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Search Results: 1 - 10 of 128422 matches for " George T. Calvert "
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Extra-Abdominal Desmoid Tumors Associated with Familial Adenomatous Polyposis
George T. Calvert,Michael J. Monument,Randall W. Burt,Kevin B. Jones,R. Lor Randall
Sarcoma , 2012, DOI: 10.1155/2012/726537
Abstract: Extra-abdominal desmoid tumors are a significant cause of morbidity in patients with familial adenomatous polyposis syndrome. Understanding of the basic biology and natural history of these tumors has increased substantially over the past decade. Accordingly, medical and surgical management of desmoid tumors has also evolved. This paper analyzes recent evidence pertaining to the epidemiology, molecular biology, histopathology, screening, and treatment of extra-abdominal desmoid tumors associated with familial adenomatous polyposis syndrome.
Extra-Abdominal Desmoid Tumors Associated with Familial Adenomatous Polyposis
George T. Calvert,Michael J. Monument,Randall W. Burt,Kevin B. Jones,R. Lor Randall
Sarcoma , 2012, DOI: 10.1155/2012/726537
Abstract: Extra-abdominal desmoid tumors are a significant cause of morbidity in patients with familial adenomatous polyposis syndrome. Understanding of the basic biology and natural history of these tumors has increased substantially over the past decade. Accordingly, medical and surgical management of desmoid tumors has also evolved. This paper analyzes recent evidence pertaining to the epidemiology, molecular biology, histopathology, screening, and treatment of extra-abdominal desmoid tumors associated with familial adenomatous polyposis syndrome. 1. Introduction Desmoid tumors (DTs), also known as aggressive fibromatosis, are fibroblastic neoplasms which are often locally aggressive but lack metastatic potential. They may occur sporadically or in association with familial adenomatous polyposis (FAP) syndrome. Among individuals with FAP, desmoids most frequently occur in intra-abdominal and abdominal wall locations with most arising from the peritoneum. These abdominal desmoids range in severity from indolent, asymptomatic lesions to highly invasive, sometimes fatal tumors. Although less common than abdominal desmoids and very rarely fatal, extra-abdominal desmoids are also a significant cause of morbidity in this population. This paper will review recent developments in the diagnosis, screening, treatment, and prognosis of FAP-associated extra-abdominal DTs. 2. Epidemiology of FAP-Associated Desmoid Tumors The overall incidence of DTs has frequently been quoted at 2–4 per million people per year [1, 2]. This estimate is derived from a 1986 Finnish study which used the pathologic records of several regional hospitals and their known catchment area populations to calculate an incidence figure [3]. Recently, the Dutch national pathology database was analyzed, and 519 total desmoid cases in patients over the age of ten were identified from 1999 to 2009. There were 480 sporadic DTs and 39 FAP-DTs. The annual incidence was 3.7 per million overall [4] consistent with the earlier Finnish study. The same nationwide study from The Netherlands identified 1400 patients over the age of ten with FAP during the 1999 to 2009 period. FAP-associated DTs (FAP-DTs) made up 7.5% of all DTs, and the relative risk of an FAP patient developing a DT was over 800-fold higher than the general population [4]. The Dutch study was limited by the use of pathologic specimens as many DTs may be identified based upon history, physical exam, and imaging but not biopsied or surgically excised especially in the FAP cohort. Additionally, some individuals with sporadic DTs may have had as yet
At-Risk Populations for Osteosarcoma: The Syndromes and Beyond
George T. Calvert,R. Lor Randall,Kevin B. Jones,Lisa Cannon-Albright,Stephen Lessnick,Joshua D. Schiffman
Sarcoma , 2012, DOI: 10.1155/2012/152382
Abstract: Osteosarcoma is the most common primary malignancy of bone. Most cases are sporadic without a known genetic or environmental cause. Heritable genetic predisposition syndromes are associated with a small percentage of osteosarcomas. Study of these rare disorders has provided insight into the molecular pathogenesis of osteosarcoma. Screening of at-risk families and surveillance of affected individuals for these syndromes may permit earlier diagnosis and more effective treatment of osteosarcoma in these populations. This paper reviews the genetic and clinical features of the known osteosarcoma predisposition syndromes.
At-Risk Populations for Osteosarcoma: The Syndromes and Beyond
George T. Calvert,R. Lor Randall,Kevin B. Jones,Lisa Cannon-Albright,Stephen Lessnick,Joshua D. Schiffman
Sarcoma , 2012, DOI: 10.1155/2012/152382
Abstract: Osteosarcoma is the most common primary malignancy of bone. Most cases are sporadic without a known genetic or environmental cause. Heritable genetic predisposition syndromes are associated with a small percentage of osteosarcomas. Study of these rare disorders has provided insight into the molecular pathogenesis of osteosarcoma. Screening of at-risk families and surveillance of affected individuals for these syndromes may permit earlier diagnosis and more effective treatment of osteosarcoma in these populations. This paper reviews the genetic and clinical features of the known osteosarcoma predisposition syndromes. 1. Introduction Osteosarcoma is the most common primary malignant bone tumor. It has a bimodal age distribution with the larger peak among adolescents and young adults and a second smaller peak among the elderly [1]. The majority of osteosarcoma cases are sporadic with no identifiable genetic or environmental cause [2]. A small and unknown percentage of osteosarcomas occur in individuals with cancer predisposition syndromes. A review of the Dutch National Pathology Register identified secondary malignancies in 7% of osteosarcoma patients, indicating possible hereditary cancer syndromes in these patients [3]. A nationwide study from Sweden found significant associations between childhood osteosarcoma and several parental cancers including rectal cancer, colon cancer, endocrine cancers, melanoma, and breast cancer [4]. The known osteosarcoma predisposition syndromes include Li-Fraumeni syndrome (LFS), hereditary retinoblastoma (RB), Rothmund-Thomson syndrome (RTS) type 2, Werner syndrome (WS), Bloom syndrome (BS), RAPADILINO syndrome, and Diamond Blackfan anemia (DBA). The epidemiology, clinical findings, genetics, treatment, and screening recommendations for these syndromes will be reviewed. Additionally, insights into the pathogenesis of osteosarcoma derived from these syndromes will be discussed. 2. Li-Fraumeni Syndrome (TP53) 2.1. Description and Diagnosis In 1969, Li and Fraumeni described a clinical phenotype and syndrome associated with soft tissue sarcomas, breast cancer, and other cancers [5]. Germline mutations of the TP53 gene were first identified among familial cohorts with LFS in 1990 (Table 1) [6, 7]. TP53 acts as a cell cycle regulator, and mutations of TP53 are found in approximately 50% of human cancers [8]. This mutation has subsequently been identified as causative in approximately 70% of individuals with LFS [9, 10]. Another gene, CHEK2, was initially believed to be the responsible gene in some of the LFS families who did
Continuously Variable Bandwidth Sharp FIR Filters with Low Complexity  [PDF]
James T. George, Elizabeth Elias
Journal of Signal and Information Processing (JSIP) , 2012, DOI: 10.4236/jsip.2012.33040
Abstract: In software defined radio (SDR), sharp filters of different bandwidth are required to fine tune the desired channel. This requires different computational resources and large number of filter coefficients. This paper proposes a continuously variable bandwidth sharp finite impulse response (FIR) filter with low distortion and low complexity. For this, a fixed length FIR filter is used with two arbitrary sampling rate converters. This system can be used for both the continuous increase as well as decrease of the effective bandwidth of a filter. The low complexity and sharpness are achieved by using the frequency-response masking (FRM) approach for the design of the fixed length FIR filter. The sharp transition width leads to maximum rejection to channel interference in SDR.
Qualitative research across boundaries of language: the representation of lived experiences.
G Calvert
South African Family Practice , 2003,
Abstract: Background: Qualitative methodology has a growing importance in primary care research, reflected in projects submitted for the degree of MFamMed at The Medical University of Southern Africa (Medunsa). These projects were completed in multilingual settings and sought highly subjective information. This paper aimed to demonstrate how researchers handled issues of language within their work. Methods: All dissertations successfully submitted for the degree of MFamMed at Medunsa between 1993 and 2000 were examined. Those using a predominantly qualitative methodology were subject to content analysis. Results: Researchers acknowledged issues of language and developed a range of strategies to ensure the faithful representation of their subjects' beliefs and attitudes in the language of the final dissertation. Conclusions: Working across boundaries of language presents a potential threat to the faithful representation of qualitative data. Examination of these examples of qualitative research point to some ways in which loss of meaning may be minimised. The paper calls for a close examination of issues of language in research of this nature.
Review of Gender, Health and Information Technology in Context. Edited by Ellen Balka, Eileen Green, and Flis Henwood.
Scout Calvert
International Journal of Gender, Science and Technology , 2010,
Abstract:
Wardrop equilibria in an infinite network
Bruce Calvert
Le Matematiche , 2000,
Abstract: In a finite network, there is a classical theory of traffic flow, which gives existence of a Wardrop equilibrium for given OD demands and affine route costs. In this note, the existence theory is extended to infinite networks.
Deakin University: Going online at a Dual Mode University
Jocelyn Calvert
International Review of Research in Open and Distance Learning , 2001,
Abstract: Deakin is a dual mode university with more than half of its students doing at least part of their study at a distance and with an entrepreneurial arm that provides distance education services for even larger numbers. Online provision has been developing over a decade, enriching traditional distance education in programs with mixtures of on- and off-campus students. It has been supported by central services and corporate applications, leading to reasonable consistency in the thrust. A current aim is to ensure that it is sustainable at a high level of quality.
The Isomorphism Problem for Computable Abelian p-Groups of Bounded Length
Wesley Calvert
Mathematics , 2004,
Abstract: Theories of classification distinguish classes with some good structure theorem from those for which none is possible. Some classes (dense linear orders, for instance) are non-classifiable in general, but are classifiable when we consider only countable members. This paper explores such a notion for classes of computable structures by working out a sequence of examples. We follow recent work by Goncharov and Knight in using the degree of the isomorphism problem for a class to distinguish classifiable classes from non-classifiable. In this paper, we calculate the degree of the isomorphism problem for Abelian $p$-groups of bounded Ulm length. The result is a sequence of classes whose isomorphism problems are cofinal in the hyperarithmetical hierarchy. In the process, new back-and-forth relations on such groups are calculated.
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