OALib Journal期刊

ISSN: 2333-9721



匹配条件: “Gayani Thalagoda” ,找到相关结果约9条。
Cointegration Based Regression to Analyse Linkage between Share Price Index and Macroeconomic Variables: Evidence from Colombo Stock Exchange  [PDF]
Gayani Thalagoda, Kusal Rathnayake, Sachith Abeysundara
Open Access Library Journal (OALib Journal) , 2018, DOI: 10.4236/oalib.1104955
The main objective of the study is to investigate the long run performance of the All Share Price Index (ASPI) of the Colombo Stock Exchange, based on the economic activities of Sri Lanka using cointegration and auto regressive time series. The cointegration test illustrates that share price index is cointegrated with a specific set of macroeconomic variables, i.e. exchange rate (USD/LKR), money supply, wage rates, wet foreign assets, currency in circulation, imports and exports with 95% confidence. The study also proposes a regression model using Eigen Vector coefficients to predict the behavior of ASPI index in the long run. The model performance, evaluated using the residuals of the test data, represents a random behavior indicating a valid long-run cointegration regression relationship between ASPI and other macroeconomic variables. Future studies involve analysis of the short-run relationship among the macroeconomic variables using Vector Error Correlation Model.
Teaching with wikis: improving staff development through action research
Robyn Benson,Charlotte Brack,Gayani Samarwickrema
Research in Learning Technology , 2012, DOI: 10.3402/rlt.v20i0.16149
Abstract: This paper reports on the use of action research in a case study involving two iterations of an online workshop implemented at two universities in late 2007 and early 2009 to prepare teaching staff for using wikis for student group work and assessment. Workshop participants were immersed in the experience of collaborating in a wiki as learners and then reflected on this experience as teachers. Experience of the pilot workshop suggested a need for more orientation, potentially by introducing a blended learning design. The second iteration highlighted a need to develop the orientation session further and increase support strategies throughout the workshop, suggesting the value of offering it at faculty or department level if no “reward” is available for participation. Outcomes from the two cycles illustrate the value of action research for iterative improvement of this staff development model and for implementing the scholarship of teaching and learning to develop and share professional knowledge in this emerging area. This paper outlines a staff development approach involving Web 2.0 applications on which others can build.
Bone mineral accrual and gain in skeletal width in pre-pubertal school children is independent of the mode of school transportation – one-year data from the prospective observational pediatric osteoporosis prevention (POP) study
Gayani Alwis, Christian Linden, Magnus Dencker, Susanna Stenevi-Lundgren, Per Gardsell, Magnus K Karlsson
BMC Musculoskeletal Disorders , 2007, DOI: 10.1186/1471-2474-8-66
Abstract: Ninety-seven girls and 133 boys aged 7–9 years were recruited as a part of the Malm? Pediatric Osteoporosis Prevention (POP) Study in order to evaluate the influence of self-selected school transportation for the accrual of bone mineral and bone width. Children who walked or cycled to school were compared with children who went by bus or car. Bone mineral content (BMC) was measured by dual energy X-ray absorptiometry (DXA) in the lumbar spine (L2–L4), third lumbar vertebra (L3) and hip, and bone width was calculated at L3 and femoral neck (FN). Changes during the first 12 months were compared between the groups. Subjective duration of physical activity was estimated by a questionnaire and objective level of everyday physical activity at follow-up by accelerometers worn for four consecutive days. All children remained in Tanner stage 1 throughout the study. Comparisons were made by independent student's t-tests between means, ANCOVA and Fisher's exact tests.There were no differences in baseline or annual changes in BMC or bone width when the transportation groups were compared. No differences were detected in objectively measured daily level of physical activity by accelerometer. All children reached above 60 minutes of moderate to intense daily physical activity per day, the international recommended level of daily physical activity according to the United Kingdom Expert Consensus Group.The everyday physical activity in these pre-pubertal children seems to be so high that the school transportation contributes little to their total level of physical activity. As a result, the choice of school transportation seems not to influence the accrual of bone mineral or gain in bone size during a 12-month follow-up period.Osteoporosis is a risk factor for fractures, a significant cause of morbidity and mortality in the elderly [1]. At present work is devoted to preventing low areal bone mineral density (aBMD). Over the past two decades, research has focused on whether modifiab
In silico analysis of Single Nucleotide Polymorphisms (SNPs) in the Heparin-Binding EGF-like Growth Factor (HBEGF) gene and their allelic profiles in the Sri Lankan population: a comprehensive approach to prioritise SNPs for candidate gene studies
G.Gayani Harendra,Rohan W. Jayasekara,Vajira H.W. Dissanayake
Sri Lanka Journal of Bio-Medical Informatics , 2011, DOI: doi: http://dx.doi.org/10.4038/sljbmi.v2i1.2926
Abstract: In this paper, using the Heparin-Binding EGF-like growth factor (HBEGF) gene, we illustrate a comprehensive approach to select the most appropriate SNP markers for molecular epidemiological studies. Initially an in silico functional analysis was undertaken to verify the SNPs that regulate HBEGF expression. Thereafter based on predefined criteria (the significance of the function identified, ability to represent other SNPs in the gene (being a tagSNP), presence within an evolutionary conserved region, validation status of the SNP, and the minor allele frequency of the SNP) SNPs with putative functional effects were prioritised to identify the most appropriate HBEGF markers for molecular epidemiological studies. Using 30 Sinhalese men and women, we further established the allele and genotype frequencies of the seven highest priority SNPs identified. These frequencies were compared with those of HapMap populations to understand the genetic identity of the Sinhalese in relation to HapMap populations.
Prolonged Internal Displacement and Common Mental Disorders in Sri Lanka: The COMRAID Study
Chesmal Siriwardhana, Anushka Adikari, Gayani Pannala, Sisira Siribaddana, Melanie Abas, Athula Sumathipala, Robert Stewart
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0064742
Abstract: Background Evidence is lacking on the mental health issues of internally displaced persons, particularly where displacement is prolonged. The COMRAID study was carried out in year 2011 as a comprehensive evaluation of Muslims in North-Western Sri Lanka who had been displaced since 1990 due to conflict, to investigate the prevalence and correlates of common mental disorders. Methods A cross-sectional survey was carried out among a randomly selected sample of internally displaced people who had migrated within last 20 years or were born in displacement. The total sample consisted of 450 adults aged 18–65 years selected from 141 settlements. Common mental disorders (CMDs) and post-traumatic stress disorder (PTSD) prevalences were measured using the Patient Health Questionnaire and CIDI sub-scale respectively. Results The prevalence of any CMD was 18.8%, and prevalence for subtypes was as follows: somatoform disorder 14.0%, anxiety disorder 1.3%, major depression 5.1%, other depressive syndromes 7.3%. PTSD prevalence was 2.4%. The following factors were significantly associated with CMDs: unemployment (odds ratio 2.8, 95% confidence interval 1.6–4.9), widowed or divorced status (4.9, 2.3–10.1) and food insecurity (1.7, 1.0–2.9). Conclusions This is the first study investigating the mental health impact of prolonged forced displacement in post-conflict Sri Lanka. Findings add new insight in to mental health issues faced by internally displaced persons in Sri Lanka and globally, highlighting the need to explore broader mental health issues of vulnerable populations affected by forced displacement.
A one-year exercise intervention program in pre-pubertal girls does not influence hip structure
Gayani Alwis, Christian Linden, Susanna Stenevi-Lundgren, Henrik G Ahlborg, Jack Besjakov, Per Gardsell, Magnus K Karlsson
BMC Musculoskeletal Disorders , 2008, DOI: 10.1186/1471-2474-9-9
Abstract: Fifty-three girls aged 7 – 9 years were included in a curriculum-based exercise intervention program comprising 40 minutes of general physical activity per school day (200 minutes/week). Fifty healthy age-matched girls who participated in the general Swedish physical education curriculum (60 minutes/week) served as controls. The hip was scanned by dual X-ray absorptiometry (DXA) and the hip structural analysis (HSA) software was applied to evaluate bone mineral content (BMC), areal bone mineral density (aBMD), periosteal and endosteal diameter, cortical thickness, cross-sectional moment of inertia (CSMI), section modulus (Z) and cross-sectional area (CSA) of the femoral neck (FN). Annual changes were compared. Group comparisons were done by independent student's t-test between means and analyses of covariance (ANCOVA). Pearson's correlation test was used to evaluate associations between activity level and annual changes in FN. All children remained at Tanner stage 1 throughout the study.No between-group differences were found during the 12 months study period for changes in the FN variables. The total duration of exercise during the year was not correlated with the changes in the FN traits.Evaluated by the DXA technique and the HSA software, a general one-year school-based exercise program for 7–9-year-old pre-pubertal girls seems not to influence the structure of the hip.Physical activity during growth is associated with benefits in bone mineral accrual and possibly bone structure [1-4], a clinically relevant notion, as both traits independently improve bone strength [5]. But, most prospective controlled exercise intervention trials have predominantly focused on the accrual of bone mineral [6-9], a study design that could underestimate the skeletal effects of exercise, as the effect on bone structure is then neglected. That is, also the three-dimensional structure ought to be assessed when evaluating bone strength [10,11]. As a result, the Hip Structural Analysis (
ERβ1 represses basal-like breast cancer epithelial to mesenchymal transition by destabilizing EGFR
Christoforos Thomas, Gayani Rajapaksa, Fotis Nikolos, Ruixin Hao, Anne Katchy, Catherine W McCollum, Maria Bondesson, Phil Quinlan, Alastair Thompson, Savitri Krishnamurthy, Francisco J Esteva, Jan-?ke Gustafsson
Breast Cancer Research , 2012, DOI: 10.1186/bcr3358
Abstract: Basal-like breast cancer cells (MDA-MB-231 and Hs578T), in which ERβ1 was either overexpressed or down-regulated were analyzed for their ability to migrate and invade (wound-healing assay, matrigel-coated Transwell assay) as well as for the expression of EMT markers and components of the EGFR pathway (immunoblotting, RT-PCR). Co-immunoprecipitation and ubiquitylation assays were employed to examine whether ERβ1 alters epidermal growth factor receptor (EGFR) protein degradation and the interaction between EGFR and the ubiquitin ligase c-Cbl. The metastatic potential of the ERβ1-expressing MDA-MB-231 cells was evaluated in vivo in a zebrafish xenotransplantation model and the correlation between ERβ1 and E-cadherin expression was examined in 208 clinical breast cancer specimens by immunohistochemistry.Here we show that ERβ1 inhibits EMT and invasion in basal-like breast cancer cells when they grow either in vitro or in vivo in zebrafish. The inhibition of EMT correlates with an ERβ1-mediated up-regulation of miR-200a/b/429 and the subsequent repression of ZEB1 and SIP1, which results in increased expression of E-cadherin. The positive correlation of ERβ1 and E-cadherin expression was additionally observed in breast tumor samples. Down-regulation of the basal marker EGFR through stabilization of the ubiquitin ligase c-Cbl complexes and subsequent ubiquitylation and degradation of the activated receptor is involved in the ERβ1-mediated repression of EMT and induction of EGFR signaling abolished the ability of ERβ1 to sustain the epithelial phenotype.Taken together, the results of our study strengthen the association of ERβ1 with the regulation of EMT and propose the receptor as a potential crucial marker in predicting metastasis in breast cancer.In the last decade, genomic studies have identified five breast cancer intrinsic subtypes (Luminal A, Luminal B, HER2 (overexpressing the ERBB2), basal-like and claudin-low) [1,2]. In a recent study, an integrated analysis of co
Presence of Obstetrics Cholestasis in Mothers Presenting with Pruritus in Pregnancy: In a Low Resource South Asian Setting  [PDF]
Senani Hemantha Dodampahala, Hemantha Pieris, Lal Gotabaya Chandrasena, Surangi Jayakody, Chamara Gunathilaka, Chandrika Neelakanthi Wijayaratne, Gayani Sandamali Kotuwegedara Dodampahala, Amila Ruwan Meegahawatta
Advances in Reproductive Sciences (ARSci) , 2016, DOI: 10.4236/arsci.2016.42006
Abstract: Obstetric cholestasis (also referred to as intrahepatic cholestasis of pregnancy—ICP) is a pruritic form of reversible cholestasis that is associated with significant fetal risks. There is a paucity of research regarding pregnancy outcomes of the mothers with obstetric cholestasis in the South Asian setting. Hence, the objective of this study was to determine the prevalence of obstetric cholestasis among mothers presenting with pruritus during pregnancy and to describe the characteristics and outcomes for those diagnosed with ICP in comparison with those with pruritus in the absence of ICP. Methods: All mothers presenting with pruritus to De Soyza Maternity hospital in Colombo Sri Lanka, between 1st January 2011 to 1st January 2014, were recruited for the study. A standard set of biochemical tests were used for diagnosis of ICP. An interviewer administered questionnaire and patient records were used for data collection. Presentation, characteristics and pregnancy outcomes were assessed and compared for mothers with ICP against those with pruritus in the absence of ICP. Results: The prevalence of ICP in the study population was found to be 27% (n = 27). Generalized pruritus with pruritus of the palms and soles was identified as the commonest pattern of pruritus for diagnosed with ICP. Delivery before 37 weeks (p = 0.001), meconium stained liquor (p = 0.004), placental abruption (p = 0.005), postpartum hemorrhage (p = 0.005), bleeding manifestation (p = 0.006), preterm labor (p = 0.031) and fetal distress (p = 0.035) were found to be significantly associated with the presence of ICP. Conclusions: Nearly 1/3 of mothers presenting with pruritus in pregnancy in Sri Lanka are affected by ICP which is associated with an increase in a wide range of adverse maternal and fetal outcomes compared to those with pruritus in the absence of ICP.
HDL-apoA-I Exchange: Rapid Detection and Association with Atherosclerosis
Mark S. Borja, Lei Zhao, Bradley Hammerson, Chongren Tang, Richard Yang, Nancy Carson, Gayani Fernando, Xiaoqin Liu, Madhu S. Budamagunta, Jacques Genest, Gregory C. Shearer, Franck Duclos, Michael N. Oda
PLOS ONE , 2013, DOI: 10.1371/journal.pone.0071541
Abstract: High density lipoprotein (HDL) cholesterol levels are associated with decreased risk of cardiovascular disease, but not all HDL are functionally equivalent. A primary determinant of HDL functional status is the conformational adaptability of its main protein component, apoA-I, an exchangeable apolipoprotein. Chemical modification of apoA-I, as may occur under conditions of inflammation or diabetes, can severely impair HDL function and is associated with the presence of cardiovascular disease. Chemical modification of apoA-I also impairs its ability to exchange on and off HDL, a critical process in reverse cholesterol transport. In this study, we developed a method using electron paramagnetic resonance spectroscopy (EPR) to quantify HDL-apoA-I exchange. Using this approach, we measured the degree of HDL-apoA-I exchange for HDL isolated from rabbits fed a high fat, high cholesterol diet, as well as human subjects with acute coronary syndrome and metabolic syndrome. We observed that HDL-apoA-I exchange was markedly reduced when atherosclerosis was present, or when the subject carries at least one risk factor of cardiovascular disease. These results show that HDL-apoA-I exchange is a clinically relevant measure of HDL function pertinent to cardiovascular disease.

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