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Search Results: 1 - 10 of 33346 matches for " Gemma; Martínez "
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El web de la Biblioteca de la Universitat Pompeu Fabra : un disseny orientat a l'usuari
Cantos Puig, Carme,Garcia, Gemma,Losada, Marina,Martínez, Mercè
BiD : Textos Universitaris de Biblioteconomia i Documentació , 2003,
Abstract: L article explica el desenvolupament d un estudi d usabilitat del lloc web de la Biblioteca de la Universitat Pompeu Fabra. L estudi es dugué a terme mitjan ant una enquesta que es distribuí a una mostra de 100 usuaris i un test d usabilitat que realitzaren vuit usuaris més. De l anàlisi dels resultats es van obtenir dades significatives sobre com interactuen els usuaris amb la interfície web de la Biblioteca, així com de les necessitats d informació. L estudi d usabilitat va ser un instrument molt valuós que va facilitar la introducció de millores en l organització, el disseny i la navegació del lloc web.
L’Anaphore associative: contigüité métonymique
Gemma Pe?a Martínez,Ma Amparo Olivares Pardo
Ibérica , 2008,
Abstract: Cet article porte sur les rapports de contigüité exigés lors de la résolution des anaphores associatives. Il s’agit en général de relations métonymiques, car les différents rapports, à caractère notamment socioculturel, entre référent et marque anaphorique convergent dans un même cadre conceptuel, se faisant écho d’éléments ou caractéristiques du même domaine cognitif. L’anaphore associative reprenant ainsi un attribut concret du référent, nous envisageons donc une classification de ces marques anaphoriques d’après des rapports métonymiques, tels que partie à tout, objet à matière et caractéristique ou propriété à objet.
La comunidad Recursos y datos primarios de la Universitat Pompeu Fabra: los repositorios institucionales como infraestructuras científicas: estudio de caso
Arano, Silvia,Martínez, Gemma,Losada, Marina,Villegas, Marta
Revista Espa?ola de Documentación Científica , 2011,
Abstract: This article presents an initial approach to open access publication of research data from the humanities. It is a case study of the creation of two data collections at the institutional repository of the Universitat Pompeu Fabra, one containing the annexes of doctoral theses and the other, language tools and resources. Finally, we analyze the experience and draw conclusions regarding the use of repositories as infrastructure. El artículo presenta una primera aproximación a la publicación en acceso abierto de datos resultantes de la investigación en el área de humanidades. Describe el estudio de caso implementado en el repositorio institucional de la Universitat Pompeu Fabra, a partir de la creación de dos colecciones con datos, una para los anexos presentes en las tesis y otra para las herramientas y recursos lingüísticos. Finalmente se analiza la experiencia realizada y se extraen algunas conclusiones respecto a la utilización de los repositorios como infraestructuras.
La evaluación del abuso sexual infantil: comparación entre informes periciales en función del diagnóstico de abuso
Pons-Salvador,Gemma; Martínez,Alicia; Pérez,María; Borrás,Juan J.;
Intervención Psicosocial , 2006, DOI: 10.4321/S1132-05592006000300006
Abstract: the aim of this study was to compare the characteristics of confirmed cases of child sexual abuse assessed by skilled professionals versus cases where abuse was not confirmed. the study examined data concerning 61 children who were referred for diagnosis to a specialized team of evaluators. the factors were grouped in three areas: family characteristics, assessment process and psychological impact. the results showed that in the confirmed cases the children were more likely to be in families with severe relation problems and/or drug addictions in one or both parents and reporting negative feelings toward the alleged perpetrator. moreover, it was also more likely that in the confirmed cases, the victim was one to report the abuse and showed sexualized behavior or sexual knowledge inappropriate for their age.
Genetic origin, admixture, and asymmetry in maternal and paternal human lineages in Cuba
Isabel Mendizabal, Karla Sandoval, Gemma Berniell-Lee, Francesc Calafell, Antonio Salas, Antonio Martínez-Fuentes, David Comas
BMC Evolutionary Biology , 2008, DOI: 10.1186/1471-2148-8-213
Abstract: The Native American contribution to present-day Cubans accounted for 33% of the maternal lineages, whereas Africa and Eurasia contributed 45% and 22% of the lineages, respectively. This Native American substrate in Cuba cannot be traced back to a single origin within the American continent, as previously suggested by ancient DNA analyses. Strikingly, no Native American lineages were found for the Y-chromosome, for which the Eurasian and African contributions were around 80% and 20%, respectively.While the ancestral Native American substrate is still appreciable in the maternal lineages, the extensive process of population admixture in Cuba has left no trace of the paternal Native American lineages, mirroring the strong sexual bias in the admixture processes taking place during colonial times.At the time of the arrival of Columbus to Cuba in 1492, two different Native American groups inhabited the island: the Ciboneys, spread across the whole island, and the Tainos, mainly occupying the Central and Eastern regions of Cuba [1]. Although not much is known of Ciboney culture including their language, it is known that their economy was based on hunter-gathering (mainly fishing and hunting) and lacked pottery, unlike the Tainos, who were sedentary people living in large settlements and whose culture was supported by technically advanced agriculture. The social organization of the Tainos was based on chiefdoms, in which the caciques were the social authority. The Tainos spoke Arawakan, a language belonging to both the Equatorial sub-family and the Equatorial-Tucanoan family [1].Who first colonized the Caribbean islands is still a matter of debate. Geographical, archaeological and linguistic evidence [2-4], as well as ancient DNA data [5,6] suggest that the Caribbean was most likely populated by successive waves of migration originating in the Lower Orinoco Valley in South America, taking advantage of the close geographical proximity of the islands in the Caribbean. Therefo
D-cycloserine in Prelimbic Cortex Reverses Scopolamine-Induced Deficits in Olfactory Memory in Rats
Marta Portero-Tresserra, Paula Cristóbal-Narváez, Margarita Martí-Nicolovius, Gemma Guillazo-Blanch, Anna Vale-Martínez
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0070584
Abstract: A significant interaction between N-methyl-D-aspartate (NMDA) and muscarinic receptors has been suggested in the modulation of learning and memory processes. The present study further investigates this issue and explores whether d-cycloserine (DCS), a partial agonist at the glycine binding site of the NMDA receptors that has been regarded as a cognitive enhancer, would reverse scopolamine (SCOP)-induced amnesia in two olfactory learning tasks when administered into the prelimbic cortex (PLC). Thus, in experiment 1, DCS (10 μg/site) was infused prior to acquisition of odor discrimination (ODT) and social transmission of food preference (STFP), which have been previously characterized as paradigms sensitive to PLC muscarinic blockade. Immediately after learning such tasks, SCOP was injected (20 μg/site) and the effects of both drugs (alone and combined) were tested in 24-h retention tests. To assess whether DCS effects may depend on the difficulty of the task, in the STFP the rats expressed their food preference either in a standard two-choice test (experiment 1) or a more challenging three-choice test (experiment 2). The results showed that bilateral intra-PLC infusions of SCOP markedly disrupted the ODT and STFP memory tests. Additionally, infusions of DCS alone into the PLC enhanced ODT but not STFP retention. However, the DCS treatment reversed SCOP-induced memory deficits in both tasks, and this effect seemed more apparent in ODT and 3-choice STFP. Such results support the interaction between the glutamatergic and the cholinergic systems in the PLC in such a way that positive modulation of the NMDA receptor/channel, through activation of the glycine binding site, may compensate dysfunction of muscarinic neurotransmission involved in stimulus-reward and relational learning tasks.
Spain in the Construction of the Euro- African Migrations Scenario
Gemma Pinyol Jiménez
Revista CIDOB d'Afers Internacionals , 2007,
Abstract: During 2005, several events took place on the external borders of the European Union that caught the attention of the media and brought management and control of these borders onto the EU political agenda. Having acknowledged that a global approach to migrations is required, the EU has stated the need for its immigration policy to possessa coherent external affairs dimension, and recognises that both the Mediterranean and Africa have become priority regions. In December 2005, and in the Conclusions of the Presidency of the Council of Brussels, the Union acknowledged the growing importance of the phenomenon of migration within its territory, and highlighted the need to find an approach that would signify, at the very minimum, increased dialogue and cooperation with the African nations and with all the countries within the Mediterranean space. To this end,the Euro-African Conference on Migrations and Development, held in Rabat in 2006, was the first and the most visible gesture toward a consolidation of the acknowledgment that the management of migration flows requires the participation of the countries of origin, transitand destination; that is to say, the countries of Europe, North Africa and the sub-Saharan region. The aim of this article is to reflect on the role that Spain has played in the political organisation of the Euro-African migrations scenario.
Selection of Reference Genes for Quantitative Real Time PCR (qPCR) Assays in Tissue from Human Ascending Aorta
Carmen Rueda-Martínez, Oscar Lamas, María José Mataró, Juan Robledo-Carmona, Gemma Sánchez-Espín, Manuel Jiménez-Navarro, Miguel Such-Martínez, Borja Fernández
PLOS ONE , 2014, DOI: 10.1371/journal.pone.0097449
Abstract: Dilatation of the ascending aorta (AAD) is a prevalent aortopathy that occurs frequently associated with bicuspid aortic valve (BAV), the most common human congenital cardiac malformation. The molecular mechanisms leading to AAD associated with BAV are still poorly understood. The search for differentially expressed genes in diseased tissue by quantitative real-time PCR (qPCR) is an invaluable tool to fill this gap. However, studies dedicated to identify reference genes necessary for normalization of mRNA expression in aortic tissue are scarce. In this report, we evaluate the qPCR expression of six candidate reference genes in tissue from the ascending aorta of 52 patients with a variety of clinical and demographic characteristics, normal and dilated aortas, and different morphologies of the aortic valve (normal aorta and normal valve n = 30; dilated aorta and normal valve n = 10; normal aorta and BAV n = 4; dilated aorta and BAV n = 8). The expression stability of the candidate reference genes was determined with three statistical algorithms, GeNorm, NormFinder and Bestkeeper. The expression analyses showed that the most stable genes for the three algorithms employed were CDKN1β, POLR2A and CASC3, independently of the structure of the aorta and the valve morphology. In conclusion, we propose the use of these three genes as reference genes for mRNA expression analysis in human ascending aorta. However, we suggest searching for specific reference genes when conducting qPCR experiments with new cohort of samples.
Common Variants of the Liver Fatty Acid Binding Protein Gene Influence the Risk of Type 2 Diabetes and Insulin Resistance in Spanish Population
Maria Luisa Mansego,Fernando Martínez,Maria Teresa Martínez-Larrad,Carina Zabena,Gemma Rojo,Sonsoles Morcillo,Federico Soriguer,Juan Carlos Martín-Escudero,Manuel Serrano-Ríos,Josep Redon,Felipe Javier Chaves
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0031853
Abstract: The main objective was to evaluate the association between SNPs and haplotypes of the FABP1-4 genes and type 2 diabetes, as well as its interaction with fat intake, in one general Spanish population. The association was replicated in a second population in which HOMA index was also evaluated.
Heat Shock Response in Yeast Involves Changes in Both Transcription Rates and mRNA Stabilities
Laia Castells-Roca,José García-Martínez,Joaquín Moreno,Enrique Herrero,Gemma Bellí,José E. Pérez-Ortín
PLOS ONE , 2012, DOI: 10.1371/journal.pone.0017272
Abstract: We have analyzed the heat stress response in the yeast Saccharomyces cerevisiae by determining mRNA levels and transcription rates for the whole transcriptome after a shift from 25°C to 37°C. Using an established mathematical algorithm, theoretical mRNA decay rates have also been calculated from the experimental data. We have verified the mathematical predictions for selected genes by determining their mRNA decay rates at different times during heat stress response using the regulatable tetO promoter. This study indicates that the yeast response to heat shock is not only due to changes in transcription rates, but also to changes in the mRNA stabilities. mRNA stability is affected in 62% of the yeast genes and it is particularly important in shaping the mRNA profile of the genes belonging to the environmental stress response. In most cases, changes in transcription rates and mRNA stabilities are homodirectional for both parameters, although some interesting cases of antagonist behavior are found. The statistical analysis of gene targets and sequence motifs within the clusters of genes with similar behaviors shows that both transcriptional and post-transcriptional regulons apparently contribute to the general heat stress response by means of transcriptional factors and RNA binding proteins.
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