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Search Results: 1 - 10 of 224604 matches for " Garg R "
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Garg R
Annals of Thoracic Medicine , 2011,
Abstract:
Visual loss with papilloedema in Guillian-Barrei- Syndrome
Garg R
Neurology India , 2003,
Abstract:
Medical management of neurocysticercosis.
Garg R
Neurology India , 2001,
Abstract: Neurocysticercosis is the most common parasitic disease of the central nervous system. Praziquantel and albendazole, the two antiparasitic drugs, have been reported to be effective against cysticercosis. Both the drugs effectively destroy the cerebral parenchymal cystic lesions. However, albendazole is possibly more effective in subarachnoidal, ventricular and spinal forms of cysticercosis, and frequently obviates the need for surgery. Initially, longer courses of albendazole and praziquantel had been advocated. Now even shorter treatment regimens are found equally effective. Complete course of praziquantel therapy can be administered in a single day with comparable efficacy instead of conventional treatment of 15 days. Similarly, one week therapy of albendazole is as effective as 30 days′ treatment regimen. Recently, there is an intense debate whether anticysticercal treatment is useful and safe. Opponents of anticysticercal therapy argue that effectiveness of therapy is possibly a reflection of natural course of the disease. It has been observed that even if cysticercal lesions are left untreated, they either disappear spontaneously or calcify. Anticysticercal therapy is potentially risky, it may aggravate cerebral oedema, and may produce vasculitis and stroke, and several deaths have also been reported. To minimise these risks, concomitant corticosteroids should be administered especially, if there is a massive parasitic load. It is better to avoid anticysticercal treatment in patients with cysticercotic encephalitis. Doubts have been expressed that anticysticercal therapy really affects ultimate long-term clinical outcomes (e.g. control of seizure and possibility of seizure free state after discontinuation of antiepileptic drugs). So far, definite evidences in this regard, based on finding of well planned placebo-controlled studies, are lacking and an opinion that, there is an urgent need for such a study, has been expressed. Measures for effective prevention like provision for safe drinking water and safe excreta disposal should be emphasisfxed.
RS-GIS Based Assessment of River Dynamics of Brahmaputra River in India  [PDF]
Archana Sarkar, R. D. Garg, Nayan Sharma
Journal of Water Resource and Protection (JWARP) , 2012, DOI: 10.4236/jwarp.2012.42008
Abstract: The Brahmaputra River is one of the largest alluvial rivers in the world characterized by frequent bank erosion leading to channel pattern changes and shifting of bank line. This study is aimed at quantifying the actual bank erosion/deposi- tion along the Brahmaputra River within India for a period of eighteen years (1990-2008). The entire course of Brah- maputra River in Assam from upstream of Dibrugarh up to the town Dhubri near Bangladesh border for a stretch of around 620 kms has been studied using an integrated approach of Remote Sensing and Geographical Information Sys- tem (GIS). The channel configuration of the Brahmaputra River has been mapped for the years 1990 and 2008 using IRS 1A LISS-I, and IRS-P6 LISS-III satellite images respectively. The analysis of satellite data has provided not only the information on the channel configuration of the river system on repetitive basis but also has brought out several sig- nificant facts about the changes in river morphology, stable and unstable reaches of the river banks and changes in the main channel. The results provide latest and reliable information on the dynamic fluvio-geomorphology of the Brah- maputra River for designing and implementation of drainage development programmes and erosion control schemes in the north eastern region of the country.
Possible nitric oxide modulation in the protective effect of trazodone against sleep deprivation-induced anxiety like behavior and oxidative damage in mice
A Kumar, R Garg
International Journal of Health Research , 2008,
Abstract: Purpose: The present study was designed to explore the possible nitric oxide modulation in the protective effect of trazodone against sleep deprivation-induced behavioral alterations and oxidative damage in mice. Methods: In a controlled study, sleep deprivation was induced in 10 groups of mice (6 in each group) for 72 hr by using grid suspended over water method. Trazodone (5 and 10 mg/kg, ip), L-arginine (50 mg/kg, ip), L-NAME (10 mg/kg, ip) and methylene blue (10 mg/kg, i.p) were administered for 5 days, 2 days prior to the 72 hr sleep deprivation. Various behavioral tests (plus maze, zero maze, mirror chamber, actophotometer) followed by oxidative stress parameters (malondialdehyde level, reduced glutathione, catalase, nitrite and protein) were assessed in the animals. Results: The trazodone treatment significantly indcued anti-anxiety like effect, improved locomotor activity and antioxidant effect as indicated by reduced lipid peroxidation, nitrite concentration and restoration of depleted reduced glutathione and catalase activity. Further, prior treatment of the animals with L-NAME and methylene blue potentiated the protective effect of trazodone (5 mg/kg) (p<0.05). However, L-arginine combined with trazodone (5mg/kg) reversed the protective effect of trazodone (p<0.05). Conclusion: Results of present study suggest that NO modulation is involved in the protective effect of trazodone against sleep deprivation-induced anxiety like behavior and oxidative damage in mice.
Progress in Controlled Gastroretentive Delivery Systems
R Garg, GD Gupta
Tropical Journal of Pharmaceutical Research , 2008,
Abstract: Controlled release (CR) dosage forms have been extensively used to improve therapy with several important drugs. However, the development processes are faced with several physiological difficulties such as the inability to restrain and localize the system within the desired region of the gastrointestinal tract and the highly variable nature of the gastric emptying process. This variability may lead to unpredictable bioavailability and times to achieve peak plasma levels. On the other hand, incorporation of the drug in a controlled release gastroretentive dosage forms (CR-GRDF) which can remain in the gastric region for several hours would significantly prolong the gastric residence time of drugs and improve bioavailability, reduce drug waste, and enhance the solubility of drugs that are less soluble in high pH environment. Gastroretention would also facilitate local drug delivery to the stomach and proximal small intestine. Thus, gastroretention could help to provide greater availability of new products and consequently improved therapeutic activity and substantial benefits to patients. Controlled gastric retention of solid dosage form may be achieved by the mechanisms of floatation, mucoadhesion, sedimentation, expansion or by a modified shaped system. The purpose of this paper is to review the recent literature and current technology used in the development of gastroretentive dosage forms.
Progressive increase in cavitation with the evolution of fungus ball: A clue to the diagnosis of chronic necrotizing pulmonary aspergillosis
Prasad R,Garg Sanjay
Lung India , 2009,
Abstract: Chronic necrotizing pulmonary aspergillosis (CNPA) is an uncommon pulmonary infection seen in the patients with chronic obstructive pulmonary disease, bronchiectasis, pneumoconiosis, diabetes mellitus, alcoholism, poor nutrition or low dose corticosteroid therapy. Here, we are presenting a case of CNPA with diabetes mellitus that was misdiagnosed as pulmonary tuberculosis.
Scope of dacryocystorhinostomy
Saxena R,Garg K
Indian Journal of Ophthalmology , 1969,
Abstract:
Probiotics
Gupta V,Garg R
Indian Journal of Medical Microbiology , 2009,
Abstract: The term "probiotic" was first used in 1965, by Lilly and Stillwell, to describe substances secreted by one organism which stimulate the growth of another. The use of antibiotics, immunosuppressive therapy and irradiation, amongst other means of treatment, may cause alterations in the composition and have an effect on the GIT flora. Therefore, the introduction of beneficial bacterial species to GI tract may be a very attractive option to re-establish the microbial equilibrium and prevent disease. Prebiotic is a non-digestible food ingredient that confers benefits on the host by selectively stimulating one bacterium or a group of bacteria in the colon with probiotic properties. Both probiotics and prebiotics are together called as Synbiotics. Various bacterial genera most commonly used in probiotic preparations are Lactobacillus, Bifidobacterium, Escherichia, Enterococcus, Bacillus and Streptococcus . Some fungal strains belonging to Saccharomyces have also been used. Probiotics have been shown to be effective in varied clinical conditions- ranging from infantile diarrhoea, necrotizing enterocolitis, antibiotic-associated diarrhoea, relapsing Clostridium difficle colitis, Helicobacter pylori infections, inflammatory bowel disease to cancer, female uro-genital infection and surgical infections. Lactobacillus rhamnosus strain GG has proven beneficial affects on intestinal immunity. It increases the number of IgA and other immunoglobulins secreting cells in the intestinal mucosa. It also stimulates local release of interferons. It facilitates antigen transport to underlying lymphoid cells, which serves to increase antigen uptake in Peyer′s patches. Probiotics are live microorganisms, so it is possible that they may result in infection in the host. The risk and morbidity of sepsis due to probiotic bacteria should be weighed against the potential for sepsis due to more pathological bacteria and the morbidity of diseases for which probiotic bacteria are being used as therapeutic agents. Also, future, well-designed placebo controlled studies with validated results are required for ascertaining the true health benefits of probiotics The important point in this regard is careful selection of the probiotic agent, its dose standardization and a thorough knowledge of its beneficial effects.
Cytopathological study of cervical smears and corelation of findings with risk factors
Bhojani KR, Garg R
International Journal of Biological and Medical Research , 2011,
Abstract: Cervical malignancy is the second most common cancer in women worldwide, In present study, results of 400 Pap smears are analyzed ,which had been examined in cytology section (Department of Pathology, P.D.U. Medical College, Rajkot) during 2 years time duration (2009-2010). All cervical smears collected and stained by Pap staining method. The smears were reported using The Bethesda system 2001. The commonest complaints observed during study were abnormal vaginal discharge (46.5%) and menstrual abnormalities (20.5%). According to classification of smears by Bethesda system, 18(4.5%) were unsatisfactory, 148(37%) were normal, 07(1.25%) had atrophic changes, 190(47.5%) were inflammatory, 03(0.75%) were ASCUS, 20(5%) were LSIL, 11(2.75%) were HSIL and 03(0.75%) were squamous cell carcinoma. , majority patients had 2 children 144(36%) and study showed that high parity was associated with higher occurrence of premalignant and malignant lesions of cervix. Pap smear is a simple, cheap, safe and practical diagnostic tool for early detection of cervical cancer in high risk group population and therefore should be established as routine screening procedure. It is recommended that reporting should be done by The Bethesda System as it improves the reproducibility and helps in identification of ASCUS and AGUS lesions and plays a key role to diagnose various intraepithelial lesions and invasive lesions at an early stage and manage them properly.
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