrations of A1AT and ferritin while that between A1AT and transferrin levels was not significant. Plasma CRP concentrations were not significantly different between MM, MZ, and ZZ individuals. ICPAES measurement of metals confirmed elevated plasma concentrations of nonheme iron among ZZ individuals. Nonheme iron concentrations correlated (negatively) with levels of A1AT. A1AT deficiency is associated with evidence of a disruption in iron homeostasis with plasma ferritin and nonheme iron concentrations being elevated among those with the ZZ genotype.
Littérature populaire et urgence littéraire : le cas du rap fran ais
Bettina Ghio
Trans : Revue de Littérature Générale et Comparée , 2010,
Abstract: Le rap, phénomène musical en même temps que pratique esthétique de la langue, s’est développé et ancré en France à partir d’un besoin littéraire de la jeunesse des quartiers défavorisés, exprimé avant et au moment de son apparition. Pourtant, son classement au sein de la littérature soulève des contradictions. En analysant l’écriture propre aux textes de rap et les différentes conceptions de ce qu’on appelle "littérature populaire", nous nous demandons, dans cet article, si ces définitions suffisent à elles seules pour classer le rap dans l’univers de la littérature, ou s’il ne serait pas plut t au croisement des cultures dites classiques et populaires. Rap, a musical phenomenon and at the same time an aesthetic practice of language, was developed and anchored in France based on a literary need of the youth from disadvantaged neighborhoods, expressed before and at the time of its emergence. Nevertheless, its classification at the heart of literature raises contradictions. While analyzing the writing of rap texts and the different conceptions of what is defined as “popular literature,” we ask ourselves in this article if these definitions alone suffice to classify rap within the universe of literature, or if it would be more appropriate to classify it at the intersection of what are referred to as high and popular cultures. El rap, fenómeno musical al mismo tiempo que práctica estética de la lengua, se desarrolla y fija en Francia a partir de una necesidad literaria que los jóvenes de los barrios desfavorecidos manifestaban antes y en el momento mismo de su aparición. Sin embargo, su inclusión en la literatura produce contradicciones. Al analizar la pertinencia de la expresión estética de la lengua en el rap y de lo que comúnmente se denomina literatura popular, nos cuestionaremos en este articulo si éstas definiciones son suficientes para ubicar el rap en el mundo de la literatura, o si éste no se encuentra más bien en el cruce entre la cultura clásica y la popular.
Promoting early presentation of breast cancer
AJ Ramirez
Breast Cancer Research , 2008, DOI: 10.1186/bcr2005
Abstract: Ideally an intervention to reduce delayed presentation of breast cancer would promote early help-seeking behaviour by patients at high risk of having cancer, but would not promote anxiety amongst people at low risk. It is important that patients should not be made unnecessarily anxious, and nor should general practitioners be overburdened with consultations with the worried well population. Based on the empirical evidence for the risk factors for patient delay and using effective behavioural change techniques, we have developed and are evaluating a psycho-educational intervention to promote early presentation of breast cancer by older women. We have focused our intervention on older women who are at greater risk of breast cancer and are also more likely to delay their presentation. The intervention is delivered by trained diagnostic radiographers at the point when the women leave the routine protection afforded by the National Health Service Breast Screening Programme and is in line with government recommended practice and complementary to the Breast Screening Programme. The ultimate aim of the intervention is to reduce the proportion of older women with breast cancer who delay their presentation, and thereby save lives.I will outline this work and other current initiatives within the United Kingdom to promote awareness and early presentation of breast cancer and how these might inform the development of policy initiatives to improve outcomes for patients within the National Health Service.
Sex ratio at birth and racial differences: Why do Black women give birth to more females than non- Black women?
AJ Kaba
African Journal of Reproductive Health , 2008,
Abstract: The two important questions that this paper will attempt to answer are: (1) why is it that regardless of race/ethnicity or geographic location, the sex ratio data at birth show more males than females?; and (2) Why is it that regardless of geographic location compared to other racial/ethnic groups, Black women or Women of sub-Saharan Black African descent tend to give birth to more females? Or to put this question the other way around, compared to Black women, why do non-Black women give birth to more males? (Afr J Reprod Health 2008; 12[3]:139-150).
Deletion of amino acid residues 33-46 in growth hormone alters the hydrophobicity of the molecule
AJ Sami
African Journal of Biotechnology , 2010,
Abstract: Growth hormone (GH) variants have been studied for the structure-function relationship of the molecule. The presence of a potential alternate splicing point in mRNA in bGH gene at exon 3, similar to hGH has been reported by workers. Early investigation on the characteristics of the chemistry of 20k oGH showed that the molecule was produced by site-directed mutagenesis by deleting amino acid residues 33-46 and the resultant DNA was expressed in E. coli under the control of lac promoter in pUC based plasmid. The mutant protein remained insoluble and did not refold. To investigate the effect of deletion on the chemistry of the molecule, computational biology tools were employed. The mutant with the deletion of amino acid residues 33-46, was designed and the model was visualized on computer. The structure of 20k bGH was compared with bGH and dissected for hydrogen bonds and hydrophobicity. Computational biology tools were helpful in elucidating the role of 33-46 amino acid residues domain in the chemistry of the molecule. Furthermore, it was revealed that removal of amino acid residues 33-46 which formed the hydrogen bonds involving Glu 33, Gln 46, Pro 38, Arg 42, Tyr 43,Ala 51, Thr 48, Asn 47, led to the formation of new hydrogen bonds between Thr 33, Tyr 144, Asn 32, Asn 32 and Ser and Asp 153. The removal of the amino acids 33-46 decreased the hydro-phobicity of the first helix of bGH molecule, as compared to 20k hGH, thus altering the solubility of the molecule, confirming the earlier reported results for ovine growth hormone with same deletion.
Book Review: Christian faith for ordinary Christians
AJ Groenewald
HTS Theological Studies/Teologiese Studies , 2011,
Abstract: Book Title: Kijk op Geloof Christelijk geloof uitgelegd Author: Henri Veldhuis ISBN: 9789023918134 Publisher: Boekencentrum, Zoetermeer, 2005, p. 287,
The Admissibility of Subregional Courts’ Decisions before the African Commission or African Court
AJ Ali
Mizan Law Review , 2012,
Abstract: Some courts of Regional Economic Communities deal with human rights and they base their decisions on the African Charter on Human and Peoples’ Rights. Other subregional courts have directly or indirectly considered human rights matters. However, it is not clear whether the cases decided by subregional courts are admissible before the African Commission on Human and Peoples’ Rights or the African Court on Human and Peoples’ Rights. Focusing on the Economic Community of West African States Court of Justice, the East African Court of Justice, and the Southern African Development Community Tribunal, I argue that the African Commission or the African Court should not admit cases decided by subregional courts. First, accepting such cases would overburden the African Commission and the African Court. Second, the decisions of subregional courts are final according to the treaties establishing them. Third, states should not be tried twice by international institutions for the same violation. Fourth, decisions of subregional courts have res judicata effect. Fifth, subregional courts are envisaged under Article 56(7) of the African Charter. Finally, the African Court or the African Commission can interpret the text of the African Charter to preclude the admissibility of cases decided by subregional courts.
Karl Barth's role in church and politics from 1930 to 1935
AJ Groenewald
HTS Theological Studies/Teologiese Studies , 2007,
Abstract: Karl Barth saw in natural theology a threat to the church of Christ. He was convinced that the so-called “German Christians” under the influence of the National Socialist Party practised natural theology. He advocated the need for the church of Christ to be church according to the Word of God. The church can be true church of Christ when it listens to and obeys the true calling of God. Barth's critique of an exclusive “Volkskirche” can serve as a corrective for the definition of the Nederduitsch Hervormde Kerk as a “volkskerk”. HTS Theological Studies Vol. 63 (4) 2007: pp. 1613-1641
High molecular weight hyaluronan for treatment of chronic shoulder pain associated with glenohumeral arthritis
Weil AJ
Medical Devices: Evidence and Research , 2011, DOI: http://dx.doi.org/10.2147/MDER.S22423
Abstract: h molecular weight hyaluronan for treatment of chronic shoulder pain associated with glenohumeral arthritis Original Research (2226) Total Article Views Authors: Weil AJ Published Date July 2011 Volume 2011:4 Pages 99 - 105 DOI: http://dx.doi.org/10.2147/MDER.S22423 Arnold J Weil Non-Surgical Orthopedics PC, Marietta, GA, USA Background: There is insufficient evidence to determine whether intra-articular injections may be effective for treatment of glenohumeral osteoarthritis. Euflexxa (high molecular weight hyaluronate), a bioengineered high molecular weight hyaluronan, has been shown to be a safe and effective treatment for patients with knee osteoarthritis. There is also support for the use of hyaluronate injection for the treatment of chronic shoulder pain associated with osteoarthritis or rotator cuff damage. This small-scale exploratory study was conducted to evaluate the safety and efficacy of high molecular weight hyaluronate for the treatment of chronic shoulder pain associated with osteoarthritis. Methods: Subjects with glenohumeral osteoarthritis and chronic pain (n = 27) received one injection per week for 3 weeks of high molecular weight hyaluronate and were assessed for changes in pain (100 mm visual analog scale [VAS]), range of motion, and the subject’s and physician’s global assessment over 26 weeks. Subjects were also assessed for pain, stiffness, and physical functioning using the Western Ontario and McMaster Universities Arthritis Index (WOMAC). Finally, responses were evaluated using modified Outcome Measures in Rheumatoid Arthritis Clinical Trials (OMERACT)-Osteoarthritis Research Society International (OARSI) Proposition D criteria. Safety was assessed by recording adverse events. Results: High molecular weight hyaluronate significantly improved pain (VAS, WOMAC), range of motion, stiffness, and physical functioning scores; 77.8% of subjects were rated as having an OMERACT-OARSI Proposition D high response. There were no serious adverse events, and none were considered to be related to treatment. Conclusion: Treatment with high molecular weight hyaluronate improves pain, stiffness, and range of motion, and may have an acceptable safety and tolerability profile. A randomized, double-blind, placebo-controlled clinical trial may be warranted to investigate further the efficacy and safety of intra-articular high molecular weight hyaluronate for treatment of chronic shoulder pain in patients with glenohumeral osteoarthritis.
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