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Search Results: 1 - 10 of 202057 matches for " Gerardo Baró Román "
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Evaluación de la toxicidad aguda oral y de la actividad antimicrobiana de una mezcla de aceite de hígado de tiburones de Cuba Assessment of the oral acute toxicity and the antimicrobial activity of an oily mixture from shark's liver of Cuba
Caridad Margarita García Pe?a,Addis Bellma Menéndez,Gerardo Baró Román,Mirna Fernández Cervera
Revista Cubana de Farmacia , 2010,
Abstract: Se evaluó la toxicidad aguda oral y la actividad antimicrobiana de una mezcla de aceites de hígado de tiburón, de las especies Rhincodon typu (tiburón ballena) y Galeocerdo cuvier (tiburón tigre), que habitan en zonas aleda as a las costas del litoral norte occidental de Cuba, para su posterior uso farmacéutico, debido a que presenta un alto contenido de vitaminas y de ácidos grasos, que le confieren actividad antioxidante y antiinflamatoria. El estudio de la toxicidad aguda oral demostró que la mezcla de aceites de hígado de tiburones, no provocó alteraciones macroscópicas en los órganos extraídos, ni síntomas tóxicos severos, ni mortalidad de ninguno de los animales empleados en el estudio a la dosis de 20 mL/kg. Los resultados del estudio de la actividad antimicrobiana demostraron una ligera actividad bacteriostática frente a K. pneumoniae; además una actividad antifúngica frente a Microsporum canis; y resistencia frente a C. albicans y T. mentagrophytes a las concentraciones evaluadas. The total acute toxicity and the antimicrobial activity of an oil mixtures from shark liver of Rhicodon typu (whale-shark) and Galeocerdo cuvier (tigger-shark) was assessed in species leaving in the adjacent costs of Cuban northern coastal for its subsequent pharmaceutical use due to its high content of vitamins and fatty acids and its antioxidant and anti-inflammatory activity. Study of oral acute toxicity demonstrated that oil mixture of shark liver hasn't macroscopic alterations in removed organs, severe toxic symptoms and on mortality of any animals used in study at 20 mL/kg dose. Study results of antimicrobial activity showed a slight bacteriostatic activity against K. pneumoniae and an antifungal activity against Microsporum canis, and a resistance against C. albicans and T. mentagrophytes at assessed concentrations.
Dise?o de una formulación de fenilefrina 10 % y tropicamida 1 % colirio: eyedrops
Zu?iga Dedorite,Georgy Armando; García Pe?a,Caridad Margarita; Botet García,Martha; Troche Concepción,Yenilen; Montes de Oca Porto,Yanet; Baró Román,Gerardo;
Revista Cubana de Farmacia , 2010,
Abstract: the 10 % phenylephrine and 1 % tropicamide eyedrops is used in medical practice as antihistaminic, analgesic, mydiatric and cycloplegic. the aim of present paper was to develop a 10% phenylephrine and 1 % tropicamide formula fulfilling the quality specifications established by manufacturer physically, chemically and microbiologically stable with the performing of a design and pre-formula studies. also, we studied the quality specifications of selected formula, the product stability and its expiry time. an analytical method was developed and validated to quality control and stability study of the finished product by high-performance liquid chromatography. analytical results of accelerated stability study and by shelf life using 3 batches of product at pilot scale. eyedrops was physically, chemically and microbiologically stable when it was bottling in low density polyethylene flasks during 12 months of storage at room temperature.
Evaluación de la toxicidad aguda oral y de la actividad antimicrobiana de una mezcla de aceite de hígado de tiburones de Cuba
García Pe?a,Caridad Margarita; Bellma Menéndez,Addis; Baró Román,Gerardo; Fernández Cervera,Mirna; Casti?eira Díaz,Mirta; Wong Trujillo,Lyi; Guerra Sardi?as,Isbel; Couret Trápaga,Micaela;
Revista Cubana de Farmacia , 2010,
Abstract: the total acute toxicity and the antimicrobial activity of an oil mixtures from shark liver of rhicodon typu (whale-shark) and galeocerdo cuvier (tigger-shark) was assessed in species leaving in the adjacent costs of cuban northern coastal for its subsequent pharmaceutical use due to its high content of vitamins and fatty acids and its antioxidant and anti-inflammatory activity. study of oral acute toxicity demonstrated that oil mixture of shark liver hasn't macroscopic alterations in removed organs, severe toxic symptoms and on mortality of any animals used in study at 20 ml/kg dose. study results of antimicrobial activity showed a slight bacteriostatic activity against k. pneumoniae and an antifungal activity against microsporum canis, and a resistance against c. albicans and t. mentagrophytes at assessed concentrations.
Influencia de factores de riesgo y terapia farmacológica en la mortalidad de hipertensos esenciales
Román A,Oscar; Cuevas S,Gerardo; Bunout B,Daniel;
Revista médica de Chile , 1998, DOI: 10.4067/S0034-98871998000700001
Abstract: background: the vjn consensus stated that although new antihypertensive agents, such as angiotensin converting enzyme inhibitors and calcium channel blockers, are considered safer drugs, there is no firm evidence from large controlled trials that these drugs are associated with a lower cardiovascular mortality. aim: to study the association between cardiovascular risk factors, blood pressure levels, pharmacological treatment and mortality in a group of hypertensive patients followed at an hypertension outpatient clinic. patients and methods: patients with essential hypertension were treated with different antihypertensive medications, according to physicians criteria, and controlled until death or loss from follow up. causes of death were obtained from hospital records and death certificates. survival was analyzed using life tables, comparisons between groups of patients were done using chi square or a cox?s proportional hazards model. results: three hundred thirty nine hypertensive patients aged 33 to 80 years old were followed for a mean period of 9.8 ± 4.9 years. eighty six were treated with beta blockers, 64 with diuretics, 133 with calcium antagonists and 56 with ace inhibitors. blood pressure dropped similarly with all medications. during follow up, 79 patients died. life table analysis showed that patients with a history of angina, diabetes or myocardial infarction had higher mortality rates. similarly, patients treated with beta blockers and diuretics had higher mortality than patients treated with calcium antagonists or angiotensin converting enzyme inhibitors. the proportional hazards model showed that the effect of treatment modality persisted after correction for the other risk factors for mortality. conclusions: in this series of hypertensive patients, those treated with beta blockers or diuretics had higher mortality rates than those receiving calcium channel antagonists or angiotensin converting enzyme inhibitors.
Influencia de factores de riesgo y terapia farmacológica en la mortalidad de hipertensos esenciales
Oscar Román A,Gerardo Cuevas S,Daniel Bunout B
Revista médica de Chile , 1998,
Abstract: Background: The VJN consensus stated that although new antihypertensive agents, such as angiotensin converting enzyme inhibitors and calcium channel blockers, are considered safer drugs, there is no firm evidence from large controlled trials that these drugs are associated with a lower cardiovascular mortality. Aim: To study the association between cardiovascular risk factors, blood pressure levels, pharmacological treatment and mortality in a group of hypertensive patients followed at an hypertension outpatient clinic. Patients and methods: Patients with essential hypertension were treated with different antihypertensive medications, according to physicians criteria, and controlled until death or loss from follow up. Causes of death were obtained from hospital records and death certificates. Survival was analyzed using life tables, comparisons between groups of patients were done using chi square or a Cox s proportional hazards model. Results: Three hundred thirty nine hypertensive patients aged 33 to 80 years old were followed for a mean period of 9.8 ± 4.9 years. Eighty six were treated with beta blockers, 64 with diuretics, 133 with calcium antagonists and 56 with ACE inhibitors. Blood pressure dropped similarly with all medications. During follow up, 79 patients died. Life table analysis showed that patients with a history of angina, diabetes or myocardial infarction had higher mortality rates. Similarly, patients treated with beta blockers and diuretics had higher mortality than patients treated with calcium antagonists or angiotensin converting enzyme inhibitors. The proportional hazards model showed that the effect of treatment modality persisted after correction for the other risk factors for mortality. Conclusions: In this series of hypertensive patients, those treated with beta blockers or diuretics had higher mortality rates than those receiving calcium channel antagonists or angiotensin converting enzyme inhibitors.
Morbimortalidad de la hipertensión arterial esencial tratada en un seguimiento de 26 a os Mortality and morbidity of treated essential arterial hypertension. A 26 years follow up
Oscar Román A,Gerardo Cuevas S,Marta Badilla S,Angélica Valenzuela C
Revista médica de Chile , 2002,
Abstract: Background: Treatment has a definitive impact on mortality in hypertension. The magnitude of blood pressure reduction, the type of drug used and the associated risk factors may modulate the effect of treatment on mortality. Aim: To report the effects of treatment of essential hypertension, in a cohort followed for up to 26 years. Patients and methods: A cohort of 1,172 essential hypertensive patients followed up to 26 years. Patients were treated with different antihypertensive drugs, alone or in combination (diuretics, beta blockers, calcium channel blockers and angiotensin converting enzyme inhibitors) according to international rules and consensus. Subjects were followed until death or loss from follow-up. Blood pressure reduction was aimed to obtain figures near 140/ 90 mm Hg. Causes of death and complications were obtained from hospital records, phone and death certificates. Survival was studied using life tables (Kaplan Meier method and intention to treat analysis) and Cox proportional hazard analysis. Results: Initial blood pressure dropped significantly from 181/109 to 154/92 mm Hg, p <0.001. Mean follow-up time was 10.6±6.1 years. There were 143 cardiovascular deaths, 142 acute myocardial infarctions, 101 strokes, 83 subjects had cardiac failure and 49 had renal failure. The observed rates were 0.92% per year for cardiovascular mortality, 1.36% per year for coronary heart disease, 0.94% per year for stroke. Conclusions: Our mortality rate is lower than that found in classical randomized studies but similar or slightly higher than the more recent ones. Morbidity rates were also very similar. Except for mortality rate, frequency of complications did not change in comparison to our previous report after 15 year of follow up. Aging did not seem to negatively influence mortality rates in adequately treated hypertensive patients (Rev Méd Chile 2002; 130: 379-38 )
Factores predictores de riesgo de morbimortalidad en hipertensos esenciales seguidos 25 a os Risk factors for morbidity and mortality in subjects with essential hypertension, followed for 25 years
Oscar Román A,Gerardo Cuevas,Marta Badilla S,María Angélica Valenzuela C
Revista médica de Chile , 2001,
Abstract: Background: Among hypertensive patients, other risk factors for mortality and morbidity, besides blood pressure, must be considered when therapeutic decisions are done. Aim: To assess the incidence and relevance of cardiovascular risk factors in a cohort of patients with essential hypertension. Material and methods: A cohort of 1.072 treated patients with essential hypertension was followed for a period up to 25 years. Four hundred eighty six were men and 586 were women, age ranged from 31 to 70 years. At entry, 56% of subjects did not have any organic complications associated to hypertension (stage I WHO criteria), 30% had mild alterations (Stage II) and 14% had major complications (myocardial infarction, stroke, heart failure or renal failure). Likewise, 43.8% had mild, 14.5%, moderate and 41.7%, severe hypertension. Patients were treated with monotherapy or combined therapy based on diuretics, beta blockers, calcium antagonists and angiotensin converting enzyme inhibitors. Goal of therapy was 140/90 mm Hg. Risk factors associated diseases and complications were registered carefully. Causes of death were obtained from hospital records and death certificates. Mortality was analyzed using life tables (intention to treat method included). Results: Blood pressure dropped significantly during follow up from a mean of 182/110 to 154/92 mm Hg. During follow up, 143 patients died and 429 complications (lethal or non lethal) were recorded. Twenty four percent of patients smoked, 24% reported alcohol intake, 56% had hypercholesterolemia, 11% were obese, 13% had diabetes and 3% had gout. The proportional hazard model showed that the existence of previous complications, the presence of more than 3 risk factors, and age over 60 and mean systolic and diastolic pressure during therapy, were independent and significant risk factors for mortality. Conclusions: The incidence of risk factors among our hypertensive patients is very similar to that of other national or international cohorts (Rev Méd Chile 2001; 129: 1253-61)
Deep Near-Infrared Survey of the Pipe Nebula II: Data, Methods, and Dust Extinction Maps
Carlos Gerardo Román-Zú?iga,Jo?o F. Alves,Charles J. Lada,Marco Lombardi
Physics , 2010, DOI: 10.1088/0004-637X/725/2/2232
Abstract: We present a new set of high resolution dust extinction maps of the nearby and essentially starless Pipe Nebula molecular cloud. The maps were constructed from a concerted deep near-infrared imaging survey with the ESO-VLT, ESO-NTT, CAHA 3.5m telescopes, and 2MASS data. The new maps have a resolution three times higher than the previous extinction map of this cloud by Lombardi et al. (2006) and are able to resolve structure down to 2600 AU. We detect 244 significant extinction peaks across the cloud. These peaks have masses between 0.1 and 18.4 M_sun, diameters between 1.2 and 5.7e4 AU (0.06 and 0.28 pc), and mean densities of about 1e4 cm${^-3}$, all in good agreement with previous results. From the analysis of the Mean Surface Density of Companions we find a well defined scale near 1.4e4 AU below which we detect a significant decrease in structure of the cloud. This scale is smaller than the Jeans Length calculated from the mean density of the peaks. The surface density of peaks is not uniform but instead it displays clustering. Extinction peaks in the Pipe Nebula appear to have a spatial distribution similar to the stars in Taurus, suggesting that the spatial distribution of stars evolves directly from the primordial spatial distribution of high density material.
Ontogenia de los estróbilos, desarrollo de los esporangios y esporogénesis de Equisetum giganteum (Equisetaceae) en los Andes de Colombia
Edgar Javier Rincón Barón,Helkin Giovani Forero Ballesteros,Leidy Viviana Gélvez Landazábal,Gerardo Andrés Torres
Revista de Biología Tropical , 2011,
Abstract: Estudios sobre la ontogenia del estróbilo, los esporangios y la biología reproductiva de Equisetum son escasos, por lo tanto, para la especie E. giganteum, se estudiaron estos aspectos en especímenes recolectados a orillas del Río Frío, Santander, Colombia (2 200m). Los estróbilos en diferentes etapas de maduración fueron fijados, deshidratados, embebidos en parafina, seccionados en micrótomo rotatorio y te idos con safranina O-fast green. Las observaciones se efectuaron mediante un microscopio óptico de alta resolución con contraste diferencial de interferencia (DIC) y microscopio de fluorescencia. Los estróbilos se inician a partir del meristemo apical, tanto en el eje principal como en los laterales, sin diferencias en el proceso de ontogenia y esporogénesis entre estróbilos de diferentes ejes. Sucesivas mitosis y diferenciación celular conducen al crecimiento del estróbilo, y a la formación de los esporangióforos peltados, formados por el manubrio, o porción basal con aspecto de pedicelo, el escutelo, o porción apical aplanada y las iniciales del esporangio, los cuales se diferenciarán para formar la pared del esporangio, los esporocitos y el tapete. No se forma arquesporio y los esporocitos experimentan meiosis para formar tétradas de esporas. El tapete mantiene la integridad histológica hasta la formación de las tétradas y en esa etapa forma un plasmodio que invade la cavidad esporangial la cual rodea parcialmente las tétradas y luego las esporas, y aparecen las cámaras plasmodiales, un término propuesto aquí para las formaciones designadas en inglés "tapetal gaps". La pared del esporangio queda reducida a dos capas celulares: una externa con engrosamientos lignificados en todas las paredes celulares y una interna picnótica. Al finalizar la esporogénesis, el tapete degenera, y las esporas, con exosporio, perisporio delgado, casi membranáceo y eláteres quedan libres en la cavidad esporangial. El esporodermo, los núcleos y nucléolos presentan fluorescencia roja, inducida por coloración con safranina O, mientras que los eláteres y las células de la pared del esporangio presentan autofluorescencia amarillo-naranja. Ontogeny of strobili, sporangia development and sporogenesis in Equisetum giganteum (Equisetaceae) from the Colombian Andes. Studies on the ontogeny of the strobilus, sporangium and reproductive biology of this group of ferns are scarce. Here we describe the ontogeny of the strobilus and sporangia, and the process of sporogenesis using specimens of E. giganteum from Colombia collected along the Rio Frio, Distrito de Sevilla, Piedecuesta, San
Evaluación de hidrogeles para aplicaciones agroforestales
Barón Cortés,Andrés; Barrera Ramírez,Ingrid Xiomara; Boada Eslava,Luis Francisco; Rodríguez Ni?o,Gerardo;
Ingeniería e Investigación , 2007,
Abstract: hydrogels synthesised by inverse suspension polymerisation (isp) technique consisting of acrylamide and potassium acrylate interlinked with n, n? methylene-bis-acrylamide and presenting different behaviour in terms of rooting ability and speed, elastic module and release properties were studied. markedly clayey soil properties were modified by drawing up moisture-retention curves using ceramic plate pressure waves and developing montages for evaluating modifications made to their retention, regarding prolonged and instantaneous irrigation-water dosage conditions. acacia and radish crops were grown in nursery phase in soil conditioned with different hydrogels. delayed specie withering was simultaneously evaluated in the first crop and difference in growth in the second one. follow-up of in situ soil moisture content was also evaluated over a fixed period of time. a method was achieved for measuring elastic module and release properties and model was established for predicting hydrogel behaviour in soil having known basic properties in free state. the results revealed the usefulness of hydrogels in such applications: greater facility in usable water release and retention by soil, notable delay in withering in hostile conditions and greater growth of species. guidelines were also established for defining the characteristics of hydrogel more adequately, depending on the desired application and a projection was made concerning reducing water consumption for maintaining a particular crop.
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