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Search Results: 1 - 10 of 1307 matches for " Georgios Sakas "
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BiopSee – transperineal stereotactic navigated prostate biopsy
Pawel Zogal,Georgios Sakas,Woerner R?sch,Dimos Baltas
Journal of Contemporary Brachytherapy , 2011,
Abstract: In the recent years, prostate cancer was the most commonly diagnosed cancer in men. Currently secure diagnosis confirmation is done by a transrectal biopsy and following histopathological examination. Conventional transrectal biopsy success rates are rather low with ca. 30% detection upon the first and ca 20% after re-biopsy. The paper presents a novel system for stereotactic navigated prostate biopsy. The approach results into higher accuracy, reproducibility and unrestricted and effective access to all prostate regions. Custom designed ultrasound, new template design and integrated 2-axes stepper allows superior 2D and 3D prostate imaging quality and precise needle navigation. DICOM functionality and image fusion enable to import pre-operative datasets (e.g. multiparametric MRI, targets etc.) and overlay all available radiological information into the biopsy planning and guiding procedure. The biopsy needle insertion itself is performed under augmented reality ultrasound guidance. Each procedure step is automatically documented in order to provide quality assurance and permit data re-usage for the further treatment. First clinical results indicates success rates of ca. 70% by first biopsies by our approach.
ErbB Receptors and ErbB Targeted Therapies in Endometrial Cancer  [PDF]
Georgios Androutsopoulos, Georgios Michail, Georgios Adonakis, Georgios Decavalas
Journal of Cancer Therapy (JCT) , 2014, DOI: 10.4236/jct.2014.56055

The Epidermal Growth Factor system is present in human organs and plays an important role in cell proliferation, differentiation and apoptosis during embryogenesis and postnatal development. It has four receptors (EGFR, ErbB-2, ErbB-3 and ErbB-4) and numerous ligands. Dysregulation of the Epidermal Growth Factor signaling network is implicated in the pathogenesis of various disorders. Especially in cancer, the Epidermal Growth Factor system becomes hyperactivated with various mechanisms (ligand overproduction, receptor overproduction, constitutive receptor activation). EGFR overexpression may have a dual role in endometrial cancer. It seems that in type I endometrial cancer, EGFR overexpression did not affect disease progression. However in type II endometrial cancer, EGFR overexpression associated with high grade disease and adverse clinical outcome. Moreover ΕrbB-2 overexpression especially in type II endometrial cancer, is an indicator of a highly aggressive disease with poor overall survival. The potential role of ErbB receptors (especially EGFR and ErbB-2) as targets for cancer therapy has been investigated for over 20 years. There are 2 major classes of ErbB targeted therapies: anti-ErbB monoclonal antibodies (MoAbs) and ErbB-specific tyrosine kinase inhibitors (TKIs). ErbB targeted therapies have still shown modest effect in unselected endometrial cancer patients. However, they may be clinically active as adjuvant therapy in well-defined subgroups of type II endometrial cancer patients with EGFR and ErbB-2 overexpression.

Pitfalls in the diagnosis of a tumefactive demyelinating lesion: A case report
Maria Gavra, Efstathios Boviatsis, Lampis C Stavrinou, Damianos Sakas
Journal of Medical Case Reports , 2011, DOI: 10.1186/1752-1947-5-217
Abstract: A 20-year-old Caucasian woman with acute onset of left-sided weakness and numbness was admitted to hospital with neurologic signs of left-sided hemiparesis and hypoesthesia. Brain magnetic resonance imaging showed a mass lesion of abnormal signal intensity with concentric enhancing rings in the right parietal lobe, without perifocal edema. The characteristic concentric pattern detected on the magnetic resonance images was highly suggestive of Balo disease, and corticosteroids were administered. Evoked potentials, cerebrospinal fluid analysis, and magnetic spectroscopy findings were not specific, and glioma was also included in the differential diagnosis. A stereotactic biopsy was not diagnostic.After one month the patient showed moderate clinical improvement, and during 12 months follow-up, no further relapses occurred. In the follow-up magnetic resonance imaging, the concentric pattern had completely disappeared, and only a low-signal, gliotic lesion remained.We hope this case presentation will advance our understanding of clinical and radiologic appearance of Balo concentric sclerosis, which is a rare demyelinating disease. Although this is a specific entity, it has a broader clinical impact across medicine, because it must be differentiated from other space-occupying lesions in the central nervous system.Tumefactive demyelinating brain lesions present a diagnostic challenge, because their clinical, radiologic, and even histologic features may complicate the identification of their true nature. This often leads to invasive and costly procedures, which frequently yield non-diagnostic results. We report a patient with a right parietal white matter lesion, who presented a serious diagnostic dilemma, as the lesion was difficult to differentiate between a rare demyelinating disease such as Balo concentric sclerosis (BCS) and a glioma. The characteristic magnetic resonance findings of the case, its acute onset, and its clinical improvement after corticosteroid therapy f
Liquid Column Deformation and Particle Size Distribution in Gas Atomization  [PDF]
Georgios S. E. Antipas
Materials Sciences and Applications (MSA) , 2011, DOI: 10.4236/msa.2011.22012
Abstract: A water-gas flow injected by a close coupled atomizer was studied via High Speed Photography and Phase Doppler Anemometry. The formation of a wave disturbance on the surface of the water column was confirmed. The flow converged within an area approximately 3 mm in diameter, independent of atomization conditions. The particle size distribution across the spray suggested a trend of decreasing particle sizes and particle velocities with increasing distance from the spray axis of symmetry.
Ore Microscopy and Microanalysis of the Nickeliferous Iron Ores from Komnina Vermion Area (N.W. Greece)  [PDF]
Georgios Alevizos, Eftychia Repouskou
Geomaterials (GM) , 2011, DOI: 10.4236/gm.2011.12008
Abstract: Nickel laterites are considerable sources of nickel. To be successfully exploited it is important to know the mineralogical and microstructural characteristics of the ore. Besides, the identification of the mineralogical components as well as the fabric description, can lead to the interpretation of the mechanism of deposit genesis. The aim of the present study is the microscopic and microanalytical investigation of the Fe-Ni ores from Komnina Vermion area (N.W. Greece). The mineralogical composition of the ore is mainly hematite, quartz, chromite and chlorite, while in minor quantities goethite, nickeliferous chlorite, serpentine, talc and calcite are also present. The ore structure is allotriomorphic inequigranular and the texture is oolitic-pisolitic. According to microscopic examination the deposit can be registered as a secondary pseudo-autochthonous.
The Transmission Channels between Financial Sector and Real Economy in Light of the Current Financial Crisis a Critical Survey of the Literature  [PDF]
Georgios L. Vousinas
Modern Economy (ME) , 2013, DOI: 10.4236/me.2013.44028

The present study undertakes a critical review of the research around the major issue of the transmission channels between financial sector and real economy. The aim of the study is to shed light on the interaction between the financial system and the economy, in the shadow of the current crisis. The literature documents the importance of these channels in the determination of economic activity and therefore, real economy as a whole. The study highlights the emergence of the liquidity channel as a key factor of the transmission of bank credit shocks to real economy and underlines the existing “regulation gaps”. The paper concludes that the financial sector plays an even more crucial role these days and drastic measures along with intense supervision must be undertaken so as to work properly and serve the economic world.

Eurasian Economic Community: Towards Integration. Economic Challenges and Geostrategic Aspects  [PDF]
Georgios L. Vousinas
Modern Economy (ME) , 2014, DOI: 10.4236/me.2014.59088

The present study deals with Eurasian Economic Community (EurAsEC), a relatively new entity that appeared in the post-Soviet region, which tries to join the neighboring countries into a strong and structured union. The paper presents the integration steps that have been taken so far and examines the economic challenges faced as well as the geostrategic aspects. A comparison with the benchmark of the surrounding area, the European Union, is also undertaken in order to investigate both the similarities and differences among them and show if they could co-exist in the years to come. The main purpose of this study is to examine the reasons for the union’s formation, shed light on its economic prospects and highlight the newly established geostrategic conditions in such a crucial territory of the world.

Trends in Central Bank Transparency  [PDF]
Georgios Oikonomou, Eleftherios Spyromitros
Theoretical Economics Letters (TEL) , 2017, DOI: 10.4236/tel.2017.77142
Abstract: In this paper we have updated Central Bank Transparency Index from 2011 to 2016, following the methodology of Eijffinger and Geraats (2006) [1]. Then, we break down the index’s aspects and we analyze which are more likely to be changed through time. This, in respect to the annual data we have collected, makes clearer how the recent financial crisis has affected the Central Banks’ transparency trend and offers interesting insights for monetary policy transmission. Also, we divided the countries into developed, emerging and frontiers, as there is difference in their indexes changes, probably related to their economic and financial development.
Strong Electric Field in 2D Graphene: The Integer Quantum Hall Regime from a Different (Many-Body) Perspective  [PDF]
Georgios Konstantinou, Konstantinos Moulopoulos
Advances in Materials Physics and Chemistry (AMPC) , 2018, DOI: 10.4236/ampc.2018.81003
Abstract: We investigate the emerging consequences of an applied strong in-plane electric field on a macroscopically large graphene sheet subjected to a perpendicular magnetic field, by determining in exact analytical form various many-body thermodynamic properties and the Hall coefficient. The results suggest exotic possibilities that necessitate very careful experimental investigation. In this alternate form of Quantum Hall Effect, non-linear phenomena related to the global magnetization, energy and Hall conductivity (the latter depending on the strengths of magnetic B- and electric E-fields) emerge without using perturbation methods, to all orders of E-field and B-field strengths. Interestingly enough, when the value of the electric field is sufficiently strong, fractional quantization also emerges, whose topological stability has to be verified.
Global Production Estimation of Rare Earth Elements and Their Environmental Impacts on Soils  [PDF]
Georgios Charalampides, Konstantinos I. Vatalis
Journal of Geoscience and Environment Protection (GEP) , 2015, DOI: 10.4236/gep.2015.38007
Abstract: Due to high demand and limited availability of rare earth elements (REEs), Europe is unable to meet its industrial needs, especially High Tech needs, today for the manufacturing sector. Therefore, the EU has included them in the group of 14 critical minerals. China currently controls completely the mining activity, the enrichment technologies and metallurgy, and end-metal products of rare earths, resulting both Europe and the U.S.A. in full industrial dependency. The exploitation and wide use of REEs in fertilizers have led to accumulation of these elements in soils, resulting in an agriculture field pollution, which affects directly the soil microfauna with a toxic potential effect.
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