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Search Results: 1 - 10 of 464666 matches for " Gary A. McGilvary "
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V-BOINC: The Virtualization of BOINC
Gary A. McGilvary,Adam Barker,Ashley Lloyd,Malcolm Atkinson
Computer Science , 2013,
Abstract: The Berkeley Open Infrastructure for Network Computing (BOINC) is an open source client-server middleware system created to allow projects with large computational requirements, usually set in the scientific domain, to utilize a technically unlimited number of volunteer machines distributed over large physical distances. However various problems exist deploying applications over these heterogeneous machines using BOINC: applications must be ported to each machine architecture type, the project server must be trusted to supply authentic applications, applications that do not regularly checkpoint may lose execution progress upon volunteer machine termination and applications that have dependencies may find it difficult to run under BOINC. To solve such problems we introduce virtual BOINC, or V-BOINC, where virtual machines are used to run computations on volunteer machines. Application developers can then compile their applications on a single architecture, checkpointing issues are solved through virtualization API's and many security concerns are addressed via the virtual machine's sandbox environment. In this paper we focus on outlining a unique approach on how virtualization can be introduced into BOINC and demonstrate that V-BOINC offers acceptable computational performance when compared to regular BOINC. Finally we show that applications with dependencies can easily run under V-BOINC in turn increasing the computational potential volunteer computing offers to the general public and project developers.
Enhanced Usability of Managing Workflows in an Industrial Data Gateway
Gary A. McGilvary,Malcolm Atkinson,Sandra Gesing,Alvaro Aguilera,Richard Grunzke,Eva Sciacca
Computer Science , 2015,
Abstract: The Grid and Cloud User Support Environment (gUSE) enables users convenient and easy access to grid and cloud infrastructures by providing a general purpose, workflow-oriented graphical user interface to create and run workflows on various Distributed Computing Infrastructures (DCIs). Its arrangements for creating and modifying existing workflows are, however, non-intuitive and cumbersome due to the technologies and architecture employed by gUSE. In this paper, we outline the first integrated web-based workflow editor for gUSE with the aim of improving the user experience for those with industrial data workflows and the wider gUSE community. We report initial assessments of the editor's utility based on users' feedback. We argue that combining access to diverse scalable resources with improved workflow creation tools is important for all big data applications and research infrastructures.
C2MS: Dynamic Monitoring and Management of Cloud Infrastructures
Gary A. McGilvary,Josep Rius,í?igo Goiri,Francesc Solsona,Adam Barker,Malcolm Atkinson
Computer Science , 2013,
Abstract: Server clustering is a common design principle employed by many organisations who require high availability, scalability and easier management of their infrastructure. Servers are typically clustered according to the service they provide whether it be the application(s) installed, the role of the server or server accessibility for example. In order to optimize performance, manage load and maintain availability, servers may migrate from one cluster group to another making it difficult for server monitoring tools to continuously monitor these dynamically changing groups. Server monitoring tools are usually statically configured and with any change of group membership requires manual reconfiguration; an unreasonable task to undertake on large-scale cloud infrastructures. In this paper we present the Cloudlet Control and Management System (C2MS); a system for monitoring and controlling dynamic groups of physical or virtual servers within cloud infrastructures. The C2MS extends Ganglia - an open source scalable system performance monitoring tool - by allowing system administrators to define, monitor and modify server groups without the need for server reconfiguration. In turn administrators can easily monitor group and individual server metrics on large-scale dynamic cloud infrastructures where roles of servers may change frequently. Furthermore, we complement group monitoring with a control element allowing administrator-specified actions to be performed over servers within service groups as well as introduce further customized monitoring metrics. This paper outlines the design, implementation and evaluation of the C2MS.
Ad hoc Cloud Computing: From Concept to Realization
Gary Andrew McGilvary,Adam Barker,Malcolm Atkinson
Computer Science , 2015,
Abstract: This paper presents the first complete, integrated and end-to-end solution for ad hoc cloud computing environments. Ad hoc clouds harvest resources from existing sporadically available, non-exclusive (i.e. primarily used for some other purpose) and unreliable infrastructures. In this paper we discuss the problems ad hoc cloud computing solves and outline our architecture which is based on BOINC.
Improved Solid-Phase Peptide Synthesis of Wild-Type and Phosphorylated Phospholamban Using a Pseudoproline Dipeptide  [PDF]
Shadi Abu-Baker, Gary A. Lorigan
Open Journal of Synthesis Theory and Applications (OJSTA) , 2012, DOI: 10.4236/ojsta.2012.12002
Abstract: In this study, we report that the insertion of a pseudoproline dipeptide for the solid-phase peptide synthesis of wild-type Phospholamban protein (WT-PLB) has two important advantages. First, it disrupts the formation of different secondary structures, which is responsible for poor couplings during the preparation of highly aggregated sequences. Second, it enhances the purities and solubility of crude products leading to easier HPLC purification.
Solid-State NMR Spectroscopic Approaches to Investigate Dynamics, Secondary Structure and Topology of Membrane Proteins  [PDF]
Shadi Abu-Baker, Gary A. Lorigan
Open Journal of Biophysics (OJBIPHY) , 2012, DOI: 10.4236/ojbiphy.2012.24014
Abstract: Solid-state NMR spectroscopy is routinely used to determine the structural and dynamic properties of both membrane proteins and peptides in phospholipid bilayers [1-26]. From the perspective of the perpetuated lipids, 2H solid-state NMR spectroscopy can be used to probe the effect of embedded proteins on the order and dynamics of the acyl chains of phospholipid bilayers [8-13]. Moreover, 31P solid-state NMR spectroscopy can be used to investigate the interaction of peptides, proteins and drugs with phospholipid head groups [11-14]. The secondary structure of 13C = O site-specific isotopically labeled peptides or proteins inserted into lipid bilayers can be probed utilizing 13C CPMAS solid-state NMR spectroscopy [15-18]. Also, solid-state NMR spectroscopic studies can be utilized to ascertain pertinent informa- tion on the backbone and side-chain dynamics of 2H- and 15N-labeled proteins, respectively, in phospholipid bilayers [19-26]. Finally, specific 15N-labeled amide sites on a protein embedded inside oriented bilayers can be used to probe the alignment of the helices with respect to the bilayer normal [2]. A brief summary of all these solid-state NMR ap- proaches are provided in this minireview.
Anatomic and functional leg-length inequality: A review and recommendation for clinical decision-making. Part II, the functional or unloaded leg-length asymmetry
Gary A Knutson
Chiropractic & Manual Therapies , 2005, DOI: 10.1186/1746-1340-13-12
Abstract: Online databases: Medline, CINAHL and Mantis. Plus library searches for the time frame of 1970–2005 were done using the term "leg-length inequality".The evidence suggests that an unloaded leg-length asymmetry is a different phenomenon than an anatomic leg-length inequality, and may be due to suprapelvic muscle hypertonicity. Anatomic leg-length inequality and unloaded functional or leg-length alignment asymmetry may interact in a loaded (standing) posture, but not in an unloaded (prone/supine) posture.The unloaded, functional leg-length alignment asymmetry is a likely phenomenon, although more research regarding reliability of the measurement procedure and validity relative to spinal dysfunction is needed. Functional leg-length alignment asymmetry should be eliminated before any necessary treatment of anatomic LLI.In Part I of this review, the literature regarding the prevalence, magnitude, effects and clinical significance of anatomic leg-length inequality (LLI) was examined. Using data on leg-length inequality obtained by accurate and reliable x-ray methods, the prevalence of anatomic inequality was found to be 90%; the mean was 5.2 mm (SD 4.1). The evidence suggested that, for most people, anatomic leg-length inequality is not clinically significant until the magnitude reaches ~20 mm (~3/4"). The phenomenon of the functional "short leg" will be considered in Part II of this review. The objective is to define functional "short leg", how it differs from anatomic LLI and explore any association with neuromuscular dysfunction. In addition we will review the apparent efficacy of heel lifts in some cases of mild anatomic LLI, plus muscular reactions to, and causes of, pelvic torsion.The functional short leg, or unloaded leg-length alignment asymmetry (hereafter abbreviated as LLAA) is itself a phenomenon much discussed and little understood. Essentially, when a subject lies prone or supine, unloading the pelvis, the feet are examined, most often at the welt (heel-sole
Anatomic and functional leg-length inequality: A review and recommendation for clinical decision-making. Part I, anatomic leg-length inequality: prevalence, magnitude, effects and clinical significance
Gary A Knutson
Chiropractic & Manual Therapies , 2005, DOI: 10.1186/1746-1340-13-11
Abstract: Online database – Medline, CINAHL and MANTIS – and library searches for the time frame of 1970–2005 were done using the term "leg-length inequality".Using data on leg-length inequality obtained by accurate and reliable x-ray methods, the prevalence of anatomic inequality was found to be 90%, the mean magnitude of anatomic inequality was 5.2 mm (SD 4.1). The evidence suggests that, for most people, anatomic leg-length inequality does not appear to be clinically significant until the magnitude reaches ~ 20 mm (~3/4").Anatomic leg-length inequality is near universal, but the average magnitude is small and not likely to be clinically significant.Leg-length inequality (LLI) is a topic that seemingly has been exhaustively examined; yet much is left to be understood. Reviews by Mannello [1] and Gurney [2] on leg-length inequality and Cooperstein and Lisi on pelvic torsion [3] are highly recommended as sources to provide expanded and longer time-frame background information on this topic. The information provided by these authors, however extensive, is incomplete relative to clinical decision-making. Further, several questions have remained largely unanswered regarding anatomic leg-length inequality and the so-called functional short leg, or more accurately, unloaded leg-length alignment asymmetry (LLAA). These include: how common is anatomic LLI, what is the average amount of anatomic LLI, what are the effects of anatomic LLI, how much anatomic LLI is necessary to be clinically significant, and what are the incidental and functional relationships of anatomic LLI to unloaded leg-length alignment asymmetry? The purpose of this review is to highlight current research to answer these questions and help in clinical decision-making.In the 1970's studies began to show that clinical measurements of LLI were inaccurate and the use of x-ray, controlling for magnification and distortion, was necessary [4-6]. By 1980 the accuracy of the measurements with the standing x-ray had been es
Limits of policy intervention in a world of neoliberal mechanism designs: Paradoxes of the global crisis
Dymski Gary A.
Panoeconomicus , 2011, DOI: 10.2298/pan1103285d
Abstract: The current global context poses several paradoxes: the recovery from the 2009 recession was not a recovery; investment, normally driven by profit rates, is lagging and not leading economic activity; the crisis is global but debate involves sub-global levels; and public safety-nets, which have helped to stabilize national income, are being cut. These paradoxes can be traced, in part, to the impact of the “truce” that followed the Keynesian-Monetarist controversy on economists’ ideas about policy activism. This implicit “truce” has removed activist macro policy from discussion, and shifted attention toward institutions as mechanisms for solving game-theoretic coordination problems. Policy activism then centers on how the “agents” (nations) can achieve optimal use of their available resources (or optimal access to resources) at the global level; and this involves creating and fine-tuning compacts - neoliberal mechanism designs - that can capture rents and attract globally mobile capital. This approach leads economists to see the key problem in the current global crisis as fixing broken neoliberal mechanisms. However, a global economy dominated by mechanisms that feed on aggregate demand without generating it faces the prospect of stagnation or collapse.
Distance Learning in Higher Education
Gary A. Berg
Education Policy Analysis Archives , 1998,
Abstract: The Western Governors University (WGU) and the California Virtual University (CVU) are revealing examples of the complex issues involved in implementing distance learning on the public policy level. Although technology is certainly important, it has masked the fact that the WGU and CVU initiatives mark the rise of learner-centered higher education and the increased role of business in the academy. In comparing and contrasting WGU and CVU, it is clear that the WGU is a more radical proposition because of competency-based credit and the connection with private industry. Two important issues driving public policy are raised in these two efforts: First, are the California and Western Governors Association initiatives the product of the commercialization of education or the result of a reform of higher education that may lead to an increased learner-centered orientation? Second, what is the appropriate role of private industry in higher education?
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