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Search Results: 1 - 10 of 193220 matches for " Gary G. Poehling "
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Achieving Accurate Ligament Balancing Using Robotic-Assisted Unicompartmental Knee Arthroplasty
Johannes F. Plate,Ali Mofidi,Sandeep Mannava,Beth P. Smith,Jason E. Lang,Gary G. Poehling,Michael A. Conditt,Riyaz H. Jinnah
Advances in Orthopedics , 2013, DOI: 10.1155/2013/837167
Abstract: Unicompartmental knee arthroplasty (UKA) allows replacement of a single compartment in patients with limited disease. However, UKA is technically challenging and relies on accurate component positioning and restoration of natural knee kinematics. This study examined the accuracy of dynamic, real-time ligament balancing using a robotic-assisted UKA system. Surgical data obtained from the computer system were prospectively collected from 51 patients (52 knees) undergoing robotic-assisted medial UKA by a single surgeon. Dynamic ligament balancing of the knee was obtained under valgus stress prior to component implantation and then compared to final ligament balance with the components in place. Ligament balancing was accurate up to 0.53?mm compared to the preoperative plan, with 83% of cases within 1?mm at 0°, 30°, 60°, 90°, and 110° of flexion. Ligamentous laxity of ?mm at 30° of flexion was corrected successfully to ?mm ( ). Robotic-assisted UKA allows accurate and precise reproduction of a surgical balance plan using dynamic, real-time soft-tissue balancing to help restore natural knee kinematics, potentially improving implant survival and functional outcomes. 1. Introduction Unicompartmental knee arthroplasty (UKA) has seen resurgence in the past decade with approximately 51,300 cases performed in 2009 and an estimated growth of 32.5% annually [1–3]. Benefits of UKA compared to total knee arthroplasty include reduced blood loss, reduced perioperative morbidity, faster recovery, shorter rehabilitation, increased postoperative range of motion, and reduced surgical cost [4–9]. However, proper patient selection is vital and the procedure remains technically demanding as the minimally invasive procedure limits surgical exposure and impedes precise component alignment and fixation [3, 6, 10–14]. UKA failures have mainly been attributed to improper component alignment leading to altered knee biomechanics with accelerated polyethylene wear if deformity is undercorrected, disease progression in other compartments if overcorrected, and anterior knee pain [6, 8, 15–17]. UKA component position and alignment are intricately associated with soft-tissue balancing during this procedure. UKA allows for minimal disruption of the patient’s native anatomy and is intended to restore the normal height of the affected compartment to produce normal ligament tension during the flexion-extension cycle. The success of UKA relies on proper soft-tissue tensioning to obtain a balanced flexion-extension gap and varus-valgus stability [14]. While advances in surgical instrumentation
Effects of extracellular matrix proteins on expansion, proliferation and insulin-producing-cell differentiation of ARIP cells  [PDF]
Gary G. Adams, Yu-Xin Cui
Journal of Biomedical Science and Engineering (JBiSE) , 2009, DOI: 10.4236/jbise.2009.24035
Abstract: Regeneration of transplantable pancreatic islet cells has been considered to be a promising alternative therapy for type 1 diabetes. Re-search has suggested that adult pancreatic stem and progenitor cells can be derived into insulin-producing cells or cultivated islet-like clusters given appropriate stimulating condi- tions. In this study we explored the effect of selective extracellular matrix (ECM) proteins on the potential of insulin-producing cell differen-tiation using ARIP cells, an adult rat pancreatic ductal epithelial cell line, as a model in vitro. Quantitative single cell morphology analysis indicated that all the four ECM proteins we have used (type I collagen, laminin, fibronectin and vitronectin) increased the single cell area and diameter of ARIP cells. In addition, se-rum-free cell cultivation was dependent on cell density and particular components; and serum could be replaced when systematic optimisa-tion could be performed. Surface treated with laminin was shown to be able to enhance overall cell expansion in the presence of de-fined serum-free medium conditions. Collagen treated surfaces enhanced insulin production in the presence of GLP-1 although the insulin gene expression was however weak accord-ingly. Our results suggest that selective ECM proteins have effects on single cell morphol-ogy, adhesion and proliferation of ARIP cells. These ECM molecules however do not have a potent effect on the insulin-producing cell dif-ferentiation potential of ARIP cells even com-bining with GLP-1.
Mathematics Achievement by Immigrant Children
Gary G. Huang
Education Policy Analysis Archives , 2000,
Abstract: In this study, I examined academic achievement of immigrant children in the United States, Canada, England, Australia, and New Zealand. Analyzing data from the Third International Mathematics and Science Study (TIMSS), I gauged the performance gaps relating to the generation of immigration and the home language background. I found immigrant children's math and science achievement to be lower than the others only in England, the U.S., and Canada. Non-English language background was found in each country to relate to poor math and science learning and this disadvantage was stronger among native-born children presumably children of indigenous groups than among immigrant children. I also examined the school variation in math performance gaps, using hierarchical linear modeling (HLM) to each country's data. The patterns in which language- and generation-related math achievement gaps varied between schools are different in the five countries.
Questions on meromorphic functions and complex differential equations
Gary G. Gundersen
Mathematics , 2015,
Abstract: Thirty research questions on meromorphic functions and complex differential equations are listed and discussed. The main purpose of this paper is to make this collection of problems available to everyone.
West Nile virus activity in Latin America and the Caribbean
Komar,Nicholas; Clark,Gary G.;
Revista Panamericana de Salud Pública , 2006, DOI: 10.1590/S1020-49892006000200006
Abstract: objectives: west nile virus (flavivirus: flaviviridae; wnv) has spread rapidly throughout the caribbean basin since its initial detection there in 2001. this report summarizes our current knowledge of wnv transmission in tropical america. methods: we reviewed the published literature and consulted with key public health officials to obtain unpublished data. results: west nile virus infections first appeared in human residents of the cayman islands and the florida keys in 2001, and in apparently healthy jamaican birds sampled early in 2002. serologic evidence of wnv infection in 2002 was detected in horses, chickens and resident free-ranging birds in guadeloupe, the dominican republic, and eastern mexico. in 2003, wnv spread in mexico and northern central america, and serologic evidence was detected in the bahamas, puerto rico and cuba. in 2004, the first serologic evidence of wnv activity in south american ecosystems surfaced in september-october in colombia and trinidad, where domestic animals circulated wnv-neutralizing antibodies. conclusions: the sparse reports of equine, human and avian disease in latin america and the caribbean is puzzling. isolates are needed to evaluate viral attenuation or other possible explanations for reduced disease burden in tropical ecosystems.
District Fiscal Policy and Student Achievement
Gary G. Huang,Binbing Yu
Education Policy Analysis Archives , 2002,
Abstract: School restructuring raises questions about the role of school districts in improving student learning. Centralization by state governments and decentralization to individual schools as proposed in systemic reform leave districts' role unsettled. Empirical research on the district role in the context of ongoing reform is inadequate. This analysis of combined data from the NAEP and the Common Core of Data (CCD) was intended to address the issue. We analyzed 1990, 1992, and 1996 NAEP 8th grade mathematics national assessment data in combination with CCD data of corresponding years to examine the extent to which student achievement was related to districts' control over instructional expenditure, adjusting for relevant key factors at both district and student levels. Upon sample modification, we used hierarchical linear modeling (HLM) to estimate the relationships of student achievement to two district fiscal policy indictors, current expenditure per pupil (CEPP) and districts' discretionary rates for instructional expenditure (DDR). Net of relevant district factors, DDR was found unrelated to districts' average 8th grade math performance. The null effect was consistent in the analysis of the combined NAEP-CCD data for 1990, 1992, and 1996. In contrast, CEPP was found related to higher math performance in a modest yet fairly consistent way. Future research may be productive to separately study individual states and integrate the findings onto the national level.
Light-Cone Quantization of Gauge Fields
Gary McCartor,David G. Robertson
Physics , 1993, DOI: 10.1007/BF01560250
Abstract: Light-cone quantization of gauge field theory is considered. With a careful treatment of the relevant degrees of freedom and where they must be initialized, the results obtained in equal-time quantization are recovered, in particular the Mandelstam-Leibbrandt form of the gauge field propagator. Some aspects of the ``discretized'' light-cone quantization of gauge fields are discussed.
The Mandelstam-Leibbrandt Prescription in Light-Cone Quantized Gauge Theories
Gary McCartor,David G. Robertson
Physics , 1995, DOI: 10.1007/BF01566681
Abstract: Quantization of gauge theories on characteristic surfaces and in the light-cone gauge is discussed. Implementation of the Mandelstam-Leibbrandt prescription for the spurious singularity is shown to require two distinct null planes, with independent degrees of freedom initialized on each. The relation of this theory to the usual light-cone formulation of gauge field theory, using a single null plane, is described. A connection is established between this formalism and a recently given operator solution to the Schwinger model in the light-cone gauge.
A Consistency Relation for Single-Field Inflation with Power Spectrum Oscillations
Mark G. Jackson,Gary Shiu
Physics , 2013, DOI: 10.1103/PhysRevD.88.123511
Abstract: We derive a theoretical upper bound on the oscillation frequency in the scalar perturbation power spectrum of single-field inflation. Oscillations are most naturally produced by modified vacua with varying phase. When this phase changes rapidly, it induces strong interactions between the scalar fluctuations. If the interactions are sufficiently strong the theory cannot be evaluated using perturbation theory, hence imposing a limit on the oscillation frequency. This complements the bound found by Weinberg governing the validity of effective field theory. The generalized consistency relation also allows one to use squeezed configurations of higher-point correlations to place constraints on the power spectrum oscillations.
“Medioglycaemia”: A new concept in glycaemic control in intensive care (ICU) units?  [PDF]
Victoria H. Tomlinson, Jane Langley, Andrew G. Meal, Gary G. Adams
Journal of Diabetes Mellitus (JDM) , 2012, DOI: 10.4236/jdm.2012.24056
Abstract: Introduction: Critically ill patients can experience stress-induced hyperglycaemia. Glycaemic control therapy (GCT) is administered to control patients’ blood glycaemic levels and reduce the incidence of infection, myocardial infarctions and organ failure. However, there are many factors influencing the effectiveness of glycaemic control for patients. This investigation aimed to review the method of Glycaemic Control Therapy (GCT) used in two hospital settings, to assess the effectiveness of glycaemic control on patients’ blood glycaemic levels and examine any barriers that may be in place. Method: A retnrospective audit was carried out on patients’ case notes in Intensive Care Units (ICU) within the East Midlands, UK. This method prevents the study outcomes being swayed because GCT has already taken place. To reduce selection bias the most recent available case notes were selected. All the patients who were admitted to these adult ICU’s between March and April 2010 had their case notes examined, those who were administered GCT were included in the study, this involved 79 from Hospital A and 50 from Hospital B. The patients’ notes were retrospectively audited. Results: Different glycaemic control protocols were being implemented in each hospital, despite both belonging to the same ICU network. In most incidences, regardless of age, diabetes status or diagnosis, patients were administered the same sliding scale insulin (SSI). It was also found that GCT commenced for 41.9% (n = 52) of ICU patients (across both Hospitals) when glycaemic levels were below the established threshold of 10mmol/L. Additionally, a new glycaemic range has been discovered, where 88.3% (n = 113) of patients (across both Hospitals) receiving GCT were not controlled in hypoglycaemia, normoglycaemia or hyperglycaemia. They had mean blood glycaemic levels maintained between 5.6 - 9.9 mmol/L, now being described as medioglycaemia. Conclusions: The majority of patients receiving GCT were controlled in medioglycaemia and therefore a new comprehensive guideline needs to be developed incorporating this new range. Recommendations also need to be established to adapt the titration regimen to individual patients, to improve the effectiveness and safety of glycaemic control.
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