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Search Results: 1 - 10 of 3624 matches for " Gastric ulcer "
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Posterior Gastric Perforation in Liberia: A Case Report and Review of the Literature  [PDF]
Edet Ikpi, Solomane Konneh, Bashir Yunusa, Ansumana Camara, Swaliho Sheriff, Romel Chinneh, David Alele
Health (Health) , 2018, DOI: 10.4236/health.2018.1010103
Abstract: Background: The incidence of posterior gastric perforation worldwide is low; the literature has no previous record of its occurrence in Liberia. The diffuse symptoms of a perforated posterior gastric ulcer, delay by patients before they present to hospital, and the lack of skilled personnel and facilities in Liberia to diagnose and treat this condition increase the mortality associated with posterior gastric perforation. Objective: To report the first case of posterior gastric perforation encountered in Liberia. Materials and Method: Case report. Case Presentation/Report: A 44 year old male was referred to John F. Kennedy Memorial Hospital (Liberia’s principal teaching hospital) with a diagnosis of gastritis after six days of worsening epigastric pain. He had a history of NSAID use for a chronic leg and foot ulcer. Physical examination revealed a moderately distended, markedly tender abdomen characterized by guarding, rigidity and low-pitched bowel sounds. Patient was resuscitated with intravenous fluids, antibiotics and analgesics. An emergency exploratory laparotomy subsequently performed revealed a large collection of purulent peritoneal fluid, a 3 × 4 cm perforation on the posterior wall of the stomach and a 3 × 2.5 cm perforation of the transverse mesocolon. The perforations were repaired and the patient recovered satisfactorily. Conclusion: Though relatively rare and associated with a high morbidity and mortality, this case report shows that the paucity of reported cases of posterior gastric perforation may also be attributable to lack of specialist staff with capacity for clinical diagnosis and surgical intervention in a resource poor setting. Identifying patients with gastric perforation and having the skill to repair the perforations significantly enhance the clinical outcome.
Etiologies of Dyspepsia among a Chinese Population: One Hospital-Based Study  [PDF]
Shou-Wu Lee, Han-Chung Lien, Teng-Yu Lee, Sheng-Shun Yang, Hong-Zen Yeh, Chi-Sen Chang
Open Journal of Gastroenterology (OJGas) , 2014, DOI: 10.4236/ojgas.2014.46037
Abstract: Background and Methods: Dyspepsia refers to a collection of upper gastrointestinal symptoms, and the causes may be either organic or functional. The aim of this study was to investigate the etiologies of dyspepsia among a Chinese population in Taiwan. Patients who underwent upper endoscopy for symptoms of dyspepsia were retrospectively analyzed between January and December 2008. Exclusion criteria included cirrhosis with varices, heart-burn sensation as the main symptom, gastrointestinal bleeding, hepatobiliary abnormalities, prior gastric surgery, and use of anti-acid medication for more than 2 months. Patients were classified according to the findings of upper endoscopy. Results: Data from the medical records of 2062 patients were collected and retrospectively analyzed. Normal endoscopic findings, gastritis, gastric ulcers, duodenal ulcers, reflux esophagitis and esophageal or gastric malignancy accounted for 1174 (56.9%), 215 (10.4%), 254 (12.3%), 194 (9.4%), 182 (8.8%) and 43 (2.1%) cases, respectively. The overall ratio of H. pylori infection was 28.4%. The ratio was the highest in duodenal ulcers and the lowest in reflux esophagitis. A significantly higher ratio of patients with gastric ulcers had a history of aspirin or non-steroidal anti-inflammatory drugs (NSAIDs) usage. Conclusion: Patients with organic dyspepsia, compared to those with functional dyspepsia, were older, male, and had a higher H. pylori infection ratio, a positive relationship with aspirin or NSAIDs usage, and more risk factors. These findings demonstrate that upper endoscopy has a high diagnostic yield in patients in this group.
Lipoma of the Stomach Prolapsing into the Duodenal Bulb and Causing a Duodenal Ulcer: A Case Report  [PDF]
Tateki Yamane, Akihiko Takeda, Takayuki Ishii, Toshio Morisane
International Journal of Clinical Medicine (IJCM) , 2011, DOI: 10.4236/ijcm.2011.24075
Abstract: We report a case of lipoma in the antum of the stomach which prolapsed into the duodenal bulb and caused a duodenal ulcer, speculated to have been induced by the friction of its top against the duodenal mucosa. Although the ulcer healed after the administration of a proton pump inhibitor, the symptom of epigastric discomfort continued, suggested to be due to prolapsing. Therefore, a laparoscopic operation was conducted. The incidence of lipoma of the stomach is rare, and cases of its prolapse into the duodenum are very few. Furthermore, it is extremely rare for it to cause a duodenal ulcer. Because these features made this case clinically interesting, we report it here.
Dipsacussaponin C from Dipsacus asper Reduces the Risk of Gastritis and Gastric Ulcer in Rats  [PDF]
Seon A. Hwang, In Young Hwang, Joohee Jung, Hye Kyung Kang, Kun Ho Son, Choon Sik Jeong
Food and Nutrition Sciences (FNS) , 2012, DOI: 10.4236/fns.2012.37123
Abstract: The roots of Dipsacus asper (DA) have been used as a tonic and analgesic agent in traditional Chinese medicine for the treatment of osteoporosis, low back pain, knee pain, and as an anti-inflammatory agent. Few studies have reported pharmacological gastric activities. In this study, we investigated the effects of dipsacussaponin C (DSC) and 70% ethanol and water extracts of DA on gastritis and gastric ulcer in rat. First, we examined the free radical scavenging effect by the 2,2-Diphenyl-1-picrylhydrazyl (DPPH) radical-scavenging assay. Second, we examined the Helicobacter pylori (H. pylori) colonization inhibitory effect and found that DSC has a mild anti-H. pylori effect. Third, the cytotoxicity was assessed by measuring the cell viability of human gastric cancer cells (SNU638 and AGS). Also, we observed the acid-neutralizing capacity by measuring NaOH consumption volume and found that DSC is effective as an antacid agent. For these reasons, we observed the effect of DSC on HCl?ethanol-induced gastritis and indomethacin-induced gastric ulcer in rat. In pylorus-ligated rats, DSC (200 mg/kg) also decreased the volume of gastric secretion (approximately 2.2 mL) and gastric acid output (0.16 mEq/4 hrs). From these results, we suggest that DSC isolated from DA may be useful for the treatment and/or protection of gastritis and gastric ulcer.
Biochemical Syndrome in Adult Pyloric Stenosis, a Clue to Diagnosis in Emergency Department  [PDF]
Ahmed M. Badi, Vamanjore A. Naushad, Abraham John, Khalid H. Elnour
Open Journal of Gastroenterology (OJGas) , 2014, DOI: 10.4236/ojgas.2014.412051
Abstract: Characteristic biochemical changes have been documented in patients presenting with the symptoms and signs of gastric outlet obstruction. These changes usually consist of hypochloremic, hypokalemic metabolic alkalosis and hypocalcaemia with or without renal failure. The aim of this report is to highlight these biochemical abnormalities again. Moreover, we suggest conversely that the presence of these changes should prompt the clinician for further evaluation to rule out gastric outlet obstruction especially in the emergency department. Early intervention resulted in dramatic improvement in patient’s clinical and biochemical status.
Update of Aetiological Patterns of Adult Gastric Outlet Obstruction in Accra, Ghana  [PDF]
Samuel Essoun, Jonathan C. B. Dakubo
International Journal of Clinical Medicine (IJCM) , 2014, DOI: 10.4236/ijcm.2014.517136
Abstract: Background: The aetiology of gastric outlet obstruction globally has evolved from benign to malignant causes, but there seem to be no recent data on the trends in Ghana. The aim was, therefore, to identify the current patterns in the aetiology of gastric outlet obstruction in the adult population in Ghana. Methodology: This was a retrospective review of all confirmed cases of gastric outlet obstruction in the last decade, spanning from June 2004 to May 2014, that were managed at the Korle Bu Teaching Hospital. Results: A total of 107 patients were managed for gastric outlet obstruction with a male to female ratio of 2.15:1 and most of the patients making 71.3% of cases belonged to the age range of 40 to 60 years. The predominant aetiology for gastric outlet obstruction was found to be gastric cancer (55.140%), followed by peptic ulcer disease (27.103%). Conclusion: The aetiology of gastric outlet obstruction in Ghana has evolved from benign to malignant causes, following current global trends. Gastric cancer is now the most important cause of gastric outlet obstruction in Ghana, followed by peptic ulcer disease which predominates as the commonest benign cause.
úlcera gastroduodenal em potros
Dearo, Antonio Cezar de Oliveira;Lopes, Marco Aurélio Ferreira;
Ciência Rural , 1995, DOI: 10.1590/S0103-84781995000200027
Abstract: among the great number of pathologies that affect young horses, gastric ulcers are considered one of the most important. murray et al. (1987) working with clinically normal foals established a prevalence of gastric ulcers of 51%. the same author after carrying out 1988). although its aethiology hasn't been well established, a variety of factors are suspected to be involved in its genesis, where stress plays an important role. a disruption of the balance between protective and aggressive factors is suggested and once the last is predominant the ulcer would be established. according to the kind, presence or absence of clinical signs, the locadon of lesions on gastric mucosa and its complications, four clinical syndromes are described in foals: 1) silent ulcers, 2) active ulcers, 3) perforated ulcers and 4) gastric or duodenal obstruction. diagnosis should be based on history, clinical signs, response to treatment and mainly on endoscopic findings. gastric ulcers can be treated with drugs such as acid secretions inhibitors, local antacids, mucosal protectants, prostaglandin analogs and motility stimulants. if necessary, the surgical treatment can be used.
Non-healing gastric ulcer associated with Candida infection
Ramaswamy K,Correa M,Koshy A
Indian Journal of Medical Microbiology , 2007,
Abstract: Candida bezoars of the stomach usually occur after gastric surgery. We report a small Candida mass occurring on a non-healing gastric ulcer in a 40-year-old male non-smoker. The ulcer healed with fluconazole and withdrawal of the proton pump inhibitor.
A case of hypereosinophilic syndrome presenting with intractable gastric ulcers
Tae Young Park, Chang Hwan Choi, Suh Yoon Yang, In Soo Oh, In-Do Song, Hyun Woong Lee, Hyung Joon Kim, Jae Hyuk Do, Sae Kyung Chang, Ah Ra Cho, Young Joo Cha
World Journal of Gastroenterology , 2009,
Abstract: We report a rare case of hypereosinophilic syndrome (HES) presenting with intractable gastric ulcers. A 71-year-old man was admitted with epigastric pain. Initial endoscopic findings revealed multiple, active gastric ulcers in the gastric antrum. He underwent Helicobacter pylori (H pylori) eradication therapy followed by proton pump inhibitor (PPI) therapy. However, follow-up endoscopy at 4, 6, 10 and 14 mo revealed persistent multiple gastric ulcers without significant improvement. The proportion of his eosinophil count increased to 43% (total count: 7903/mm3). Abdominal-pelvic and chest computed tomography scans showed multiple small nodules in the liver and both lungs. The endoscopic biopsy specimen taken from the gastric antrum revealed prominent eosinophilic infiltration, and the liver biopsy specimen also showed eosinophilic infiltration in the portal tract and sinusoid. A bone marrow biopsy disclosed eosinophilic hyperplasia as well as increased cellularity of 70%. The patient was finally diagnosed with HES involving the stomach, liver, lung, and bone marrow. When gastric ulcers do not improve despite H pylori eradication and prolonged PPI therapy, infiltrative gastric disorders such as HES should be considered.
Acquired double pylorus, due to penetrating gastric ulcer, presenting with melena
Cristina Linea,Emanuele Sinagra,Francesco La Seta,Marco Giunta
World Journal of Gastrointestinal Endoscopy , 2012, DOI: 10.4253/wjge.v4.i3.94
Abstract: Acquired double pylorus (DP) is an uncommon condition consisting of two communicating channels between the gastric antrum and the first part of duodedum. Little is known about the origin of DP. As there is no specific gastrointestinal symptom due to DP, most often it is diagnosed by gastroscopy while performing for other indicationsFew data are also known about the clinical course of DP. In the patients with peptic ulcer symptoms, the pyloroplasty-like drainage effect, improving gastric emptying after the estabilishment of the fistula, could relieve these symptoms. This represents an unresolved issues about the necessity of repeating endoscopy to document in the patients with DP its final outcome, as the risk of ulcer recurrence. We describe a case of a 76-years-old woman admitted to our department for hyposideremic anemia associated to a recent history of melena.
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