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Search Results: 1 - 10 of 702 matches for " Gemma Fuster "
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Formoterol May Activate Rat Muscle Regeneration During Cancer Cachexia
Elisabet Ametller,Sílvia Busquets,Gemma Fuster,Maria T. Figueras
Insciences Journal , 2011,
Abstract: PURPOSE: The development of cancer cachexia is the most common manifestation of advanced malignant disease. METHOD: The effects on muscle regeneration of 2-adrenoceptor agonist formoterol (0.3 mg/kg) were tested in cachectic tumour-bearing rats (Yoshida AH-130 ascites hepatoma). RESULTS: Administration of formoterol results in a significant increase in the mass and protein content of tibialis muscle in tumour-bearing-rats. This increase is associated with a decreased myogenin mRNA content together with an increased Pax-7 gene expression. Bupivacaine treatment by local injection results in an important reduction in tibialis weight together with significant increases in Pax-7, myogenin and MyoD gene expression. Formoterol treatment in bupivacaine-treated rats results in significant increases in Pax-7 together with significant decreases in myogenin mRNA content, suggesting that this 2-agonist is favouring muscle regeneration by stimulating the proliferation of satellite cells.Altogether, the data reinforce the potential role of formoterol in the treatment of muscle wasting diseases.
Barrier-Protective Effects of Activated Protein C in Human Alveolar Epithelial Cells
Ferranda Puig, Gemma Fuster, Mélanie Adda, Lluís Blanch, Ramon Farre, Daniel Navajas, Antonio Artigas
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0056965
Abstract: Acute lung injury (ALI) is a clinical manifestation of respiratory failure, caused by lung inflammation and the disruption of the alveolar-capillary barrier. Preservation of the physical integrity of the alveolar epithelial monolayer is of critical importance to prevent alveolar edema. Barrier integrity depends largely on the balance between physical forces on cell-cell and cell-matrix contacts, and this balance might be affected by alterations in the coagulation cascade in patients with ALI. We aimed to study the effects of activated protein C (APC) on mechanical tension and barrier integrity in human alveolar epithelial cells (A549) exposed to thrombin. Cells were pretreated for 3 h with APC (50 μg/ml) or vehicle (control). Subsequently, thrombin (50 nM) or medium was added to the cell culture. APC significantly reduced thrombin-induced cell monolayer permeability, cell stiffening, and cell contraction, measured by electrical impedance, optical magnetic twisting cytometry, and traction microscopy, respectively, suggesting a barrier-protective response. The dynamics of the barrier integrity was also assessed by western blotting and immunofluorescence analysis of the tight junction ZO-1. Thrombin resulted in more elongated ZO-1 aggregates at cell-cell interface areas and induced an increase in ZO-1 membrane protein content. APC attenuated the length of these ZO-1 aggregates and reduced the ZO-1 membrane protein levels induced by thrombin. In conclusion, pretreatment with APC reduced the disruption of barrier integrity induced by thrombin, thus contributing to alveolar epithelial barrier protection.
Injurious mechanical ventilation affects neuronal activation in ventilated rats
María Quilez, Gemma Fuster, Jesús Villar, Carlos Flores, Octavi Martí-Sistac, Lluís Blanch, Josefina López-Aguilar
Critical Care , 2011, DOI: 10.1186/cc10230
Abstract: Male Sprague Dawley rats were randomized to three groups: 1) Basal: anesthetized unventilated animals, 2) low Vt (LVt): MV for three hours with Vt 8 ml/kg and zero positive end-expiratory pressure (ZEEP), and 3) high Vt (HVt) MV for three hours with Vt 30 ml/kg and ZEEP. We measured lung mechanics, mean arterial pressure (MAP), arterial blood gases, and plasma and lung levels of cytokines. We used immunohistochemistry to examine c-fos as a marker of neuronal activation. An additional group of spontaneously breathing rats was added to discriminate the effect of surgical procedure and anesthesia in the brain.After three hours on LVt, PaO2 decreased and PaCO2 increased significantly. MAP and compliance remained stable in MV groups. Systemic and pulmonary inflammation was higher in MV rats than in unventilated rats. Plasma TNFα was significantly higher in HVt than in LVt. Immunopositive cells to c-fos in the retrosplenial cortex and thalamus increased significantly in HVt rats but not in LVt or unventilated rats.MV promoted brain activation. The intensity of the response was higher in HVt animals, suggesting an iatrogenic effect of MV on the brain. These findings suggest that this novel cross-talking mechanism between the lung and the brain should be explored in patients undergoing MV.Acute lung injury (ALI) and the acute respiratory distress syndrome (ARDS) are associated with high morbidity and mortality [1], and ARDS survivors present significant long-term cognitive impairment [2]. These consequences may result from complex interactions between different clinical protocols and endogenous factors occurring simultaneously in critically ill patients [3]. In this context, mechanical ventilation (MV) is a lifesaving procedure but not without complications. Even in healthy lungs, MV may contribute to a positive feedback loop that starts with mechanotransduction (in lungs) at the epithelial and endothelial levels leading to a deleterious inflammatory cascade that might affe
Especies de hormigas asociadas a Prosopis ruscifolia Griseb. en ambientes salinos del Chaco Semiárido
Fuster,A.;
Quebracho (Santiago del Estero) , 2012,
Abstract: different species of ants establish narrow associations among determined families of plants. the ants have beneficial effects on pollination, dispersion of seeds and protection, in exchange for nutritious resources and nesting places offered by the vegetation. prosopis ruscifolia possesses structural and ecological characteristics that may allow it to establish mutually beneficial relationships with ant species present in the environments they inhabit. the goal of this work was to carry out a preliminary study of assembles of ants that it is associated to p. ruscifolia in environmental saline and contributes to the knowledge of the myrmecofauna of the region. the collections of ants were carried out on 52 individuals of p. ruscifolia of saline environments located in the south of santiago del estero. we identified 16 species of ants, six of which would use the "vinal" as a resource for nesting and the other to obtain food. an average of 13,17 individuals was determined and 2,35 species of ants by tree. the diversity and specific richness of ants found in this study offer a valuable knowledge about assembles of ants of saline environments and it is a base line for future studies about the relationship plant-ant in the region, specifically on the "vinal".
Iglesia de la Colonia Güell: Antoni Gaudí (1898-1915)
Fuster, Albert
DC PAPERS : Revista de Crítica y Teoría de la Arquitectura , 2006,
Abstract:
Non-abelian Yang-Mills in Kundt spacetimes
Andrea Fuster
Physics , 2005, DOI: 10.1063/1.2218206
Abstract: We present new exact solutions of the Einstein-Yang-Mills system. The solutions are described by a null Yang-Mills field in a Kundt spacetime. They generalize a previously known solution for a metric of $pp$ wave type. The solutions are formally of Petrov type III.
Magnetic Theory and Applications in the Naples Bay (Southern Tyrrhenian Sea, Italy): Magnetic Anomaly Fields and Relationships with Morpho-Structural Lineaments  [PDF]
Gemma Aiello, Ennio Marsella
World Journal of Condensed Matter Physics (WJCMP) , 2016, DOI: 10.4236/wjcmp.2016.63020
Abstract: Magnetic theory and application to a complex volcanic area located in Southern Italy are here discussed showing the example of the Gulf of Naples, located at Southern Italy Tyrrhenian margin. A magnetic anomaly map of the Gulf of Naples has been constructed aimed at highlighting new knowledge on geophysics and volcanology of this area of the Eastern Tyrrhenian margin, characterized by a complex geophysical setting, strongly depending on sea bottom topography. The theoretical aspects of marine magnetometry and multibeam bathymetry have been discussed. Magnetic data processing included the correction of the data for the diurnal variation, the correction of the data for the offset and the leveling of the data as a function of the correction at the cross-points of the navigation lines. Multibeam and single-beam bathymetric data processing has been considered. Magnetic anomaly fields in the Naples Bay have been discussed through a detailed geological interpretation and correlated with main morpho-structural features recognized through morpho- bathymetric interpretation. Details of magnetic anomalies have been selected, represented and correlated with significant seismic profiles, recorded on the same navigation lines of magnetometry. They include the continental shelf offshore the Somma-Vesuvius volcanic complex, the outer shelf of the Gulf of Pozzuoli offshore the Phlegrean Fields volcanic complex, the relict volcanic banks of Pentapalummo, Nisida and Miseno, the Gaia volcanic bank on the Naples slope, the western slope of the Dohrn canyon, the Magnaghi canyon’s head and the magnetic anomalies among the Ischia and Procida islands.
Chromosomal Bands Affected by Acute Oil Exposure and DNA Repair Errors
Gemma Monyarch, Fernanda de Castro Reis, Jan-Paul Zock, Jesús Giraldo, Francisco Pozo-Rodríguez, Ana Espinosa, Gema Rodríguez-Trigo, Hector Verea, Gemma Casta?o-Vinyals, Federico P. Gómez, Josep M. Antó, Maria Dolors Coll, Joan Albert Barberà, Carme Fuster
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0081276
Abstract: Background In a previous study, we showed that individuals who had participated in oil clean-up tasks after the wreckage of the Prestige presented an increase of structural chromosomal alterations two years after the acute exposure had occurred. Other studies have also reported the presence of DNA damage during acute oil exposure, but little is known about the long term persistence of chromosomal alterations, which can be considered as a marker of cancer risk. Objectives We analyzed whether the breakpoints involved in chromosomal damage can help to assess the risk of cancer as well as to investigate their possible association with DNA repair efficiency. Methods Cytogenetic analyses were carried out on the same individuals of our previous study and DNA repair errors were assessed in cultures with aphidicolin. Results Three chromosomal bands, 2q21, 3q27 and 5q31, were most affected by acute oil exposure. The dysfunction in DNA repair mechanisms, expressed as chromosomal damage, was significantly higher in exposed-oil participants than in those not exposed (p= 0.016). Conclusion The present study shows that breaks in 2q21, 3q27 and 5q31 chromosomal bands, which are commonly involved in hematological cancer, could be considered useful genotoxic oil biomarkers. Moreover, breakages in these bands could induce chromosomal instability, which can explain the increased risk of cancer (leukemia and lymphomas) reported in chronically benzene-exposed individuals. In addition, it has been determined that the individuals who participated in clean-up of the oil spill presented an alteration of their DNA repair mechanisms two years after exposure.
Ciencia, salud y educación. Una prioridad (SHE) y un modelo (CNIC)
Fuster, Valentín;
Archivos de cardiología de México , 2010,
Abstract: myocardial infarction and brain infarction are personally dramatic events. however, these cardiovascular events are also globally dramatic not just for being the first cause of death all over the world. in addition, their prevalence is increasing and the high economic cost of treatment -technological and pharmacological- is already inaccessible in many regions of the world. in light of the above, we have established an international foundation under the priority concept "science, health and education" (she). this foundation is based on a new spanish research and funding model, the "national cardiovascular research center" (cnic). the research aspect is geared towards promoting cardiovascular health and disease management both individually and among the population. funding is public and private, excluding the pharmaceutical industry, which thus prevents conflicts of interest. in the cardiovascular setting, the entity she as conceptual priority, and the cnic as scientific basis or model can be pilot or applicable to other health and disease issues in general.
The fixed point property for renormings of 2
Enrique Llorens-Fuster
Arabian Journal of Mathematics , 2012, DOI: 10.1007/s40065-012-0054-x
Abstract:
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