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Search Results: 1 - 10 of 15896 matches for " Gerard Jan Blauw "
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Total Joint Replacement in the Past Does Not Relate to a Deteriorated Functional Level and Health Status in the Oldest Old
Wiebe Chr. Verra,Anton J. M. de Craen,Coen C. M. M. Jaspars,Jacobijn Gussekloo,Gerard Jan Blauw,Rudi G. J. Westendorp,Andrea B. Maier,Rob G. H. H. Nelissen
Journal of Aging Research , 2012, DOI: 10.1155/2012/968389
Abstract: Total hip or knee replacement is effective in improving joint function, quality of life, and pain reduction. The oldest old population with joint replacements (TJR) is underrepresented in current literature. We compared health-related and functional characteristics of oldest olds with and without TJR. Participants (aged 85 years) were divided into a group with and without TJR. Comorbidity, physical and joint functioning, daily living activities, quality of life, and mortality were recorded. Thirty-eight of 599 participants (6.3%) received a TJR in the past. Participants with a TJR had slightly less comorbidities, walked slower ( ?? = 0 . 0 0 6 ), and complained more about hip-pain ( ?? = 0 . 0 0 7 ). Mortality of those with a TJR was lower during the first 8-year followup ( ?? = 0 . 0 4 ). All other characteristics were comparable between groups. We conclude that subjects with a TJR performed equally well, besides showing a lower gait speed and a higher frequency of hip-pain. Except for the lower gaitspeed, having a TJR is not associated with poorer health. 1. Introduction The population of oldest olds (i.e., 85 years and older) is the fastest growing segment of the elderly population in the western society [1]. The health status decreases with increasing chronological age [2]. One of the major age-related diseases is osteoarthritis (OA), which is more common in females [3–5]. In subjects between 60 and 70 years of age, prevalences of symptomatic knee OA are reported of approximately 10 percent in males and 20 percent in females [4]. Prevalence of knee OA is comparable in subjects aged 80 years and older [4, 5]. Symptomatic OA of the hip is present in approximately five percent of the 60 to 70 years old females and up to 18 percent in females of 80 years and older. In males, prevalences are slightly lower [3, 4]. Due to the demographic changes, the number of total hip replacement (THR) and total knee replacement (TKR) procedures steadily increases [6]. Increasing age is associated with a higher complication and mortality rate after total joint replacement [6]. However, the results of total joint replacement in elderly patients have been proven effective in terms of pain reduction, functional improvement, and cost-effectiveness and show similar results compared to younger patients receiving total joint replacement [7, 8]. OA of the hip or the knee impairs physical activity [4]. Restriction of physical activity is associated with numerous detrimental effects on general health status, physical function, and quality of life [4, 9]. Maintaining physical
Lipoprotein Particle Profiles Mark Familial and Sporadic Human Longevity
Bastiaan T Heijmans ,Marian Beekman,Jeanine J Houwing-Duistermaat,Mark R Cobain,Jonathan Powell,Gerard Jan Blauw,Frans van der Ouderaa,Rudi G. J Westendorp,P. Eline Slagboom
PLOS Medicine , 2006, DOI: 10.1371/journal.pmed.0030495
Abstract: Background Genetic and biochemical studies have indicated an important role for lipid metabolism in human longevity. Ashkenazi Jewish centenarians and their offspring have large low-density lipoprotein (LDL) and high-density lipoprotein (HDL) particles as compared with control individuals. This profile also coincided with a lower prevalence of disease. Here, we investigate whether this observation can be confirmed for familial longevity in an outbred European population and whether it can be extended to sporadic longevity in the general population. Methods and Findings NMR-measured lipoprotein profiles were analyzed in 165 families from the Leiden Longevity Study, consisting of 340 long-lived siblings (females >91 y, males >89 y), 511 of their offspring, and 243 partners of the offspring. Offspring had larger (21.3 versus 21.1 nm; p = 0.020) and fewer (1,470 versus 1,561 nmol/l; p = 0.011) LDL particles than their same-aged partners. This effect was even more prominent in the long-lived siblings (p < 10?3) and could be pinpointed to a reduction specifically in the concentration of small LDL particles. No differences were observed for HDL particle phenotypes. The mean LDL particle sizes in 259 90-y-old singletons from a population-based study were similar to those in the long-lived siblings and thus significantly larger than in partners of the offspring, suggesting that the relevance of this phenotype extends beyond familial longevity. A low concentration of small LDL particles was associated with better overall health among both long-lived siblings (p = 0.003) and 90-y-old singletons (p = 0.007). Conclusions Our study indicates that LDL particle profiles mark both familial and sporadic human longevity already in middle age.
Impact of valvular heart disease on activities of daily living of nonagenarians: the leiden 85-plus study a population based study
Thomas van Bemmel, Victoria Delgado, Jeroen J Bax, Jacobijn Gussekloo, Gerard J Blauw, Rudi G Westendorp, Eduard R Holman
BMC Geriatrics , 2010, DOI: 10.1186/1471-2318-10-17
Abstract: The left ventricular (LV) dimensions, function and the presence and severity of heart valvular disease were evaluated by echocardiography. Significant valvular heart disease included any mitral or aortic stenosis severity, moderate or severe mitral regurgitation, moderate or severe aortic regurgitation and moderate or severe tricuspid regurgitation. Activities of daily living were assessed using the Groningen Activity Restriction Scale (GARS).LV cavity diameters (end-diastolic diameter 47 ± 8 mm, end-systolic diameter 30 ± 8 mm) and systolic LV function (LV ejection fraction 66 ± 13%) were within normal for the majority of the participants. Significant valvular disease was present in 57 (70%) individuals, with mitral regurgitation and aortic regurgitation as the most frequent valve diseases (49% and 28% respectively). The GARS score between individuals with and without significant valvular heart disease was similar (36.2 ± 9.2 vs. 34.4 ± 13.2, p = 0.5).Nonagenarian, outpatient individuals have a high prevalence of significant valvular heart disease. However, no relation was observed between the presence of significant valvular heart disease and the ability to perform activities of daily living.The increasing life expectancy of the population in the Western countries has determined an increase of chronic diseases, with cardiovascular disease being one of the most prevalent pathologies[1]. The elderly individuals comprise a growing demographic subgroup characterized by a high frequency of cardiovascular risk factors and co-morbidities[2]. Furthermore, this subgroup of individuals is often excluded from randomized trials, resulting in important implications for clinical management[3,4]. Particularly, data on the prevalence of valvular heart disease in very old individuals are scarce and based mostly on in-hospital series, introducing an important selection bias [4-7]. In addition, the potential detrimental effect of valvular heart disease on the activities of daily liv
Randomised Controlled Trial of Unsolicited Occupational Therapy in Community-Dwelling Elderly People: The LOTIS Trial
Anton J. M de Craen, Jacobijn Gussekloo, Gerard J Blauw, Charles G Willems, Rudi G. J Westendorp
PLOS ONE , 2006, DOI: 10.1371/journal.pctr.0010002
Abstract: Objective The objective of this trial, the Leiden 85-Plus Occupational Therapy Intervention Study (LOTIS), was to assess whether unsolicited occupational therapy, as compared to no therapy, can decelerate the increase in disability in high-risk elderly people. Design This was a randomised controlled trial with 2-y follow-up. Setting The study took place in the municipality of Leiden in the Netherlands. Participants The participants were 402 community-dwelling 85-y-old people, with a Mini-Mental State Examination score of >18 points at baseline. Interventions Participants in the intervention group were visited by an occupational therapist who provided training and education about assistive devices that were already present and who gave recommendations and information about procedures, possibilities, and costs of assistive devices and community-based services. Control participants were not visited by an occupational therapist. Outcome Measures The primary outcome measure was the score achieved on the Groningen Activity Restriction Scale. Secondary outcome measures included self-evaluations of well-being and feelings of loneliness. Results The participants were evenly divided between the two groups: 202 participants were allocated to the intervention group and 200 participants to the control group. Of the 202 participants randomised to occupational therapy, 55 participants declined the proposed intervention. An occupational therapist indicated that of the remaining 147 participants, 66 (45%) needed an occupational therapy intervention. A total of 44 new assistive devices and five community-based services were implemented. During follow-up there was a progressive increase in disability in the intervention group (mean annual increase, 2.0 points; SE 0.2; p < 0.001) and control group (mean annual increase, 2.1 points; SE 0.2; p < 0.001). The increase in disability was not significantly different between study groups (0.08 points; 95% CI, ?1.1–1.2; p = 0.75). There was also no difference between study groups for any of the secondary outcome measures. Conclusion Unsolicited occupational therapy in high-risk elderly participants does not decelerate the increase in disability over time. Trial Registration ClinicalTrials.gov NCT00278096
Associations between Total Cerebral Blood Flow and Age Related Changes of the Brain
Adriaan C. G. M. van Es,Jeroen van der Grond,V. Hester ten Dam,Anton J. M. de Craen,Gerard J. Blauw,Rudi G. J. Westendorp,Faiza Admiraal-Behloul,Mark A. van Buchem
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0009825
Abstract: Although total cerebral blood flow (tCBF) is known to be related to age, less is known regarding the associations between tCBF and the morphologic changes of the brain accompanying cerebral aging. The purpose of this study was to investigate whether total cerebral blood flow (tCBF) is related to white matter hyperintensity (WMH) volume and/or cerebral atrophy. Furthermore, we investigate whether tCBF should be expressed in mL/min, as was done in all previous MR studies, or in mL/100 mL/min, which yielded good results in precious SPECT, PET and perfusion MRI studies investigating regional cerebral blood flow.
L1 Educational Studies in Language and Literature , 2008,
Abstract: Oral language education is important throughout primary school for the development of language and learning. Yet in today's educational practice this core principle is neglected and classroom interactions lack quality. Teachers know that supporting students to participate actively in learning is important but they do not master the interaction skills to apply this knowledge in practice. However, as small scale studies demonstrate, teachers can acquire the necessary skills to improve the quality of classroom interaction and can learn to adopt a new teacher role. To promote this on a national scale we developed a checklist for teachers that focuses on acquisition oriented interaction strategies. These teacher strategies are linked to complementary child participation. In order to yield actual changes in classroom conversations professional learning must be well structured. Major course elements on the checklist are: the use of video footage of teachers’ own classroom conversations, and team meetings combined with individually oriented teacher guidance in the classroom. Evaluations of this course yielded positive reactions. In order to guarantee implementation we developed courses for teacher facilitators as well. Presently efforts are being directed at science education in primary schools, and integration of the language and learning course in the teacher training college curriculum.
Tetrahedral zinc in tetrakis(1-methyl-1H-imidazole-κN3)zinc bis(tetrafluoridoborate)
Jan Reedijk,Gerard A. van Albada,Bart Limburg,Ilpo Mutikainen
Acta Crystallographica Section E , 2012, DOI: 10.1107/s1600536811054821
Abstract: In the title compound, [Zn(C4H6N2)4](BF4)2, the ZnII ion is in a slightly distorted tetrahedral coordination geometry, with Zn—N distances in the range 1.980 (2)–1.991 (2) . The tetrahedral angles are in the range 104.93 (9)–118.81 (9)°.
Classifying Groups of Small Order  [PDF]
Gerard Thompson
Advances in Pure Mathematics (APM) , 2016, DOI: 10.4236/apm.2016.62007
Abstract: The classification of groups of order less than 16 is reconsidered. The goal of the paper is partly historical and partly pedagogical and aims to achieve the classification as simply as possible in a way which can be easily incorporated into a first course in abstract algebra and without appealing to the Sylow Theorems. The paper concludes with some exercises for students.
Weighted gene co-expression network analysis of the peripheral blood from Amyotrophic Lateral Sclerosis patients
Christiaan GJ Saris, Steve Horvath, Paul WJ van Vught, Michael A van Es, Hylke M Blauw, Tova F Fuller, Peter Langfelder, Joseph DeYoung, John HJ Wokke, Jan H Veldink, Leonard H van den Berg, Roel A Ophoff
BMC Genomics , 2009, DOI: 10.1186/1471-2164-10-405
Abstract: Our transcriptional study showed dramatic changes in blood of ALS patients; 2,300 probes (9.4%) showed significant differential expression in a discovery dataset consisting of 30 ALS patients and 30 healthy controls. Weighted gene co-expression network analysis (WGCNA) was used to find disease-related networks (modules) and disease related hub genes. Two large co-expression modules were found to be associated with ALS. Our findings were replicated in a second (30 patients and 30 controls) and third dataset (63 patients and 63 controls), thereby demonstrating a highly significant and consistent association of two large co-expression modules with ALS disease status. Ingenuity Pathway Analysis of the ALS related module genes implicates enrichment of functional categories related to genetic disorders, neurodegeneration of the nervous system and inflammatory disease. The ALS related modules contain a number of candidate genes possibly involved in pathogenesis of ALS.This first large-scale blood gene expression study in ALS observed distinct patterns between cases and controls which may provide opportunities for biomarker development as well as new insights into the molecular mechanisms of the disease.Amyotrophic lateral sclerosis (ALS) is a devastating disease characterized by progressive degeneration of motor neurons in brain and spinal cord leading to muscle weakness. ALS can occur at anytime in adulthood. Initial manifestations are weakness of limbs, or weakness in the bulbar region leading to abnormalities of speech, swallowing difficulties and facial weakness. The patient eventually becomes paralyzed and approximately 50% of patients die within 3 years after onset of symptoms, usually as the result of respiratory failure. The predominant presentation of ALS is sporadic accounting for >90% of cases whereas familiar ALS affects less than 10% of the patients, usually with autosomal dominant inheritance. Genetic linkage studies have successfully identified several ALS-r
Biometriese egtheidsbevestiging tydens intydse bankdienste
Frans F. Blauw,Sebastiaan H. von Solms
Suid-Afrikaanse Tydskrif vir Natuurwetenskap en Tegnologie , 2013, DOI: 10.4102/satnt.v32i1.403
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