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Search Results: 1 - 10 of 3115 matches for " Gerardo; Denman "
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Mortalidad infantil y marginación urbana: análisis espacial de su relación en una ciudad de tama?o medio del noroeste mexicano
álvarez,Gerardo; Lara,Francisco; Harlow,Siobán D.; Denman,Catalina;
Revista Panamericana de Salud Pública , 2009, DOI: 10.1590/S1020-49892009000700005
Abstract: objective: to identify areas with high risk of infant mortality and any possible correlation with the population’s socioeconomic status through the use of a geographicinformation system and spacial analysis techniques. methods: an exploratory ecologic study was conducted in hermosillo, the capital of sonora, mexico, in 2000-2003. the urban marginalization index (umi) and the infantmortality rate (imr) were determined for each of the city’s basic geostatistical areas(bga). the umi and imr were statistically calculated to identify geographic areas inwhich they were concentrated and to determine the degree of spatial correlation between these indicators. to determine the general spatial autocorrelation and spatialclustering of umis and imrs within the city and the bgas, morans i index, ipop statistics, and besag and newell’s method were employed. results: the mean imr was 14.3 per 1000 live births, higher in the bgas withgreater social marginalization (16.2 per 1000) and lower in those with less (11.7 per 1000). the umi range was -3.1-6.6 (maximum: 4.3; minimum: -2.7). autocorrelation was found among the umi (moran i = 0.62), with significant clustering in the city’s northwest, northeast, and southeast parts. local clustering of high imrs was found in hermosillo’s central and western areas, albeit without autocorrelation (moran i = -0.007). high risk areas (high imr and high umi) were found in the city’s north-western section. conclusions: spatial clusters with high imr were found in socially marginalizedareas in the northwestern part of hermosillo, a city of medium size located in north-western mexico. these results, reached through a combination of spatial analysistechniques and geographic information tools can help guide interventions specifically designed for these high risk residential areas.
Quality of cause-of-death statements and its impact on infant mortality statistics in Hermosillo, Mexico
álvarez,Gerardo; Harlow,Siobán D.; Denman,Catalina; Hofmeister,Mary J.;
Revista Panamericana de Salud Pública , 2009, DOI: 10.1590/S1020-49892009000200004
Abstract: objectives: this study evaluates the quality (completeness and accuracy) of cause-of-death (cod) statements in infant death certificates as entered into a vital records system and as sesses its impact on infant mortality statistics in hermosillo, sonora, mexico. methods: cod statements in a systematic random sample of 200 infant death certificates were compared to their corresponding medical charts. the underlying cods (ucods) orig inally recorded in each death certificate were contrasted with those assigned by an expert re viewer. coding for the original and "new" ucods was based on the three-digit category of the international classification of diseases, 10th revision. measurements of agreement be tween the two sets of ucods were calculated and logistic regression was performed to deter mine factors associated with agreement. results: overall agreement between the original and new ucods was 52%. agreement was excellent for the group of deaths due to congenital malformations, deformations, and chro mosomal abnormalities (kappa = 0.77); substantial for conditions originating in the perinatal period (kappa = 0.74); and poor for certain infectious and parasitic diseases, and respiratory diseases (kappa = 0.35). overestimation (false-positive reporting) was highest (13%) for peri natal conditions, while underestimation (false-negative reporting) was highest (71%) for cer tain infectious and parasitic diseases, and respiratory diseases. agreement was associated with type of ucod (endogenous versus exogenous) and time of death. conclusion: more than half (53%) of cod statements in infant death certificates in her mosillo were inaccurately completed, which may lead to inaccurate interpretation of causes of infant mortality. systematic assessments of the quality of cod statements may improve the quality of mortality statistics.
Validity of underlying cause of death statistics in Hermosillo, Mexico
Carvalho,Mary H Freire de; álvarez-Hernández,Gerardo; Denman,Catalina; Harlow,Siobán D;
Salud Pública de México , 2011, DOI: 10.1590/S0036-36342011000400005
Abstract: objective: this paper assesses the quality of the underlying cause of death (cod) statistics in hermosillo, mexico in a random sample of 300 in-hospital adult deaths. material and methods: a "gold standard" cod, determined by a systematic review of hospital medical charts, was compared to the cod reported by the vital registry system. results: overall agreement between the reviewer and original cod at the icd-10 chapter block was 69.2%, with a weighted kappa of 0.62. agreement varied greatly by icd-10 chapter. mutual misclassification among common co-morbidities,such as diabetes mellitus and circulatory disease, minimized the net change in the mortality fraction assigned to each icd-10 chapter after physician review. conclusions: the icd-10 chapter level underlying cod codes can be used to estimate disease burden in the population. caution is recommended for use of vital registry statistics in hermosillo for individual level or disease-specific analyses.
Japanese wives in Japanese-Australian intermarriages
Jared Denman
New Voices : A Journal for Emerging Scholars of Japanese Studies in Australia and New Zealand , 2009,
Abstract: The diasporic experiences of Japanese partners married to Australians and living in Australia are largely unexamined. This article is based on a study, conducted for an Honours thesis, which invited four Japanese wives living in South East Queensland to describe, together with their Australian husbands, their family’s interactions with Japan, its language and culture, and the local Japanese community. It was recognised that the extensive social networks these wives had established and maintained with local Japanese women from other Japanese-Australian intermarriage families were an important part of their migrant experience.This article will firstly review the literature on contemporary Japanese-Australian intermarriage in Australia and Japanese lifestyle migration to Australia. It will then describe and examine the involvement and motivations of the four wives in their social networks. Entry into motherhood was found to be the impetus for developing and participating in informal, autonomous networks. Additionally, regular visits to Japan were focused on engagement with existing family and friendship networks. The contemporary experience of intermarriage for these women is decidedly transnational and fundamentally different from that of the war brides, or sensō hanayome.
Design studies for a multi-TeV gamma-ray telescope array : PeX (PeV eXplorer)
Jarrad Denman
Physics , 2014,
Abstract: (Abridged) This thesis presents work towards the design of a new array of Image Atmospheric Cherenkov Telescopes (IACTs) to detect multi-TeV gamma-ray sources. The array consists of 5 telescopes in a square layout with one central telescope, known as the Pevatron eXplorer or PeX. PeX is a PeV (10^{15} eV) cosmic ray explorer that aims to study and discover gamma-ray sources in the 1 to 500 TeV range. The initial PeX design has been influenced by the HEGRA CT-System and H.E.S.S. configurations. One important feature of multi-TeV air showers is their ability to trigger telescopes at large core distance (>400m). PeX will utilise large core distance events to improve the performance and illustrate the viability of a sparse array for multi-TeV gamma-ray astronomy. One important aspect of the thesis (Chapter 6) was the investigation of a new time-based image cleaning method. The arrival time between photons in two adjacent pixels in the camera is used to apply an extra cut which helps mitigate night sky background. To illustrate the robustness of the time cleaning cut, various level of night sky background have been considered. These levels include: off-Galactic plane, on-Galactic plane and towards the Galactic centre. The most important result is that PeX performance with a time cleaning cut improves results when a high level of night sky background is present. For a Galactic centre level of night sky background there is a factor of 1.5 improvement in angular resolution, effective area and quality factor when a time cleaning cut is applied compared to using no time cleaning cut.
Neighborhood socio-environmental vulnerability and infant mortality in Hermosillo, Sonora
Lara-Valencia,Francisco; álvarez-Hernández,Gerardo; Harlow,Siobán D; Denman,Catalina; García-Pérez,Hilda;
Salud Pública de México , 2012, DOI: 10.1590/S0036-36342012000400006
Abstract: objective: this paper explores the impact of contextual variables at the neighborhood level on a health marker in the city of hermosillo, mexico and discusses the importance of collaboration between planners and health professional to minimize the negative effect of contextual factors on urban health. materials and methods: few studies in mexico have assessed health outcomes at the intra-urban scale and their interaction with neighborhood-level contextual variables. using spatial analysis and geographical information systems, the paper explores the association between infant mortality and an index of socio-environmental vulnerability used to measure urban contextual factors. results: two high infant mortality clusters were detected within neighborhoods characterized by relatively good environmental conditions and one in a neighborhood with a poor environment. conclusions: our results show the clustering of high infant mortality areas and some association with built environment factors in hermosillo. the results support the need to reconnect public health and urban planning as a way to create healthier environments in mexican cities.
Rese a de "Donde el viento llega cansado. Sistemas y prácticas de salud en la ciudad de Potosí" de Susana Ramírez Hita
Catalina A. Denman
Región y sociedad , 2008,
Abstract:
Salud en la maquila: preguntas para la investigación
Catalina A. Denman
Nueva antropología , 1997,
Abstract:
Conformational-Dependent and Independent RNA Binding to the Fragile X Mental Retardation Protein
Xin Yan,Robert B. Denman
Journal of Nucleic Acids , 2011, DOI: 10.4061/2011/246127
Abstract: The interaction between the fragile X mental retardation protein (FMRP) and BC1 RNA has been the subject of controversy. We probed the parameters of RNA binding to FMRP in several ways. Nondenaturing agarose gel analysis showed that BC1 RNA transcripts produced by in vitro transcription contain a population of conformers, which can be modulated by preannealing. Accordingly, FMRP differentially binds to the annealed and unannealed conformer populations. Using partial RNase digestion, we demonstrate that annealed BC1 RNA contains a unique conformer that FMRP likely binds. We further demonstrate that this interaction is 100-fold weaker than that the binding of eEF-1A mRNA and FMRP, and that preannealing is not a general requirement for FMRP's interaction with RNA. In addition, binding does not require the N-terminal 204 amino acids of FMRP, methylated arginine residues and can be recapitulated by both fragile X paralogs. Altogether, our data continue to support a model in which BC1 RNA functions independently of FMRP. 1. Introduction Fragile X syndrome is the most common inherited cause of mental impairment accounting for ca. 40% of X-linked mental retardation cases. It is also the most common known cause of autism (reviewed in [1–6]). Other characteristics of the fragile X syndrome include hyperactivity [7], increased susceptibility to seizures [8], increased testicular volume [9], macrocephaly, and large ears [10]. In addition, it has been found that carriers of the fragile X premutation, once thought to be free of the effects of the disease, also suffer from subtle behavioral and physical abnormalities [11–14]. This wide and varied constellation of phenotypic features results from the loss of function of a single gene, FMR1 (summarized in: http://www.ncbi.nlm.nih.gov/bookshelf/br.fcgi?book=gene&part-fragilex). The FMR1 gene encodes the RNA-binding protein FMRP [15], a negative [16–18] and positive [19, 20] translational regulator, and it has been of considerable interest to delineate the cellular RNAs that bind to FMRP [21–25] and the mechanism(s) by which FMRP binds and controls these mRNAs [26–35]. In 2003, Zalfa et al. described a bridging mechanism in which the fragile X mental retardation protein (FMRP) via interaction with the 5′ end of the small noncoding RNA, BC1, and bound and repressed FMRP target mRNAs [36]. This model has been subject to great deal of scrutiny owing to findings that appear to be out of step with other studies. These include differences in the prime localization of FMRP with small repressed mRNPs rather than brain
Protein Methylation and Stress Granules: Posttranslational Remodeler or Innocent Bystander?
Wen Xie,Robert B. Denman
Molecular Biology International , 2011, DOI: 10.4061/2011/137459
Abstract: Stress granules contain a large number of post-translationally modified proteins, and studies have shown that these modifications serve as recruitment tags for specific proteins and even control the assembly and disassembly of the granules themselves. Work originating from our laboratory has focused on the role protein methylation plays in stress granule composition and function. We have demonstrated that both asymmetrically and symmetrically dimethylated proteins are core constituents of stress granules, and we have endeavored to understand when and how this occurs. Here we seek to integrate this data into a framework consisting of the currently known post-translational modifications affecting stress granules to produce a model of stress granule dynamics that, in turn, may serve as a benchmark for understanding and predicting how post-translational modifications regulate other granule types. 1. Introduction Stress granules are large, complex ribonucleoprotein particles that form in response to cellular insults such as heat shock, oxidative stress, energy deprivation, and glucose starvation [1–3]. They contain messenger RNA, small ribosomal subunits, eukaryotic initiation factors, and a host of RNA-Binding proteins. Stress granules are sites of RNA processing, and as such they are in dynamic equilibrium with other components of the cytosol and even the nucleus. For example, Kedersha et al. have shown that stress granules are reciprocally linked to polyribosome formation [4]. Additionally, certain RNA-Binding proteins have been shown to shuttle between stress granules and processing bodies [5]. Finally, fluorescence recovery after photobleaching studies (FRAP) have demonstrated that the components in stress granules can be replaced by their soluble counterparts in the cytosol to varying degrees and rates [5–7] leading one to the view that these entities can be modulated by a variety of forces that affect their composition (Figure 1). Figure 1: FRAP shows the dynamic exchange of FMRP between stress granules and the cytosol. (a) A representative HeLa cell treated with 1.0?mM sodium arsenite and expressing an EGFP-tagged form of the fragile X mental retardation protein (FMRP) was imaged by confocal microscopy. The region of interest (ROI) in the yellow box was photobleached to 30% of its initial intensity at time 0. The recovery of EGFP-FMRP fluorescence over the next 330 seconds within the ROI is shown in the sequentially numbered panels. A similar sized ROI shown in red that was not photobleached was quantified similarly. (b) The graph shows the
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