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Der "Frühe Patientenkontakt" im Studiengang Zahnmedizin [Community Dentistry and early patient contact at the department of dentistry at the University of Greifswald]
Ratzmann, Anja,Gedrange, Tomas,Korda?, Bernd
GMS Zeitschrift für Medizinische Ausbildung , 2006,
Abstract: [english] The "Early Patient Contact" is a relatively new "Teaching Concept" enabling students to receive an insight early on their studies about patient contact and treatment possibilities. Within the one year visiting program the students had "Hands-on" experience with "real patients". Through accompanying lectures using the "Problem-based learning method" (PBL) students were able to learn about the principles of Community Medicine/Dentistry within the Health Service, and about population relevant illnesses. An evaluation form part of a Questionaire made evident that it is possible to provide considerable improvement of the medical/dental education as regards communication skills and understanding of the patients' perceptions, by letting the student establish contact with patients at the very beginning of the curriculum. The students found that experience of high importance. [german] Das Lehrkonzept "Der Frühe Patientenkontakt" für den Studiengang der Zahnmedizin wird im Rahmen der Community Medicine/Dentistry an der Universit t Greifswald durchgeführt. Die Lehreinheit erstreckt sich über die ersten vier vorklinischen Semester. Die wesentliche Zielstellung besteht darin, den Studierenden bereits zu Beginn des Zahnmedizinstudiums einen Patientenkontakt zu erm glichen und somit das Zahnmedizinstudium frühzeitig patientennah zu gestalten. Sie lernen einen "Echt-Patienten" und dessen Lebenssituation über den Zeitraum von einem Jahr kennen. Anhand von begleitenden Vorlesungen und Seminaren wird das Prinzip der Community Medicine/Dentistry erl utert und die Studierenden werden mit bev lkerungsrelevanten Erkrankungen und Gesundheitsstrukturen bekannt gemacht. Dabei wird unter anderem die Lehrmethode "Problemorientiertes Lernen" angewendet. Das Lehrprojekt wird zu Beginn und zum Abschluss mittels eines speziellen Evaluationsbogens ausgewertet. Die Ergebnisse zeigen, dass die Studierenden den "Frühen Patientenkontakt" zu Beginn des Studiums mehrheitlich positiv bewerten. Das Projekt erm glicht den Teilnehmern erste Erfahrungen im dialogischen Beziehungsaufbau und einen Einblick in die komplexe Pers nlichkeitsstruktur eines "echten Patienten". Die Studierenden halten es für wichtig, bereits frühzeitig reale "Patientenwirklichkeiten" kennen zu lernen.
Cryopreserved tissue engineered mucosa.
Gabriele Spoerl,Ronald Mai,Edith Klingner,Tomas Gedrange
Folia Histochemica et Cytobiologica , 2009, DOI: 10.5603/4392
Abstract: Single cells suspensions used for grafting in the clinical setting may be reliably cryopreserved by established protocols. However, for tissue engineered constructs which now also get used as grafts in the clinic such established protocols and assays which indicate graft viability and their function as graft do not exist. a) The purpose was to develop a cryoprotocol and an animal model to test the efficacy of tissue engineered to act as graft after cryopreservation. b) Therefore, tissue engineered mucosa grafts consisting of keratinocytes and fibroblasts grown in a collagen sponge were cryopreserved and grafted in the nude rat to test its efficacy to function as mucosa graft. At different points after cryopreservation the mucosa was grafted into the nude rats. Healing of grafts was allowed for one or three weeks. c) Sufficient cells survived the cryopreservation allowing for the development of epithelial-fibroblast tissue in the collagen sponge. After three weeks of healing the formation of mucosa tissue was more complete and more collagen sponge had disappeared. d) The nude rat model is suitable to assess the efficacy of tissue engineered mucosa to function as graft after cryopreservation. The formation of human epithelial-fibroblast tissue in vivo has to be interpreted as proof of principle that the approach of cryopreservation of tissue engineered grafts is working.
The role of apoptosis in early embryonic development of the adenohypophysis in rats
Jens Weing?rtner, Kristina Lotz, Andreas Faltermeier, Oliver Driemel, Johannes Kleinheinz, Tomas Gedrange, Peter Proff
Head & Face Medicine , 2008, DOI: 10.1186/1746-160x-4-13
Abstract: The developing adenohypophysis area of rat fetuses was studied at the embryonic stage 13.5 (gestational day) for apoptotic and proliferative cell activities using histological serial sections.A high cell proliferation rate was observed throughout the adenohypophysis. In contrast, apoptotic cells visualized by evidence of active caspase-3, were detected only in the basal epithelial cones as an introducing event for fusion and closure of the pharyngeal roof.We can clearly show an increasing number of apoptotic events only at the basic fusion sides of the adenohypophysis as well as in the opening region of this organ. Apoptotic destruction of epithelial cells at the basal cones of the adenohypophysis begins even before differentiation of the adenohypophyseal cells and their contact with the neurohypophysis. In early stages of development, thus, apoptotic activity of the adenohypophysis is restricted to the basal areas mentioned. In our test animals, the adenohypophysis develops after closure of the anterior neuroporus.The adenohypophysis (Rathke pouch) is derived from the ectoderm and develops during the embryonic stage in the pharyngeal roof in front of the pharyngeal membrane before the anterior neuroporus closes. According to Starck (1975), the primordial Rathke pouch (saccus hypophysealis) is a transverse depression in the pharyngeal roof abutting the bottom of the diencephalon without interposed mesenchymal cells [1]. Later, the pouch loses connection with the pharyngeal roof, while a multitude of mesenchymal cells moves between the pharygeal roof and the bottom of the brain [2]. These mesenchymal cells later differentiate into the primordia of the cranial base. The cells of the adenohypophysis proliferate toward the bottom of the brain and further differentiate into hormone-secreting cells. An epithelial bridge may persist between the closed adenohypophysis and the pharyngeal roof (canalis craniophanryngeus) for a longer period. Occasionally, in 2% of the cases [
Early loading of plalatal implants (ortho-type II) a prospective multicenter randomized controlled clinical trial
Britta A Jung, Heinrich Wehrbein, Werner Hopfenmüller, Winfried Harzer, Tomasz Gedrange, Peter Diedrich, Martin Kunkel
Trials , 2007, DOI: 10.1186/1745-6215-8-24
Abstract: The intended study is designed as a prospective, multicenter randomized controlled trial (RCT), comparing and contrasting the effect of early loading of palatal implant therapy versus implant loading after 12 weeks post implantation using the new ortho-implant type II anchor system device (Orthosystem Straumann, Basel, Switzerland).124 participants, mainly adult males or females, whose diagnoses require temporary stationary implant-based anchorage treatment will be randomized 1:1 to one of two treatment groups: group 1 will receive a loading of implant standard therapy after a healing period of 12 week (gold standard), whereas group 2 will receive an early loading of orthodontic implants within 1 week after implant insertion. Participants will be at least followed for 12 months after implant placement.The primary endpoint is to investigate the behavior of early loaded palatal implants in order to find out if shorter healing periods might be justified to accelerate active orthodontic treatment. Secondary outcomes will focus e.g. on achievement of orthodontic treatment goals and quantity of direct implant-bone interface of removed bone specimens. As tertiary objective, a histologic and microtomography evaluation of all retrieved implants will be performed to obtain data on the performance of the SLA surface in human bone evaluation of all retrieved implants. Additionally, resonance frequency analysis (RFA, Osstell? mentor) will be used at different times for clinically monitoring the implant stability and for histological comparison in order to measure the reliability of the resonance frequency measuring device.Current Controlled Trials ISRCTN97142521.Control of anchorage for orthodontic tooth movements represents a fundamental problem in the treatment of dental and skeletal dysgnathia. Available anchorage potential [1,2], and that required for each anchoring task, must be taken into consideration if undesired tooth movements and anchorage loss are to be avoided. To a
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