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Search Results: 1 - 10 of 283 matches for " Geilich BM "
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Reduced adhesion of Staphylococcus aureus to ZnO/PVC nanocomposites
Geilich BM, Webster TJ
International Journal of Nanomedicine , 2013, DOI: http://dx.doi.org/10.2147/IJN.S42010
Abstract: uced adhesion of Staphylococcus aureus to ZnO/PVC nanocomposites Original Research (23) Total Article Views Authors: Geilich BM, Webster TJ Published Date March 2013 Volume 2013:8 Pages 1177 - 1184 DOI: http://dx.doi.org/10.2147/IJN.S42010 Received: 23 December 2012 Accepted: 14 January 2013 Published: 21 March 2013 Benjamin M Geilich,1 Thomas J Webster2 1Program in Bioengineering, 2Department of Chemical Engineering, College of Engineering, Northeastern University, Boston, MA, USA Abstract: In hospitals and clinics worldwide, medical device surfaces have become a rapidly growing source of nosocomial infections. In particular, patients requiring mechanical ventilation (and, thus, intubation with an endotracheal tube) for extended lengths of time are faced with a high probability of contracting ventilator-associated pneumonia. Once inserted into the body, the endotracheal tube provides a surface to which bacteria can adhere and form a biofilm (a robust, sticky matrix that provides protection against the host immune system and antibiotic treatment). Adding to the severity of this problem is the spread of bacterial genetic tolerance to antibiotics, in part demonstrated by the recent and significant increase in the prevalence of methicillin-resistant Staphylococcus aureus. To combat these trends, different techniques in biomaterial design must be explored. Recent research has shown that nanomaterials (materials with at least one dimension less than 100 nm) may have the potential to prevent or disrupt bacterial processes that lead to infections. In this study, polyvinyl chloride (PVC) taken from a conventional endotracheal tube was embedded with varying concentrations of zinc oxide (ZnO) nanoparticles. S. aureus biofilms were then grown on these nanocomposite surfaces during a 24-hour culture. Following this, biofilms were removed from the surfaces and the number of colony forming units present was assessed. Bacterial proliferation on the samples embedded with the highest concentration of ZnO nanoparticles was 87% less when compared to the control, indicating that this technique is effective at reducing biofilm formation on PVC surfaces without the use of antibiotics.
Reduced adhesion of Staphylococcus aureus to ZnO/PVC nanocomposites
Geilich BM,Webster TJ
International Journal of Nanomedicine , 2013,
Abstract: Benjamin M Geilich,1 Thomas J Webster21Program in Bioengineering, 2Department of Chemical Engineering, College of Engineering, Northeastern University, Boston, MA, USAAbstract: In hospitals and clinics worldwide, medical device surfaces have become a rapidly growing source of nosocomial infections. In particular, patients requiring mechanical ventilation (and, thus, intubation with an endotracheal tube) for extended lengths of time are faced with a high probability of contracting ventilator-associated pneumonia. Once inserted into the body, the endotracheal tube provides a surface to which bacteria can adhere and form a biofilm (a robust, sticky matrix that provides protection against the host immune system and antibiotic treatment). Adding to the severity of this problem is the spread of bacterial genetic tolerance to antibiotics, in part demonstrated by the recent and significant increase in the prevalence of methicillin-resistant Staphylococcus aureus. To combat these trends, different techniques in biomaterial design must be explored. Recent research has shown that nanomaterials (materials with at least one dimension less than 100 nm) may have the potential to prevent or disrupt bacterial processes that lead to infections. In this study, polyvinyl chloride (PVC) taken from a conventional endotracheal tube was embedded with varying concentrations of zinc oxide (ZnO) nanoparticles. S. aureus biofilms were then grown on these nanocomposite surfaces during a 24-hour culture. Following this, biofilms were removed from the surfaces and the number of colony forming units present was assessed. Bacterial proliferation on the samples embedded with the highest concentration of ZnO nanoparticles was 87% less when compared to the control, indicating that this technique is effective at reducing biofilm formation on PVC surfaces without the use of antibiotics.Keywords: nanomaterials, endotracheal tube, biofilm, zinc oxide, nanoparticles, Staphylococcus aureus
Genetics and molecular diagnosis of cardiomyopathy: What every doctor should know
BM Mayosi
Continuing Medical Education , 2005,
Abstract:
Determination of pollen viability, germination ratios and morphology of eight apricot genotypes
BM Asma
African Journal of Biotechnology , 2008,
Abstract: Turkey is a leading apricot producing country, with the majority of dried apricot production centered in Malatya. Currently, there are breeding programs to develop superior apricot cultivars for several different utilizations. Determining the components of reproduction biology is critical for optimizing yields from apricot orchards and is therefore important for breeding programs. In this study, the pollen viability and germination ratios were determined for eight apricot cultivars. The genotypes tested included a local cultivar (Kabaay), foreign-origin cultivars (Roksana and Canino), and selections from the n nü University program (Levent, zal, Akyürek, 44-2005-01, 44 K 07). The results indicated that viable, semi-viable and dead pollen rates differed among cultivars, where Roksana had the least amount of viable pollen (41.5%). The genotypes had their highest germination rates at 20°C, whereas Roksana and Levent had the lowest germination rates (46.8 and 48.5%). The germination rates were also affected by sucrose concentrations, and media containing a 15% sucrose concentration had the highest germination rates, while Roksana again had the lowest germination rate (36.4%). While the differences in anther number/flower were not significantly different among genotypes, there were significant differences in pollen number for both anther and flower bases. 44- 2005-01 and Canino had the highest pollen numbers. Pollen morphology was also evaluated using a Scanning Electron Microscope (SEM). Although some size and index differences were measured, the pollen of the genotypes was generally similar in morphology. The findings provide important insight into improving our understanding of apricot reproduction biology.
Caring for the deaf child in the sub-Saharan Africa
BM Ahmad
Nigerian Journal of Surgical Research , 2003,
Abstract: Nigerian Journal of Surgical Research Vol.5(1&2) 2003: 181-184
The Politics Underpinning the Non-realisation of the Right to Development
BM Fikre
Mizan Law Review , 2011,
Abstract: The right to development stands out as one of the controversial rights ever since its articulation in the 1970s. The adoption of the 1986 United Nations Declaration on the Right to Development underlines the importance of international cooperation for it to be realised. I argue that the emphasis on ‘development aid’ rather than the broader ‘development cooperation’ has contributed a great deal to the politicisation of the right and consequently undermined its materialisation. Indeed, there is the need for semantic and conceptual clarity in the use of the term ‘international assistance and cooperation’ that has deceptively supplanted ‘international cooperation.’ While the former is a term used under Article 2(1) of the International Covenant on Economic, Social and Cultural Rights with a view to laying down the broader States Parties’ obligations, the latter is what the Declaration on the Right to Development exclusively employs. I argue that even if development assistance is indispensable, taking it as the sole approach to the realisation of the right to development is both wrong and unhelpful.
Acute peri-operative beta-blockade in South Africa
BM Biccard
Southern African Journal of Anaesthesia and Analgesia , 2006,
Abstract:
Postoperative risk stratification for cardiovascular complications
BM Biccard
Southern African Journal of Anaesthesia and Analgesia , 2012,
Abstract:
Predicting outcome
BM Biccard
Southern African Journal of Anaesthesia and Analgesia , 2012,
Abstract:
Perioperative hyperglycaemia
BM Gardner
South African Family Practice , 2012,
Abstract:
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