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Search Results: 1 - 10 of 325159 matches for " Gattás "
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Interdisciplinaridade: uma contextualiza??o
Gattás, Maria Lúcia Borges;Furegato, Antonia Regina Ferreira;
Acta Paulista de Enfermagem , 2006, DOI: 10.1590/S0103-21002006000300011
Abstract: this paper discusses the theoretical bases for an empirical approach to interdisciplinary work. various aspects have been considered in this reflection, such as, difficulties to understand the theme in terms of theoretical underpinning, practice application of the theme, and scholars' disagreements about the theme.
Biomarcadores moleculares em cancer: implica??es para a pesquisa epidemiológica e a saúde pública
Wünsch Filho, Victor;Gattás, Gilka J Figaro.;
Cadernos de Saúde Pública , 2001, DOI: 10.1590/S0102-311X2001000300003
Abstract: identification of molecular biomarkers is a common result of current cancer epidemiological research. both genetic and molecular epidemiology have enjoyed impressive developments in recent decades, with important repercussions on traditional epidemiological approaches. in this paper we evaluate the new frontiers of cancer epidemiology, incorporating both genetic and molecular biology approaches. we examine the current knowledge of molecular biomarkers for exposure and susceptibility to cancer, the role of gene mutations in carcinogenesis, and their application to epidemiological studies. by exploring the status of relevant biomarkers, these approaches become effective in evaluating exposure and susceptibility and show enormous potential for elucidating mechanisms of carcinogenesis and the effect of risk factors in cancer. however, these approaches are necessarily more invasive and raise several ethical issues for consideration by both researchers in public health and society as a whole.
The scientific production of full professors of the faculdade de medicina da universidade de S?o Paulo: a view of the period of 2001-2006
Cardoso, Suely Campos;Gattás, Gilka Jorge Figaro;
Clinics , 2009, DOI: 10.1590/S1807-59322009000900012
Abstract: introduction: the scientific production of institutions of higher education, as well as the dissemination and use of this published work by peer institutions, can be assessed by means of quantitative and qualitative measurements. this type of analysis can also serve as the basis of further academic actions. variables such as the type of evaluation, the number of faculty members and the decision to include or exclude researchers who are not professors are difficult to measure when comparing different schools and institutions. objectives: the purpose of this study was to assess the scientific production of tenured faculty from the universidade de s?o paulo, faculdade de medicina performed from 2001 to 2006. methods: medline/pubmed database was considered and the impact factors (ifs - journal citation report, 2006) and the number of generated citations (web of science/isi thomson) were also evaluated. results: the analysis of the scientific production of 66 full professors (level ms-6) revealed 1,960 scientific articles published in 630 scientific journals, of which 31.3% were brazilian and 68.7% were from international sources. among these, 47% of the articles were published in 62.9% of the journals with ifs above 10, although 16.4% of the journals did not have assigned if values. we verified that 45% of the published articles received 9,335 citations (average of 11 + 17), with the majority of these (8,968 citations) appearing in international scientific journals. conclusions: our results indicate that it is possible to analyze the scientific production of a learning institution by the number of papers published by full professors, taking into account not only their academic position and influence, but also the fact that publication is an opportunity to stimulate joint projects with other members of the same institution.
Effectiveness of the Brazilian influenza vaccination policy, a systematic review
Luna, Expedito J.A.;Gattás, Vera L.;
Revista do Instituto de Medicina Tropical de S?o Paulo , 2010, DOI: 10.1590/S0036-46652010000400002
Abstract: since 1999, brazil has undertaken annual influenza vaccine campaigns, free of charge, targeting the elderly population, health professionals, and immune-deficient patients. we conducted a systematic review of literature in order to evaluate the effectiveness of the initiative. we used the keywords influenza, vaccine, brazil and effectiveness to search the main databases. thirty-one studies matched our inclusion and exclusion criteria. influenza vaccine coverage among the elderly is high, though not as high as suggested by the official figures. estimates on effectiveness are scarce. the majority come from ecological studies that show a modest reduction in mortality and hospital admissions due to influenza-related causes. such reduction is not evident in the north and northeastern states of brazil, a finding that is probably related to the different seasonal pattern of influenza in equatorial and tropical regions. brazilian epidemiologists still owe society better-designed studies addressing the effectiveness of influenza vaccine campaigns.
Imobiliza § £o de Aspergillus SP por encapsula § £o em alginato de c lcio para produ § £o de poligalacturonase
Immobilization of Aspergillus sp for production of polygalacturonase

M. C. BUENO,E. A. L. GATT??S
Alimentos e Nutri??o , 2010,
Abstract: Esporos de tr as linhagens de Aspergillus sp. isolados do solo foram imobilizados em alginato de c lcio e crescidos em cultura submersa contendo pectina como onica fonte de carbono, para a produ § £o de poligalacturonase (PG). O mic lio imobilizado foi lavado e reutilizado at seis vezes, em sistema de produ § £o em batelada, sem agita § £o. Foram estudados, a infl u ancia da concentra § £o do alginato de s 3dio e do cloreto de c lcio, a quantidade de esferas e tempo de dura § £o de cada ciclo de fermenta § £o. A melhor condi § £o de produ § £o de PG foi obtida usando a concentra § £o de 3% de alginato, 2% de cloreto de c lcio, 10 unidades de esferas contendo 106 esporos/mL, e tempo de 48 horas para cada ciclo de fermenta § £o. A atividade extracelular de poligalacturonase foi induzida pela pectina e dependente da linhagem do fungo. A m xima atividade da enzima (1,56 U/mL) foi obtida no filtrado do crescimento do Aspergillus sp CFCF-0492, ap 3s o 2 o ciclo de fermenta § £o.
Biomarcadores moleculares em cancer: implica es para a pesquisa epidemiológica e a saúde pública
Wünsch Filho Victor,Gattás Gilka J Figaro.
Cadernos de Saúde Pública , 2001,
Abstract: O desenvolvimento das áreas de genética e biologia molecular tem sido admirável nas últimas décadas e isso tem repercutido intensamente na epidemiologia. Neste artigo, discute-se a amplia o das fronteiras da pesquisa epidemiológica em cancer com a incorpora o das técnicas da genética e da biologia molecular. Examina-se o conhecimento atual dos biomarcadores de exposi o e de suscetibilidade, o papel das muta es genéticas na carcinogênese, a aplica o destas nos estudos epidemiológicos e implica es para a preven o. Perscrutando o meio interno dos indivíduos, a epidemiologia molecular e a genética representam um avan o tanto para a avalia o da exposi o, quanto para a detec o de indivíduos suscetíveis, e possuem imenso potencial para ampliar a compreens o dos mecanismos da carcinogênese e dos efeitos de fatores de risco no cancer. Entretanto, por serem necessariamente mais invasivas, essas abordagens remetem a importantes quest es no campo da ética. A comunidade científica de saúde pública e a sociedade devem guardar vigilancia sobre os usos e aplica es deste novo conhecimento, avaliando seus desdobramentos à luz da bioética
RECOVERY STATE EVALUATED BY TWO METHODS AFTER PHYSICAL FITNESS TEST
Victor Magalh?es Curty,Maurício Gattás Bara Filho
Brazilian Journal of Biomotricity , 2011,
Abstract: CURTY, V. M.; BARA FILHO, M. G. Recovery state evaluated by two methods after physical fitness test. Brazilian Journal of Biomotricity. v. 5, n. 3, p. 186-199, 2011. Currently, search is a simple and effective method to control the training load and recovery. This purpose, the total quality recovery scale is an interesting method to be used with other methods. The aim of this study was to analyze the behavior of the recovery after the physical fitness test through the use of the total quality recovery scale and creatine kinase. Twenty-eight men (age: 18,5 ± 0,4 years), that would perform the the physical fitness test, participated voluntarily in the study. Intensity of effort was classified by the scale of perceived exertion created by Borg (1982). All were submitted to three blood samples (pre-test, 24 and 72 hours after the tests) and they answered how they felt physically by according to the recovery scale to assess the quality of recovery before and after the physical tests. ANOVA was used to test the significance of effects of physically test about the creatine kinase levels and the recovery scale. The level of creatine kinase didn’t answer significantly both in samples 24 (192,9 ± 41,3) as in samples in 72 hours (178,0 ± 33,2a) after the test related to pre-test levels (182,7 ± 52,1). However, observing the quality of recovery through of scale, was observed less values at the recovery as 24 (12,5 ± 3,4) as 72 hours (14,6 ± 4,3) after the tests, related to the values pre-tests (18,3 ± 1,6). Could be observed an inadequate recovery 72 hours after the test through of scale, even the serum activity of creatine kinase not showing significant changes in relation to the physical test run.
Doping Dependence of the Superconducting Leading Edge Gap in Bi2212
R. Gatt
Physics , 1999,
Abstract: The paper compares the K-dependence of the superconducting gap in different doping ranges. The fine behavior of the leading edge gap indicates that the pairing susceptibility is peaked at special regions on the Fermi surface. These hot regions are found to be centered away from nominal "hot spots". This behavior is attributed to a feedback effect on the pairing boson. Identification is made through comparison with neutron diffraction results.
Aspectos toxicológicos do bissulfito e outros agentes tóxicos sobre a síntese de glicerol-3-fosfato desidrogenase citoplasmática de levedura de panifica o
E. A.L. GATTáS,M. F.S. PERES
Revista de Ciências Farmacêuticas Básica e Aplicada , 2009,
Abstract: A síntese de glicerol-3-fosfato desidrogenase intracelular (EC 1.1.1.8) foi investigada a partir de fermento de panifica o em cultivos submersos, contendo glicose ou glicerol como únicas fontes de carbono. Agentes inibitórios da via glicolítica, do ciclo de Krebs e da Cadeia Respiratória inibiram a síntese da enzima quando adicionados em baixas concentra es até 7,5 x 10-4 mol/L. A repress o exercida pela glicose sobre a síntese da glicerol-3-fosfato desidrogenase em meio YP-glicose foi reduzida, com a adi o de produtos de fermenta o e de bissulfito de sódio. Observou-se aumentos de 22-110% na síntese da enzima. Entretanto, em meio YP-glicerol, a adi o de bissulfito de sódio 0,06 % (p/v) reduziu a síntese da enzima em 29%, enquanto, o acetaldeído 0,012 % (v/v) estimulou a síntese de glicerol-3-fosfato desidrogenase em 12%. Palavras-chave: fermento de panifica o; glicerol-3-fosfato desidrogenase; inibidores.
Effects of sorghum (sorghum bicolor L.) root exudates on the cell cycle of the bean plant (phaseolus vulgaris L.) root
Hallak, Angela Maria Gattás;Davide, Lisete Chamma;Souza, Itamar Ferreira;
Genetics and Molecular Biology , 1999, DOI: 10.1590/S1415-47571999000100018
Abstract: two experiments were conducted to test the allelopathic effect of sorghum (sorghum bicolor l.) root exudates on bean (phaseolus vulgaris l.) cell division. research was conducted in the greenhouse of the wistock agricultural research institute of minas gerais state (epamig) and in a laboratory of the federal university of lavras (ufla). sorghum variety br-601 and bean variety carioca mg were used. the exudate, called sorgoleone (sgl), was obtained by methylene chloride and acetic acid extraction from sorghum roots seven days after sowing on petri dishes, and refrigerated until use. solutions of 0.01, 0.05, 0.10, and 0.15 mm were prepared using johanson solution as the sgl solvent. seven-day-old bean seedlings grown in vermiculite in a greenhouse were transplanted to the solution. seven days after transplantation, the beans did not show any sign of phytotoxicity; however, cytogenetic observations showed that sgl reduced the number of cells in prophase, metaphase, and anaphase stages. colchicine effects were observed among cells in metaphase on the third and fifth days after treatments and varied with sgl concentrations. by the seventh day, the colchicine effects were inversely proportional to concentration, which varied from 34.3% for 0.01 mm to 6.6% for 0.15 mm. sgl acts as a mitotic inhibitor. it probably depolymerizes the microtubular proteins and induces the formation of colchicine metaphases causing polyploid nuclei. a largest period of sgl treatment also induced chromosome breaks and bridge formation in anaphase and telophase. although sgl cannot be used as a herbicide for bean cultures, its allelochemical effects on other cultures are the factors that will define the use of sorghum as a natural herbicide.
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